Muscular glucose metabolism in middle-age trained rats
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s11332-017-0377-2 http://hdl.handle.net/11449/169882 |
Resumo: | Aging decreases the normal organism physiological functions. On the other hand, physical exercise shows health benefits, but little information is known about physical deconditioning at aging. The aim of the present study was to analyze the glucose muscle metabolism in middle-age Wistar rats in response to conditioning and physical deconditioning. The study included three groups: Control (C)—not performed physical training; Trained (T)—performed physical training from 4 to 12 months—swimming exercise for 1 h per day, 5 days per week at 80% of maximal lactate stead state—MLSS; Detrained (D)—performed to physical training from 4 to 8 months and assessed at 12 months (D). Physical training at submaximal intensities induced decreases in body weight (C 588 ± 71, T 515 ± 72, D 576 ± 62 g), and the weight of mesenteric adipose tissue (C 4399 ± 643, T 3007 ± 811, D 4085 ± 540 mg/g), and increases in exercise workload in MLSS intensity (C 4.6 ± 0.4, T 5.8 ± 1.3, D 5.3 ± 0.4% body weight), glucose tolerance (C 12314 ± 1122, T 8428 ± 853, D 9433 ± 1200 mg/dL 120 min), glycogen deposits (C 0.48 ± 0.07, T 0.66 ± 0.18, D 0.46 ± 0.10 mg/100 mg) and glucose uptake by skeletal muscle (C 1.96 ± 0.54, T 3.28 ± 0.53, D 2.55 ± 0.35 μmol/g/h) in trained animals. Additionally, the improvement in exercise load in MLSS, glucose tolerance and glucose uptake was maintained after physical detraining. In summary, the physical training promotes alterations in body weight, fat tissue, aerobic capacity and muscular glucose metabolism in middle-age rats. However, only the aerobic capacity and muscular glucose metabolism were maintained after detraining. |
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Muscular glucose metabolism in middle-age trained ratsAgingGlucose uptakeGlycogenMaximal lactate steady state (MLSS)Physical exerciseAging decreases the normal organism physiological functions. On the other hand, physical exercise shows health benefits, but little information is known about physical deconditioning at aging. The aim of the present study was to analyze the glucose muscle metabolism in middle-age Wistar rats in response to conditioning and physical deconditioning. The study included three groups: Control (C)—not performed physical training; Trained (T)—performed physical training from 4 to 12 months—swimming exercise for 1 h per day, 5 days per week at 80% of maximal lactate stead state—MLSS; Detrained (D)—performed to physical training from 4 to 8 months and assessed at 12 months (D). Physical training at submaximal intensities induced decreases in body weight (C 588 ± 71, T 515 ± 72, D 576 ± 62 g), and the weight of mesenteric adipose tissue (C 4399 ± 643, T 3007 ± 811, D 4085 ± 540 mg/g), and increases in exercise workload in MLSS intensity (C 4.6 ± 0.4, T 5.8 ± 1.3, D 5.3 ± 0.4% body weight), glucose tolerance (C 12314 ± 1122, T 8428 ± 853, D 9433 ± 1200 mg/dL 120 min), glycogen deposits (C 0.48 ± 0.07, T 0.66 ± 0.18, D 0.46 ± 0.10 mg/100 mg) and glucose uptake by skeletal muscle (C 1.96 ± 0.54, T 3.28 ± 0.53, D 2.55 ± 0.35 μmol/g/h) in trained animals. Additionally, the improvement in exercise load in MLSS, glucose tolerance and glucose uptake was maintained after physical detraining. In summary, the physical training promotes alterations in body weight, fat tissue, aerobic capacity and muscular glucose metabolism in middle-age rats. However, only the aerobic capacity and muscular glucose metabolism were maintained after detraining.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Physical Education Institute of Biosciences São Paulo State University (UNESP), AV: 24-A, 1515, Bela VistaCampinas State University (UNICAMP)Department of Physical Education Federal University of Mato Grosso (UFMT)Department of Physical Education Institute of Biosciences São Paulo State University (UNESP), AV: 24-A, 1515, Bela VistaFAPESP: 2010/12896-0Universidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Federal University of Mato Grosso (UFMT)Ghezzi, Ana Carolina [UNESP]Cambri, Lucieli Teresa [UNESP]Botezelli, José Diego [UNESP]de Mello, Maria Alice Rostom [UNESP]2018-12-11T16:48:01Z2018-12-11T16:48:01Z2017-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article527-533application/pdfhttp://dx.doi.org/10.1007/s11332-017-0377-2Sport Sciences for Health, v. 13, n. 3, p. 527-533, 2017.1824-7490http://hdl.handle.net/11449/16988210.1007/s11332-017-0377-22-s2.0-850217174912-s2.0-85021717491.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSport Sciences for Health0,311info:eu-repo/semantics/openAccess2023-12-28T06:16:34Zoai:repositorio.unesp.br:11449/169882Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-28T06:16:34Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Muscular glucose metabolism in middle-age trained rats |
