Estrogenic activities of diuron metabolites in female Nile tilapia (Oreochromis niloticus)
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.chemosphere.2015.12.073 http://hdl.handle.net/11449/172593 |
Resumo: | Some endocrine disrupting chemicals (EDCs) can alter the estrogenic activities of the organism by directly interacting with estrogen receptors (ER) or indirectly through the hypothalamus-pituitary-gonadal axis. Recent studies in male Nile tilapia (Oreochromis niloticus) indicated that diuron may have anti-androgenic activity augmented by biotransformation. In this study, the effects of diuron and three of its metabolites were evaluated in female tilapia. Sexually mature female fish were exposed for 25 days to diuron, as well as to its metabolites 3,4-dichloroaniline (DCA), 3,4-dichlorophenylurea (DCPU) and 3,4-dichlorophenyl-N-methylurea (DCPMU), at concentrations of 100 ng/L. Diuron metabolites caused increases in E2 plasma levels, gonadosomatic indices and in the percentage of final vitellogenic oocytes. Moreover, diuron and its metabolites caused a decrease in germinative cells. Significant differences in plasma concentrations of the estrogen precursor and gonadal regulator17α-hydroxyprogesterone (17α-OHP) were not observed. These results show that diuron metabolites had estrogenic effects potentially mediated through enhanced estradiol biosynthesis and accelerated the ovarian development of O. niloticus females. |
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Estrogenic activities of diuron metabolites in female Nile tilapia (Oreochromis niloticus)DiuronDiuron metabolitesEndocrine disrupting chemicalsGametogenesisNile tilapiaSome endocrine disrupting chemicals (EDCs) can alter the estrogenic activities of the organism by directly interacting with estrogen receptors (ER) or indirectly through the hypothalamus-pituitary-gonadal axis. Recent studies in male Nile tilapia (Oreochromis niloticus) indicated that diuron may have anti-androgenic activity augmented by biotransformation. In this study, the effects of diuron and three of its metabolites were evaluated in female tilapia. Sexually mature female fish were exposed for 25 days to diuron, as well as to its metabolites 3,4-dichloroaniline (DCA), 3,4-dichlorophenylurea (DCPU) and 3,4-dichlorophenyl-N-methylurea (DCPMU), at concentrations of 100 ng/L. Diuron metabolites caused increases in E2 plasma levels, gonadosomatic indices and in the percentage of final vitellogenic oocytes. Moreover, diuron and its metabolites caused a decrease in germinative cells. Significant differences in plasma concentrations of the estrogen precursor and gonadal regulator17α-hydroxyprogesterone (17α-OHP) were not observed. These results show that diuron metabolites had estrogenic effects potentially mediated through enhanced estradiol biosynthesis and accelerated the ovarian development of O. niloticus females.Department of Zoology and Botany Universidade Estadual Paulista (IBILCE/UNESP), Rua Cristóvão Colombo, 2265Department of Chemistry and Environmental Sciences Universidade Estadual Paulista (IBILCE/UNESP), Rua Cristóvão Colombo, 2265Aquaculture Center Universidade Estadual Paulista (CAUNESP), Via de Acesso Prof. Paulo Donato Castelane, s/n.Department of Environmental Sciences University of California Riverside, 3401 Watkins DrDepartment of Zoology and Botany Universidade Estadual Paulista (IBILCE/UNESP), Rua Cristóvão Colombo, 2265Department of Chemistry and Environmental Sciences Universidade Estadual Paulista (IBILCE/UNESP), Rua Cristóvão Colombo, 2265Aquaculture Center Universidade Estadual Paulista (CAUNESP), Via de Acesso Prof. Paulo Donato Castelane, s/n.Universidade Estadual Paulista (Unesp)RiversideBoscolo Pereira, Thiago Scremin [UNESP]Pereira Boscolo, Camila Nomura [UNESP]Felício, Andreia Arantes [UNESP]Batlouni, Sergio Ricardo [UNESP]Schlenk, DanielAlves de Almeida, Eduardo [UNESP]2018-12-11T17:01:16Z2018-12-11T17:01:16Z2016-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article497-502application/pdfhttp://dx.doi.org/10.1016/j.chemosphere.2015.12.073Chemosphere, v. 146, p. 497-502.1879-12980045-6535http://hdl.handle.net/11449/17259310.1016/j.chemosphere.2015.12.0732-s2.0-849592350132-s2.0-84959235013.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengChemosphere1,435info:eu-repo/semantics/openAccess2023-12-26T06:18:07Zoai:repositorio.unesp.br:11449/172593Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-26T06:18:07Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Estrogenic activities of diuron metabolites in female Nile tilapia (Oreochromis niloticus) |
