Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index

Detalhes bibliográficos
Autor(a) principal: Pereira, Guilherme L. [UNESP]
Data de Publicação: 2016
Outros Autores: Matteis, Rafael de [UNESP], Meira, Camila Tangari, Regitano, Luciana C. A., Silva, Josineudson Augusto V., Chardulo, Luis Arthur L., Curi, Rogerio A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.jevs.2015.07.001
http://hdl.handle.net/11449/158781
Resumo: Different selection objectives within the Quarter Horse breed led to the formation of groups with distinct skills, including the racing and cutting lines. With a smaller population size in Brazil, but of great economic representativeness, the racing line is characterized by animals that can reach high speeds over short distances and within a short period of time. The cutting line is destined for functional tests, exploring skills such as agility and obedience. Although the athletic performance of horses is likely to be influenced by a large number of genes, few genetic variants have so far been related to this trait and this was done exclusively in Thoroughbreds, including the g.38973231G>A single nucleotide polymorphism in the PDK4 gene and the g.22684390C>T single-nucleotide polymorphism in the COX412 gene. The results of the present study demonstrate the presence of polymorphic PDK4 and COX412 genes in Quarter Horses. The analysis of 296 racing animals and 68 cutting animals revealed significant differences in allele and genotype frequencies between the two lines. The same was not observed when these frequencies were compared between extreme racing performance phenotypes. There were also no significant associations between alleles of the two polymorphisms and the speed index. These results suggest that the alleles of the PDK4 and COX412 genes, which are related to better racecourse performance in Thoroughbreds, are probably associated with beneficial adaptations in aerobic metabolism and therefore play secondary roles in sprint racing performance in Quarter Horses, which is mainly anaerobic. (C) 2016 Elsevier Inc. All rights reserved.
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spelling Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed IndexCandidate geneEquinePolymorphismQTLSIDifferent selection objectives within the Quarter Horse breed led to the formation of groups with distinct skills, including the racing and cutting lines. With a smaller population size in Brazil, but of great economic representativeness, the racing line is characterized by animals that can reach high speeds over short distances and within a short period of time. The cutting line is destined for functional tests, exploring skills such as agility and obedience. Although the athletic performance of horses is likely to be influenced by a large number of genes, few genetic variants have so far been related to this trait and this was done exclusively in Thoroughbreds, including the g.38973231G>A single nucleotide polymorphism in the PDK4 gene and the g.22684390C>T single-nucleotide polymorphism in the COX412 gene. The results of the present study demonstrate the presence of polymorphic PDK4 and COX412 genes in Quarter Horses. The analysis of 296 racing animals and 68 cutting animals revealed significant differences in allele and genotype frequencies between the two lines. The same was not observed when these frequencies were compared between extreme racing performance phenotypes. There were also no significant associations between alleles of the two polymorphisms and the speed index. These results suggest that the alleles of the PDK4 and COX412 genes, which are related to better racecourse performance in Thoroughbreds, are probably associated with beneficial adaptations in aerobic metabolism and therefore play secondary roles in sprint racing performance in Quarter Horses, which is mainly anaerobic. (C) 2016 Elsevier Inc. All rights reserved.Fundação para o Desenvolvimento da UNESP (FUNDUNESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Estadual Paulista, Fac Ciencias Agr & Vet, Sao Paulo, BrazilUniv Estadual Paulista, Fac Med Vet & Zootecnia, BR-18618970 Sao Paulo, BrazilEmpresa Brasileira Pesquisa Agr, Embrapa Pecuaria Sudeste, Sao Paulo, BrazilUniv Estadual Paulista, Fac Ciencias Agr & Vet, Sao Paulo, BrazilUniv Estadual Paulista, Fac Med Vet & Zootecnia, BR-18618970 Sao Paulo, BrazilElsevier B.V.Universidade Estadual Paulista (Unesp)Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Pereira, Guilherme L. [UNESP]Matteis, Rafael de [UNESP]Meira, Camila TangariRegitano, Luciana C. A.Silva, Josineudson Augusto V.Chardulo, Luis Arthur L.Curi, Rogerio A.2018-11-26T15:29:11Z2018-11-26T15:29:11Z2016-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-6application/pdfhttp://dx.doi.org/10.1016/j.jevs.2015.07.001Journal Of Equine Veterinary Science. New York: Elsevier Science Inc, v. 39, p. 1-6, 2016.0737-0806http://hdl.handle.net/11449/15878110.1016/j.jevs.2015.07.001WOS:000372942000001WOS000372942000001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Equine Veterinary Science0,390info:eu-repo/semantics/openAccess2023-12-23T06:15:56Zoai:repositorio.unesp.br:11449/158781Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:04:19.138096Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index
title Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index
spellingShingle Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index
Pereira, Guilherme L. [UNESP]
Candidate gene
Equine
Polymorphism
QTL
SI
title_short Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index
title_full Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index
title_fullStr Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index
title_full_unstemmed Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index
title_sort Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index
author Pereira, Guilherme L. [UNESP]
author_facet Pereira, Guilherme L. [UNESP]
Matteis, Rafael de [UNESP]
Meira, Camila Tangari
Regitano, Luciana C. A.