title |
Muscular glucose metabolism in middle-age trained rats |
spellingShingle |
Muscular glucose metabolism in middle-age trained rats Ghezzi, Ana Carolina [UNESP] Aging Glucose uptake Glycogen Maximal lactate steady state (MLSS) Physical exercise |
title_short |
Muscular glucose metabolism in middle-age trained rats |
title_full |
Muscular glucose metabolism in middle-age trained rats |
title_fullStr |
Muscular glucose metabolism in middle-age trained rats |
title_full_unstemmed |
Muscular glucose metabolism in middle-age trained rats |
title_sort |
Muscular glucose metabolism in middle-age trained rats |
author |
Ghezzi, Ana Carolina [UNESP] |
author_facet |
Ghezzi, Ana Carolina [UNESP] Cambri, Lucieli Teresa [UNESP] Botezelli, José Diego [UNESP] de Mello, Maria Alice Rostom [UNESP] |
author_role |
author |
author2 |
Cambri, Lucieli Teresa [UNESP] Botezelli, José Diego [UNESP] de Mello, Maria Alice Rostom [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual de Campinas (UNICAMP) Federal University of Mato Grosso (UFMT) |
dc.contributor.author.fl_str_mv |
Ghezzi, Ana Carolina [UNESP] Cambri, Lucieli Teresa [UNESP] Botezelli, José Diego [UNESP] de Mello, Maria Alice Rostom [UNESP] |
dc.subject.por.fl_str_mv |
Aging Glucose uptake Glycogen Maximal lactate steady state (MLSS) Physical exercise |
topic |
Aging Glucose uptake Glycogen Maximal lactate steady state (MLSS) Physical exercise |
description |
Aging decreases the normal organism physiological functions. On the other hand, physical exercise shows health benefits, but little information is known about physical deconditioning at aging. The aim of the present study was to analyze the glucose muscle metabolism in middle-age Wistar rats in response to conditioning and physical deconditioning. The study included three groups: Control (C)—not performed physical training; Trained (T)—performed physical training from 4 to 12 months—swimming exercise for 1 h per day, 5 days per week at 80% of maximal lactate stead state—MLSS; Detrained (D)—performed to physical training from 4 to 8 months and assessed at 12 months (D). Physical training at submaximal intensities induced decreases in body weight (C 588 ± 71, T 515 ± 72, D 576 ± 62 g), and the weight of mesenteric adipose tissue (C 4399 ± 643, T 3007 ± 811, D 4085 ± 540 mg/g), and increases in exercise workload in MLSS intensity (C 4.6 ± 0.4, T 5.8 ± 1.3, D 5.3 ± 0.4% body weight), glucose tolerance (C 12314 ± 1122, T 8428 ± 853, D 9433 ± 1200 mg/dL 120 min), glycogen deposits (C 0.48 ± 0.07, T 0.66 ± 0.18, D 0.46 ± 0.10 mg/100 mg) and glucose uptake by skeletal muscle (C 1.96 ± 0.54, T 3.28 ± 0.53, D 2.55 ± 0.35 μmol/g/h) in trained animals. Additionally, the improvement in exercise load in MLSS, glucose tolerance and glucose uptake was maintained after physical detraining. In summary, the physical training promotes alterations in body weight, fat tissue, aerobic capacity and muscular glucose metabolism in middle-age rats. However, only the aerobic capacity and muscular glucose metabolism were maintained after detraining. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-12-01 2018-12-11T16:48:01Z 2018-12-11T16:48:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s11332-017-0377-2 Sport Sciences for Health, v. 13, n. 3, p. 527-533, 2017. 1824-7490 http://hdl.handle.net/11449/169882 10.1007/s11332-017-0377-2 2-s2.0-85021717491 2-s2.0-85021717491.pdf |
url |
http://dx.doi.org/10.1007/s11332-017-0377-2 http://hdl.handle.net/11449/169882 |
identifier_str_mv |
Sport Sciences for Health, v. 13, n. 3, p. 527-533, 2017. 1824-7490 10.1007/s11332-017-0377-2 2-s2.0-85021717491 2-s2.0-85021717491.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Sport Sciences for Health 0,311 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
527-533 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803047150931673088 |