Comparação entre o Disease Activity Score-28 e o Juvenile Arthritis Disease Activity Score na artrite idiopática juvenil

Detalhes bibliográficos
Autor(a) principal: Capela, Renata Campos [UNESP]
Data de Publicação: 2015
Outros Autores: Corrente, Jose Eduardo [UNESP], Magalhaes, Claudia Saad [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.scielo.br/scielo.php?pid=S0482-50042015000100031&script=sci_arttext
http://hdl.handle.net/11449/128393
Resumo: Introduction: the assessment of the activity of rheumatoid arthritis and juvenile idiopathic arthritis is made by means of different tools, respectively DAS-28 and JADAS.Objective: To compare DAS-28 and JADAS with scores of 71, 27 and 10 joint counts in juvenile idiopathic arthritis.Method: A secondary analysis of a phase III placebo-controlled trial, testing safety and efficacy of abatacept was conducted in 8 patients with 178 assessment visits. Joint count scores for active and limited joints, physician's and parents'global assessment by 0-10 cm Visual Analog Scale, and erythrocyte sedimentation rate normalized to 0-10 scale, in all visits. The comparison among the activity indices in different observations was made through Anova or adjusted gamma model. The paired observations between DAS-28 and JADAS 71, 27 and 10, respectively, were analyzed by linear regression.Results: There were significant differences among individual measures, except for ESR, in the first four months of biological treatment, when five of the eight patients reached ACR-Pedi 30, with improvement. The indices of DAS-28, JADAS 71, 27 and 10 also showed significant difference during follow-up. Linear regression adjusted model between DAS-28 and JADAS resulted in mathematical formulas for conversion: [DAS-28 = 0.0709 (JADAS 71) + 1.267] (R-2 = 0.49); [DAS-28 = 0.084 (JADAS 27) + 1.7404] (R-2 = 0.47) and [DAS-28 = 0.1129 (JADAS-10) + 1.5748] (R-2 = 0.50).Conclusion: The conversion of scores of DAS-28 and JADAS 71, 27 and 10 for this mathematical model would allow equivalent application of both in adolescents with arthritis. (C) 2014 Elsevier Editora Ltda. All rights reserved.
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spelling Comparação entre o Disease Activity Score-28 e o Juvenile Arthritis Disease Activity Score na artrite idiopática juvenilComparison of the Disease Activity Score-28 and Juvenile Arthritis Disease Activity Score in the juvenile idiopathic arthritisJuvenile idiopathic arthritisRheumatoid arthritisDisease Activity Score-28Juvenile Arthritis DiseaseActivity ScoreArtrite idiopática juvenilArtrite reumatoideDisease Activity Score-28Juvenile Arthritis Disease Activity ScoreIntroduction: the assessment of the activity of rheumatoid arthritis and juvenile idiopathic arthritis is made by means of different tools, respectively DAS-28 and JADAS.Objective: To compare DAS-28 and JADAS with scores of 71, 27 and 10 joint counts in juvenile idiopathic arthritis.Method: A secondary analysis of a phase III placebo-controlled trial, testing safety and efficacy of abatacept was conducted in 8 patients with 178 assessment visits. Joint count scores for active and limited joints, physician's and parents'global assessment by 0-10 cm Visual Analog Scale, and erythrocyte sedimentation rate normalized to 0-10 scale, in all visits. The comparison among the activity indices in different observations was made through Anova or adjusted gamma model. The paired observations between DAS-28 and JADAS 71, 27 and 10, respectively, were analyzed by linear regression.Results: There were significant differences among individual measures, except for ESR, in the first four months of biological treatment, when five of the eight patients reached ACR-Pedi 30, with improvement. The indices of DAS-28, JADAS 71, 27 and 10 also showed significant difference during follow-up. Linear regression adjusted model between DAS-28 and JADAS resulted in mathematical formulas for conversion: [DAS-28 = 0.0709 (JADAS 71) + 1.267] (R-2 = 0.49); [DAS-28 = 0.084 (JADAS 27) + 1.7404] (R-2 = 0.47) and [DAS-28 = 0.1129 (JADAS-10) + 1.5748] (R-2 = 0.50).Conclusion: The conversion of scores of DAS-28 and JADAS 71, 27 and 10 for this