Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/226024 |
Resumo: | Background: To investigate the effect of lisinopril on cardiac remodeling induced by smoking. Material/Methods: Rats were allocated into 3 groups: group CON (n=8): control; group CSE (n=8): cigarette smoke exposure; group CSE-LIS (n=8): exposed to tobacco smoke and treated with lisinopril. Results: After 2 months, the tail systolic pressure was lower in CSE-LIS (CON=116 ±27 mm Hg, CSE=126±16, CSE-LIS=89±12; P<.001). CSE animals showed higher left ventricular systolic diameter (CON=8.25±2.16 mm/kg, CSE=11.5±1.3, CSE-LIS=9.27±2.00; P=.009) and myocyte cross-sectional area (CON=245±8 μm2, CSE=260±17, CSE-LIS=238±12; P=.01) than CON and CSE-LIS. The ejection fraction (CON =0.91±0.02, CSE=0.86±0.02, CSE-LIS=0.92±0.03; P=.002) and fractional shortening (CON=55.7±4.41%, CSE=48.7±3.43, CSE-LI=58.2±7.63; P=.006) were lower in CSE group than CON and CSE-LIS. CSE and CSE-LIS animals showed higher collagen amounts (CON=3.49±0.95%, CSE= 5.01±1.58, CSE-LIS=5.27±0.62; P=.009) than CON. CON group showed a higher connexin 43 amount in the intercalated disc (CON=3.70±0.38, CSE=2.13±0.53; CSE-LIS=2.17±0.73; P=.004) than CSE and CSE-LIS. There were no differences in IFN-g or TNF-a cardiac levels among the groups. Conclusions: Lisinopril attenuated both morphologic and functional abnormalities induced by exposure to tobacco smoke. In addition, this effect was associated with diminished blood pressure, but not alterations in connexin 43 distribution, cytokine production or collagen amount. © Med Sci Monit, 2010. |
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Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposureHeart failureHypertrophySmokingVentricular functionBackground: To investigate the effect of lisinopril on cardiac remodeling induced by smoking. Material/Methods: Rats were allocated into 3 groups: group CON (n=8): control; group CSE (n=8): cigarette smoke exposure; group CSE-LIS (n=8): exposed to tobacco smoke and treated with lisinopril. Results: After 2 months, the tail systolic pressure was lower in CSE-LIS (CON=116 ±27 mm Hg, CSE=126±16, CSE-LIS=89±12; P<.001). CSE animals showed higher left ventricular systolic diameter (CON=8.25±2.16 mm/kg, CSE=11.5±1.3, CSE-LIS=9.27±2.00; P=.009) and myocyte cross-sectional area (CON=245±8 μm2, CSE=260±17, CSE-LIS=238±12; P=.01) than CON and CSE-LIS. The ejection fraction (CON =0.91±0.02, CSE=0.86±0.02, CSE-LIS=0.92±0.03; P=.002) and fractional shortening (CON=55.7±4.41%, CSE=48.7±3.43, CSE-LI=58.2±7.63; P=.006) were lower in CSE group than CON and CSE-LIS. CSE and CSE-LIS animals showed higher collagen amounts (CON=3.49±0.95%, CSE= 5.01±1.58, CSE-LIS=5.27±0.62; P=.009) than CON. CON group showed a higher connexin 43 amount in the intercalated disc (CON=3.70±0.38, CSE=2.13±0.53; CSE-LIS=2.17±0.73; P=.004) than CSE and CSE-LIS. There were no differences in IFN-g or TNF-a cardiac levels among the groups. Conclusions: Lisinopril attenuated both morphologic and functional abnormalities induced by exposure to tobacco smoke. In addition, this effect was associated with diminished blood pressure, but not alterations in connexin 43 distribution, cytokine production or collagen amount. © Med Sci Monit, 2010.Department of Internal Medicine Botucatu Medical School UNESP - São Paulo State University, BotucatuDepartment of Microbiology and Immunology Institute of Biosciences São Paulo State University, BotucatuDepartment of Internal Medicine Botucatu Medical School UNESP - São Paulo State University, BotucatuDepartment of Microbiology and Immunology Institute of Biosciences São Paulo State University, BotucatuUniversidade Estadual Paulista (UNESP)Duarte, Daniella R. [UNESP]Minicucci, Marcos F. [UNESP]Azevedo, Paula S. [UNESP]Chiuso-Minicucci, Fernanda [UNESP]Matsubara, Beatriz B. [UNESP]Matsubara, Luiz S. [UNESP]Campana, Álvaro O. [UNESP]Paiva, Sergio A. R. [UNESP]Zornoff, Leonardo A. M. [UNESP]2022-04-28T21:24:24Z2022-04-28T21:24:24Z2010-08-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCase Reports and Clinical Practice Review, v. 16, n. 8, 2010.1507-61641643-3742http://hdl.handle.net/11449/2260242-s2.0-77956208051Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCase Reports and Clinical Practice Reviewinfo:eu-repo/semantics/openAccess2024-08-14T17:22:59Zoai:repositorio.unesp.br:11449/226024Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:22:59Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure |
title |
Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure |
spellingShingle |
Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure Duarte, Daniella R. [UNESP] Heart failure Hypertrophy Smoking Ventricular function |
title_short |
Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure |
title_full |
Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure |
title_fullStr |
Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure |
title_full_unstemmed |
Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure |
title_sort |
Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure |
author |
Duarte, Daniella R. [UNESP] |
author_facet |
Duarte, Daniella R. [UNESP] Minicucci, Marcos F. [UNESP] Azevedo, Paula S. [UNESP] Chiuso-Minicucci, Fernanda [UNESP] Matsubara, Beatriz B. [UNESP] Matsubara, Luiz S. [UNESP] Campana, Álvaro O. [UNESP] Paiva, Sergio A. R. [UNESP] Zornoff, Leonardo A. M. [UNESP] |
author_role |
author |
author2 |
Minicucci, Marcos F. [UNESP] Azevedo, Paula S. [UNESP] Chiuso-Minicucci, Fernanda [UNESP] Matsubara, Beatriz B. [UNESP] Matsubara, Luiz S. [UNESP] Campana, Álvaro O. [UNESP] Paiva, Sergio A. R. [UNESP] Zornoff, Leonardo A. M. [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Duarte, Daniella R. [UNESP] Minicucci, Marcos F. [UNESP] Azevedo, Paula S. [UNESP] Chiuso-Minicucci, Fernanda [UNESP] Matsubara, Beatriz B. [UNESP] Matsubara, Luiz S. [UNESP] Campana, Álvaro O. [UNESP] Paiva, Sergio A. R. [UNESP] Zornoff, Leonardo A. M. [UNESP] |
dc.subject.por.fl_str_mv |
Heart failure Hypertrophy Smoking Ventricular function |
topic |
Heart failure Hypertrophy Smoking Ventricular function |
description |
Background: To investigate the effect of lisinopril on cardiac remodeling induced by smoking. Material/Methods: Rats were allocated into 3 groups: group CON (n=8): control; group CSE (n=8): cigarette smoke exposure; group CSE-LIS (n=8): exposed to tobacco smoke and treated with lisinopril. Results: After 2 months, the tail systolic pressure was lower in CSE-LIS (CON=116 ±27 mm Hg, CSE=126±16, CSE-LIS=89±12; P<.001). CSE animals showed higher left ventricular systolic diameter (CON=8.25±2.16 mm/kg, CSE=11.5±1.3, CSE-LIS=9.27±2.00; P=.009) and myocyte cross-sectional area (CON=245±8 μm2, CSE=260±17, CSE-LIS=238±12; P=.01) than CON and CSE-LIS. The ejection fraction (CON =0.91±0.02, CSE=0.86±0.02, CSE-LIS=0.92±0.03; P=.002) and fractional shortening (CON=55.7±4.41%, CSE=48.7±3.43, CSE-LI=58.2±7.63; P=.006) were lower in CSE group than CON and CSE-LIS. CSE and CSE-LIS animals showed higher collagen amounts (CON=3.49±0.95%, CSE= 5.01±1.58, CSE-LIS=5.27±0.62; P=.009) than CON. CON group showed a higher connexin 43 amount in the intercalated disc (CON=3.70±0.38, CSE=2.13±0.53; CSE-LIS=2.17±0.73; P=.004) than CSE and CSE-LIS. There were no differences in IFN-g or TNF-a cardiac levels among the groups. Conclusions: Lisinopril attenuated both morphologic and functional abnormalities induced by exposure to tobacco smoke. In addition, this effect was associated with diminished blood pressure, but not alterations in connexin 43 distribution, cytokine production or collagen amount. © Med Sci Monit, 2010. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-08-13 2022-04-28T21:24:24Z 2022-04-28T21:24:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Case Reports and Clinical Practice Review, v. 16, n. 8, 2010. 1507-6164 1643-3742 http://hdl.handle.net/11449/226024 2-s2.0-77956208051 |
identifier_str_mv |
Case Reports and Clinical Practice Review, v. 16, n. 8, 2010. 1507-6164 1643-3742 2-s2.0-77956208051 |
url |
http://hdl.handle.net/11449/226024 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Case Reports and Clinical Practice Review |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128143265890304 |