Hindbrain serotonin and the rapid induction of sodium appetite
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://ajpregu.physiology.org/content/279/1/R126 http://hdl.handle.net/11449/39505 |
Resumo: | Both systemically administered furosemide and isoproterenol produce water intake (i.e., thirst). Curiously, however, in light of the endocrine and hemodynamic effects produced by these treatments, they are remarkably ineffective in eliciting intake of hypertonic saline solutions (i.e., operationally defined as sodium appetite). Recent work indicates that bilateral injections of the serotonin receptor antagonist methysergide into the lateral parabrachial nuclei (LPBN) markedly enhance a preexisting sodium appetite. The present studies establish that a de novo sodium appetite can be induced with LPBN-methysergide treatment under experimental conditions in which only water is typically ingested. The effects of bilateral LPBN injections of methysergide were studied on the intake of water and 0.3 M NaCl following acute (beginning 1 h after treatment) diuretic (furosemide)-induced sodium and water depletion and following subcutaneous isoproterenol treatment. With vehicle injected into the LPBN, furosemide treatment and isoproterenol injection both caused water drinking but essentially no intake of hypertonic saline. In contrast, bilateral treatment of the LPBN with methysergide induced the intake of 0.3 M NaCl after subcutaneous furosemide and isoproterenol. Water intake induced by subcutaneous furosemide or isoproterenol was not changed by LPBN-methysergide injections. The results indicate that blockade of LPBN-serotonin receptors produces a marked intake of hypertonic NaCl (i.e., a de novo sodium appetite) after furosemide treatment as well as subcutaneous isoproterenol. |
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Hindbrain serotonin and the rapid induction of sodium appetitefurosemidesodium intakewater intake5-hydroxytryptamineBoth systemically administered furosemide and isoproterenol produce water intake (i.e., thirst). Curiously, however, in light of the endocrine and hemodynamic effects produced by these treatments, they are remarkably ineffective in eliciting intake of hypertonic saline solutions (i.e., operationally defined as sodium appetite). Recent work indicates that bilateral injections of the serotonin receptor antagonist methysergide into the lateral parabrachial nuclei (LPBN) markedly enhance a preexisting sodium appetite. The present studies establish that a de novo sodium appetite can be induced with LPBN-methysergide treatment under experimental conditions in which only water is typically ingested. The effects of bilateral LPBN injections of methysergide were studied on the intake of water and 0.3 M NaCl following acute (beginning 1 h after treatment) diuretic (furosemide)-induced sodium and water depletion and following subcutaneous isoproterenol treatment. With vehicle injected into the LPBN, furosemide treatment and isoproterenol injection both caused water drinking but essentially no intake of hypertonic saline. In contrast, bilateral treatment of the LPBN with methysergide induced the intake of 0.3 M NaCl after subcutaneous furosemide and isoproterenol. Water intake induced by subcutaneous furosemide or isoproterenol was not changed by LPBN-methysergide injections. The results indicate that blockade of LPBN-serotonin receptors produces a marked intake of hypertonic NaCl (i.e., a de novo sodium appetite) after furosemide treatment as well as subcutaneous isoproterenol.Univ Iowa, Dept Psychol, Iowa City, IA 52242 USAUniv Iowa, Dept Pharmacol, Iowa City, IA 52242 USAUniv Iowa, Ctr Cardiovasc, Iowa City, IA 52242 USAPaulista State Univ, Sch Dent, Dept Physiol, BR-14801903 São Paulo, BrazilPaulista State Univ, Sch Dent, Dept Physiol, BR-14801903 São Paulo, BrazilAmer Physiological SocUniv IowaUniversidade Estadual Paulista (Unesp)Menani, José Vanderlei [UNESP]De Luca, L. A.Thunhorst, R. L.Johnson, A. K.2014-05-20T15:30:03Z2014-05-20T15:30:03Z2000-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleR126-R131http://ajpregu.physiology.org/content/279/1/R126American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 279, n. 1, p. R126-R131, 2000.0363-6119http://hdl.handle.net/11449/39505WOS:0000881714000171023597870118105Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAmerican Journal of Physiology: Regulatory Integrative and Comparative Physiology3.0821,550info:eu-repo/semantics/openAccess2021-10-23T10:45:21Zoai:repositorio.unesp.br:11449/39505Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T10:45:21Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Hindbrain serotonin and the rapid induction of sodium appetite |
