Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jevs.2015.07.001 http://hdl.handle.net/11449/158781 |
Resumo: | Different selection objectives within the Quarter Horse breed led to the formation of groups with distinct skills, including the racing and cutting lines. With a smaller population size in Brazil, but of great economic representativeness, the racing line is characterized by animals that can reach high speeds over short distances and within a short period of time. The cutting line is destined for functional tests, exploring skills such as agility and obedience. Although the athletic performance of horses is likely to be influenced by a large number of genes, few genetic variants have so far been related to this trait and this was done exclusively in Thoroughbreds, including the g.38973231G>A single nucleotide polymorphism in the PDK4 gene and the g.22684390C>T single-nucleotide polymorphism in the COX412 gene. The results of the present study demonstrate the presence of polymorphic PDK4 and COX412 genes in Quarter Horses. The analysis of 296 racing animals and 68 cutting animals revealed significant differences in allele and genotype frequencies between the two lines. The same was not observed when these frequencies were compared between extreme racing performance phenotypes. There were also no significant associations between alleles of the two polymorphisms and the speed index. These results suggest that the alleles of the PDK4 and COX412 genes, which are related to better racecourse performance in Thoroughbreds, are probably associated with beneficial adaptations in aerobic metabolism and therefore play secondary roles in sprint racing performance in Quarter Horses, which is mainly anaerobic. (C) 2016 Elsevier Inc. All rights reserved. |
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Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed IndexCandidate geneEquinePolymorphismQTLSIDifferent selection objectives within the Quarter Horse breed led to the formation of groups with distinct skills, including the racing and cutting lines. With a smaller population size in Brazil, but of great economic representativeness, the racing line is characterized by animals that can reach high speeds over short distances and within a short period of time. The cutting line is destined for functional tests, exploring skills such as agility and obedience. Although the athletic performance of horses is likely to be influenced by a large number of genes, few genetic variants have so far been related to this trait and this was done exclusively in Thoroughbreds, including the g.38973231G>A single nucleotide polymorphism in the PDK4 gene and the g.22684390C>T single-nucleotide polymorphism in the COX412 gene. The results of the present study demonstrate the presence of polymorphic PDK4 and COX412 genes in Quarter Horses. The analysis of 296 racing animals and 68 cutting animals revealed significant differences in allele and genotype frequencies between the two lines. The same was not observed when these frequencies were compared between extreme racing performance phenotypes. There were also no significant associations between alleles of the two polymorphisms and the speed index. These results suggest that the alleles of the PDK4 and COX412 genes, which are related to better racecourse performance in Thoroughbreds, are probably associated with beneficial adaptations in aerobic metabolism and therefore play secondary roles in sprint racing performance in Quarter Horses, which is mainly anaerobic. (C) 2016 Elsevier Inc. All rights reserved.Fundação para o Desenvolvimento da UNESP (FUNDUNESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Estadual Paulista, Fac Ciencias Agr & Vet, Sao Paulo, BrazilUniv Estadual Paulista, Fac Med Vet & Zootecnia, BR-18618970 Sao Paulo, BrazilEmpresa Brasileira Pesquisa Agr, Embrapa Pecuaria Sudeste, Sao Paulo, BrazilUniv Estadual Paulista, Fac Ciencias Agr & Vet, Sao Paulo, BrazilUniv Estadual Paulista, Fac Med Vet & Zootecnia, BR-18618970 Sao Paulo, BrazilElsevier B.V.Universidade Estadual Paulista (Unesp)Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Pereira, Guilherme L. [UNESP]Matteis, Rafael de [UNESP]Meira, Camila TangariRegitano, Luciana C. A.Silva, Josineudson Augusto V.Chardulo, Luis Arthur L.Curi, Rogerio A.2018-11-26T15:29:11Z2018-11-26T15:29:11Z2016-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-6application/pdfhttp://dx.doi.org/10.1016/j.jevs.2015.07.001Journal Of Equine Veterinary Science. New York: Elsevier Science Inc, v. 39, p. 1-6, 2016.0737-0806http://hdl.handle.net/11449/15878110.1016/j.jevs.2015.07.001WOS:000372942000001WOS000372942000001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Equine Veterinary Science0,390info:eu-repo/semantics/openAccess2023-12-23T06:15:56Zoai:repositorio.unesp.br:11449/158781Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:04:19.138096Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index |