mathematical model would allow equivalent application of both in adolescents with arthritis. (C) 2014 Elsevier Editora Ltda. All rights reserved.Introdução: A avaliação de atividade da artrite reumatoide e da artrite idiopática juvenil é feita por meio de instrumentos distintos, respectivamente pelo DAS-28 e pelo JADAS. Objetivo: Comparar o DAS-28 e o JADAS com a pontuação de 71, 27 e 10 articulações, na artrite idiopática juvenil. Método: Foram avaliadas 178 visitas em oito pacientes com artrite idiopática juvenil, participantes de um ensaio clínico controlado de fase III, testando eficácia e segurança do abatacepte. Pontuaram-se as articulações ativas e limitadas, a avaliação global pelo médico e pelos pais em escala analógica visual de 0-10 cm e a velocidade de hemossedimentação convertida em escala de 0-10, em todas as visitas. A comparação entre os índices de atividade entre diferentes observações foi por Anova ou modelo ajustado Gama. As observações pareadas entre o DAS-28 e o JADAS 71, 27 e 10, respectivamente, foram analisadas por meio de regressão linear. Resultados: Houve diferença significativa entre as medidas individuais, exceto a VHS, nos primeiros quatro meses de tratamento com biológico, quando cinco entre os oito pacientes atingiram a resposta ACR-Pedi 30, com melhora. Os índices DAS-28, JADAS 71, 27 e 10 também apresentaram diferença relevante durante o período de observação. O ajustamento por meio de regressão linear entre o DAS-28 e o JADAS resultou em fórmulas matemáticas para conversão: [DAS-28 = 0,0709 (JADAS 71) + 1,267] (R2 = 0,49); [DAS-28 = 0,084 (JADAS 27) + 1,7404] (R2 = 0,47) e [DAS-28 = 0,1129 (JADAS-10) + 1,5748] (R2 = 0,50). Conclusão: A conversão da pontuação do DAS-28 e do JADAS 71, 27 e 10 por esse modelo matemático permitiria a aplicação equivalente de ambos em adolescentes com artrite.Univ Estadual Paulista, Botucatu, SP, BrazilUniv Estadual Paulista, Faculdade de Medicina de Botucatu, Departamento de Pediatria, Botucatu, SP, BrazilElsevier B.V.Universidade Estadual Paulista (Unesp)Capela, Renata Campos [UNESP]Corrente, Jose Eduardo [UNESP]Magalhaes, Claudia Saad [UNESP]2015-10-21T13:09:30Z2015-10-21T13:09:30Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article31-36application/pdfapplication/pdfhttp://www.scielo.br/scielo.php?pid=S0482-50042015000100031&script=sci_arttextRevista Brasileira De Reumatologia. New York: Elsevier Science Inc, v. 55, n. 1, p. 31-36, 2015.0482-5004http://hdl.handle.net/11449/12839310.1016/j.rbr.2014.08.010S0482-50042015000100031WOS:000351951300003S0482-50042015000100031-pt.pdfS0482-50042015000100031-en.pdf70983100083716320000-0001-5478-49960000-0002-7631-7093Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista Brasileira De Reumatologia1.3500,340info:eu-repo/semantics/openAccess2024-09-03T13:46:51Zoai:repositorio.unesp.br:11449/128393Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:46:51Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Comparação entre o Disease Activity Score-28 e o Juvenile Arthritis Disease Activity Score na artrite idiopática juvenil
Comparison of the Disease Activity Score-28 and Juvenile Arthritis Disease Activity Score in the juvenile idiopathic arthritis
title Comparação entre o Disease Activity Score-28 e o Juvenile Arthritis Disease Activity Score na artrite idiopática juvenil
spellingShingle Comparação entre o Disease Activity Score-28 e o Juvenile Arthritis Disease Activity Score na artrite idiopática juvenil
Capela, Renata Campos [UNESP]
Juvenile idiopathic arthritis
Rheumatoid arthritis
Disease Activity Score-28
Juvenile Arthritis Disease
Activity Score
Artrite idiopática juvenil
Artrite reumatoide
Disease Activity Score-28
Juvenile Arthritis Disease Activity Score
title_short Comparação entre o Disease Activity Score-28 e o Juvenile Arthritis Disease Activity Score na artrite idiopática juvenil
title_full Comparação entre o Disease Activity Score-28 e o Juvenile Arthritis Disease Activity Score na artrite idiopática juvenil
title_fullStr Comparação entre o Disease Activity Score-28 e o Juvenile Arthritis Disease Activity Score na artrite idiopática juvenil