title |
Hindbrain serotonin and the rapid induction of sodium appetite |
spellingShingle |
Hindbrain serotonin and the rapid induction of sodium appetite Menani, José Vanderlei [UNESP] furosemide sodium intake water intake 5-hydroxytryptamine |
title_short |
Hindbrain serotonin and the rapid induction of sodium appetite |
title_full |
Hindbrain serotonin and the rapid induction of sodium appetite |
title_fullStr |
Hindbrain serotonin and the rapid induction of sodium appetite |
title_full_unstemmed |
Hindbrain serotonin and the rapid induction of sodium appetite |
title_sort |
Hindbrain serotonin and the rapid induction of sodium appetite |
author |
Menani, José Vanderlei [UNESP] |
author_facet |
Menani, José Vanderlei [UNESP] De Luca, L. A. Thunhorst, R. L. Johnson, A. K. |
author_role |
author |
author2 |
De Luca, L. A. Thunhorst, R. L. Johnson, A. K. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Univ Iowa Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Menani, José Vanderlei [UNESP] De Luca, L. A. Thunhorst, R. L. Johnson, A. K. |
dc.subject.por.fl_str_mv |
furosemide sodium intake water intake 5-hydroxytryptamine |
topic |
furosemide sodium intake water intake 5-hydroxytryptamine |
description |
Both systemically administered furosemide and isoproterenol produce water intake (i.e., thirst). Curiously, however, in light of the endocrine and hemodynamic effects produced by these treatments, they are remarkably ineffective in eliciting intake of hypertonic saline solutions (i.e., operationally defined as sodium appetite). Recent work indicates that bilateral injections of the serotonin receptor antagonist methysergide into the lateral parabrachial nuclei (LPBN) markedly enhance a preexisting sodium appetite. The present studies establish that a de novo sodium appetite can be induced with LPBN-methysergide treatment under experimental conditions in which only water is typically ingested. The effects of bilateral LPBN injections of methysergide were studied on the intake of water and 0.3 M NaCl following acute (beginning 1 h after treatment) diuretic (furosemide)-induced sodium and water depletion and following subcutaneous isoproterenol treatment. With vehicle injected into the LPBN, furosemide treatment and isoproterenol injection both caused water drinking but essentially no intake of hypertonic saline. In contrast, bilateral treatment of the LPBN with methysergide induced the intake of 0.3 M NaCl after subcutaneous furosemide and isoproterenol. Water intake induced by subcutaneous furosemide or isoproterenol was not changed by LPBN-methysergide injections. The results indicate that blockade of LPBN-serotonin receptors produces a marked intake of hypertonic NaCl (i.e., a de novo sodium appetite) after furosemide treatment as well as subcutaneous isoproterenol. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-07-01 2014-05-20T15:30:03Z 2014-05-20T15:30:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://ajpregu.physiology.org/content/279/1/R126 American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 279, n. 1, p. R126-R131, 2000. 0363-6119 http://hdl.handle.net/11449/39505 WOS:000088171400017 1023597870118105 |
url |
http://ajpregu.physiology.org/content/279/1/R126 http://hdl.handle.net/11449/39505 |
identifier_str_mv |
American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 279, n. 1, p. R126-R131, 2000. 0363-6119 WOS:000088171400017 1023597870118105 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
American Journal of Physiology: Regulatory Integrative and Comparative Physiology 3.082 1,550 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
R126-R131 |
dc.publisher.none.fl_str_mv |
Amer Physiological Soc |
publisher.none.fl_str_mv |
Amer Physiological Soc |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964807230652416 |