Oxidative stress in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis: Possible association with major depressive disorder?
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.yebeh.2017.12.025 http://hdl.handle.net/11449/175817 |
Resumo: | Objective: The objective was to evaluate the genetic and biochemical profiles associated with oxidative stress (OS) in patients with temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS) and a healthy control group, and also to verify the possible existence of association between OS markers and psychiatric disorders (PD) in group with TLE-MTS. Methods: Forty-six patients with refractory TLE-MTS and 112 healthy controls were included. Psychiatric evaluation occurred through Diagnostical and Statistical Manual of Mental Disorders (DSM-5) criteria. A peripheral blood sample was collected for analysis of glutathione S-transferase (GST) T1/M1 polymorphisms and serum levels of malondialdehyde (MDA) and antioxidant capacity equivalent to the trolox (TEAC), serum markers of OS. Student's t-test, Fisher's exact test, Chi-square test, and Analysis of Variance (ANOVA) were used, with a significance level of P < 0.05. Results: The PD were observed in 27 patients of the group with TLE-MTS (58.6%); major depressive disorder (MDD) was the most frequent. Serum levels of MDA (P < 0.0001) and TEAC (P < 0.0001) were higher in group with TLE-MTS. When patients with MDD were compared with patients without PD, significant differences were observed between MDA (P = 0.002) and TEAC (P = 0.003) serum levels. Patients with TLE-MTS and MDD presented higher levels when compared with patients with TLE-MTS without PD and with another PD except MDD. Conclusions: The present study observed significantly higher serum levels of MDA and of TEAC in patients with refractory TLE-MTS in comparison with the control group. The MDD was observed as an important issue associated with higher OS levels in refractory TLE-MTS. Further studies are needed to investigate the association of OS, TLE-MTS, and PD. |
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Oxidative stress in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis: Possible association with major depressive disorder?Major depressive disorderOxidative stress markersRefractory epilepsyTemporal lobe epilepsyObjective: The objective was to evaluate the genetic and biochemical profiles associated with oxidative stress (OS) in patients with temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS) and a healthy control group, and also to verify the possible existence of association between OS markers and psychiatric disorders (PD) in group with TLE-MTS. Methods: Forty-six patients with refractory TLE-MTS and 112 healthy controls were included. Psychiatric evaluation occurred through Diagnostical and Statistical Manual of Mental Disorders (DSM-5) criteria. A peripheral blood sample was collected for analysis of glutathione S-transferase (GST) T1/M1 polymorphisms and serum levels of malondialdehyde (MDA) and antioxidant capacity equivalent to the trolox (TEAC), serum markers of OS. Student's t-test, Fisher's exact test, Chi-square test, and Analysis of Variance (ANOVA) were used, with a significance level of P < 0.05. Results: The PD were observed in 27 patients of the group with TLE-MTS (58.6%); major depressive disorder (MDD) was the most frequent. Serum levels of MDA (P < 0.0001) and TEAC (P < 0.0001) were higher in group with TLE-MTS. When patients with MDD were compared with patients without PD, significant differences were observed between MDA (P = 0.002) and TEAC (P = 0.003) serum levels. Patients with TLE-MTS and MDD presented higher levels when compared with patients with TLE-MTS without PD and with another PD except MDD. Conclusions: The present study observed significantly higher serum levels of MDA and of TEAC in patients with refractory TLE-MTS in comparison with the control group. The MDD was observed as an important issue associated with higher OS levels in refractory TLE-MTS. Further studies are needed to investigate the association of OS, TLE-MTS, and PD.Faculdade de Medicina de São José do Rio PretoConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Psychiatry and Medical Psychology Faculdade de Medicina de São José do Rio Preto (FAMERP)Department of Biochemistry and Molecular Biology-NPBIM Faculdade de Medicina de São José do Rio Preto (FAMERP)Department of Neurological Sciences Faculdade de Medicina de São José do Rio Preto (FAMERP)Department of Chemistry and Environmental Sciences - IBILCE Universidade Estadual Paulista (UNESP)Department of Chemistry and Environmental Sciences - IBILCE Universidade Estadual Paulista (UNESP)Faculdade de Medicina de São José do Rio Preto: 110400CNPq: 443742/2014-6Faculdade de Medicina de São José do Rio Preto (FAMERP)Universidade Estadual Paulista (Unesp)de Araújo Filho, Gerardo MariaMartins, Denise PoltronieriLopes, Angélica Martade Jesus Brait, BeatrizFurlan, Ana Eliza RomanoOliveira, Camila Ive FerreiraMarques, Lucia Helena NevesSouza, Dorotéia Rossi Silvade Almeida, Eduardo Alves [UNESP]2018-12-11T17:17:42Z2018-12-11T17:17:42Z2018-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article191-196application/pdfhttp://dx.doi.org/10.1016/j.yebeh.2017.12.025Epilepsy and Behavior, v. 80, p. 191-196.1525-50691525-5050http://hdl.handle.net/11449/17581710.1016/j.yebeh.2017.12.0252-s2.0-850413983402-s2.0-85041398340.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEpilepsy and Behavior1,1311,131info:eu-repo/semantics/openAccess2023-12-19T06:18:26Zoai:repositorio.unesp.br:11449/175817Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:42:25.459664Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Oxidative stress in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis: Possible association with major depressive disorder? |
