Clinical, radiographic and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis: A 12-month multicenter clinical trial
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/JPER.20-0493 http://hdl.handle.net/11449/209632 |
Resumo: | Background The aim of this study was to evaluate the clinical, radiographic and patient-centered results of enamel matrix derivative (EMD) therapy in intrabony defects in aggressive periodontitis (AgP) patients and compare them with those in chronic periodontitis (CP) patients. Methods Sixty intrabony defects in AgP and CP patients associated with >= 6 mm residual probing pocket depth (PPD) were included and randomly assigned to one of three groups: AgP+CS (conservative surgery) (n = 20); AgP+CS/EMD (n = 20); CP+CS/EMD (n = 20). Clinical parameters were measured at baseline and after 6 and 12 months. Defect resolution (DR) and bone filling (BF) were used for radiographic analysis. The quality of life was recorded at baseline and 6 months using OHIP-14 and VAS scale in the early post-therapy period. Results PPD and relative clinical attachment level (rCAL) improved for all groups during follow-up (P <= 0.05), and AgP+CS/EMD presented a higher rCAL gain (2.4 +/- 1.0 mm) when compared to AgP control patients (1.6 +/- 1.6 mm, P <= 0.05) after 12 months. No difference was observed between AgP+CS/EMD and CP+CS/EMD groups (P > 0.05). No radiographic differences were observed among groups at any time point (P > 0.05). All the groups reported a positive impact on OHIP-14 total score, without differences among them. Conclusions EMD therapy of intrabony defects promotes additional benefits in AgP patients, presenting a similar regeneration rate compared to CP patients, and has proven to be a viable therapy for the treatment of individuals with AgP. |
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Clinical, radiographic and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis: A 12-month multicenter clinical trialaggressive periodontitisalveolar bone losschronic periodontitisenamel matrix proteinsBackground The aim of this study was to evaluate the clinical, radiographic and patient-centered results of enamel matrix derivative (EMD) therapy in intrabony defects in aggressive periodontitis (AgP) patients and compare them with those in chronic periodontitis (CP) patients. Methods Sixty intrabony defects in AgP and CP patients associated with >= 6 mm residual probing pocket depth (PPD) were included and randomly assigned to one of three groups: AgP+CS (conservative surgery) (n = 20); AgP+CS/EMD (n = 20); CP+CS/EMD (n = 20). Clinical parameters were measured at baseline and after 6 and 12 months. Defect resolution (DR) and bone filling (BF) were used for radiographic analysis. The quality of life was recorded at baseline and 6 months using OHIP-14 and VAS scale in the early post-therapy period. Results PPD and relative clinical attachment level (rCAL) improved for all groups during follow-up (P <= 0.05), and AgP+CS/EMD presented a higher rCAL gain (2.4 +/- 1.0 mm) when compared to AgP control patients (1.6 +/- 1.6 mm, P <= 0.05) after 12 months. No difference was observed between AgP+CS/EMD and CP+CS/EMD groups (P > 0.05). No radiographic differences were observed among groups at any time point (P > 0.05). All the groups reported a positive impact on OHIP-14 total score, without differences among them. Conclusions EMD therapy of intrabony defects promotes additional benefits in AgP patients, presenting a similar regeneration rate compared to CP patients, and has proven to be a viable therapy for the treatment of individuals with AgP.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Estadual Campinas, Dept Prosthesis & Periodontol, Piracicaba, BrazilState Univ Sao Paulo, Dept Diag & Surg, Sao Jose Dos Campos, BrazilState Univ Sao Paulo, Dept Diag & Surg, Sao Jose Dos Campos, BrazilFAPESP: 2015/19731-0CAPES: 001Wiley-BlackwellUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Fileto Mazzonetto, Ana LiviaCasarin, Renato Correa VianaSantamaria, Mauro Pedrine [UNESP]Andere, Naira Maria Rebelatto Bechara [UNESP]Araujo, Cassia Fernandes [UNESP]Videira Clima da Silva, RafaelaPurisaca, Javier Eduardo VivancoSallum, Enilson AntonioSallum, Antonio Wilson2021-06-25T12:24:28Z2021-06-25T12:24:28Z2020-11-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12http://dx.doi.org/10.1002/JPER.20-0493Journal Of Periodontology. Hoboken: Wiley, 12 p., 2020.0022-3492http://hdl.handle.net/11449/20963210.1002/JPER.20-0493WOS:000587655400001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Periodontologyinfo:eu-repo/semantics/openAccess2021-10-23T19:28:22Zoai:repositorio.unesp.br:11449/209632Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T19:28:22Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Clinical, radiographic and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis: A 12-month multicenter clinical trial |
