Determinants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort study
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/s12879-014-0578-0 http://hdl.handle.net/11449/117332 |
Resumo: | Background: Immunity plays an important role in controlling human papillomavirus (HPV) infection and associated lesions. Unlike infections caused by other viruses, natural HPV infection does not always result in a protective antibody response. Therefore, HPV antibodies are also considered markers of cumulative exposure. The aim of this study was to identify determinants of HPV16 seroreactivity at enrollment among women from the Ludwig-McGill cohort, a natural history study of HPV infection and risk of cervical neoplasia.Methods: HPV16 serology was assessed by ELISA for L1 and L2 capsid antigens, while HPV typing and viral load measurements were performed by PCR-based methods. The associations were analyzed by unconditional logistic regression.Results: Of 2049 subjects, 425 (20.7%) were strongly seropositive for HPV16. In multivariate analysis, seroreactivity was positively correlated with age, lifetime number of sexual partners, frequency of sex, and HPV16 viral load, and negatively associated with duration of smoking.Conclusions: HPV16 seroreactivity is determined by factors that reflect viral exposure. |
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Repositório Institucional da UNESP |
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Determinants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort studySerologyHPVNatural antibodiesHPV16 seropositivityBackground: Immunity plays an important role in controlling human papillomavirus (HPV) infection and associated lesions. Unlike infections caused by other viruses, natural HPV infection does not always result in a protective antibody response. Therefore, HPV antibodies are also considered markers of cumulative exposure. The aim of this study was to identify determinants of HPV16 seroreactivity at enrollment among women from the Ludwig-McGill cohort, a natural history study of HPV infection and risk of cervical neoplasia.Methods: HPV16 serology was assessed by ELISA for L1 and L2 capsid antigens, while HPV typing and viral load measurements were performed by PCR-based methods. The associations were analyzed by unconditional logistic regression.Results: Of 2049 subjects, 425 (20.7%) were strongly seropositive for HPV16. In multivariate analysis, seroreactivity was positively correlated with age, lifetime number of sexual partners, frequency of sex, and HPV16 viral load, and negatively associated with duration of smoking.Conclusions: HPV16 seroreactivity is determined by factors that reflect viral exposure.Ludwig Institute for Cancer ResearchU.S. National Cancer InstituteCanadian Institutes of Health ResearchLudwig Inst Canc Res, Sao Paulo, BrazilUniv Fed Fluminense, Dept Immunobiol, Niteroi, RJ, BrazilBrazilian Natl Canc Inst, Program Cellular Biol, Rio De Janeiro, BrazilMcGill Univ, Dept Oncol, Montreal, PQ, CanadaUniv Estadual Paulista, Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, BrazilInst Gynaecol Canc Res, Sao Paulo, BrazilUniv Montreal, CHUM, Div Gynecol Oncol, Montreal, PQ, CanadaMcGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, CanadaICESP, Sao Paulo Canc Inst, Mol Biol Lab, Sao Paulo, BrazilUniv Sao Paulo, Sch Med, Dept Radiol & Oncol, Sao Paulo, BrazilUniv Sao Paulo, Sch Med, Sao Paulo, BrazilSanta Casa Sao Paulo, Sao Paulo, BrazilUniv Estadual Paulista, Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, BrazilU.S. National Cancer InstituteCA70269Canadian Institutes of Health Research49396Canadian Institutes of Health Research83320Biomed Central LtdLudwig Inst Canc ResUniversidade Federal Fluminense (UFF)Brazilian Natl Canc InstMcGill UnivUniversidade Estadual Paulista (Unesp)Inst Gynaecol Canc ResUniv MontrealICESPUniversidade de São Paulo (USP)Santa Casa Sao PauloAraujo-Souza, Patricia S. deRamanakumar, Agnihotram V.Candeias, Joao M. G. [UNESP]Thomann, PatriciaTrevisan, AndreaFranco, Eduardo L.Villa, Luisa L.2015-03-18T15:55:51Z2015-03-18T15:55:51Z2014-11-18info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://dx.doi.org/10.1186/s12879-014-0578-0Bmc Infectious Diseases. London: Biomed Central Ltd, v. 14, 9 p., 2014.1471-2334http://hdl.handle.net/11449/11733210.1186/s12879-014-0578-0WOS:000345710200001WOS000345710200001.pdf0000-0003-1515-702XWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBmc Infectious Diseases2.6201,576info:eu-repo/semantics/openAccess2024-01-25T06:33:51Zoai:repositorio.unesp.br:11449/117332Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:57:56.413419Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Determinants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort study |
