Understanding the role of electrostatic interactions on the association of 5-fluorouracil to chitosan-TPP nanoparticles
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.colsurfa.2022.128417 http://hdl.handle.net/11449/234093 |
Resumo: | Judicious design strategies should be considered powerful tools to better control the properties of chitosan (CS) and tripolyphosphate (TPP) particles. This study focused on understanding the role of the charge properties of 5-fluorouracil (5-FU) on the formation and properties of CS-TPP nanoparticles. The effect of synthesis variables of CS-TPP nanoparticles (CS to TPP ratio and order of addition) under pH 4.5 and 5.5 was evaluated, where CS and TPP were charged, and 5-FU had two different charges (positive and negative), maximizing the interactions between them for the formation of nanoparticles. The order of addition and drug location resulted in changes in the interaction forces, influencing the particle size and size distribution. 5-FU addition into CS resulted in stronger interactions, favoring the formation of smaller particles. The pH of reactional medium and CS to TPP ratio affected the properties of particles, in terms of size and potential zeta, which led to greater 5-FU entrapment. These results demonstrated that the particle properties still depends of the synthesis factors, but the physicochemical properties of drug also influence the reactions/interactions involved in the formation of CS-TPP nanoparticles. |
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Repositório Institucional da UNESP |
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Understanding the role of electrostatic interactions on the association of 5-fluorouracil to chitosan-TPP nanoparticlesChitosan-based nanoparticlesElectrostatic interactionsIonic crosslinkingSodium tripolyphosphateJudicious design strategies should be considered powerful tools to better control the properties of chitosan (CS) and tripolyphosphate (TPP) particles. This study focused on understanding the role of the charge properties of 5-fluorouracil (5-FU) on the formation and properties of CS-TPP nanoparticles. The effect of synthesis variables of CS-TPP nanoparticles (CS to TPP ratio and order of addition) under pH 4.5 and 5.5 was evaluated, where CS and TPP were charged, and 5-FU had two different charges (positive and negative), maximizing the interactions between them for the formation of nanoparticles. The order of addition and drug location resulted in changes in the interaction forces, influencing the particle size and size distribution. 5-FU addition into CS resulted in stronger interactions, favoring the formation of smaller particles. The pH of reactional medium and CS to TPP ratio affected the properties of particles, in terms of size and potential zeta, which led to greater 5-FU entrapment. These results demonstrated that the particle properties still depends of the synthesis factors, but the physicochemical properties of drug also influence the reactions/interactions involved in the formation of CS-TPP nanoparticles.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)São Paulo State University (UNESP) School of Pharmaceutical SciencesNanomedicine and Nanotoxicology Group (GNANO) University of São Paulo (USP)São Paulo State University (UNESP) School of Pharmaceutical SciencesFAPESP: 2014/50928-2FAPESP: 2016/01464-9CNPq: 465687/2014-8Universidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)dos Santos, Aline Martins [UNESP]Carvalho, Suzana Gonçalves [UNESP]Ferreira, Leonardo Miziara Barboza [UNESP]Chorilli, Marlus [UNESP]Gremião, Maria Palmira Daflon [UNESP]2022-05-01T13:41:26Z2022-05-01T13:41:26Z2022-05-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.colsurfa.2022.128417Colloids and Surfaces A: Physicochemical and Engineering Aspects, v. 640.1873-43590927-7757http://hdl.handle.net/11449/23409310.1016/j.colsurfa.2022.1284172-s2.0-85123935816Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengColloids and Surfaces A: Physicochemical and Engineering Aspectsinfo:eu-repo/semantics/openAccess2024-06-24T13:46:23Zoai:repositorio.unesp.br:11449/234093Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:13:32.547642Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Understanding the role of electrostatic interactions on the association of 5-fluorouracil to chitosan-TPP nanoparticles |
