Pathogenesis II: Fungal responses to host responses: Interaction of host cells with fungi

Detalhes bibliográficos
Autor(a) principal: Mendes-Giannini, Maria José Soares [UNESP]
Data de Publicação: 2000
Outros Autores: Taylor, M. L., Bouchara, J. B., Burger, E., Calich, V. L.G., Escalante, E. D., Hanna, S. A. [UNESP], Lenzi, H. L., Machado, M. P., Miyaji, M., da Silva, J. L. Monteiro [UNESP], Mota, E. M., Restrepo, A., Restrepo, S., Tronchin, G., Vincenzi, L. R. [UNESP], Xidieh, C. F., Zenteno, E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1080/714030878
http://hdl.handle.net/11449/230909
Resumo: Most of our knowledge concerning the virulence determinants of pathogenic fungi comes from the infected host, mainly from animal models and more recently from in vitro studies with cell cultures. The fungi usually present intra- and/or extracellular host-parasite interfaces, with the parasitism phenomenon dependent on complementary surface molecules. Among living organisms, this has been characterized as a cohabitation event, where the fungus is able to recognize specific host tissues acting as an attractant, creating stable conditions for its survival. Several fungi pathogenic for humans and animals have evolved special strategies to deliver elements to their cellular targets that may be relevant to their pathogenicity. Most of these pathogens express surface factors that mediate binding to host cells either directly or indirectly, in the latter case binding to host adhesion components such as extracellular matrix (ECM) proteins, which act as 'interlinking' molecules. The entry of the pathogen into the host cell is initiated by fungal adherence to the cell surface, which generates an uptake signal that may induce its cytoplasmic internalization. Once this is accomplished, some fungi are able to alter the host cytoskeletal architecture, as manifested by a rearrangement of microtubule and microfilament proteins, and this can also induce epithelial host cells to become apoptotic. It is possible that fungal pathogens induce modulation of different host cell pathways in order to evade host defences and to foster their own proliferation. For a number of pathogens, the ability to bind ECM glycoproteins, the capability of internalization and the induction of apoptosis are considered important factors in virulence. Furthermore, specific recognition between fungal parasites and their host cell targets may be mediated by the interaction of carbohydrate-binding proteins, e.g., lectins on the surface of one type of cell, probably a parasite, that combine with complementary sugars on the surface of host-cell. These interactions supply precise models to study putative adhesins and receptor-containing molecules in the context of the fungus-host interface. The recognition of the host molecules by fungi such as Aspergillus fumigatus, Paracoccidioides brasiliensis and Histoplasma capsulatum, and their molecular mechanisms of adhesion and invasion, are reviewed in this paper. © Oxford University Press 2001.
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spelling Pathogenesis II: Fungal responses to host responses: Interaction of host cells with fungiAspergillus fumigatusFungus interactionHistoplasma capsulatumParacoccidioides trasiliensisMost of our knowledge concerning the virulence determinants of pathogenic fungi comes from the infected host, mainly from animal models and more recently from in vitro studies with cell cultures. The fungi usually present intra- and/or extracellular host-parasite interfaces, with the parasitism phenomenon dependent on complementary surface molecules. Among living organisms, this has been characterized as a cohabitation event, where the fungus is able to recognize specific host tissues acting as an attractant, creating stable conditions for its survival. Several fungi pathogenic for humans and animals have evolved special strategies to deliver elements to their cellular targets that may be relevant to their pathogenicity. Most of these pathogens express surface factors that mediate binding to host cells either directly or indirectly, in the latter case binding to host adhesion components such as extracellular matrix (ECM) proteins, which act as 'interlinking' molecules. The entry of the pathogen into the host cell is initiated by fungal adherence to the cell surface, which