Aging-related episodic-like memory decline in dogs
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.bbr.2022.113762 http://hdl.handle.net/11449/230298 |
Resumo: | Episodic memory, in humans, is the memory most affected by age-related deterioration or the constitution of neurodegenerative pathologies, such as Alzheimer's disease. However, it is unknown whether this relationship is also present in nonhuman animals. Since studies in birds, rats, primates, and dogs have been shown to have episodic-like memory, more studies aiming to improve the present understanding of this relationship in nonhuman animals are important to aid the development of new translational models for neurodegenerative disorders. Knowing that dogs (Canis familiaris) represent a promising experimental model for neurodegenerative disorders, a memory retrieval test was conducted with 90 clinically healthy domestic dogs of different ages, both sexes, and distinct breeds, for the purpose of evaluating episodic-like memory. The present study adapted a test that corroborates episodic memory requirements through incidental codification of experienced events. We performed a test with two exposure phases, with different characteristics between them, so that in the third phase it was necessary to integrate previous experiences in order to achieve success in the test. In our study, it was possible to verify the decline of episodic memory in elderly dogs, even clinically healthy, regardless of the dogs’ sex and size. This episodic-like memory decline observed in elderly dogs may be related to the physiological process of aging or preclinical pathological manifestation of cognitive impairment, similar as reported in humans. More studies should be carried out evaluating episodic-like memory in dogs with suspected of canine cognitive dysfunction syndrome in order to better understand the physiological and pathological behavior of this type of memory in canine species. |
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Aging-related episodic-like memory decline in dogsCognitive deficitCognitive testDementiaIncidental memoryEpisodic memory, in humans, is the memory most affected by age-related deterioration or the constitution of neurodegenerative pathologies, such as Alzheimer's disease. However, it is unknown whether this relationship is also present in nonhuman animals. Since studies in birds, rats, primates, and dogs have been shown to have episodic-like memory, more studies aiming to improve the present understanding of this relationship in nonhuman animals are important to aid the development of new translational models for neurodegenerative disorders. Knowing that dogs (Canis familiaris) represent a promising experimental model for neurodegenerative disorders, a memory retrieval test was conducted with 90 clinically healthy domestic dogs of different ages, both sexes, and distinct breeds, for the purpose of evaluating episodic-like memory. The present study adapted a test that corroborates episodic memory requirements through incidental codification of experienced events. We performed a test with two exposure phases, with different characteristics between them, so that in the third phase it was necessary to integrate previous experiences in order to achieve success in the test. In our study, it was possible to verify the decline of episodic memory in elderly dogs, even clinically healthy, regardless of the dogs’ sex and size. This episodic-like memory decline observed in elderly dogs may be related to the physiological process of aging or preclinical pathological manifestation of cognitive impairment, similar as reported in humans. More studies should be carried out evaluating episodic-like memory in dogs with suspected of canine cognitive dysfunction syndrome in order to better understand the physiological and pathological behavior of this type of memory in canine species.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Sao Paulo State University (UNESP) School of Veterinary Medicine and Animal Science Department of Veterinary Clinical Science, SPSao Paulo State University (UNESP) Institute of Biosciences Department of Biostatistics, SPSao Paulo State University (UNESP) School of Medicine Department of Neurology Psychology and Psychiatry, SPSao Paulo State University (UNESP) School of Veterinary Medicine and Animal Science Department of Veterinary Clinical Science, SPSao Paulo State University (UNESP) Institute of Biosciences Department of Biostatistics, SPSao Paulo State University (UNESP) School of Medicine Department of Neurology Psychology and Psychiatry, SPUniversidade Estadual Paulista (UNESP)Sanches, Felipe Jacques [UNESP]de Melo, Jéssica Cardia [UNESP]Ferreira, Sabrina Palha [UNESP]Trinca, Luzia Aparecida [UNESP]Arambula, Omar Gurrola [UNESP]Padovani, Flavia Helena Pereira [UNESP]Schelp, Arthur Oscar [UNESP]Amorim, Rogério Martins [UNESP]2022-04-29T08:38:54Z2022-04-29T08:38:54Z2022-03-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.bbr.2022.113762Behavioural Brain Research, v. 422.1872-75490166-4328http://hdl.handle.net/11449/23029810.1016/j.bbr.2022.1137622-s2.0-85123717255Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBehavioural Brain Researchinfo:eu-repo/semantics/openAccess2022-04-29T08:38:54Zoai:repositorio.unesp.br:11449/230298Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:38:54Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Aging-related episodic-like memory decline in dogs |