title |
Oxidative stress in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis: Possible association with major depressive disorder? |
spellingShingle |
Oxidative stress in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis: Possible association with major depressive disorder? de Araújo Filho, Gerardo Maria Major depressive disorder Oxidative stress markers Refractory epilepsy Temporal lobe epilepsy |
title_short |
Oxidative stress in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis: Possible association with major depressive disorder? |
title_full |
Oxidative stress in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis: Possible association with major depressive disorder? |
title_fullStr |
Oxidative stress in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis: Possible association with major depressive disorder? |
title_full_unstemmed |
Oxidative stress in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis: Possible association with major depressive disorder? |
title_sort |
Oxidative stress in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis: Possible association with major depressive disorder? |
author |
de Araújo Filho, Gerardo Maria |
author_facet |
de Araújo Filho, Gerardo Maria Martins, Denise Poltronieri Lopes, Angélica Marta de Jesus Brait, Beatriz Furlan, Ana Eliza Romano Oliveira, Camila Ive Ferreira Marques, Lucia Helena Neves Souza, Dorotéia Rossi Silva de Almeida, Eduardo Alves [UNESP] |
author_role |
author |
author2 |
Martins, Denise Poltronieri Lopes, Angélica Marta de Jesus Brait, Beatriz Furlan, Ana Eliza Romano Oliveira, Camila Ive Ferreira Marques, Lucia Helena Neves Souza, Dorotéia Rossi Silva de Almeida, Eduardo Alves [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Faculdade de Medicina de São José do Rio Preto (FAMERP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
de Araújo Filho, Gerardo Maria Martins, Denise Poltronieri Lopes, Angélica Marta de Jesus Brait, Beatriz Furlan, Ana Eliza Romano Oliveira, Camila Ive Ferreira Marques, Lucia Helena Neves Souza, Dorotéia Rossi Silva de Almeida, Eduardo Alves [UNESP] |
dc.subject.por.fl_str_mv |
Major depressive disorder Oxidative stress markers Refractory epilepsy Temporal lobe epilepsy |
topic |
Major depressive disorder Oxidative stress markers Refractory epilepsy Temporal lobe epilepsy |
description |
Objective: The objective was to evaluate the genetic and biochemical profiles associated with oxidative stress (OS) in patients with temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS) and a healthy control group, and also to verify the possible existence of association between OS markers and psychiatric disorders (PD) in group with TLE-MTS. Methods: Forty-six patients with refractory TLE-MTS and 112 healthy controls were included. Psychiatric evaluation occurred through Diagnostical and Statistical Manual of Mental Disorders (DSM-5) criteria. A peripheral blood sample was collected for analysis of glutathione S-transferase (GST) T1/M1 polymorphisms and serum levels of malondialdehyde (MDA) and antioxidant capacity equivalent to the trolox (TEAC), serum markers of OS. Student's t-test, Fisher's exact test, Chi-square test, and Analysis of Variance (ANOVA) were used, with a significance level of P < 0.05. Results: The PD were observed in 27 patients of the group with TLE-MTS (58.6%); major depressive disorder (MDD) was the most frequent. Serum levels of MDA (P < 0.0001) and TEAC (P < 0.0001) were higher in group with TLE-MTS. When patients with MDD were compared with patients without PD, significant differences were observed between MDA (P = 0.002) and TEAC (P = 0.003) serum levels. Patients with TLE-MTS and MDD presented higher levels when compared with patients with TLE-MTS without PD and with another PD except MDD. Conclusions: The present study observed significantly higher serum levels of MDA and of TEAC in patients with refractory TLE-MTS in comparison with the control group. The MDD was observed as an important issue associated with higher OS levels in refractory TLE-MTS. Further studies are needed to investigate the association of OS, TLE-MTS, and PD. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:17:42Z 2018-12-11T17:17:42Z 2018-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.yebeh.2017.12.025 Epilepsy and Behavior, v. 80, p. 191-196. 1525-5069 1525-5050 http://hdl.handle.net/11449/175817 10.1016/j.yebeh.2017.12.025 2-s2.0-85041398340 2-s2.0-85041398340.pdf |
url |
http://dx.doi.org/10.1016/j.yebeh.2017.12.025 http://hdl.handle.net/11449/175817 |
identifier_str_mv |
Epilepsy and Behavior, v. 80, p. 191-196. 1525-5069 1525-5050 10.1016/j.yebeh.2017.12.025 2-s2.0-85041398340 2-s2.0-85041398340.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Epilepsy and Behavior 1,131 1,131 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
191-196 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129237202239488 |