Increased vaginal pH in Ugandan women: What does it indicate?
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10096-016-2664-2 http://hdl.handle.net/11449/173706 |
Resumo: | Abnormal vaginal flora (AVF),indicative of bacterial vaginosis (BV) and/or aerobic vaginitis (AV),amongst other abnormalities,is a risk factor for multiple complications in pregnant as well as non-pregnant women. Screening for such conditions could help prevent these complications. Can self-testing for increased vaginal pH reliably detect BV and other high-riskmicroflora types,and is this more accurate than performing Gram stain-based Nugent score when screening for high-risk microflora? A total of 344 women presenting at different outpatient clinics in Mulago Hospital and Mbuikwe Outpatient clinics in Kampala,Uganda,were asked to test themselves by introducing a gloved finger into the vagina and smearing it on a microscopy slide,on which a pH strip was attached. Self-assessed categories of normal (pH 3.6-4.4),intermediate (4.5-4.7) or high pH (>4.7) were compared with demographic and with centralised microscopic data,both in air-dried rehydrated wet mounts (Femicare),as well as in Gram-stained specimens (Nugent). AVF was present in 38 %,BV in 25 % and AV in 11 % of patients. High pH and AVF is correlated with human immunodeficiency virus (HIV),infertility,frequent sex,but not vaginal douching. Screening for raised pH detects 90 % of AVF cases,but would require testing over half of the population. As AV and non-infectious conditions are frequent in women with AVF and high pH,Nugent score alone is an insufficient technique to screen women for a high-risk vaginal microflora,especially in infertile and HIV-infected women. |
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Increased vaginal pH in Ugandan women: What does it indicate?Abnormal vaginal flora (AVF),indicative of bacterial vaginosis (BV) and/or aerobic vaginitis (AV),amongst other abnormalities,is a risk factor for multiple complications in pregnant as well as non-pregnant women. Screening for such conditions could help prevent these complications. Can self-testing for increased vaginal pH reliably detect BV and other high-riskmicroflora types,and is this more accurate than performing Gram stain-based Nugent score when screening for high-risk microflora? A total of 344 women presenting at different outpatient clinics in Mulago Hospital and Mbuikwe Outpatient clinics in Kampala,Uganda,were asked to test themselves by introducing a gloved finger into the vagina and smearing it on a microscopy slide,on which a pH strip was attached. Self-assessed categories of normal (pH 3.6-4.4),intermediate (4.5-4.7) or high pH (>4.7) were compared with demographic and with centralised microscopic data,both in air-dried rehydrated wet mounts (Femicare),as well as in Gram-stained specimens (Nugent). AVF was present in 38 %,BV in 25 % and AV in 11 % of patients. High pH and AVF is correlated with human immunodeficiency virus (HIV),infertility,frequent sex,but not vaginal douching. Screening for raised pH detects 90 % of AVF cases,but would require testing over half of the population. As AV and non-infectious conditions are frequent in women with AVF and high pH,Nugent score alone is an insufficient technique to screen women for a high-risk vaginal microflora,especially in infertile and HIV-infected women.Femicare vzw Clinical Research for Women, Gasthuismolenstraat 31Department of Obstetrics and Gynecology Antwerp University HospitalDepartment of Obstetrics and Gynecology General Hospital H HartDepartment of Obstetrics and Gynecology Mulago University HospitalDepartment of Pathology Botucatu Medical School UNESP—Universidade Estadual PaulistaFaculty of Medicine University of LeuvenFaculty of Medicine Ghent UniversityDepartment of Pathology Botucatu Medical School UNESP—Universidade Estadual PaulistaClinical Research for WomenAntwerp University HospitalGeneral Hospital H HartMulago University HospitalUniversidade Estadual Paulista (Unesp)University of LeuvenGhent UniversityDonders, G. G.G.Gonzaga, A.Marconi, C. [UNESP]Donders, F.Michiels, T.Eggermont, N.Bellen, G.Lule, J.Byamughisa, J.2018-12-11T17:07:22Z2018-12-11T17:07:22Z2016-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1297-1303application/pdfhttp://dx.doi.org/10.1007/s10096-016-2664-2European Journal of Clinical Microbiology and Infectious Diseases, v. 35, n. 8, p. 1297-1303, 2016.1435-43730934-9723http://hdl.handle.net/11449/17370610.1007/s10096-016-2664-22-s2.0-849938488652-s2.0-84993848865.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEuropean Journal of Clinical Microbiology and Infectious Diseases1,3121,312info:eu-repo/semantics/openAccess2024-09-03T13:14:32Zoai:repositorio.unesp.br:11449/173706Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:14:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Increased vaginal pH in Ugandan women: What does it indicate? |