title |
Determinants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort study |
spellingShingle |
Determinants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort study Araujo-Souza, Patricia S. de Serology HPV Natural antibodies HPV16 seropositivity |
title_short |
Determinants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort study |
title_full |
Determinants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort study |
title_fullStr |
Determinants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort study |
title_full_unstemmed |
Determinants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort study |
title_sort |
Determinants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort study |
author |
Araujo-Souza, Patricia S. de |
author_facet |
Araujo-Souza, Patricia S. de Ramanakumar, Agnihotram V. Candeias, Joao M. G. [UNESP] Thomann, Patricia Trevisan, Andrea Franco, Eduardo L. Villa, Luisa L. |
author_role |
author |
author2 |
Ramanakumar, Agnihotram V. Candeias, Joao M. G. [UNESP] Thomann, Patricia Trevisan, Andrea Franco, Eduardo L. Villa, Luisa L. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Ludwig Inst Canc Res Universidade Federal Fluminense (UFF) Brazilian Natl Canc Inst McGill Univ Universidade Estadual Paulista (Unesp) Inst Gynaecol Canc Res Univ Montreal ICESP Universidade de São Paulo (USP) Santa Casa Sao Paulo |
dc.contributor.author.fl_str_mv |
Araujo-Souza, Patricia S. de Ramanakumar, Agnihotram V. Candeias, Joao M. G. [UNESP] Thomann, Patricia Trevisan, Andrea Franco, Eduardo L. Villa, Luisa L. |
dc.subject.por.fl_str_mv |
Serology HPV Natural antibodies HPV16 seropositivity |
topic |
Serology HPV Natural antibodies HPV16 seropositivity |
description |
Background: Immunity plays an important role in controlling human papillomavirus (HPV) infection and associated lesions. Unlike infections caused by other viruses, natural HPV infection does not always result in a protective antibody response. Therefore, HPV antibodies are also considered markers of cumulative exposure. The aim of this study was to identify determinants of HPV16 seroreactivity at enrollment among women from the Ludwig-McGill cohort, a natural history study of HPV infection and risk of cervical neoplasia.Methods: HPV16 serology was assessed by ELISA for L1 and L2 capsid antigens, while HPV typing and viral load measurements were performed by PCR-based methods. The associations were analyzed by unconditional logistic regression.Results: Of 2049 subjects, 425 (20.7%) were strongly seropositive for HPV16. In multivariate analysis, seroreactivity was positively correlated with age, lifetime number of sexual partners, frequency of sex, and HPV16 viral load, and negatively associated with duration of smoking.Conclusions: HPV16 seroreactivity is determined by factors that reflect viral exposure. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-11-18 2015-03-18T15:55:51Z 2015-03-18T15:55:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/s12879-014-0578-0 Bmc Infectious Diseases. London: Biomed Central Ltd, v. 14, 9 p., 2014. 1471-2334 http://hdl.handle.net/11449/117332 10.1186/s12879-014-0578-0 WOS:000345710200001 WOS000345710200001.pdf 0000-0003-1515-702X |
url |
http://dx.doi.org/10.1186/s12879-014-0578-0 http://hdl.handle.net/11449/117332 |
identifier_str_mv |
Bmc Infectious Diseases. London: Biomed Central Ltd, v. 14, 9 p., 2014. 1471-2334 10.1186/s12879-014-0578-0 WOS:000345710200001 WOS000345710200001.pdf 0000-0003-1515-702X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Bmc Infectious Diseases 2.620 1,576 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
9 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd |
publisher.none.fl_str_mv |
Biomed Central Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129567365267456 |