Conjugation of superparamagnetic iron oxide nanoparticles and curcumin photosensitizer to assist in photodynamic therapy
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.colsurfb.2020.111297 http://hdl.handle.net/11449/202002 |
Resumo: | In this work, we describe the synthesis and characterization of the SPIONP-CUR conjugate between curcumin (CUR) and superparamagnetic iron oxide nanoparticles (SPIONPs), in addition to its application in photodynamic therapy (PDT) using a protocol free of organic solvents as a dispersant. The SPIONP-CUR conjugate was characterized by X-ray diffraction, transmission electron microscopy, zeta potential measurements, Fourier transform infrared spectroscopy, thermogravimetry, magnetometry and magnetic hyperthermia assays. The SPIONP-CUR conjugation occurred by bonding between the keto-enol moiety of CUR and the iron atoms present on the surfaces of the SPIONPs. The conjugate showed heating power under an alternating magnetic field (AMF) and photodynamic action when irradiated with blue LED light. In experiments using PDT against Staphylococcus aureus in the planktonic phase, it was demonstrated that with application of blue light at 3.12 J cm−2, the conjugate (dispersed in water) caused a total reduction of the bacterial load. In the absence of light, the reduction was insignificant, even after 24 h of contact with the bacteria. |
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Conjugation of superparamagnetic iron oxide nanoparticles and curcumin photosensitizer to assist in photodynamic therapyAntimicrobialCurcuminMagnetic nanoparticlesPhotodynamic therapyStaphylococcus aureusIn this work, we describe the synthesis and characterization of the SPIONP-CUR conjugate between curcumin (CUR) and superparamagnetic iron oxide nanoparticles (SPIONPs), in addition to its application in photodynamic therapy (PDT) using a protocol free of organic solvents as a dispersant. The SPIONP-CUR conjugate was characterized by X-ray diffraction, transmission electron microscopy, zeta potential measurements, Fourier transform infrared spectroscopy, thermogravimetry, magnetometry and magnetic hyperthermia assays. The SPIONP-CUR conjugation occurred by bonding between the keto-enol moiety of CUR and the iron atoms present on the surfaces of the SPIONPs. The conjugate showed heating power under an alternating magnetic field (AMF) and photodynamic action when irradiated with blue LED light. In experiments using PDT against Staphylococcus aureus in the planktonic phase, it was demonstrated that with application of blue light at 3.12 J cm−2, the conjugate (dispersed in water) caused a total reduction of the bacterial load. In the absence of light, the reduction was insignificant, even after 24 h of contact with the bacteria.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Institute of Chemistry São Paulo State University (UNESP)School of Pharmaceutical Sciences São Paulo State University (UNESP)Soft Matter Sciences and Engineering ESPCI Paris PSL University Sorbonne Université CNRSPHysico-chimie des Electrolytes et Nanosystèmes InterfaciauX PHENIX Sorbonne Université CNRSInstitute of Chemistry São Paulo State University (UNESP)School of Pharmaceutical Sciences São Paulo State University (UNESP)CNPq: #132543/2017-6CNPq: #147402/2019-0FAPESP: #2017/07822-7FAPESP: #2018/09088-1FAPESP: #2018/23015-7CNPq: #304900/2011-7Universidade Estadual Paulista (Unesp)CNRSde Santana, Willian Max O.S. [UNESP]Caetano, Bruno L. [UNESP]de Annunzio, Sarah Raquel [UNESP]Pulcinelli, Sandra H. [UNESP]Ménager, ChristineFontana, Carla Raquel [UNESP]Santilli, Celso V. [UNESP]2020-12-12T02:47:19Z2020-12-12T02:47:19Z2020-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.colsurfb.2020.111297Colloids and Surfaces B: Biointerfaces, v. 196.1873-43670927-7765http://hdl.handle.net/11449/20200210.1016/j.colsurfb.2020.1112972-s2.0-8508922505555842986818708650000-0002-8356-8093Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengColloids and Surfaces B: Biointerfacesinfo:eu-repo/semantics/openAccess2021-10-23T04:24:02Zoai:repositorio.unesp.br:11449/202002Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T04:24:02Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Conjugation of superparamagnetic iron oxide nanoparticles and curcumin photosensitizer to assist in photodynamic therapy |