title |
Estrogenic activities of diuron metabolites in female Nile tilapia (Oreochromis niloticus) |
spellingShingle |
Estrogenic activities of diuron metabolites in female Nile tilapia (Oreochromis niloticus) Boscolo Pereira, Thiago Scremin [UNESP] Diuron Diuron metabolites Endocrine disrupting chemicals Gametogenesis Nile tilapia |
title_short |
Estrogenic activities of diuron metabolites in female Nile tilapia (Oreochromis niloticus) |
title_full |
Estrogenic activities of diuron metabolites in female Nile tilapia (Oreochromis niloticus) |
title_fullStr |
Estrogenic activities of diuron metabolites in female Nile tilapia (Oreochromis niloticus) |
title_full_unstemmed |
Estrogenic activities of diuron metabolites in female Nile tilapia (Oreochromis niloticus) |
title_sort |
Estrogenic activities of diuron metabolites in female Nile tilapia (Oreochromis niloticus) |
author |
Boscolo Pereira, Thiago Scremin [UNESP] |
author_facet |
Boscolo Pereira, Thiago Scremin [UNESP] Pereira Boscolo, Camila Nomura [UNESP] Felício, Andreia Arantes [UNESP] Batlouni, Sergio Ricardo [UNESP] Schlenk, Daniel Alves de Almeida, Eduardo [UNESP] |
author_role |
author |
author2 |
Pereira Boscolo, Camila Nomura [UNESP] Felício, Andreia Arantes [UNESP] Batlouni, Sergio Ricardo [UNESP] Schlenk, Daniel Alves de Almeida, Eduardo [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Riverside |
dc.contributor.author.fl_str_mv |
Boscolo Pereira, Thiago Scremin [UNESP] Pereira Boscolo, Camila Nomura [UNESP] Felício, Andreia Arantes [UNESP] Batlouni, Sergio Ricardo [UNESP] Schlenk, Daniel Alves de Almeida, Eduardo [UNESP] |
dc.subject.por.fl_str_mv |
Diuron Diuron metabolites Endocrine disrupting chemicals Gametogenesis Nile tilapia |
topic |
Diuron Diuron metabolites Endocrine disrupting chemicals Gametogenesis Nile tilapia |
description |
Some endocrine disrupting chemicals (EDCs) can alter the estrogenic activities of the organism by directly interacting with estrogen receptors (ER) or indirectly through the hypothalamus-pituitary-gonadal axis. Recent studies in male Nile tilapia (Oreochromis niloticus) indicated that diuron may have anti-androgenic activity augmented by biotransformation. In this study, the effects of diuron and three of its metabolites were evaluated in female tilapia. Sexually mature female fish were exposed for 25 days to diuron, as well as to its metabolites 3,4-dichloroaniline (DCA), 3,4-dichlorophenylurea (DCPU) and 3,4-dichlorophenyl-N-methylurea (DCPMU), at concentrations of 100 ng/L. Diuron metabolites caused increases in E2 plasma levels, gonadosomatic indices and in the percentage of final vitellogenic oocytes. Moreover, diuron and its metabolites caused a decrease in germinative cells. Significant differences in plasma concentrations of the estrogen precursor and gonadal regulator17α-hydroxyprogesterone (17α-OHP) were not observed. These results show that diuron metabolites had estrogenic effects potentially mediated through enhanced estradiol biosynthesis and accelerated the ovarian development of O. niloticus females. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03-01 2018-12-11T17:01:16Z 2018-12-11T17:01:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.chemosphere.2015.12.073 Chemosphere, v. 146, p. 497-502. 1879-1298 0045-6535 http://hdl.handle.net/11449/172593 10.1016/j.chemosphere.2015.12.073 2-s2.0-84959235013 2-s2.0-84959235013.pdf |
url |
http://dx.doi.org/10.1016/j.chemosphere.2015.12.073 http://hdl.handle.net/11449/172593 |
identifier_str_mv |
Chemosphere, v. 146, p. 497-502. 1879-1298 0045-6535 10.1016/j.chemosphere.2015.12.073 2-s2.0-84959235013 2-s2.0-84959235013.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Chemosphere 1,435 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
497-502 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965413171265536 |