title_full_unstemmed Comparação entre o Disease Activity Score-28 e o Juvenile Arthritis Disease Activity Score na artrite idiopática juvenil
title_sort Comparação entre o Disease Activity Score-28 e o Juvenile Arthritis Disease Activity Score na artrite idiopática juvenil
author Capela, Renata Campos [UNESP]
author_facet Capela, Renata Campos [UNESP]
Corrente, Jose Eduardo [UNESP]
Magalhaes, Claudia Saad [UNESP]
author_role author
author2 Corrente, Jose Eduardo [UNESP]
Magalhaes, Claudia Saad [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Capela, Renata Campos [UNESP]
Corrente, Jose Eduardo [UNESP]
Magalhaes, Claudia Saad [UNESP]
dc.subject.por.fl_str_mv Juvenile idiopathic arthritis
Rheumatoid arthritis
Disease Activity Score-28
Juvenile Arthritis Disease
Activity Score
Artrite idiopática juvenil
Artrite reumatoide
Disease Activity Score-28
Juvenile Arthritis Disease Activity Score
topic Juvenile idiopathic arthritis
Rheumatoid arthritis
Disease Activity Score-28
Juvenile Arthritis Disease
Activity Score
Artrite idiopática juvenil
Artrite reumatoide
Disease Activity Score-28
Juvenile Arthritis Disease Activity Score
description Introduction: the assessment of the activity of rheumatoid arthritis and juvenile idiopathic arthritis is made by means of different tools, respectively DAS-28 and JADAS.Objective: To compare DAS-28 and JADAS with scores of 71, 27 and 10 joint counts in juvenile idiopathic arthritis.Method: A secondary analysis of a phase III placebo-controlled trial, testing safety and efficacy of abatacept was conducted in 8 patients with 178 assessment visits. Joint count scores for active and limited joints, physician's and parents'global assessment by 0-10 cm Visual Analog Scale, and erythrocyte sedimentation rate normalized to 0-10 scale, in all visits. The comparison among the activity indices in different observations was made through Anova or adjusted gamma model. The paired observations between DAS-28 and JADAS 71, 27 and 10, respectively, were analyzed by linear regression.Results: There were significant differences among individual measures, except for ESR, in the first four months of biological treatment, when five of the eight patients reached ACR-Pedi 30, with improvement. The indices of DAS-28, JADAS 71, 27 and 10 also showed significant difference during follow-up. Linear regression adjusted model between DAS-28 and JADAS resulted in mathematical formulas for conversion: [DAS-28 = 0.0709 (JADAS 71) + 1.267] (R-2 = 0.49); [DAS-28 = 0.084 (JADAS 27) + 1.7404] (R-2 = 0.47) and [DAS-28 = 0.1129 (JADAS-10) + 1.5748] (R-2 = 0.50).Conclusion: The conversion of scores of DAS-28 and JADAS 71, 27 and 10 for this mathematical model would allow equivalent application of both in adolescents with arthritis. (C) 2014 Elsevier Editora Ltda. All rights reserved.
publishDate 2015
dc.date.none.fl_str_mv 2015-10-21T13:09:30Z
2015-10-21T13:09:30Z
2015-01-01
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Revista Brasileira De Reumatologia. New York: Elsevier Science Inc, v. 55, n. 1, p. 31-36, 2015.
0482-5004
http://hdl.handle.net/11449/128393
10.1016/j.rbr.2014.08.010
S0482-50042015000100031
WOS:000351951300003
S0482-50042015000100031-pt.pdf
S0482-50042015000100031-en.pdf
7098310008371632
0000-0001-5478-4996
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url http://www.scielo.br/scielo.php?pid=S0482-50042015000100031&script=sci_arttext
http://hdl.handle.net/11449/128393
identifier_str_mv Revista Brasileira De Reumatologia. New York: Elsevier Science Inc, v. 55, n. 1, p. 31-36, 2015.
0482-5004
10.1016/j.rbr.2014.08.010
S0482-50042015000100031
WOS:000351951300003
S0482-50042015000100031-pt.pdf
S0482-50042015000100031-en.pdf
7098310008371632
0000-0001-5478-4996
0000-0002-7631-7093
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dc.relation.none.fl_str_mv Revista Brasileira De Reumatologia
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dc.format.none.fl_str_mv 31-36
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dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
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repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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