Avaliação dos efeitos da terapia fotodinâmica com hipericina-glucamina no tratamento da doen ça periodontal induzida em ratos
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/123893 |
Resumo: | The Photodynamic Therapy (TFD) has shown satisfactory results when coupled with mechanical treatment of periodontal diseases. The aim of this work was to evaluate whether PDT with the photosensitizer hypericin-glucamine, enabled by amber LED (34.10 J/cm2) and combined with scaling and root planning (RAR), promotes better repair of the periodontal disease induced experimentally in rats. The periodontal diseases was installed by randomly inserting ligatures in the grooves of the superior second molars. The bandages were removed after 15 days and the animals were randomized into 4 experimental groups (n = 5): IPD group (Induced Periodontal Disease); RAR group; TFD group; and RAR+TDF group. The animals were sacrificed after 7, 15 and 30 days of the performed treatment. Digital microtomography and histometric analyses were carried out on their hemimaxillas. Shapiro-Wilk normality test was applied to data. The groups were assessed among each other and parametric data were evaluated using ANOVA test. All tests were conducted with p<0.05. Statistical differences were not observed among the groups. Therefore, we concluded that TFD combined with RAR or isolated obtained similar results to scaling and root planning. |
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Avaliação dos efeitos da terapia fotodinâmica com hipericina-glucamina no tratamento da doen ça periodontal induzida em ratosFotoquimioterapiaPeriodontiteTomografiaPeriodontitisThe Photodynamic Therapy (TFD) has shown satisfactory results when coupled with mechanical treatment of periodontal diseases. The aim of this work was to evaluate whether PDT with the photosensitizer hypericin-glucamine, enabled by amber LED (34.10 J/cm2) and combined with scaling and root planning (RAR), promotes better repair of the periodontal disease induced experimentally in rats. The periodontal diseases was installed by randomly inserting ligatures in the grooves of the superior second molars. The bandages were removed after 15 days and the animals were randomized into 4 experimental groups (n = 5): IPD group (Induced Periodontal Disease); RAR group; TFD group; and RAR+TDF group. The animals were sacrificed after 7, 15 and 30 days of the performed treatment. Digital microtomography and histometric analyses were carried out on their hemimaxillas. Shapiro-Wilk normality test was applied to data. The groups were assessed among each other and parametric data were evaluated using ANOVA test. All tests were conducted with p<0.05. Statistical differences were not observed among the groups. Therefore, we concluded that TFD combined with RAR or isolated obtained similar results to scaling and root planning.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)CNPq: 133436/2012-8Universidade Estadual Paulista (Unesp)Marcantonio, Rosemary Adriana Chiérici [UNESP]Universidade Estadual Paulista (Unesp)Macedo, Paula Delello [UNESP]2015-06-17T19:34:13Z2015-06-17T19:34:13Z2014-03-24info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis59 f. : il., anexoapplication/pdfMACEDO, Paula Delello. Avaliação dos efeitos da terapia fotodinâmica com hipericina-glucamina no tratamento da doen ça periodontal induzida em ratos. 2014. 59 f. , 2014.http://hdl.handle.net/11449/123893000822755000822755.pdf33004030059P13534044399884035Alephreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporinfo:eu-repo/semantics/openAccess2023-11-23T06:17:04Zoai:repositorio.unesp.br:11449/123893Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:33:04.261270Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Avaliação dos efeitos da terapia fotodinâmica com hipericina-glucamina no tratamento da doen ça periodontal induzida em ratos |
title |
Avaliação dos efeitos da terapia fotodinâmica com hipericina-glucamina no tratamento da doen ça periodontal induzida em ratos |
spellingShingle |
Avaliação dos efeitos da terapia fotodinâmica com hipericina-glucamina no tratamento da doen ça periodontal induzida em ratos Macedo, Paula Delello [UNESP] Fotoquimioterapia Periodontite Tomografia Periodontitis |
title_short |
Avaliação dos efeitos da terapia fotodinâmica com hipericina-glucamina no tratamento da doen ça periodontal induzida em ratos |
title_full |
Avaliação dos efeitos da terapia fotodinâmica com hipericina-glucamina no tratamento da doen ça periodontal induzida em ratos |
title_fullStr |
Avaliação dos efeitos da terapia fotodinâmica com hipericina-glucamina no tratamento da doen ça periodontal induzida em ratos |
title_full_unstemmed |
Avaliação dos efeitos da terapia fotodinâmica com hipericina-glucamina no tratamento da doen ça periodontal induzida em ratos |
title_sort |
Avaliação dos efeitos da terapia fotodinâmica com hipericina-glucamina no tratamento da doen ça periodontal induzida em ratos |
author |
Macedo, Paula Delello [UNESP] |
author_facet |
Macedo, Paula Delello [UNESP] |
author_role |
author |
dc.contributor.none.fl_str_mv |
Marcantonio, Rosemary Adriana Chiérici [UNESP] Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Macedo, Paula Delello [UNESP] |
dc.subject.por.fl_str_mv |
Fotoquimioterapia Periodontite Tomografia Periodontitis |
topic |
Fotoquimioterapia Periodontite Tomografia Periodontitis |
description |
The Photodynamic Therapy (TFD) has shown satisfactory results when coupled with mechanical treatment of periodontal diseases. The aim of this work was to evaluate whether PDT with the photosensitizer hypericin-glucamine, enabled by amber LED (34.10 J/cm2) and combined with scaling and root planning (RAR), promotes better repair of the periodontal disease induced experimentally in rats. The periodontal diseases was installed by randomly inserting ligatures in the grooves of the superior second molars. The bandages were removed after 15 days and the animals were randomized into 4 experimental groups (n = 5): IPD group (Induced Periodontal Disease); RAR group; TFD group; and RAR+TDF group. The animals were sacrificed after 7, 15 and 30 days of the performed treatment. Digital microtomography and histometric analyses were carried out on their hemimaxillas. Shapiro-Wilk normality test was applied to data. The groups were assessed among each other and parametric data were evaluated using ANOVA test. All tests were conducted with p<0.05. Statistical differences were not observed among the groups. Therefore, we concluded that TFD combined with RAR or isolated obtained similar results to scaling and root planning. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-03-24 2015-06-17T19:34:13Z 2015-06-17T19:34:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
MACEDO, Paula Delello. Avaliação dos efeitos da terapia fotodinâmica com hipericina-glucamina no tratamento da doen ça periodontal induzida em ratos. 2014. 59 f. , 2014. http://hdl.handle.net/11449/123893 000822755 000822755.pdf 33004030059P1 3534044399884035 |
identifier_str_mv |
MACEDO, Paula Delello. Avaliação dos efeitos da terapia fotodinâmica com hipericina-glucamina no tratamento da doen ça periodontal induzida em ratos. 2014. 59 f. , 2014. 000822755 000822755.pdf 33004030059P1 3534044399884035 |
url |
http://hdl.handle.net/11449/123893 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
59 f. : il., anexo application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.source.none.fl_str_mv |
Aleph reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128946479300608 |