Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.eurpsy.2018.07.008 http://hdl.handle.net/11449/176719 |
Resumo: | Background: Apathy is a very common behavioural and psychological symptom across brain disorders. In the last decade, there have been considerable advances in research on apathy and motivation. It is thus important to revise the apathy diagnostic criteria published in 2009. The main objectives were to: a) revise the definition of apathy; b) update the list of apathy dimensions; c) operationalise the diagnostic criteria; and d) suggest appropriate assessment tools including new technologies. Methods: The expert panel (N = 23) included researchers and health care professionals working on brain disorders and apathy, a representative of a regulatory body, and a representative of the pharmaceutical industry. The revised diagnostic criteria for apathy were developed in a two-step process. First, following the standard Delphi methodology, the experts were asked to answer questions via web-survey in two rounds. Second, all the collected information was discussed on the occasion of the 26th European Congress of Psychiatry held in Nice (France). Results: Apathy was defined as a quantitative reduction of goal-directed activity in comparison to the patient's previous level of functioning (criterion A). Symptoms must persist for at least four weeks, and affect at least two of the three apathy dimensions (behaviour/cognition; emotion; social interaction; criterion B). Apathy should cause identifiable functional impairments (criterion C), and should not be fully explained by other factors, such as effects of a substance or major changes in the patient's environment (Criterion D). Conclusions: The new diagnostic criteria for apathy provide a clinical and scientific framework to increase the validity of apathy as a clinical construct. This should also help to pave the path for apathy in brain disorders to be an interventional target. |
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Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus groupApathyBehaviourBrain disordersEmotionMotivationNeuropsychiatrySocial interactionTreatmentBackground: Apathy is a very common behavioural and psychological symptom across brain disorders. In the last decade, there have been considerable advances in research on apathy and motivation. It is thus important to revise the apathy diagnostic criteria published in 2009. The main objectives were to: a) revise the definition of apathy; b) update the list of apathy dimensions; c) operationalise the diagnostic criteria; and d) suggest appropriate assessment tools including new technologies. Methods: The expert panel (N = 23) included researchers and health care professionals working on brain disorders and apathy, a representative of a regulatory body, and a representative of the pharmaceutical industry. The revised diagnostic criteria for apathy were developed in a two-step process. First, following the standard Delphi methodology, the experts were asked to answer questions via web-survey in two rounds. Second, all the collected information was discussed on the occasion of the 26th European Congress of Psychiatry held in Nice (France). Results: Apathy was defined as a quantitative reduction of goal-directed activity in comparison to the patient's previous level of functioning (criterion A). Symptoms must persist for at least four weeks, and affect at least two of the three apathy dimensions (behaviour/cognition; emotion; social interaction; criterion B). Apathy should cause identifiable functional impairments (criterion C), and should not be fully explained by other factors, such as effects of a substance or major changes in the patient's environment (Criterion D). Conclusions: The new diagnostic criteria for apathy provide a clinical and scientific framework to increase the validity of apathy as a clinical construct. This should also help to pave the path for apathy in brain disorders to be an interventional target.CoBTeK IA Memory Centre University Cote d'AzurSunnybrook Research Institute and Departments of Pharmacology/Toxicology and Psychiatry University of