Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis

Detalhes bibliográficos
Autor(a) principal: Holzhausen, M. [UNESP]
Data de Publicação: 2005
Outros Autores: Spolidório, Luis Carlos [UNESP], Vergnolle, N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0074-02762005000900030
http://hdl.handle.net/11449/16332
Resumo: Proteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes. PAR2 can be activated by serine proteases such as trypsin, mast cell tryptase, and bacterial proteases, such as gingipain produced by Porphyromonas gingivalis. This review describes the current stage of knowledge of the possible mechanisms that link PAR2 activation with periodontal disease, and proposes future therapeutic strategies to modulate the host response in the treatment of periodontitis.
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spelling Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitisproteaseactivated receptor-2alveolar bone lossinflammationhost responsePorphyromonas gingivalisperiodontitisProteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes. PAR2 can be activated by serine proteases such as trypsin, mast cell tryptase, and bacterial proteases, such as gingipain produced by Porphyromonas gingivalis. This review describes the current stage of knowledge of the possible mechanisms that link PAR2 activation with periodontal disease, and proposes future therapeutic strategies to modulate the host response in the treatment of periodontitis.University of Calgary Faculty of Medicine Department of Pharmacology and TherapeuticsUniversidade Estadual de São Paulo Escola Dental de Araraquara Departamento de Periodontologia e Patologia OralAlberta Heritage Foundation for Medical Research ScholarCanadian Institute for Health Research InvestigatorInstituto Oswaldo Cruz, Ministério da SaúdeUniversity of CalgaryUniversidade Estadual Paulista (Unesp)Alberta Heritage Foundation for Medical Research ScholarCanadian Institute for Health Research InvestigatorHolzhausen, M. [UNESP]Spolidório, Luis Carlos [UNESP]Vergnolle, N.2014-05-20T13:46:13Z2014-05-20T13:46:13Z2005-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article177-180application/pdfhttp://dx.doi.org/10.1590/S0074-02762005000900030Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 100, p. 177-180, 2005.0074-0276http://hdl.handle.net/11449/1633210.1590/S0074-02762005000900030S0074-02762005000900030S0074-02762005000900030.pdf2640929291808415SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMemórias do Instituto Oswaldo Cruz2.8331,172info:eu-repo/semantics/openAccess2024-09-27T14:05:35Zoai:repositorio.unesp.br:11449/16332Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-27T14:05:35Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis
title Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis
spellingShingle Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis
Holzhausen, M. [UNESP]
protease
activated receptor-2
alveolar bone loss
inflammation
host response
Porphyromonas gingivalis
periodontitis
title_short Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis
title_full Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis
title_fullStr Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis
title_full_unstemmed Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis
title_sort Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis
author Holzhausen, M. [UNESP]
author_facet Holzhausen, M. [UNESP]
Spolidório, Luis Carlos [UNESP]
Vergnolle, N.
author_role author
author2 Spolidório, Luis Carlos [UNESP]
Vergnolle, N.
author2_role author
author
dc.contributor.none.fl_str_mv University of Calgary
Universidade Estadual Paulista (Unesp)
Alberta Heritage Foundation for Medical Research Scholar
Canadian Institute for Health Research Investigator
dc.contributor.author.fl_str_mv Holzhausen, M. [UNESP]
Spolidório, Luis Carlos [UNESP]
Vergnolle, N.
dc.subject.por.fl_str_mv protease
activated receptor-2
alveolar bone loss
inflammation
host response
Porphyromonas gingivalis
periodontitis
topic protease
activated receptor-2
alveolar bone loss
inflammation
host response
Porphyromonas gingivalis
periodontitis
description Proteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes. PAR2 can be activated by serine proteases such as trypsin, mast cell tryptase, and bacterial proteases, such as gingipain produced by Porphyromonas gingivalis. This review describes the current stage of knowledge of the possible mechanisms that link PAR2 activation with periodontal disease, and proposes future therapeutic strategies to modulate the host response in the treatment of periodontitis.
publishDate 2005
dc.date.none.fl_str_mv 2005-03-01
2014-05-20T13:46:13Z
2014-05-20T13:46:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0074-02762005000900030
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 100, p. 177-180, 2005.
0074-0276
http://hdl.handle.net/11449/16332
10.1590/S0074-02762005000900030
S0074-02762005000900030
S0074-02762005000900030.pdf
2640929291808415
url http://dx.doi.org/10.1590/S0074-02762005000900030
http://hdl.handle.net/11449/16332
identifier_str_mv Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 100, p. 177-180, 2005.
0074-0276
10.1590/S0074-02762005000900030
S0074-02762005000900030
S0074-02762005000900030.pdf
2640929291808415
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Memórias do Instituto Oswaldo Cruz
2.833
1,172
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 177-180
application/pdf
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1813546493198467072

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