In situ protocol for the detemination of dose-response effect of low-fluoride dentifrices on enamel remineralization

• Autor(a) principal: Afonso, Rebeca Lima [UNESP]
• Data de Publicação: 2013
• Outros Autores: Pessan, Juliano Pelim [UNESP], Igreja, Bruna Babler [UNESP], Cantagallo, Camila Fernandes [UNESP], Danelon, Marcelle [UNESP], Delbem, Alberto Carlos Botazzo [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/1679-775720130309; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572013000600525&lng=en&nrm=iso&tlng=en; http://hdl.handle.net/11449/112457
• topic: Dentifrices; Dental enamel; Fluorides; Tooth remineralization

No in situ protocol has assessed the dose-response effects of fluoride dentifrices involving low-fluoride formulations. Objective: To assess the ability of an in situ remineralization model in determining dose-response effects of dentifrices containing low fluoride concentrations ([F]) on bovine enamel. Material and Methods: Volunteers wore palatal appliances containing demineralized enamel blocks and brushed their teeth and devices with the dentifrices supplied (double-blind, crossover protocol) separately for 3 and 7 days. Surface hardness (SH), integrated subsurface hardness (AKHN) and [F] in enamel were determined. Data were analyzed by ANOVA, Tukey's test and Pearson's correlation (p<0.05). Results: Dose-response relationships were verified between [F] in dentifrices and SH, AKHN and enamel [F]. Higher correlation coefficients between enamel [F] and SH and AKHN were obtained for the 3-day period. Significant differences in SH and AKHN were observed among all groups for the 3-day period, but not between 0-275, 275-550, and 550-1,100 mu g F/g dentifrices for the 7-day period, nor between 3- and 7-day periods for the 1,100 mu g F/g groups. Conclusions: Considering that the peak remineralization capacity of the conventional dentifrice (1,100 mu g F/g) was achieved in 3 days, this experimental period could be used in future studies assessing new dentifrice formulations, especially at low-fluoride concentrations.