title |
Increased vaginal pH in Ugandan women: What does it indicate? |
spellingShingle |
Increased vaginal pH in Ugandan women: What does it indicate? Donders, G. G.G. |
title_short |
Increased vaginal pH in Ugandan women: What does it indicate? |
title_full |
Increased vaginal pH in Ugandan women: What does it indicate? |
title_fullStr |
Increased vaginal pH in Ugandan women: What does it indicate? |
title_full_unstemmed |
Increased vaginal pH in Ugandan women: What does it indicate? |
title_sort |
Increased vaginal pH in Ugandan women: What does it indicate? |
author |
Donders, G. G.G. |
author_facet |
Donders, G. G.G. Gonzaga, A. Marconi, C. [UNESP] Donders, F. Michiels, T. Eggermont, N. Bellen, G. Lule, J. Byamughisa, J. |
author_role |
author |
author2 |
Gonzaga, A. Marconi, C. [UNESP] Donders, F. Michiels, T. Eggermont, N. Bellen, G. Lule, J. Byamughisa, J. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Clinical Research for Women Antwerp University Hospital General Hospital H Hart Mulago University Hospital Universidade Estadual Paulista (Unesp) University of Leuven Ghent University |
dc.contributor.author.fl_str_mv |
Donders, G. G.G. Gonzaga, A. Marconi, C. [UNESP] Donders, F. Michiels, T. Eggermont, N. Bellen, G. Lule, J. Byamughisa, J. |
description |
Abnormal vaginal flora (AVF),indicative of bacterial vaginosis (BV) and/or aerobic vaginitis (AV),amongst other abnormalities,is a risk factor for multiple complications in pregnant as well as non-pregnant women. Screening for such conditions could help prevent these complications. Can self-testing for increased vaginal pH reliably detect BV and other high-riskmicroflora types,and is this more accurate than performing Gram stain-based Nugent score when screening for high-risk microflora? A total of 344 women presenting at different outpatient clinics in Mulago Hospital and Mbuikwe Outpatient clinics in Kampala,Uganda,were asked to test themselves by introducing a gloved finger into the vagina and smearing it on a microscopy slide,on which a pH strip was attached. Self-assessed categories of normal (pH 3.6-4.4),intermediate (4.5-4.7) or high pH (>4.7) were compared with demographic and with centralised microscopic data,both in air-dried rehydrated wet mounts (Femicare),as well as in Gram-stained specimens (Nugent). AVF was present in 38 %,BV in 25 % and AV in 11 % of patients. High pH and AVF is correlated with human immunodeficiency virus (HIV),infertility,frequent sex,but not vaginal douching. Screening for raised pH detects 90 % of AVF cases,but would require testing over half of the population. As AV and non-infectious conditions are frequent in women with AVF and high pH,Nugent score alone is an insufficient technique to screen women for a high-risk vaginal microflora,especially in infertile and HIV-infected women. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08-01 2018-12-11T17:07:22Z 2018-12-11T17:07:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10096-016-2664-2 European Journal of Clinical Microbiology and Infectious Diseases, v. 35, n. 8, p. 1297-1303, 2016. 1435-4373 0934-9723 http://hdl.handle.net/11449/173706 10.1007/s10096-016-2664-2 2-s2.0-84993848865 2-s2.0-84993848865.pdf |
url |
http://dx.doi.org/10.1007/s10096-016-2664-2 http://hdl.handle.net/11449/173706 |
identifier_str_mv |
European Journal of Clinical Microbiology and Infectious Diseases, v. 35, n. 8, p. 1297-1303, 2016. 1435-4373 0934-9723 10.1007/s10096-016-2664-2 2-s2.0-84993848865 2-s2.0-84993848865.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
European Journal of Clinical Microbiology and Infectious Diseases 1,312 1,312 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1297-1303 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
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1810021365516861440 |