Evaluation of the influence of protein p53 in penile carcinoma
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/219263 |
Resumo: | Introduction: The expression of protein p53 and its influence in the biological behavior of penile epidermoid carcinoma (PEC) were studied according to its effect on the following parameters: histologic staging, clinical and pathologic staging, and prognostic factors, such as survival curve and risk of death due to the tumor. Material and Methods: We studied 55 patients with PEC who underwent surgical treatment from 1979 to 1995. Protein p53 was studied by immunohistochemical analysis (clone DO-7-DAKO A/S, Denmark) in the most representative surgical specimens of the primary tumor and their metastasis. The intensity of p53 expression was determined by the number of tumor cell nuclei stained in the tumor and was classified into four groups: group 1 - up to 25%; group 2 - 26 to 50%; group 3 - 51 to 75% and group 4 - more than 75% stained nuclei. The relationship between the p53 expression in the tumor cells and the studied parameters was analyzed. Results: Rising rates of p53 expression correlate with low degrees of cell differentiation (p = 0.053). Twelve patients died due to the tumor during this study. Our data have shown that higher p53 expression in the tumor correlates with worse prognosis (p = 0.025). There was no significant correlation between the presence of p53 and the clinical or pathological stage of the tumor. Conclusion: Our data show that there is significant p53 expression in the PEC. The higher p53 expression, the worse the patient prognosis and the greater is the tumor biological agressiveness. The tumor becomes more aggressive in accordance with the increase in protein intensity in the tumor cell nuclei. |
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Evaluation of the influence of protein p53 in penile carcinomaCarcinomaPenisPrognosisProtein p53TumorIntroduction: The expression of protein p53 and its influence in the biological behavior of penile epidermoid carcinoma (PEC) were studied according to its effect on the following parameters: histologic staging, clinical and pathologic staging, and prognostic factors, such as survival curve and risk of death due to the tumor. Material and Methods: We studied 55 patients with PEC who underwent surgical treatment from 1979 to 1995. Protein p53 was studied by immunohistochemical analysis (clone DO-7-DAKO A/S, Denmark) in the most representative surgical specimens of the primary tumor and their metastasis. The intensity of p53 expression was determined by the number of tumor cell nuclei stained in the tumor and was classified into four groups: group 1 - up to 25%; group 2 - 26 to 50%; group 3 - 51 to 75% and group 4 - more than 75% stained nuclei. The relationship between the p53 expression in the tumor cells and the studied parameters was analyzed. Results: Rising rates of p53 expression correlate with low degrees of cell differentiation (p = 0.053). Twelve patients died due to the tumor during this study. Our data have shown that higher p53 expression in the tumor correlates with worse prognosis (p = 0.025). There was no significant correlation between the presence of p53 and the clinical or pathological stage of the tumor. Conclusion: Our data show that there is significant p53 expression in the PEC. The higher p53 expression, the worse the patient prognosis and the greater is the tumor biological agressiveness. The tumor becomes more aggressive in accordance with the increase in protein intensity in the tumor cell nuclei.General Hospital School of Medicine State Univ. of São Paulo USP, Rua Cotoxó 611/105, São Paulo SP 05021-000Universidade de São Paulo (USP)Gil, Antonio O.Pompeo, Antonio C.L.Sarkis, Álvaro S.Matsuo, MarioDa Motta, Tania H.B.V.Arap, Sami2022-04-28T18:54:36Z2022-04-28T18:54:36Z2002-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article33-39Brazilian Journal of Urology, v. 28, n. 1, p. 33-39, 2002.1517-6878http://hdl.handle.net/11449/2192632-s2.0-0036196122Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Urologyinfo:eu-repo/semantics/openAccess2022-04-28T18:54:36Zoai:repositorio.unesp.br:11449/219263Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:47:15.712269Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evaluation of the influence of protein p53 in penile carcinoma |
title |
Evaluation of the influence of protein p53 in penile carcinoma |
spellingShingle |
Evaluation of the influence of protein p53 in penile carcinoma Gil, Antonio O. Carcinoma Penis Prognosis Protein p53 Tumor |
title_short |
Evaluation of the influence of protein p53 in penile carcinoma |
title_full |
Evaluation of the influence of protein p53 in penile carcinoma |
title_fullStr |
Evaluation of the influence of protein p53 in penile carcinoma |
title_full_unstemmed |
Evaluation of the influence of protein p53 in penile carcinoma |
title_sort |
Evaluation of the influence of protein p53 in penile carcinoma |
author |
Gil, Antonio O. |
author_facet |
Gil, Antonio O. Pompeo, Antonio C.L. Sarkis, Álvaro S. Matsuo, Mario Da Motta, Tania H.B.V. Arap, Sami |
author_role |
author |
author2 |
Pompeo, Antonio C.L. Sarkis, Álvaro S. Matsuo, Mario Da Motta, Tania H.B.V. Arap, Sami |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Gil, Antonio O. Pompeo, Antonio C.L. Sarkis, Álvaro S. Matsuo, Mario Da Motta, Tania H.B.V. Arap, Sami |
dc.subject.por.fl_str_mv |
Carcinoma Penis Prognosis Protein p53 Tumor |
topic |
Carcinoma Penis Prognosis Protein p53 Tumor |
description |
Introduction: The expression of protein p53 and its influence in the biological behavior of penile epidermoid carcinoma (PEC) were studied according to its effect on the following parameters: histologic staging, clinical and pathologic staging, and prognostic factors, such as survival curve and risk of death due to the tumor. Material and Methods: We studied 55 patients with PEC who underwent surgical treatment from 1979 to 1995. Protein p53 was studied by immunohistochemical analysis (clone DO-7-DAKO A/S, Denmark) in the most representative surgical specimens of the primary tumor and their metastasis. The intensity of p53 expression was determined by the number of tumor cell nuclei stained in the tumor and was classified into four groups: group 1 - up to 25%; group 2 - 26 to 50%; group 3 - 51 to 75% and group 4 - more than 75% stained nuclei. The relationship between the p53 expression in the tumor cells and the studied parameters was analyzed. Results: Rising rates of p53 expression correlate with low degrees of cell differentiation (p = 0.053). Twelve patients died due to the tumor during this study. Our data have shown that higher p53 expression in the tumor correlates with worse prognosis (p = 0.025). There was no significant correlation between the presence of p53 and the clinical or pathological stage of the tumor. Conclusion: Our data show that there is significant p53 expression in the PEC. The higher p53 expression, the worse the patient prognosis and the greater is the tumor biological agressiveness. The tumor becomes more aggressive in accordance with the increase in protein intensity in the tumor cell nuclei. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-01-01 2022-04-28T18:54:36Z 2022-04-28T18:54:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Brazilian Journal of Urology, v. 28, n. 1, p. 33-39, 2002. 1517-6878 http://hdl.handle.net/11449/219263 2-s2.0-0036196122 |
identifier_str_mv |
Brazilian Journal of Urology, v. 28, n. 1, p. 33-39, 2002. 1517-6878 2-s2.0-0036196122 |
url |
http://hdl.handle.net/11449/219263 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Urology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
33-39 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128858252115968 |