Increased vaginal pH in Ugandan women: What does it indicate?

Detalhes bibliográficos
Autor(a) principal: Donders, G. G.G.
Data de Publicação: 2016
Outros Autores: Gonzaga, A., Marconi, C. [UNESP], Donders, F., Michiels, T., Eggermont, N., Bellen, G., Lule, J., Byamughisa, J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s10096-016-2664-2
http://hdl.handle.net/11449/173706
Resumo: Abnormal vaginal flora (AVF),indicative of bacterial vaginosis (BV) and/or aerobic vaginitis (AV),amongst other abnormalities,is a risk factor for multiple complications in pregnant as well as non-pregnant women. Screening for such conditions could help prevent these complications. Can self-testing for increased vaginal pH reliably detect BV and other high-riskmicroflora types,and is this more accurate than performing Gram stain-based Nugent score when screening for high-risk microflora? A total of 344 women presenting at different outpatient clinics in Mulago Hospital and Mbuikwe Outpatient clinics in Kampala,Uganda,were asked to test themselves by introducing a gloved finger into the vagina and smearing it on a microscopy slide,on which a pH strip was attached. Self-assessed categories of normal (pH 3.6-4.4),intermediate (4.5-4.7) or high pH (>4.7) were compared with demographic and with centralised microscopic data,both in air-dried rehydrated wet mounts (Femicare),as well as in Gram-stained specimens (Nugent). AVF was present in 38 %,BV in 25 % and AV in 11 % of patients. High pH and AVF is correlated with human immunodeficiency virus (HIV),infertility,frequent sex,but not vaginal douching. Screening for raised pH detects 90 % of AVF cases,but would require testing over half of the population. As AV and non-infectious conditions are frequent in women with AVF and high pH,Nugent score alone is an insufficient technique to screen women for a high-risk vaginal microflora,especially in infertile and HIV-infected women.
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spelling Increased vaginal pH in Ugandan women: What does it indicate?Abnormal vaginal flora (AVF),indicative of bacterial vaginosis (BV) and/or aerobic vaginitis (AV),amongst other abnormalities,is a risk factor for multiple complications in pregnant as well as non-pregnant women. Screening for such conditions could help prevent these complications. Can self-testing for increased vaginal pH reliably detect BV and other high-riskmicroflora types,and is this more accurate than performing Gram stain-based Nugent score when screening for high-risk microflora? A total of 344 women presenting at different outpatient clinics in Mulago Hospital and Mbuikwe Outpatient clinics in Kampala,Uganda,were asked to test themselves by introducing a gloved finger into the vagina and smearing it on a microscopy slide,on which a pH strip was attached. Self-assessed categories of normal (pH 3.6-4.4),intermediate (4.5-4.7) or high pH (>4.7) were compared with demographic and with centralised microscopic data,both in air-dried rehydrated wet mounts (Femicare),as well as in Gram-stained specimens (Nugent). AVF was present in 38 %,BV in 25 % and AV in 11 % of patients. High pH and AVF is correlated with human immunodeficiency virus (HIV),infertility,frequent sex,but not vaginal douching. Screening for raised pH detects 90 % of AVF cases,but would require testing over half of the population. As AV and non-infectious conditions are frequent in women with AVF and high pH,Nugent score alone is an insufficient technique to screen women for a high-risk vaginal microflora,especially in infertile and HIV-infected women.Femicare vzw Clinical Research for Women, Gasthuismolenstraat 31Department of Obstetrics and Gynecology Antwerp University HospitalDepartment of Obstetrics and Gynecology General Hospital H HartDepartment of Obstetrics and Gynecology Mulago University HospitalDepartment of Pathology Botucatu Medical School UNESP—Universidade Estadual PaulistaFaculty of Medicine University of LeuvenFaculty of Medicine Ghent UniversityDepartment of Pathology Botucatu Medical School UNESP—Universidade Estadual PaulistaClinical Research for WomenAntwerp University HospitalGeneral Hospital H HartMulago University HospitalUniversidade Estadual Paulista (Unesp)University of LeuvenGhent UniversityDonders, G. G.G.Gonzaga, A.Marconi, C. [UNESP]Donders, F.Michiels, T.Eggermont, N.Bellen, G.Lule, J.Byamughisa, J.2018-12-11T17:07:22Z2018-12-11T17:07:22Z2016-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1297-1303application/pdfhttp://dx.doi.org/10.1007/s10096-016-2664-2European Journal of Clinical Microbiology and Infectious Diseases, v. 35, n. 8, p. 1297-1303, 2016.1435-43730934-9723http://hdl.handle.net/11449/17370610.1007/s10096-016-2664-22-s2.0-849938488652-s2.0-84993848865.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEuropean Journal of Clinical Microbiology and Infectious Diseases1,3121,312info:eu-repo/semantics/openAccess2024-09-03T13:14:32Zoai:repositorio.unesp.br:11449/173706Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:14:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Increased vaginal pH in Ugandan women: What does it indicate?
