Head and neck carcinogenesis: Impact of MTHFD1 G1958A polymorphism
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://dx.doi.org/10.1016/S2255-4823(11)70043-1 http://hdl.handle.net/11449/72320 |
Resumo: | Objective: To investigate the MTHFD1 G1958A polymorphism involved in the folate metabolism as a risk for head and neck cancer, and to find the association of the polymorphism with the risk factors and clinical and histopathological characteristics. Methods: Retrospective study investigating MTHFD1 G1958A polymorphism in 694 subjects (240 patients in the Case Group and 454 in the Control Group) by Restriction Fragment Length Polymorphism (RFLP) Analysis. Multiple logistic regression and chi-square tests were used in the statistical analysis. Results: Multivariable analysis showed that smoking and age over 42 years were disease predictors (p < 0.05). MTHFD1 1958GA or AA genotypes were associated with smoking (p = 0.04) and alcoholism (p = 0.03) and were more ofen found in more advanced stage tumors (p = 0.04) and in patients with a shorter survival (p = 0.03). Conclusion: Te presence of MTHFD1 G1948A polymorphism associated with smoking and alcoholism raises the head and neck cancer risk. |
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Head and neck carcinogenesis: Impact of MTHFD1 G1958A polymorphismAlcoholismGeneticHead and neck neoplasmsMe-hylenetetrahydrofolate dehydrogenase (NADP)PolymorphismSmokingObjective: To investigate the MTHFD1 G1958A polymorphism involved in the folate metabolism as a risk for head and neck cancer, and to find the association of the polymorphism with the risk factors and clinical and histopathological characteristics. Methods: Retrospective study investigating MTHFD1 G1958A polymorphism in 694 subjects (240 patients in the Case Group and 454 in the Control Group) by Restriction Fragment Length Polymorphism (RFLP) Analysis. Multiple logistic regression and chi-square tests were used in the statistical analysis. Results: Multivariable analysis showed that smoking and age over 42 years were disease predictors (p < 0.05). MTHFD1 1958GA or AA genotypes were associated with smoking (p = 0.04) and alcoholism (p = 0.03) and were more ofen found in more advanced stage tumors (p = 0.04) and in patients with a shorter survival (p = 0.03). Conclusion: Te presence of MTHFD1 G1948A polymorphism associated with smoking and alcoholism raises the head and neck cancer risk.Research in Genetics and Molecular Biology -UPGEM Medical College of São José do Rio Preto - FAMERP, São José do Rio Preto, SPLanguage and Hearing Sciences FAMERP, São José do Rio Preto, SPUPGEM/ FAMERP, São José do Rio Preto, SPUniversidade Estadual Paulista Júlio de Mesquita Filho - Unesp, São José do Rio Preto, SPFAMERP, São José do Rio Preto, SPDepartment of Otorhinolaryngology and Head and Neck Surgery FAMERP, São José do RioDepartment of Molecular Biology FAMERP, São José do Rio Preto, SPUniversidade Estadual Paulista Júlio de Mesquita Filho - Unesp, São José do Rio Preto, SPFaculdade de Medicina de São José do Rio Preto (FAMERP)Universidade Estadual Paulista (Unesp)da Silva, Lidia Maria Rebolho Batistada Silva, Jéssika Nunes GomesGalbiatti, Ana Lívia SilvaSucci, MaysaRuiz, Mariangela Torreglosa [UNESP]Raposo, Luiz SérgioManiglia, José VíctorPavarino-Bertelli, Érika CristinaGoloni-Bertollo, Eny Maria2014-05-27T11:25:28Z2014-05-27T11:25:28Z2011-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article188-193application/pdfhttp://dx.doi.org/10.1016/S2255-4823(11)70043-1Revista da Associacao Medica Brasileira, v. 57, n. 2, p. 188-193, 2011.0104-4230http://hdl.handle.net/11449/7232010.1016/S2255-4823(11)70043-12-s2.0-799557394452-s2.0-79955739445.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista da Associação Médica Brasileira0.7360,265info:eu-repo/semantics/openAccess2024-01-21T06:19:26Zoai:repositorio.unesp.br:11449/72320Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-21T06:19:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Head and neck carcinogenesis: Impact of MTHFD1 G1958A polymorphism |
| title |