Silva, Josineudson Augusto V.
Chardulo, Luis Arthur L.
Curi, Rogerio A.
author_role author
author2 Matteis, Rafael de [UNESP]
Meira, Camila Tangari
Regitano, Luciana C. A.
Silva, Josineudson Augusto V.
Chardulo, Luis Arthur L.
Curi, Rogerio A.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.author.fl_str_mv Pereira, Guilherme L. [UNESP]
Matteis, Rafael de [UNESP]
Meira, Camila Tangari
Regitano, Luciana C. A.
Silva, Josineudson Augusto V.
Chardulo, Luis Arthur L.
Curi, Rogerio A.
dc.subject.por.fl_str_mv Candidate gene
Equine
Polymorphism
QTL
SI
topic Candidate gene
Equine
Polymorphism
QTL
SI
description Different selection objectives within the Quarter Horse breed led to the formation of groups with distinct skills, including the racing and cutting lines. With a smaller population size in Brazil, but of great economic representativeness, the racing line is characterized by animals that can reach high speeds over short distances and within a short period of time. The cutting line is destined for functional tests, exploring skills such as agility and obedience. Although the athletic performance of horses is likely to be influenced by a large number of genes, few genetic variants have so far been related to this trait and this was done exclusively in Thoroughbreds, including the g.38973231G>A single nucleotide polymorphism in the PDK4 gene and the g.22684390C>T single-nucleotide polymorphism in the COX412 gene. The results of the present study demonstrate the presence of polymorphic PDK4 and COX412 genes in Quarter Horses. The analysis of 296 racing animals and 68 cutting animals revealed significant differences in allele and genotype frequencies between the two lines. The same was not observed when these frequencies were compared between extreme racing performance phenotypes. There were also no significant associations between alleles of the two polymorphisms and the speed index. These results suggest that the alleles of the PDK4 and COX412 genes, which are related to better racecourse performance in Thoroughbreds, are probably associated with beneficial adaptations in aerobic metabolism and therefore play secondary roles in sprint racing performance in Quarter Horses, which is mainly anaerobic. (C) 2016 Elsevier Inc. All rights reserved.
publishDate 2016
dc.date.none.fl_str_mv 2016-04-01
2018-11-26T15:29:11Z
2018-11-26T15:29:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.jevs.2015.07.001
Journal Of Equine Veterinary Science. New York: Elsevier Science Inc, v. 39, p. 1-6, 2016.
0737-0806
http://hdl.handle.net/11449/158781
10.1016/j.jevs.2015.07.001
WOS:000372942000001
WOS000372942000001.pdf
url http://dx.doi.org/10.1016/j.jevs.2015.07.001
http://hdl.handle.net/11449/158781
identifier_str_mv Journal Of Equine Veterinary Science. New York: Elsevier Science Inc, v. 39, p. 1-6, 2016.
0737-0806
10.1016/j.jevs.2015.07.001
WOS:000372942000001
WOS000372942000001.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal Of Equine Veterinary Science
0,390
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1-6
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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