Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina

Detalhes bibliográficos
Autor(a) principal: Chiku, Vanessa Marim [UNESP]
Data de Publicação: 2015
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/144050
Resumo: Dogs infected with Leishmania infantum showed a reduction in the number of lymphocytes T. PD-1 (Programmed cell death 1) a new member of the B7-CD28 family, it is expressed by cells of the immune system and its binding to PD-L1 (CD274) or PD-L2 (CD273) induces deactivation of T cells or apoptosis. This study aimed to evaluate the PD-1 expression and its ligands as well as their role in T lymphocyte induction of apoptosis, TNF-α and IL-4 secretion, nitric oxide production and parasite load in dogs with visceral leishmaniasis. We observed that in canine visceral leishmaniasis PD-1 and its ligands involved in induction of apoptosis of T lymphocytes, are regulating the nitric oxide production, TNF-α, IL-4, as well as the parasitic load. This study helps to clarify the mechanism of immune response and immunotherapeutic drugs such as blocking monoclonal antibodies that can influence the LVC
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spelling Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral caninaCãesLeishmaniose visceralLeishmanioseAnticorpos monoclonaisCelulas TLeishmania infantumDogs infected with Leishmania infantum showed a reduction in the number of lymphocytes T. PD-1 (Programmed cell death 1) a new member of the B7-CD28 family, it is expressed by cells of the immune system and its binding to PD-L1 (CD274) or PD-L2 (CD273) induces deactivation of T cells or apoptosis. This study aimed to evaluate the PD-1 expression and its ligands as well as their role in T lymphocyte induction of apoptosis, TNF-α and IL-4 secretion, nitric oxide production and parasite load in dogs with visceral leishmaniasis. We observed that in canine visceral leishmaniasis PD-1 and its ligands involved in induction of apoptosis of T lymphocytes, are regulating the nitric oxide production, TNF-α, IL-4, as well as the parasitic load. This study helps to clarify the mechanism of immune response and immunotherapeutic drugs such as blocking monoclonal antibodies that can influence the LVCFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)FAPESP: 2013/066849Universidade Estadual Paulista (Unesp)Lima, Valéria Marçal Felix de [UNESP]Universidade Estadual Paulista (Unesp)Chiku, Vanessa Marim [UNESP]2016-09-27T13:39:59Z2016-09-27T13:39:59Z2015-12-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis67 f.application/pdfCHIKU, Vanessa Marim. Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina. 2015. 67 f. Dissertação (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina Veterinária, 2015.http://hdl.handle.net/11449/144050000870645000870645.pdf33004021075P84875352337860036Alephreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporinfo:eu-repo/semantics/openAccess2023-12-21T06:23:31Zoai:repositorio.unesp.br:11449/144050Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:56:53.737562Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina
title Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina
spellingShingle Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina
Chiku, Vanessa Marim [UNESP]
Cães
Leishmaniose visceral
Leishmaniose
Anticorpos monoclonais
Celulas T
Leishmania infantum
title_short Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina
title_full Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina
title_fullStr Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina
title_full_unstemmed Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina
title_sort Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina
author Chiku, Vanessa Marim [UNESP]
author_facet Chiku, Vanessa Marim [UNESP]
author_role author
dc.contributor.none.fl_str_mv Lima, Valéria Marçal Felix de [UNESP]
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Chiku, Vanessa Marim [UNESP]
dc.subject.por.fl_str_mv Cães
Leishmaniose visceral
Leishmaniose
Anticorpos monoclonais
Celulas T
Leishmania infantum
topic Cães
Leishmaniose visceral
Leishmaniose
Anticorpos monoclonais
Celulas T
Leishmania infantum
description Dogs infected with Leishmania infantum showed a reduction in the number of lymphocytes T. PD-1 (Programmed cell death 1) a new member of the B7-CD28 family, it is expressed by cells of the immune system and its binding to PD-L1 (CD274) or PD-L2 (CD273) induces deactivation of T cells or apoptosis. This study aimed to evaluate the PD-1 expression and its ligands as well as their role in T lymphocyte induction of apoptosis, TNF-α and IL-4 secretion, nitric oxide production and parasite load in dogs with visceral leishmaniasis. We observed that in canine visceral leishmaniasis PD-1 and its ligands involved in induction of apoptosis of T lymphocytes, are regulating the nitric oxide production, TNF-α, IL-4, as well as the parasitic load. This study helps to clarify the mechanism of immune response and immunotherapeutic drugs such as blocking monoclonal antibodies that can influence the LVC
publishDate 2015
dc.date.none.fl_str_mv 2015-12-04
2016-09-27T13:39:59Z
2016-09-27T13:39:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv CHIKU, Vanessa Marim. Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina. 2015. 67 f. Dissertação (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina Veterinária, 2015.
http://hdl.handle.net/11449/144050
000870645
000870645.pdf
33004021075P8
4875352337860036
identifier_str_mv CHIKU, Vanessa Marim. Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina. 2015. 67 f. Dissertação (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina Veterinária, 2015.
000870645
000870645.pdf
33004021075P8
4875352337860036
url http://hdl.handle.net/11449/144050
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 67 f.
application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp)
publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.source.none.fl_str_mv Aleph
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129265113235456

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