Introdução ao problema de enovelamento de proteínas: uma abordagem utilizando modelos computacionais simplificados

• Autor(a) principal: Godoi Contessoto, Vinícius De
• Data de Publicação: 2018
• Outros Autores: Oliveira Junior, Antonio Bento De, Chahine, Jorge, Oliveira, Ronaldo Junio De, Pereira Leite, Vitor Barbanti
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/1806-9126-rbef-2018-0068; http://hdl.handle.net/11449/157816
• topic: Protein Folding; Energy Landscape; Structure-Based Models; Lattice Model; Biophysics; Enovelamento de proteínas; Superfície de energia; Modelos baseados em estrutura; Modelo de rede; Biofísica

Abstract This work aims to introduce students of physics and related areas to the problem of protein folding. Proteins are biological macromolecules of great importance to living things. The understanding of how this macromolecule finds a three-dimensional and functional structure, using the information present in a linear sequence of different amino acids, is a relevant question which involves researchers from different areas of knowledge. This work discusses the importance and the main properties of proteins and presents a brief history of protein folding studies and how these works converge to the Energy Landscape theory. There are described some theoretical and computational models from analytical approaches to the development of the Structure-Based Models for simulations. Here it is also presented and discussed some expected results for each used model.