Neurophysiological patterns of ulnar nerve neuropathy in leprosy reactions
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://go.galegroup.com/ps/i.do?id=GALE%7CA317779687&v=2.1&u=capes58&it=r&p=AONE&sw=w http://hdl.handle.net/11449/8841 |
Resumo: | Background: Leprosy neuropathy, despite being primarily demyelinating, frequently leads to axonal loss. Neurophysiological examination of the nerves during Type 1 (T1R) and Type 2 reactions (T2R) may give some insight into the pathophysiological mechanisms.Methods: Neurophysiological examinations were performed in 28 ulnar nerves during a clinical trial of steroid treatment effectiveness, 19 patients with T1R and nine with T2R. The nerves were monitored during a period of 6 months; there were eight assessments per nerve, for a total of 224 assessments. Nine neurophysiological parameters were assessed at three sites of the ulnar nerve. The compound motor action potential amplitudes elicited at wrist, elbow and above, as well as the conduction velocity and temporal dispersion across the elbow, were chosen to focus on the changes occurring in the parameters at the elbow tunnel.Results and Conclusion: Neurophysiological changes indicating axonal and demyelinating processes during both T1R and T2R were detected across the elbow. Changes in demyelination, i.e. a Conduction Block, as a primary event present during T2R, occurring as an acute phenomenon, were observed regularly; in T1R Temporal Dispersion, a subacute phenomenon, was seen. During treatment remyelination occurred after both types of reactions. |
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Neurophysiological patterns of ulnar nerve neuropathy in leprosy reactionsBackground: Leprosy neuropathy, despite being primarily demyelinating, frequently leads to axonal loss. Neurophysiological examination of the nerves during Type 1 (T1R) and Type 2 reactions (T2R) may give some insight into the pathophysiological mechanisms.Methods: Neurophysiological examinations were performed in 28 ulnar nerves during a clinical trial of steroid treatment effectiveness, 19 patients with T1R and nine with T2R. The nerves were monitored during a period of 6 months; there were eight assessments per nerve, for a total of 224 assessments. Nine neurophysiological parameters were assessed at three sites of the ulnar nerve. The compound motor action potential amplitudes elicited at wrist, elbow and above, as well as the conduction velocity and temporal dispersion across the elbow, were chosen to focus on the changes occurring in the parameters at the elbow tunnel.Results and Conclusion: Neurophysiological changes indicating axonal and demyelinating processes during both T1R and T2R were detected across the elbow. Changes in demyelination, i.e. a Conduction Block, as a primary event present during T2R, occurring as an acute phenomenon, were observed regularly; in T1R Temporal Dispersion, a subacute phenomenon, was seen. During treatment remyelination occurred after both types of reactions.Inst Lauro de Souza Lima, Bauru, SP, BrazilFdn Dermatol & Venereol Polderma, Emmeloord, NetherlandsRDTC, Moshi, TanzaniaUNESP, Dept Engn, Bauru, SP, BrazilUNESP, Dept Engn, Bauru, SP, BrazilLepraUniversidade de São Paulo (USP)Fdn Dermatol & Venereol PoldermaRDTCUniversidade Estadual Paulista (Unesp)Garbino, J. A.Naafs, B. [UNESP]Ura, S.Salgado, M. H. [UNESP]Virmond, M.2014-05-20T13:27:07Z2014-05-20T13:27:07Z2010-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article206-215http://go.galegroup.com/ps/i.do?id=GALE%7CA317779687&v=2.1&u=capes58&it=r&p=AONE&sw=wLeprosy Review. Colchester: Lepra, v. 81, n. 3, p. 206-215, 2010.0305-7518http://hdl.handle.net/11449/8841WOS:0002982667000068207092389931188Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLeprosy Review0.7520,563info:eu-repo/semantics/openAccess2024-06-28T13:17:58Zoai:repositorio.unesp.br:11449/8841Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-06-28T13:17:58Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Neurophysiological patterns of ulnar nerve neuropathy in leprosy reactions |
title |
Neurophysiological patterns of ulnar nerve neuropathy in leprosy reactions |
spellingShingle |
Neurophysiological patterns of ulnar nerve neuropathy in leprosy reactions Garbino, J. A. |
title_short |
Neurophysiological patterns of ulnar nerve neuropathy in leprosy reactions |
title_full |
Neurophysiological patterns of ulnar nerve neuropathy in leprosy reactions |
title_fullStr |
Neurophysiological patterns of ulnar nerve neuropathy in leprosy reactions |
title_full_unstemmed |
Neurophysiological patterns of ulnar nerve neuropathy in leprosy reactions |
title_sort |
Neurophysiological patterns of ulnar nerve neuropathy in leprosy reactions |
author |
Garbino, J. A. |
author_facet |
Garbino, J. A. Naafs, B. [UNESP] Ura, S. Salgado, M. H. [UNESP] Virmond, M. |
author_role |
author |
author2 |
Naafs, B. [UNESP] Ura, S. Salgado, M. H. [UNESP] Virmond, M. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Fdn Dermatol & Venereol Polderma RDTC Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Garbino, J. A. Naafs, B. [UNESP] Ura, S. Salgado, M. H. [UNESP] Virmond, M. |
description |
Background: Leprosy neuropathy, despite being primarily demyelinating, frequently leads to axonal loss. Neurophysiological examination of the nerves during Type 1 (T1R) and Type 2 reactions (T2R) may give some insight into the pathophysiological mechanisms.Methods: Neurophysiological examinations were performed in 28 ulnar nerves during a clinical trial of steroid treatment effectiveness, 19 patients with T1R and nine with T2R. The nerves were monitored during a period of 6 months; there were eight assessments per nerve, for a total of 224 assessments. Nine neurophysiological parameters were assessed at three sites of the ulnar nerve. The compound motor action potential amplitudes elicited at wrist, elbow and above, as well as the conduction velocity and temporal dispersion across the elbow, were chosen to focus on the changes occurring in the parameters at the elbow tunnel.Results and Conclusion: Neurophysiological changes indicating axonal and demyelinating processes during both T1R and T2R were detected across the elbow. Changes in demyelination, i.e. a Conduction Block, as a primary event present during T2R, occurring as an acute phenomenon, were observed regularly; in T1R Temporal Dispersion, a subacute phenomenon, was seen. During treatment remyelination occurred after both types of reactions. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-09-01 2014-05-20T13:27:07Z 2014-05-20T13:27:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://go.galegroup.com/ps/i.do?id=GALE%7CA317779687&v=2.1&u=capes58&it=r&p=AONE&sw=w Leprosy Review. Colchester: Lepra, v. 81, n. 3, p. 206-215, 2010. 0305-7518 http://hdl.handle.net/11449/8841 WOS:000298266700006 8207092389931188 |
url |
http://go.galegroup.com/ps/i.do?id=GALE%7CA317779687&v=2.1&u=capes58&it=r&p=AONE&sw=w http://hdl.handle.net/11449/8841 |
identifier_str_mv |
Leprosy Review. Colchester: Lepra, v. 81, n. 3, p. 206-215, 2010. 0305-7518 WOS:000298266700006 8207092389931188 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Leprosy Review 0.752 0,563 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
206-215 |
dc.publisher.none.fl_str_mv |
Lepra |
publisher.none.fl_str_mv |
Lepra |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1803649543876640768 |