Head and neck carcinogenesis: Impact of MTHFD1 G1958A polymorphism |
| spellingShingle |
Head and neck carcinogenesis: Impact of MTHFD1 G1958A polymorphism da Silva, Lidia Maria Rebolho Batista Alcoholism Genetic Head and neck neoplasms Me-hylenetetrahydrofolate dehydrogenase (NADP) Polymorphism Smoking |
| title_short |
Head and neck carcinogenesis: Impact of MTHFD1 G1958A polymorphism |
| title_full |
Head and neck carcinogenesis: Impact of MTHFD1 G1958A polymorphism |
| title_fullStr |
Head and neck carcinogenesis: Impact of MTHFD1 G1958A polymorphism |
| title_full_unstemmed |
Head and neck carcinogenesis: Impact of MTHFD1 G1958A polymorphism |
| title_sort |
Head and neck carcinogenesis: Impact of MTHFD1 G1958A polymorphism |
| author |
da Silva, Lidia Maria Rebolho Batista |
| author_facet |
da Silva, Lidia Maria Rebolho Batista da Silva, Jéssika Nunes Gomes Galbiatti, Ana Lívia Silva Succi, Maysa Ruiz, Mariangela Torreglosa [UNESP] Raposo, Luiz Sérgio Maniglia, José Víctor Pavarino-Bertelli, Érika Cristina Goloni-Bertollo, Eny Maria |
| author_role |
author |
| author2 |
da Silva, Jéssika Nunes Gomes Galbiatti, Ana Lívia Silva Succi, Maysa Ruiz, Mariangela Torreglosa [UNESP] Raposo, Luiz Sérgio Maniglia, José Víctor Pavarino-Bertelli, Érika Cristina Goloni-Bertollo, Eny Maria |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Faculdade de Medicina de São José do Rio Preto (FAMERP) Universidade Estadual Paulista (Unesp) |
| dc.contributor.author.fl_str_mv |
da Silva, Lidia Maria Rebolho Batista da Silva, Jéssika Nunes Gomes Galbiatti, Ana Lívia Silva Succi, Maysa Ruiz, Mariangela Torreglosa [UNESP] Raposo, Luiz Sérgio Maniglia, José Víctor Pavarino-Bertelli, Érika Cristina Goloni-Bertollo, Eny Maria |
| dc.subject.por.fl_str_mv |
Alcoholism Genetic Head and neck neoplasms Me-hylenetetrahydrofolate dehydrogenase (NADP) Polymorphism Smoking |
| topic |
Alcoholism Genetic Head and neck neoplasms Me-hylenetetrahydrofolate dehydrogenase (NADP) Polymorphism Smoking |
| description |
Objective: To investigate the MTHFD1 G1958A polymorphism involved in the folate metabolism as a risk for head and neck cancer, and to find the association of the polymorphism with the risk factors and clinical and histopathological characteristics. Methods: Retrospective study investigating MTHFD1 G1958A polymorphism in 694 subjects (240 patients in the Case Group and 454 in the Control Group) by Restriction Fragment Length Polymorphism (RFLP) Analysis. Multiple logistic regression and chi-square tests were used in the statistical analysis. Results: Multivariable analysis showed that smoking and age over 42 years were disease predictors (p < 0.05). MTHFD1 1958GA or AA genotypes were associated with smoking (p = 0.04) and alcoholism (p = 0.03) and were more ofen found in more advanced stage tumors (p = 0.04) and in patients with a shorter survival (p = 0.03). Conclusion: Te presence of MTHFD1 G1948A polymorphism associated with smoking and alcoholism raises the head and neck cancer risk. |
| publishDate |
2011 |
| dc.date.none.fl_str_mv |
2011-03-01 2014-05-27T11:25:28Z 2014-05-27T11:25:28Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/S2255-4823(11)70043-1 Revista da Associacao Medica Brasileira, v. 57, n. 2, p. 188-193, 2011. 0104-4230 http://hdl.handle.net/11449/72320 10.1016/S2255-4823(11)70043-1 2-s2.0-79955739445 2-s2.0-79955739445.pdf |
| url |
http://dx.doi.org/10.1016/S2255-4823(11)70043-1 http://hdl.handle.net/11449/72320 |
| identifier_str_mv |
Revista da Associacao Medica Brasileira, v. 57, n. 2, p. 188-193, 2011. 0104-4230 10.1016/S2255-4823(11)70043-1 2-s2.0-79955739445 2-s2.0-79955739445.pdf |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Revista da Associação Médica Brasileira 0.736 0,265 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
188-193 application/pdf |
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Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
| instname_str |
Universidade Estadual Paulista (UNESP) |
| instacron_str |
UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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1799965679096430592 |