generates an uptake signal that may induce its cytoplasmic internalization. Once this is accomplished, some fungi are able to alter the host cytoskeletal architecture, as manifested by a rearrangement of microtubule and microfilament proteins, and this can also induce epithelial host cells to become apoptotic. It is possible that fungal pathogens induce modulation of different host cell pathways in order to evade host defences and to foster their own proliferation. For a number of pathogens, the ability to bind ECM glycoproteins, the capability of internalization and the induction of apoptosis are considered important factors in virulence. Furthermore, specific recognition between fungal parasites and their host cell targets may be mediated by the interaction of carbohydrate-binding proteins, e.g., lectins on the surface of one type of cell, probably a parasite, that combine with complementary sugars on the surface of host-cell. These interactions supply precise models to study putative adhesins and receptor-containing molecules in the context of the fungus-host interface. The recognition of the host molecules by fungi such as Aspergillus fumigatus, Paracoccidioides brasiliensis and Histoplasma capsulatum, and their molecular mechanisms of adhesion and invasion, are reviewed in this paper. © Oxford University Press 2001.Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, Araraquara, SPFacultat de Medicina Universidad Nacional Autónoma de Mexico, Mexico D.FGroupe d'Etude des Interactions Hôte-Parasite Laboratoire de Parasitologie-Mycologie Centre Hospitalier Universitaire, AngersDepto. de Imunologia Instituto de Ciências Biomédicas Universidade de São PauloDepto. de Patologia Instituto Oswaldo Cruz, Rio de JaneiroResearch Center for Pathogenic and Microbial Toxicoses Chiba University, ChibaCorporacion para Investigaciones Biologicas (CIB), MedellinFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista, Araraquara, SPUniversidade Estadual Paulista (UNESP)Universidad Nacional Autónoma de MexicoCentre Hospitalier UniversitaireUniversidade de São Paulo (USP)Instituto Oswaldo CruzChiba UniversityCorporacion para Investigaciones Biologicas (CIB)Mendes-Giannini, Maria José Soares [UNESP]Taylor, M. L.Bouchara, J. B.Burger, E.Calich, V. L.G.Escalante, E. D.Hanna, S. A. [UNESP]Lenzi, H. L.Machado, M. P.Miyaji, M.da Silva, J. L. Monteiro [UNESP]Mota, E. M.Restrepo, A.Restrepo, S.Tronchin, G.Vincenzi, L. R. [UNESP]Xidieh, C. F.Zenteno, E.2022-04-29T08:42:43Z2022-04-29T08:42:43Z2000-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article113-123http://dx.doi.org/10.1080/714030878Medical Mycology, v. 38, p. 113-123.1369-3786http://hdl.handle.net/11449/23090910.1080/7140308782-s2.0-0034500452Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedical Mycologyinfo:eu-repo/semantics/openAccess2022-04-29T08:42:43Zoai:repositorio.unesp.br:11449/230909Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:54:07.963891Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Pathogenesis II: Fungal responses to host responses: Interaction of host cells with fungi
title Pathogenesis II: Fungal responses to host responses: Interaction of host cells with fungi
spellingShingle Pathogenesis II: Fungal responses to host responses: Interaction of host cells with fungi
Mendes-Giannini, Maria José Soares [UNESP]
Aspergillus fumigatus
Fungus interaction
Histoplasma capsulatum
Paracoccidioides trasiliensis
title_short Pathogenesis II: Fungal responses to host responses: Interaction of host cells with fungi
title_full Pathogenesis II: Fungal responses to host responses: Interaction of host cells with fungi
title_fullStr Pathogenesis II: Fungal responses to host responses: Interaction of host cells with fungi
title_full_unstemmed Pathogenesis II: Fungal responses to host responses: Interaction of host cells with fungi
title_sort Pathogenesis II: Fungal responses to host responses: Interaction of host cells with fungi
author Mendes-Giannini, Maria José Soares [UNESP]
author_facet Mendes-Giannini, Maria José Soares [UNESP]
Taylor, M. L.
Bouchara, J. B.
Burger, E.
Calich, V. L.G.
Escalante, E. D.
Hanna, S. A. [UNESP]
Lenzi, H. L.
Machado, M. P.
Miyaji, M.
da Silva, J. L. Monteiro [UNESP]
Mota, E. M.
Restrepo, A.
Restrepo, S.
Tronchin, G.
Vincenzi, L. R. [UNESP]
Xidieh, C. F.
Zenteno, E.
author_role author
author2 Taylor, M. L.