title |
Understanding the role of electrostatic interactions on the association of 5-fluorouracil to chitosan-TPP nanoparticles |
spellingShingle |
Understanding the role of electrostatic interactions on the association of 5-fluorouracil to chitosan-TPP nanoparticles dos Santos, Aline Martins [UNESP] Chitosan-based nanoparticles Electrostatic interactions Ionic crosslinking Sodium tripolyphosphate |
title_short |
Understanding the role of electrostatic interactions on the association of 5-fluorouracil to chitosan-TPP nanoparticles |
title_full |
Understanding the role of electrostatic interactions on the association of 5-fluorouracil to chitosan-TPP nanoparticles |
title_fullStr |
Understanding the role of electrostatic interactions on the association of 5-fluorouracil to chitosan-TPP nanoparticles |
title_full_unstemmed |
Understanding the role of electrostatic interactions on the association of 5-fluorouracil to chitosan-TPP nanoparticles |
title_sort |
Understanding the role of electrostatic interactions on the association of 5-fluorouracil to chitosan-TPP nanoparticles |
author |
dos Santos, Aline Martins [UNESP] |
author_facet |
dos Santos, Aline Martins [UNESP] Carvalho, Suzana Gonçalves [UNESP] Ferreira, Leonardo Miziara Barboza [UNESP] Chorilli, Marlus [UNESP] Gremião, Maria Palmira Daflon [UNESP] |
author_role |
author |
author2 |
Carvalho, Suzana Gonçalves [UNESP] Ferreira, Leonardo Miziara Barboza [UNESP] Chorilli, Marlus [UNESP] Gremião, Maria Palmira Daflon [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
dos Santos, Aline Martins [UNESP] Carvalho, Suzana Gonçalves [UNESP] Ferreira, Leonardo Miziara Barboza [UNESP] Chorilli, Marlus [UNESP] Gremião, Maria Palmira Daflon [UNESP] |
dc.subject.por.fl_str_mv |
Chitosan-based nanoparticles Electrostatic interactions Ionic crosslinking Sodium tripolyphosphate |
topic |
Chitosan-based nanoparticles Electrostatic interactions Ionic crosslinking Sodium tripolyphosphate |
description |
Judicious design strategies should be considered powerful tools to better control the properties of chitosan (CS) and tripolyphosphate (TPP) particles. This study focused on understanding the role of the charge properties of 5-fluorouracil (5-FU) on the formation and properties of CS-TPP nanoparticles. The effect of synthesis variables of CS-TPP nanoparticles (CS to TPP ratio and order of addition) under pH 4.5 and 5.5 was evaluated, where CS and TPP were charged, and 5-FU had two different charges (positive and negative), maximizing the interactions between them for the formation of nanoparticles. The order of addition and drug location resulted in changes in the interaction forces, influencing the particle size and size distribution. 5-FU addition into CS resulted in stronger interactions, favoring the formation of smaller particles. The pH of reactional medium and CS to TPP ratio affected the properties of particles, in terms of size and potential zeta, which led to greater 5-FU entrapment. These results demonstrated that the particle properties still depends of the synthesis factors, but the physicochemical properties of drug also influence the reactions/interactions involved in the formation of CS-TPP nanoparticles. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-01T13:41:26Z 2022-05-01T13:41:26Z 2022-05-05 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.colsurfa.2022.128417 Colloids and Surfaces A: Physicochemical and Engineering Aspects, v. 640. 1873-4359 0927-7757 http://hdl.handle.net/11449/234093 10.1016/j.colsurfa.2022.128417 2-s2.0-85123935816 |
url |
http://dx.doi.org/10.1016/j.colsurfa.2022.128417 http://hdl.handle.net/11449/234093 |
identifier_str_mv |
Colloids and Surfaces A: Physicochemical and Engineering Aspects, v. 640. 1873-4359 0927-7757 10.1016/j.colsurfa.2022.128417 2-s2.0-85123935816 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Colloids and Surfaces A: Physicochemical and Engineering Aspects |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129406607032320 |