title |
Clinical, radiographic and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis: A 12-month multicenter clinical trial |
spellingShingle |
Clinical, radiographic and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis: A 12-month multicenter clinical trial Fileto Mazzonetto, Ana Livia aggressive periodontitis alveolar bone loss chronic periodontitis enamel matrix proteins |
title_short |
Clinical, radiographic and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis: A 12-month multicenter clinical trial |
title_full |
Clinical, radiographic and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis: A 12-month multicenter clinical trial |
title_fullStr |
Clinical, radiographic and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis: A 12-month multicenter clinical trial |
title_full_unstemmed |
Clinical, radiographic and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis: A 12-month multicenter clinical trial |
title_sort |
Clinical, radiographic and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis: A 12-month multicenter clinical trial |
author |
Fileto Mazzonetto, Ana Livia |
author_facet |
Fileto Mazzonetto, Ana Livia Casarin, Renato Correa Viana Santamaria, Mauro Pedrine [UNESP] Andere, Naira Maria Rebelatto Bechara [UNESP] Araujo, Cassia Fernandes [UNESP] Videira Clima da Silva, Rafaela Purisaca, Javier Eduardo Vivanco Sallum, Enilson Antonio Sallum, Antonio Wilson |
author_role |
author |
author2 |
Casarin, Renato Correa Viana Santamaria, Mauro Pedrine [UNESP] Andere, Naira Maria Rebelatto Bechara [UNESP] Araujo, Cassia Fernandes [UNESP] Videira Clima da Silva, Rafaela Purisaca, Javier Eduardo Vivanco Sallum, Enilson Antonio Sallum, Antonio Wilson |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Fileto Mazzonetto, Ana Livia Casarin, Renato Correa Viana Santamaria, Mauro Pedrine [UNESP] Andere, Naira Maria Rebelatto Bechara [UNESP] Araujo, Cassia Fernandes [UNESP] Videira Clima da Silva, Rafaela Purisaca, Javier Eduardo Vivanco Sallum, Enilson Antonio Sallum, Antonio Wilson |
dc.subject.por.fl_str_mv |
aggressive periodontitis alveolar bone loss chronic periodontitis enamel matrix proteins |
topic |
aggressive periodontitis alveolar bone loss chronic periodontitis enamel matrix proteins |
description |
Background The aim of this study was to evaluate the clinical, radiographic and patient-centered results of enamel matrix derivative (EMD) therapy in intrabony defects in aggressive periodontitis (AgP) patients and compare them with those in chronic periodontitis (CP) patients. Methods Sixty intrabony defects in AgP and CP patients associated with >= 6 mm residual probing pocket depth (PPD) were included and randomly assigned to one of three groups: AgP+CS (conservative surgery) (n = 20); AgP+CS/EMD (n = 20); CP+CS/EMD (n = 20). Clinical parameters were measured at baseline and after 6 and 12 months. Defect resolution (DR) and bone filling (BF) were used for radiographic analysis. The quality of life was recorded at baseline and 6 months using OHIP-14 and VAS scale in the early post-therapy period. Results PPD and relative clinical attachment level (rCAL) improved for all groups during follow-up (P <= 0.05), and AgP+CS/EMD presented a higher rCAL gain (2.4 +/- 1.0 mm) when compared to AgP control patients (1.6 +/- 1.6 mm, P <= 0.05) after 12 months. No difference was observed between AgP+CS/EMD and CP+CS/EMD groups (P > 0.05). No radiographic differences were observed among groups at any time point (P > 0.05). All the groups reported a positive impact on OHIP-14 total score, without differences among them. Conclusions EMD therapy of intrabony defects promotes additional benefits in AgP patients, presenting a similar regeneration rate compared to CP patients, and has proven to be a viable therapy for the treatment of individuals with AgP. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-11-09 2021-06-25T12:24:28Z 2021-06-25T12:24:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/JPER.20-0493 Journal Of Periodontology. Hoboken: Wiley, 12 p., 2020. 0022-3492 http://hdl.handle.net/11449/209632 10.1002/JPER.20-0493 WOS:000587655400001 |
url |
http://dx.doi.org/10.1002/JPER.20-0493 http://hdl.handle.net/11449/209632 |
identifier_str_mv |
Journal Of Periodontology. Hoboken: Wiley, 12 p., 2020. 0022-3492 10.1002/JPER.20-0493 WOS:000587655400001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Periodontology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
12 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964560257449984 |