TorontoDepartment of Psychiatry Instituto de Investigación Sanitaria (imas12) Hospital Universitario 12 de Octubre & Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)School for Mental Health and Neuroscience Alzheimer Center LimburgSTARS team - INRIA Sophia AntipolisDepartment of Psychiatry and Psychotherapy Innsbruck Medical UniversityRegional Resource Centre of Old Age Psychiatry Paris Descartes University, Assistance Publique-Hôpitaux de Paris, Corentin-Celton HospitalMemory Center CMRR CHU – CoBTeK lab University Cote d'AzurCentre des Maladies Cognitives et Comportementales (IM2A) Institut du Cerveau et de la Moelle épinière (ICM) UMR-S975 AP-HP Salpêtrière Hospital Sorbonne UniversityNeurology and Movement Disorders Lille University Medical Center Inserm U1171Nuffield Department of Clinical Neurosciences (John Radcliffe Hospital Oxford OX3 9DU) & Department of Experimental Psychology University of OxfordAP-HP Neurology deparment Salpetriere hospital Inserm U 1127 CNRS UMR 7225 Sorbonne Universités UPMC Univ Paris 06 UMR S 1127 Institut du Cerveau et de la Moelle épinière ICM FRONTlab School of medicine Sorbonne UniversitésAgenzia Italiana del Farmaco, via del Tritone 181Clinical Research Neurology Lundbeck SASBracket, Waynemoebius-consult GmbHpsi-napseEA4712 “Comportement et noyaux gris centraux” Université de Rennes 1Laboratorio de Neurociencias LIM27 Departamento e Instituto de Psiquiatria Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo UNESP - Univ Estadual Paulista Biosciences Institute, Campus of Rio ClaroDepartment of Psychiatry and Behavioral Sciences Stanford University School of Medicine Stanford UniversityLaboratorio de Neurociencias LIM27 Departamento e Instituto de Psiquiatria Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo UNESP - Univ Estadual Paulista Biosciences Institute, Campus of Rio ClaroUniversity Cote d'AzurUniversity of TorontoHospital Universitario 12 de Octubre & Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)Alzheimer Center LimburgSTARS team - INRIA Sophia AntipolisInnsbruck Medical UniversityParis Descartes UniversitySorbonne UniversityInserm U1171University of OxfordSorbonne UniversitésAgenzia Italiana del FarmacoClinical Research Neurology Lundbeck SASBracketmoebius-consult GmbHpsi-napseUniversité de Rennes 1Universidade Estadual Paulista (Unesp)Stanford UniversityRobert, P.Lanctôt, K. L.Agüera-Ortiz, L.Aalten, P.Bremond, F.Defrancesco, M.Hanon, C.David, R.Dubois, B.Dujardin, K.Husain, M.König, A.Levy, R.Mantua, V.Meulien, D.Miller, D.Moebius, H. J.Rasmussen, J.Robert, G.Ruthirakuhan, M.Stella, F. [UNESP]Yesavage, J.Zeghari, R.Manera, V.2018-12-11T17:22:11Z2018-12-11T17:22:11Z2018-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article71-76application/pdfhttp://dx.doi.org/10.1016/j.eurpsy.2018.07.008European Psychiatry, v. 54, p. 71-76.1778-35850924-9338http://hdl.handle.net/11449/17671910.1016/j.eurpsy.2018.07.0082-s2.0-850516553092-s2.0-85051655309.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEuropean Psychiatry1,819info:eu-repo/semantics/openAccess2024-08-16T15:45:29Zoai:repositorio.unesp.br:11449/176719Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T15:45:29Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group |
title |
Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group |
spellingShingle |
Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group Robert, P. Apathy Behaviour Brain disorders Emotion Motivation Neuropsychiatry Social interaction Treatment |
title_short |
Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group |
title_full |
Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group |
title_fullStr |
Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group |
title_full_unstemmed |
Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group |
title_sort |
Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group |
author |
Robert, P. |
author_facet |
Robert, P. Lanctôt, K. L. Agüera-Ortiz, L. Aalten, P. Bremond, F. Defrancesco, M. Hanon, C. David, R. Dubois, B. Dujardin, K. Husain, M. König, A. Levy, R. Mantua, V. Meulien, D. Miller, D. Moebius, H. J. Rasmussen, J. Robert, G. Ruthirakuhan, M. Stella, F. [UNESP] Yesavage, J. Zeghari, R. Manera, V. |