title Increased vaginal pH in Ugandan women: What does it indicate?
spellingShingle Increased vaginal pH in Ugandan women: What does it indicate?
Donders, G. G.G.
title_short Increased vaginal pH in Ugandan women: What does it indicate?
title_full Increased vaginal pH in Ugandan women: What does it indicate?
title_fullStr Increased vaginal pH in Ugandan women: What does it indicate?
title_full_unstemmed Increased vaginal pH in Ugandan women: What does it indicate?
title_sort Increased vaginal pH in Ugandan women: What does it indicate?
author Donders, G. G.G.
author_facet Donders, G. G.G.
Gonzaga, A.
Marconi, C. [UNESP]
Donders, F.
Michiels, T.
Eggermont, N.
Bellen, G.
Lule, J.
Byamughisa, J.
author_role author
author2 Gonzaga, A.
Marconi, C. [UNESP]
Donders, F.
Michiels, T.
Eggermont, N.
Bellen, G.
Lule, J.
Byamughisa, J.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Clinical Research for Women
Antwerp University Hospital
General Hospital H Hart
Mulago University Hospital
Universidade Estadual Paulista (Unesp)
University of Leuven
Ghent University
dc.contributor.author.fl_str_mv Donders, G. G.G.
Gonzaga, A.
Marconi, C. [UNESP]
Donders, F.
Michiels, T.
Eggermont, N.
Bellen, G.
Lule, J.
Byamughisa, J.
description Abnormal vaginal flora (AVF),indicative of bacterial vaginosis (BV) and/or aerobic vaginitis (AV),amongst other abnormalities,is a risk factor for multiple complications in pregnant as well as non-pregnant women. Screening for such conditions could help prevent these complications. Can self-testing for increased vaginal pH reliably detect BV and other high-riskmicroflora types,and is this more accurate than performing Gram stain-based Nugent score when screening for high-risk microflora? A total of 344 women presenting at different outpatient clinics in Mulago Hospital and Mbuikwe Outpatient clinics in Kampala,Uganda,were asked to test themselves by introducing a gloved finger into the vagina and smearing it on a microscopy slide,on which a pH strip was attached. Self-assessed categories of normal (pH 3.6-4.4),intermediate (4.5-4.7) or high pH (>4.7) were compared with demographic and with centralised microscopic data,both in air-dried rehydrated wet mounts (Femicare),as well as in Gram-stained specimens (Nugent). AVF was present in 38 %,BV in 25 % and AV in 11 % of patients. High pH and AVF is correlated with human immunodeficiency virus (HIV),infertility,frequent sex,but not vaginal douching. Screening for raised pH detects 90 % of AVF cases,but would require testing over half of the population. As AV and non-infectious conditions are frequent in women with AVF and high pH,Nugent score alone is an insufficient technique to screen women for a high-risk vaginal microflora,especially in infertile and HIV-infected women.
publishDate 2016
dc.date.none.fl_str_mv 2016-08-01
2018-12-11T17:07:22Z
2018-12-11T17:07:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s10096-016-2664-2
European Journal of Clinical Microbiology and Infectious Diseases, v. 35, n. 8, p. 1297-1303, 2016.
1435-4373
0934-9723
http://hdl.handle.net/11449/173706
10.1007/s10096-016-2664-2
2-s2.0-84993848865
2-s2.0-84993848865.pdf
url http://dx.doi.org/10.1007/s10096-016-2664-2
http://hdl.handle.net/11449/173706
identifier_str_mv European Journal of Clinical Microbiology and Infectious Diseases, v. 35, n. 8, p. 1297-1303, 2016.
1435-4373
0934-9723
10.1007/s10096-016-2664-2
2-s2.0-84993848865
2-s2.0-84993848865.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv European Journal of Clinical Microbiology and Infectious Diseases
1,312
1,312
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1297-1303
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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