title |
Conjugation of superparamagnetic iron oxide nanoparticles and curcumin photosensitizer to assist in photodynamic therapy |
spellingShingle |
Conjugation of superparamagnetic iron oxide nanoparticles and curcumin photosensitizer to assist in photodynamic therapy de Santana, Willian Max O.S. [UNESP] Antimicrobial Curcumin Magnetic nanoparticles Photodynamic therapy Staphylococcus aureus |
title_short |
Conjugation of superparamagnetic iron oxide nanoparticles and curcumin photosensitizer to assist in photodynamic therapy |
title_full |
Conjugation of superparamagnetic iron oxide nanoparticles and curcumin photosensitizer to assist in photodynamic therapy |
title_fullStr |
Conjugation of superparamagnetic iron oxide nanoparticles and curcumin photosensitizer to assist in photodynamic therapy |
title_full_unstemmed |
Conjugation of superparamagnetic iron oxide nanoparticles and curcumin photosensitizer to assist in photodynamic therapy |
title_sort |
Conjugation of superparamagnetic iron oxide nanoparticles and curcumin photosensitizer to assist in photodynamic therapy |
author |
de Santana, Willian Max O.S. [UNESP] |
author_facet |
de Santana, Willian Max O.S. [UNESP] Caetano, Bruno L. [UNESP] de Annunzio, Sarah Raquel [UNESP] Pulcinelli, Sandra H. [UNESP] Ménager, Christine Fontana, Carla Raquel [UNESP] Santilli, Celso V. [UNESP] |
author_role |
author |
author2 |
Caetano, Bruno L. [UNESP] de Annunzio, Sarah Raquel [UNESP] Pulcinelli, Sandra H. [UNESP] Ménager, Christine Fontana, Carla Raquel [UNESP] Santilli, Celso V. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) CNRS |
dc.contributor.author.fl_str_mv |
de Santana, Willian Max O.S. [UNESP] Caetano, Bruno L. [UNESP] de Annunzio, Sarah Raquel [UNESP] Pulcinelli, Sandra H. [UNESP] Ménager, Christine Fontana, Carla Raquel [UNESP] Santilli, Celso V. [UNESP] |
dc.subject.por.fl_str_mv |
Antimicrobial Curcumin Magnetic nanoparticles Photodynamic therapy Staphylococcus aureus |
topic |
Antimicrobial Curcumin Magnetic nanoparticles Photodynamic therapy Staphylococcus aureus |
description |
In this work, we describe the synthesis and characterization of the SPIONP-CUR conjugate between curcumin (CUR) and superparamagnetic iron oxide nanoparticles (SPIONPs), in addition to its application in photodynamic therapy (PDT) using a protocol free of organic solvents as a dispersant. The SPIONP-CUR conjugate was characterized by X-ray diffraction, transmission electron microscopy, zeta potential measurements, Fourier transform infrared spectroscopy, thermogravimetry, magnetometry and magnetic hyperthermia assays. The SPIONP-CUR conjugation occurred by bonding between the keto-enol moiety of CUR and the iron atoms present on the surfaces of the SPIONPs. The conjugate showed heating power under an alternating magnetic field (AMF) and photodynamic action when irradiated with blue LED light. In experiments using PDT against Staphylococcus aureus in the planktonic phase, it was demonstrated that with application of blue light at 3.12 J cm−2, the conjugate (dispersed in water) caused a total reduction of the bacterial load. In the absence of light, the reduction was insignificant, even after 24 h of contact with the bacteria. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:47:19Z 2020-12-12T02:47:19Z 2020-12-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.colsurfb.2020.111297 Colloids and Surfaces B: Biointerfaces, v. 196. 1873-4367 0927-7765 http://hdl.handle.net/11449/202002 10.1016/j.colsurfb.2020.111297 2-s2.0-85089225055 5584298681870865 0000-0002-8356-8093 |
url |
http://dx.doi.org/10.1016/j.colsurfb.2020.111297 http://hdl.handle.net/11449/202002 |
identifier_str_mv |
Colloids and Surfaces B: Biointerfaces, v. 196. 1873-4367 0927-7765 10.1016/j.colsurfb.2020.111297 2-s2.0-85089225055 5584298681870865 0000-0002-8356-8093 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Colloids and Surfaces B: Biointerfaces |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1803649910512287744 |