Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure

Detalhes bibliográficos
Autor(a) principal: Duarte, Daniella R. [UNESP]
Data de Publicação: 2010
Outros Autores: Minicucci, Marcos F. [UNESP], Azevedo, Paula S. [UNESP], Chiuso-Minicucci, Fernanda [UNESP], Matsubara, Beatriz B. [UNESP], Matsubara, Luiz S. [UNESP], Campana, Álvaro O. [UNESP], Paiva, Sergio A. R. [UNESP], Zornoff, Leonardo A. M. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/226024
Resumo: Background: To investigate the effect of lisinopril on cardiac remodeling induced by smoking. Material/Methods: Rats were allocated into 3 groups: group CON (n=8): control; group CSE (n=8): cigarette smoke exposure; group CSE-LIS (n=8): exposed to tobacco smoke and treated with lisinopril. Results: After 2 months, the tail systolic pressure was lower in CSE-LIS (CON=116 ±27 mm Hg, CSE=126±16, CSE-LIS=89±12; P<.001). CSE animals showed higher left ventricular systolic diameter (CON=8.25±2.16 mm/kg, CSE=11.5±1.3, CSE-LIS=9.27±2.00; P=.009) and myocyte cross-sectional area (CON=245±8 μm2, CSE=260±17, CSE-LIS=238±12; P=.01) than CON and CSE-LIS. The ejection fraction (CON =0.91±0.02, CSE=0.86±0.02, CSE-LIS=0.92±0.03; P=.002) and fractional shortening (CON=55.7±4.41%, CSE=48.7±3.43, CSE-LI=58.2±7.63; P=.006) were lower in CSE group than CON and CSE-LIS. CSE and CSE-LIS animals showed higher collagen amounts (CON=3.49±0.95%, CSE= 5.01±1.58, CSE-LIS=5.27±0.62; P=.009) than CON. CON group showed a higher connexin 43 amount in the intercalated disc (CON=3.70±0.38, CSE=2.13±0.53; CSE-LIS=2.17±0.73; P=.004) than CSE and CSE-LIS. There were no differences in IFN-g or TNF-a cardiac levels among the groups. Conclusions: Lisinopril attenuated both morphologic and functional abnormalities induced by exposure to tobacco smoke. In addition, this effect was associated with diminished blood pressure, but not alterations in connexin 43 distribution, cytokine production or collagen amount. © Med Sci Monit, 2010.
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spelling Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposureHeart failureHypertrophySmokingVentricular functionBackground: To investigate the effect of lisinopril on cardiac remodeling induced by smoking. Material/Methods: Rats were allocated into 3 groups: group CON (n=8): control; group CSE (n=8): cigarette smoke exposure; group CSE-LIS (n=8): exposed to tobacco smoke and treated with lisinopril. Results: After 2 months, the tail systolic pressure was lower in CSE-LIS (CON=116 ±27 mm Hg, CSE=126±16, CSE-LIS=89±12; P<.001). CSE animals showed higher left ventricular systolic diameter (CON=8.25±2.16 mm/kg, CSE=11.5±1.3, CSE-LIS=9.27±2.00; P=.009) and myocyte cross-sectional area (CON=245±8 μm2, CSE=260±17, CSE-LIS=238±12; P=.01) than CON and CSE-LIS. The ejection fraction (CON =0.91±0.02, CSE=0.86±0.02, CSE-LIS=0.92±0.03; P=.002) and fractional shortening (CON=55.7±4.41%, CSE=48.7±3.43, CSE-LI=58.2±7.63; P=.006) were lower in CSE group than CON and CSE-LIS. CSE and CSE-LIS animals showed higher collagen amounts (CON=3.49±0.95%, CSE= 5.01±1.58, CSE-LIS=5.27±0.62; P=.009) than CON. CON group showed a higher connexin 43 amount in the intercalated disc (CON=3.70±0.38, CSE=2.13±0.53; CSE-LIS=2.17±0.73; P=.004) than CSE and CSE-LIS. There were no differences in IFN-g or TNF-a cardiac levels among the groups. Conclusions: Lisinopril attenuated both morphologic and functional abnormalities induced by exposure to tobacco smoke. In addition, this effect was associated with diminished blood pressure, but not alterations in connexin 43 distribution, cytokine production or collagen amount. © Med Sci Monit, 2010.Department of Internal Medicine Botucatu Medical School UNESP - São Paulo State University, BotucatuDepartment of Microbiology and Immunology Institute of Biosciences São Paulo State University, BotucatuDepartment of Internal Medicine Botucatu Medical School UNESP - São Paulo State University, BotucatuDepartment of Microbiology and Immunology Institute of Biosciences São Paulo State University, BotucatuUniversidade Estadual Paulista (UNESP)Duarte, Daniella R. [UNESP]Minicucci, Marcos F. [UNESP]Azevedo, Paula S. [UNESP]Chiuso-Minicucci, Fernanda [UNESP]Matsubara, Beatriz B. [UNESP]Matsubara, Luiz S. [UNESP]Campana, Álvaro O. [UNESP]Paiva, Sergio A. R. [UNESP]Zornoff, Leonardo A. M. [UNESP]2022-04-28T21:24:24Z2022-04-28T21:24:24Z2010-08-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCase Reports and Clinical Practice Review, v. 16, n. 8, 2010.1507-61641643-3742http://hdl.handle.net/11449/2260242-s2.0-77956208051Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCase Reports and Clinical Practice Reviewinfo:eu-repo/semantics/openAccess2024-08-14T17:22:59Zoai:repositorio.unesp.br:11449/226024Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:22:59Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure
title Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure
spellingShingle Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure
Duarte, Daniella R. [UNESP]
Heart failure
Hypertrophy
Smoking
Ventricular function
title_short Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure
title_full Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure
title_fullStr Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure
title_full_unstemmed Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure
title_sort Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure
author Duarte, Daniella R. [UNESP]
author_facet Duarte, Daniella R. [UNESP]
Minicucci, Marcos F. [UNESP]
Azevedo, Paula S. [UNESP]
Chiuso-Minicucci, Fernanda [UNESP]
Matsubara, Beatriz B. [UNESP]
Matsubara, Luiz S. [UNESP]
Campana, Álvaro O. [UNESP]
Paiva, Sergio A. R. [UNESP]
Zornoff, Leonardo A. M. [UNESP]
author_role author
author2 Minicucci, Marcos F. [UNESP]
Azevedo, Paula S. [UNESP]
Chiuso-Minicucci, Fernanda [UNESP]
Matsubara, Beatriz B. [UNESP]
Matsubara, Luiz S. [UNESP]
Campana, Álvaro O. [UNESP]
Paiva, Sergio A. R. [UNESP]
Zornoff, Leonardo A. M. [UNESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Duarte, Daniella R. [UNESP]
Minicucci, Marcos F. [UNESP]
Azevedo, Paula S. [UNESP]
Chiuso-Minicucci, Fernanda [UNESP]
Matsubara, Beatriz B. [UNESP]
Matsubara, Luiz S. [UNESP]
Campana, Álvaro O. [UNESP]
Paiva, Sergio A. R. [UNESP]
Zornoff, Leonardo A. M. [UNESP]
dc.subject.por.fl_str_mv Heart failure
Hypertrophy
Smoking
Ventricular function
topic Heart failure
Hypertrophy
Smoking
Ventricular function
description Background: To investigate the effect of lisinopril on cardiac remodeling induced by smoking. Material/Methods: Rats were allocated into 3 groups: group CON (n=8): control; group CSE (n=8): cigarette smoke exposure; group CSE-LIS (n=8): exposed to tobacco smoke and treated with lisinopril. Results: After 2 months, the tail systolic pressure was lower in CSE-LIS (CON=116 ±27 mm Hg, CSE=126±16, CSE-LIS=89±12; P<.001). CSE animals showed higher left ventricular systolic diameter (CON=8.25±2.16 mm/kg, CSE=11.5±1.3, CSE-LIS=9.27±2.00; P=.009) and myocyte cross-sectional area (CON=245±8 μm2, CSE=260±17, CSE-LIS=238±12; P=.01) than CON and CSE-LIS. The ejection fraction (CON =0.91±0.02, CSE=0.86±0.02, CSE-LIS=0.92±0.03; P=.002) and fractional shortening (CON=55.7±4.41%, CSE=48.7±3.43, CSE-LI=58.2±7.63; P=.006) were lower in CSE group than CON and CSE-LIS. CSE and CSE-LIS animals showed higher collagen amounts (CON=3.49±0.95%, CSE= 5.01±1.58, CSE-LIS=5.27±0.62; P=.009) than CON. CON group showed a higher connexin 43 amount in the intercalated disc (CON=3.70±0.38, CSE=2.13±0.53; CSE-LIS=2.17±0.73; P=.004) than CSE and CSE-LIS. There were no differences in IFN-g or TNF-a cardiac levels among the groups. Conclusions: Lisinopril attenuated both morphologic and functional abnormalities induced by exposure to tobacco smoke. In addition, this effect was associated with diminished blood pressure, but not alterations in connexin 43 distribution, cytokine production or collagen amount. © Med Sci Monit, 2010.
publishDate 2010
dc.date.none.fl_str_mv 2010-08-13
2022-04-28T21:24:24Z
2022-04-28T21:24:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Case Reports and Clinical Practice Review, v. 16, n. 8, 2010.
1507-6164
1643-3742
http://hdl.handle.net/11449/226024
2-s2.0-77956208051
identifier_str_mv Case Reports and Clinical Practice Review, v. 16, n. 8, 2010.
1507-6164
1643-3742
2-s2.0-77956208051
url http://hdl.handle.net/11449/226024
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Case Reports and Clinical Practice Review
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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