Peripheral spectrum neurological disorder after arbovirus infection is associated with HLA-F variants among Northeastern Brazilians

• Autor(a) principal: Sonon, Paulin
• Data de Publicação: 2021
• Outros Autores: Collares, Cristhianna V.A., Ferreira, Maria Lúcia Brito, Almeida, Renata Santos, Sadissou, Ibrahim, Cordeiro, Marli Tenório, de Fátima Militão de Albuquerque, Maria, Castelli, Erick C. [UNESP], Lucena-Silva, Norma, Donadi, Eduardo A.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1016/j.meegid.2021.104855; http://hdl.handle.net/11449/207658
• topic: Arbovirus; ESD; HLA-E; HLA-F; Pernambuco; PSD

Introduction: Non-classical class I human leukocyte antigens (HLA) molecules are known to modulate the function of cytotoxic cells (NK and T CD8+) during viral infection by interacting with inhibitory/activating receptors. However, little is known about the HLA-E/-F genetic variability on arbovirus infections. Methods: We evaluated by massive parallel sequencing the full HLA-E/-F genetic diversity among patients infected during the arbovirus (ZIKV, DENV, and CHIKV) outbreak leading to a broad range of neurological complications in the Brazilian State of Pernambuco. In parallel, healthy blood donors from the same area were also studied. Plink and R software were used for genetic association study. To limit the false-positive results and enhance the reliability of the results, we adopted P-values <0.01 as significant levels. Results: Compared to controls, the HLA-F alleles: −1610 C (rs17875375), +1383 G (rs17178385), and +3537 A (rs17875384), all in complete linkage disequilibrium with each other (r2 = 1), were overrepresented in patients presenting peripheral spectrum disorders (PSD). The HLA-F*Distal-D haplotype that harbored the −1610 C allele exhibited a trend increase in PSD group. No associations were found for HLA-E. Conclusions: Our findings showed that the HLA-F genetic background seems to be more important than HLA-E on the susceptibility to PSD complications.