title |
Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index |
spellingShingle |
Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index Pereira, Guilherme L. [UNESP] Candidate gene Equine Polymorphism QTL SI |
title_short |
Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index |
title_full |
Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index |
title_fullStr |
Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index |
title_full_unstemmed |
Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index |
title_sort |
Comparison of Sequence Variants in the PDK4 and COX412 Genes Between Racing and Cutting Lines of Quarter Horses and Associations With the Speed Index |
author |
Pereira, Guilherme L. [UNESP] |
author_facet |
Pereira, Guilherme L. [UNESP] Matteis, Rafael de [UNESP] Meira, Camila Tangari Regitano, Luciana C. A. Silva, Josineudson Augusto V. Chardulo, Luis Arthur L. Curi, Rogerio A. |
author_role |
author |
author2 |
Matteis, Rafael de [UNESP] Meira, Camila Tangari Regitano, Luciana C. A. Silva, Josineudson Augusto V. Chardulo, Luis Arthur L. Curi, Rogerio A. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) |
dc.contributor.author.fl_str_mv |
Pereira, Guilherme L. [UNESP] Matteis, Rafael de [UNESP] Meira, Camila Tangari Regitano, Luciana C. A. Silva, Josineudson Augusto V. Chardulo, Luis Arthur L. Curi, Rogerio A. |
dc.subject.por.fl_str_mv |
Candidate gene Equine Polymorphism QTL SI |
topic |
Candidate gene Equine Polymorphism QTL SI |
description |
Different selection objectives within the Quarter Horse breed led to the formation of groups with distinct skills, including the racing and cutting lines. With a smaller population size in Brazil, but of great economic representativeness, the racing line is characterized by animals that can reach high speeds over short distances and within a short period of time. The cutting line is destined for functional tests, exploring skills such as agility and obedience. Although the athletic performance of horses is likely to be influenced by a large number of genes, few genetic variants have so far been related to this trait and this was done exclusively in Thoroughbreds, including the g.38973231G>A single nucleotide polymorphism in the PDK4 gene and the g.22684390C>T single-nucleotide polymorphism in the COX412 gene. The results of the present study demonstrate the presence of polymorphic PDK4 and COX412 genes in Quarter Horses. The analysis of 296 racing animals and 68 cutting animals revealed significant differences in allele and genotype frequencies between the two lines. The same was not observed when these frequencies were compared between extreme racing performance phenotypes. There were also no significant associations between alleles of the two polymorphisms and the speed index. These results suggest that the alleles of the PDK4 and COX412 genes, which are related to better racecourse performance in Thoroughbreds, are probably associated with beneficial adaptations in aerobic metabolism and therefore play secondary roles in sprint racing performance in Quarter Horses, which is mainly anaerobic. (C) 2016 Elsevier Inc. All rights reserved. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-04-01 2018-11-26T15:29:11Z 2018-11-26T15:29:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jevs.2015.07.001 Journal Of Equine Veterinary Science. New York: Elsevier Science Inc, v. 39, p. 1-6, 2016. 0737-0806 http://hdl.handle.net/11449/158781 10.1016/j.jevs.2015.07.001 WOS:000372942000001 WOS000372942000001.pdf |
url |
http://dx.doi.org/10.1016/j.jevs.2015.07.001 http://hdl.handle.net/11449/158781 |
identifier_str_mv |
Journal Of Equine Veterinary Science. New York: Elsevier Science Inc, v. 39, p. 1-6, 2016. 0737-0806 10.1016/j.jevs.2015.07.001 WOS:000372942000001 WOS000372942000001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Equine Veterinary Science 0,390 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-6 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129280867041280 |