author_role |
author |
author2 |
Lanctôt, K. L. Agüera-Ortiz, L. Aalten, P. Bremond, F. Defrancesco, M. Hanon, C. David, R. Dubois, B. Dujardin, K. Husain, M. König, A. Levy, R. Mantua, V. Meulien, D. Miller, D. Moebius, H. J. Rasmussen, J. Robert, G. Ruthirakuhan, M. Stella, F. [UNESP] Yesavage, J. Zeghari, R. Manera, V. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
University Cote d'Azur University of Toronto Hospital Universitario 12 de Octubre & Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) Alzheimer Center Limburg STARS team - INRIA Sophia Antipolis Innsbruck Medical University Paris Descartes University Sorbonne University Inserm U1171 University of Oxford Sorbonne Universités Agenzia Italiana del Farmaco Clinical Research Neurology Lundbeck SAS Bracket moebius-consult GmbH psi-napse Université de Rennes 1 Universidade Estadual Paulista (Unesp) Stanford University |
dc.contributor.author.fl_str_mv |
Robert, P. Lanctôt, K. L. Agüera-Ortiz, L. Aalten, P. Bremond, F. Defrancesco, M. Hanon, C. David, R. Dubois, B. Dujardin, K. Husain, M. König, A. Levy, R. Mantua, V. Meulien, D. Miller, D. Moebius, H. J. Rasmussen, J. Robert, G. Ruthirakuhan, M. Stella, F. [UNESP] Yesavage, J. Zeghari, R. Manera, V. |
dc.subject.por.fl_str_mv |
Apathy Behaviour Brain disorders Emotion Motivation Neuropsychiatry Social interaction Treatment |
topic |
Apathy Behaviour Brain disorders Emotion Motivation Neuropsychiatry Social interaction Treatment |
description |
Background: Apathy is a very common behavioural and psychological symptom across brain disorders. In the last decade, there have been considerable advances in research on apathy and motivation. It is thus important to revise the apathy diagnostic criteria published in 2009. The main objectives were to: a) revise the definition of apathy; b) update the list of apathy dimensions; c) operationalise the diagnostic criteria; and d) suggest appropriate assessment tools including new technologies. Methods: The expert panel (N = 23) included researchers and health care professionals working on brain disorders and apathy, a representative of a regulatory body, and a representative of the pharmaceutical industry. The revised diagnostic criteria for apathy were developed in a two-step process. First, following the standard Delphi methodology, the experts were asked to answer questions via web-survey in two rounds. Second, all the collected information was discussed on the occasion of the 26th European Congress of Psychiatry held in Nice (France). Results: Apathy was defined as a quantitative reduction of goal-directed activity in comparison to the patient's previous level of functioning (criterion A). Symptoms must persist for at least four weeks, and affect at least two of the three apathy dimensions (behaviour/cognition; emotion; social interaction; criterion B). Apathy should cause identifiable functional impairments (criterion C), and should not be fully explained by other factors, such as effects of a substance or major changes in the patient's environment (Criterion D). Conclusions: The new diagnostic criteria for apathy provide a clinical and scientific framework to increase the validity of apathy as a clinical construct. This should also help to pave the path for apathy in brain disorders to be an interventional target. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:22:11Z 2018-12-11T17:22:11Z 2018-10-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.eurpsy.2018.07.008 European Psychiatry, v. 54, p. 71-76. 1778-3585 0924-9338 http://hdl.handle.net/11449/176719 10.1016/j.eurpsy.2018.07.008 2-s2.0-85051655309 2-s2.0-85051655309.pdf |
url |
http://dx.doi.org/10.1016/j.eurpsy.2018.07.008 http://hdl.handle.net/11449/176719 |
identifier_str_mv |
European Psychiatry, v. 54, p. 71-76. 1778-3585 0924-9338 10.1016/j.eurpsy.2018.07.008 2-s2.0-85051655309 2-s2.0-85051655309.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
European Psychiatry 1,819 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
71-76 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128121414615040 |