Análise histomorfométrica da influência do Alendronato sódico no processo de reparo ósseo em tíbia de ratas submetidas a ovariectomia

• Autor(a) principal: Preccaro, Camila Aparecida
• Data de Publicação: 2010
• Outros Autores: Vicente Neto, Pedro, Balducci, Eleny Zanella [UNESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://www.feb.br/index.php/revcientifica; http://hdl.handle.net/11449/125829
• topic: Sodic alendronate; Ovariectomy; Tibia; Bone repair; Alendronato sódico; Ovarectomia; Tíbia; Reparo ósseo

The sodium alendronate (AS), considered as inhibitor in the osteoclasts- mediated bone resorption, promotes final effect of inhibition of resorption and increases bone mass. The objective of this research was to assess, by histomorphometry, the effect of sodium alendronate in repair bone of ovariectomized rats, in which there was performed a bone defect in the right tibia. The treated rats received a subcutaneous injection of sodic alendronate once a week, at 0.7 mg / kg, diluted with saline solution; the controls received the same volume of saline solution. In the periods of 16, 30 and 44 days after the first dose of AS, the animals were sacrificed, the right tibia was removed and processed for histomorphometric analysis. Four non-serial fields were used for the density volume quantification utilizing an integrative eyepiece with 25 points, totalizing 100 points per animal. Based on the results, the present study concludes that the ovariectomy induced osteoporosis and that the AS stimulated the bone formation. In addition, the ovariectomy decreased the estrogen levels. However, this procedure did not significantly influence the action of sodic alendronate.