Bouchara, J. B.
Burger, E.
Calich, V. L.G.
Escalante, E. D.
Hanna, S. A. [UNESP]
Lenzi, H. L.
Machado, M. P.
Miyaji, M.
da Silva, J. L. Monteiro [UNESP]
Mota, E. M.
Restrepo, A.
Restrepo, S.
Tronchin, G.
Vincenzi, L. R. [UNESP]
Xidieh, C. F.
Zenteno, E.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidad Nacional Autónoma de Mexico
Centre Hospitalier Universitaire
Universidade de São Paulo (USP)
Instituto Oswaldo Cruz
Chiba University
Corporacion para Investigaciones Biologicas (CIB)
dc.contributor.author.fl_str_mv Mendes-Giannini, Maria José Soares [UNESP]
Taylor, M. L.
Bouchara, J. B.
Burger, E.
Calich, V. L.G.
Escalante, E. D.
Hanna, S. A. [UNESP]
Lenzi, H. L.
Machado, M. P.
Miyaji, M.
da Silva, J. L. Monteiro [UNESP]
Mota, E. M.
Restrepo, A.
Restrepo, S.
Tronchin, G.
Vincenzi, L. R. [UNESP]
Xidieh, C. F.
Zenteno, E.
dc.subject.por.fl_str_mv Aspergillus fumigatus
Fungus interaction
Histoplasma capsulatum
Paracoccidioides trasiliensis
topic Aspergillus fumigatus
Fungus interaction
Histoplasma capsulatum
Paracoccidioides trasiliensis
description Most of our knowledge concerning the virulence determinants of pathogenic fungi comes from the infected host, mainly from animal models and more recently from in vitro studies with cell cultures. The fungi usually present intra- and/or extracellular host-parasite interfaces, with the parasitism phenomenon dependent on complementary surface molecules. Among living organisms, this has been characterized as a cohabitation event, where the fungus is able to recognize specific host tissues acting as an attractant, creating stable conditions for its survival. Several fungi pathogenic for humans and animals have evolved special strategies to deliver elements to their cellular targets that may be relevant to their pathogenicity. Most of these pathogens express surface factors that mediate binding to host cells either directly or indirectly, in the latter case binding to host adhesion components such as extracellular matrix (ECM) proteins, which act as 'interlinking' molecules. The entry of the pathogen into the host cell is initiated by fungal adherence to the cell surface, which generates an uptake signal that may induce its cytoplasmic internalization. Once this is accomplished, some fungi are able to alter the host cytoskeletal architecture, as manifested by a rearrangement of microtubule and microfilament proteins, and this can also induce epithelial host cells to become apoptotic. It is possible that fungal pathogens induce modulation of different host cell pathways in order to evade host defences and to foster their own proliferation. For a number of pathogens, the ability to bind ECM glycoproteins, the capability of internalization and the induction of apoptosis are considered important factors in virulence. Furthermore, specific recognition between fungal parasites and their host cell targets may be mediated by the interaction of carbohydrate-binding proteins, e.g., lectins on the surface of one type of cell, probably a parasite, that combine with complementary sugars on the surface of host-cell. These interactions supply precise models to study putative adhesins and receptor-containing molecules in the context of the fungus-host interface. The recognition of the host molecules by fungi such as Aspergillus fumigatus, Paracoccidioides brasiliensis and Histoplasma capsulatum, and their molecular mechanisms of adhesion and invasion, are reviewed in this paper. © Oxford University Press 2001.
publishDate 2000
dc.date.none.fl_str_mv 2000-01-01
2022-04-29T08:42:43Z
2022-04-29T08:42:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1080/714030878
Medical Mycology, v. 38, p. 113-123.
1369-3786
http://hdl.handle.net/11449/230909
10.1080/714030878
2-s2.0-0034500452
url http://dx.doi.org/10.1080/714030878
http://hdl.handle.net/11449/230909
identifier_str_mv Medical Mycology, v. 38, p. 113-123.
1369-3786
10.1080/714030878
2-s2.0-0034500452
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Medical Mycology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 113-123
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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