Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model

Detalhes bibliográficos
Autor(a) principal: Marcos, Caroline Maria [UNESP]
Data de Publicação: 2019
Outros Autores: de Oliveira, Haroldo Cesar [UNESP], Assato, Patricia Akemi [UNESP], de Andrade, Cleverton Roberto [UNESP], Fusco-Almeida, Ana Marisa [UNESP], Mendes-Giannini, Maria José Soares [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1093/mmy/myy112
http://hdl.handle.net/11449/189646
Resumo: The Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and triggered the formation of fewer granulomas by lowering the fungal burden in the lungs. Additionally, the Pb14-3-3 aRNA showed more elongated yeast cells and less ability to induce pneumocytes apoptosis in vitro. Our results show that 14-3-3 is an important virulence factor in P. brasiliensis-induced pulmonary infection.
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spelling Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine modelParacoccidioides brasiliensis: 14-3-3 proteinpneumocytes apoptosisvirulence in murine modelThe Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and triggered the formation of fewer granulomas by lowering the fungal burden in the lungs. Additionally, the Pb14-3-3 aRNA showed more elongated yeast cells and less ability to induce pneumocytes apoptosis in vitro. Our results show that 14-3-3 is an important virulence factor in P. brasiliensis-induced pulmonary infection.Universidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Departamento de Análises Clínicas Laboratório de Micologia Clinica, Campus AraraquaraUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araraquara Departamento de Fisiologia e PatologiaUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Departamento de Análises Clínicas Laboratório de Micologia Clinica, Campus AraraquaraUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araraquara Departamento de Fisiologia e PatologiaUniversidade Estadual Paulista (Unesp)Marcos, Caroline Maria [UNESP]de Oliveira, Haroldo Cesar [UNESP]Assato, Patricia Akemi [UNESP]de Andrade, Cleverton Roberto [UNESP]Fusco-Almeida, Ana Marisa [UNESP]Mendes-Giannini, Maria José Soares [UNESP]2019-10-06T16:47:22Z2019-10-06T16:47:22Z2019-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article900-904http://dx.doi.org/10.1093/mmy/myy112Medical mycology, v. 57, n. 7, p. 900-904, 2019.1460-2709http://hdl.handle.net/11449/18964610.1093/mmy/myy1122-s2.0-8507214805124026829697768750000-0001-7015-7175Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedical mycologyinfo:eu-repo/semantics/openAccess2024-09-27T14:04:47Zoai:repositorio.unesp.br:11449/189646Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-27T14:04:47Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model
title Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model
spellingShingle Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model
Marcos, Caroline Maria [UNESP]
Paracoccidioides brasiliensis: 14-3-3 protein
pneumocytes apoptosis
virulence in murine model
title_short Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model
title_full Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model
title_fullStr Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model
title_full_unstemmed Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model
title_sort Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model
author Marcos, Caroline Maria [UNESP]
author_facet Marcos, Caroline Maria [UNESP]
de Oliveira, Haroldo Cesar [UNESP]
Assato, Patricia Akemi [UNESP]
de Andrade, Cleverton Roberto [UNESP]
Fusco-Almeida, Ana Marisa [UNESP]
Mendes-Giannini, Maria José Soares [UNESP]
author_role author
author2 de Oliveira, Haroldo Cesar [UNESP]
Assato, Patricia Akemi [UNESP]
de Andrade, Cleverton Roberto [UNESP]
Fusco-Almeida, Ana Marisa [UNESP]
Mendes-Giannini, Maria José Soares [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Marcos, Caroline Maria [UNESP]
de Oliveira, Haroldo Cesar [UNESP]
Assato, Patricia Akemi [UNESP]
de Andrade, Cleverton Roberto [UNESP]
Fusco-Almeida, Ana Marisa [UNESP]
Mendes-Giannini, Maria José Soares [UNESP]
dc.subject.por.fl_str_mv Paracoccidioides brasiliensis: 14-3-3 protein
pneumocytes apoptosis
virulence in murine model
topic Paracoccidioides brasiliensis: 14-3-3 protein
pneumocytes apoptosis
virulence in murine model
description The Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and triggered the formation of fewer granulomas by lowering the fungal burden in the lungs. Additionally, the Pb14-3-3 aRNA showed more elongated yeast cells and less ability to induce pneumocytes apoptosis in vitro. Our results show that 14-3-3 is an important virulence factor in P. brasiliensis-induced pulmonary infection.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T16:47:22Z
2019-10-06T16:47:22Z
2019-10-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1093/mmy/myy112
Medical mycology, v. 57, n. 7, p. 900-904, 2019.
1460-2709
http://hdl.handle.net/11449/189646
10.1093/mmy/myy112
2-s2.0-85072148051
2402682969776875
0000-0001-7015-7175
url http://dx.doi.org/10.1093/mmy/myy112
http://hdl.handle.net/11449/189646
identifier_str_mv Medical mycology, v. 57, n. 7, p. 900-904, 2019.
1460-2709
10.1093/mmy/myy112
2-s2.0-85072148051
2402682969776875
0000-0001-7015-7175
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Medical mycology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 900-904
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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