In vitro and in vivo studies on CCR10 regulation by Annexin A1

Detalhes bibliográficos
Autor(a) principal: Rodrigues-Lisoni, F. C.
Data de Publicação: 2006
Outros Autores: Mehemet, D. K., Peitl, P., John, C. D., Tajara, E., Buckingham, J. C., Solito, E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.febslet.2006.01.072
http://hdl.handle.net/11449/21716
Resumo: The mode of action of annexin A1 (ANXA1) is poorly understood. By using rapid subtraction hybridization we studied the effects of human recombinant ANXA1 and the N-terminal ANXA1 peptide on gene expression in a human larynx cell line. Three genes showed strong downregulation after treatment with ANXA1. In contrast, expression of CCR10, a seven transmembrane G-protein coupled receptor for chemokine CCL27 involved in mucosal immunity, was increased. Moreover the reduction in CCR10 expression induced by ANXA1 gene deletion was rescued by intravenous treatment with low doses of ANXA1. These findings provide new evidence that ANXA1 modulates gene expression. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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spelling In vitro and in vivo studies on CCR10 regulation by Annexin A1gene expressionhost defenceannexin A1-null miceepithelial cellsannexin A1The mode of action of annexin A1 (ANXA1) is poorly understood. By using rapid subtraction hybridization we studied the effects of human recombinant ANXA1 and the N-terminal ANXA1 peptide on gene expression in a human larynx cell line. Three genes showed strong downregulation after treatment with ANXA1. In contrast, expression of CCR10, a seven transmembrane G-protein coupled receptor for chemokine CCL27 involved in mucosal immunity, was increased. Moreover the reduction in CCR10 expression induced by ANXA1 gene deletion was rescued by intravenous treatment with low doses of ANXA1. These findings provide new evidence that ANXA1 modulates gene expression. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.Univ London Imperial Coll Sci Technol & Med, Fac Med, Div Neurosci & Mental Hlth, Dept Cellular & Mol Neurosci, London W12 0NN, EnglandUNESP, São Paulo State Univ, IBILCE, Sao Jose do Rio Preto, SP, BrazilUSP, Fac Med, Ribeirao Preto, BrazilUNESP, São Paulo State Univ, IBILCE, Sao Jose do Rio Preto, SP, BrazilElsevier B.V.Univ London Imperial Coll Sci Technol & MedUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Rodrigues-Lisoni, F. C.Mehemet, D. K.Peitl, P.John, C. D.Tajara, E.Buckingham, J. C.Solito, E.2014-05-20T14:01:32Z2014-05-20T14:01:32Z2006-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1431-1438application/pdfhttp://dx.doi.org/10.1016/j.febslet.2006.01.072Febs Letters. Amsterdam: Elsevier B.V., v. 580, n. 5, p. 1431-1438, 2006.0014-5793http://hdl.handle.net/11449/2171610.1016/j.febslet.2006.01.072WOS:000235597700037WOS000235597700037.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFEBS Letters1,991info:eu-repo/semantics/openAccess2023-12-24T06:17:13Zoai:repositorio.unesp.br:11449/21716Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:10:13.225239Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv In vitro and in vivo studies on CCR10 regulation by Annexin A1
title In vitro and in vivo studies on CCR10 regulation by Annexin A1
spellingShingle In vitro and in vivo studies on CCR10 regulation by Annexin A1
Rodrigues-Lisoni, F. C.
gene expression
host defence
annexin A1-null mice
epithelial cells
annexin A1
title_short In vitro and in vivo studies on CCR10 regulation by Annexin A1
title_full In vitro and in vivo studies on CCR10 regulation by Annexin A1
title_fullStr In vitro and in vivo studies on CCR10 regulation by Annexin A1
title_full_unstemmed In vitro and in vivo studies on CCR10 regulation by Annexin A1
title_sort In vitro and in vivo studies on CCR10 regulation by Annexin A1
author Rodrigues-Lisoni, F. C.
author_facet Rodrigues-Lisoni, F. C.
Mehemet, D. K.
Peitl, P.
John, C. D.
Tajara, E.
Buckingham, J. C.
Solito, E.
author_role author
author2 Mehemet, D. K.
Peitl, P.
John, C. D.
Tajara, E.
Buckingham, J. C.
Solito, E.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Univ London Imperial Coll Sci Technol & Med
Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Rodrigues-Lisoni, F. C.
Mehemet, D. K.
Peitl, P.
John, C. D.
Tajara, E.
Buckingham, J. C.
Solito, E.
dc.subject.por.fl_str_mv gene expression
host defence
annexin A1-null mice
epithelial cells
annexin A1
topic gene expression
host defence
annexin A1-null mice
epithelial cells
annexin A1
description The mode of action of annexin A1 (ANXA1) is poorly understood. By using rapid subtraction hybridization we studied the effects of human recombinant ANXA1 and the N-terminal ANXA1 peptide on gene expression in a human larynx cell line. Three genes showed strong downregulation after treatment with ANXA1. In contrast, expression of CCR10, a seven transmembrane G-protein coupled receptor for chemokine CCL27 involved in mucosal immunity, was increased. Moreover the reduction in CCR10 expression induced by ANXA1 gene deletion was rescued by intravenous treatment with low doses of ANXA1. These findings provide new evidence that ANXA1 modulates gene expression. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
publishDate 2006
dc.date.none.fl_str_mv 2006-02-01
2014-05-20T14:01:32Z
2014-05-20T14:01:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.febslet.2006.01.072
Febs Letters. Amsterdam: Elsevier B.V., v. 580, n. 5, p. 1431-1438, 2006.
0014-5793
http://hdl.handle.net/11449/21716
10.1016/j.febslet.2006.01.072
WOS:000235597700037
WOS000235597700037.pdf
url http://dx.doi.org/10.1016/j.febslet.2006.01.072
http://hdl.handle.net/11449/21716
identifier_str_mv Febs Letters. Amsterdam: Elsevier B.V., v. 580, n. 5, p. 1431-1438, 2006.
0014-5793
10.1016/j.febslet.2006.01.072
WOS:000235597700037
WOS000235597700037.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv FEBS Letters
1,991
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1431-1438
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129293367115776

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