title |
Aging-related episodic-like memory decline in dogs |
spellingShingle |
Aging-related episodic-like memory decline in dogs Sanches, Felipe Jacques [UNESP] Cognitive deficit Cognitive test Dementia Incidental memory |
title_short |
Aging-related episodic-like memory decline in dogs |
title_full |
Aging-related episodic-like memory decline in dogs |
title_fullStr |
Aging-related episodic-like memory decline in dogs |
title_full_unstemmed |
Aging-related episodic-like memory decline in dogs |
title_sort |
Aging-related episodic-like memory decline in dogs |
author |
Sanches, Felipe Jacques [UNESP] |
author_facet |
Sanches, Felipe Jacques [UNESP] de Melo, Jéssica Cardia [UNESP] Ferreira, Sabrina Palha [UNESP] Trinca, Luzia Aparecida [UNESP] Arambula, Omar Gurrola [UNESP] Padovani, Flavia Helena Pereira [UNESP] Schelp, Arthur Oscar [UNESP] Amorim, Rogério Martins [UNESP] |
author_role |
author |
author2 |
de Melo, Jéssica Cardia [UNESP] Ferreira, Sabrina Palha [UNESP] Trinca, Luzia Aparecida [UNESP] Arambula, Omar Gurrola [UNESP] Padovani, Flavia Helena Pereira [UNESP] Schelp, Arthur Oscar [UNESP] Amorim, Rogério Martins [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Sanches, Felipe Jacques [UNESP] de Melo, Jéssica Cardia [UNESP] Ferreira, Sabrina Palha [UNESP] Trinca, Luzia Aparecida [UNESP] Arambula, Omar Gurrola [UNESP] Padovani, Flavia Helena Pereira [UNESP] Schelp, Arthur Oscar [UNESP] Amorim, Rogério Martins [UNESP] |
dc.subject.por.fl_str_mv |
Cognitive deficit Cognitive test Dementia Incidental memory |
topic |
Cognitive deficit Cognitive test Dementia Incidental memory |
description |
Episodic memory, in humans, is the memory most affected by age-related deterioration or the constitution of neurodegenerative pathologies, such as Alzheimer's disease. However, it is unknown whether this relationship is also present in nonhuman animals. Since studies in birds, rats, primates, and dogs have been shown to have episodic-like memory, more studies aiming to improve the present understanding of this relationship in nonhuman animals are important to aid the development of new translational models for neurodegenerative disorders. Knowing that dogs (Canis familiaris) represent a promising experimental model for neurodegenerative disorders, a memory retrieval test was conducted with 90 clinically healthy domestic dogs of different ages, both sexes, and distinct breeds, for the purpose of evaluating episodic-like memory. The present study adapted a test that corroborates episodic memory requirements through incidental codification of experienced events. We performed a test with two exposure phases, with different characteristics between them, so that in the third phase it was necessary to integrate previous experiences in order to achieve success in the test. In our study, it was possible to verify the decline of episodic memory in elderly dogs, even clinically healthy, regardless of the dogs’ sex and size. This episodic-like memory decline observed in elderly dogs may be related to the physiological process of aging or preclinical pathological manifestation of cognitive impairment, similar as reported in humans. More studies should be carried out evaluating episodic-like memory in dogs with suspected of canine cognitive dysfunction syndrome in order to better understand the physiological and pathological behavior of this type of memory in canine species. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-29T08:38:54Z 2022-04-29T08:38:54Z 2022-03-26 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bbr.2022.113762 Behavioural Brain Research, v. 422. 1872-7549 0166-4328 http://hdl.handle.net/11449/230298 10.1016/j.bbr.2022.113762 2-s2.0-85123717255 |
url |
http://dx.doi.org/10.1016/j.bbr.2022.113762 http://hdl.handle.net/11449/230298 |
identifier_str_mv |
Behavioural Brain Research, v. 422. 1872-7549 0166-4328 10.1016/j.bbr.2022.113762 2-s2.0-85123717255 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Behavioural Brain Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1803650043872280576 |