Continuous measurement of arterial oxygenation in mechanically ventilated horses
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/evj.13542 http://hdl.handle.net/11449/230103 |
Resumo: | Background: The possibility of accurately and continuously measuring arterial oxygen partial pressure (PaO2) in horses may facilitate the management of hypoxaemia during general anaesthesia. Objectives: The aim of this study was to evaluate the ability of a novel fibreoptic sensor to measure PaO2 (PaO2Sensor) continuously and in real time in horses undergoing ventilatory manoeuvres during general anaesthesia. Study design: In vivo experimental study. Methods: Six adult healthy horses were anaesthetised and mechanically ventilated in dorsal recumbency. A fibreoptic sensor was placed in one of the facial arteries through a catheter to continuously measure and record PaO2Sensor. After an alveolar recruitment manoeuvre, a decremental positive end-expiratory pressure (PEEP) titration using 20-minute steps of 5 cm H2O from 20 to 0 cm H2O was performed. An arterial blood sample was collected at 15 minutes of ventilation at each PEEP level for PaO2 measurement using an automated blood gas machine (PaO2Ref). The agreement between PaO2Sensor and PaO2Ref was assessed by Pearson's correlation, Bland-Altman plot and four-quadrant plot analysis. In the last minute of ventilation at each PEEP level, a slow tidal inflation/deflation manoeuvre was performed. Results: The mean relative bias between PaO2Sensor and PaO2Ref was 4% with limits of agreement between −17% and 29%. The correlation coefficient between PaO2Sensor and PaO2Ref was 0.98 (P <.001). The PaO2Sensor and PaO2Ref concordance rate for changes was 95%. Measurements of PaO2Sensor during the slow inflation/deflation manoeuvre at PEEP 15 and 10 cm H2O were not possible because of significant noise on the PaO2 signal generated by a small blood clot. Main limitations: Small sample size. Conclusion: The tested fibreoptic probe was able to accurately and continuously measure PaO2Sensor in anaesthetised horses undergoing ventilatory manoeuvres. A heparinised system in the catheter used by the fibreoptic sensor should be used to avoid blood clots and artefacts in the PaO2 measurements. |
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Repositório Institucional da UNESP |
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Continuous measurement of arterial oxygenation in mechanically ventilated horsesanaesthesiaarterial oxygenationartificial ventilationhorseBackground: The possibility of accurately and continuously measuring arterial oxygen partial pressure (PaO2) in horses may facilitate the management of hypoxaemia during general anaesthesia. Objectives: The aim of this study was to evaluate the ability of a novel fibreoptic sensor to measure PaO2 (PaO2Sensor) continuously and in real time in horses undergoing ventilatory manoeuvres during general anaesthesia. Study design: In vivo experimental study. Methods: Six adult healthy horses were anaesthetised and mechanically ventilated in dorsal recumbency. A fibreoptic sensor was placed in one of the facial arteries through a catheter to continuously measure and record PaO2Sensor. After an alveolar recruitment manoeuvre, a decremental positive end-expiratory pressure (PEEP) titration using 20-minute steps of 5 cm H2O from 20 to 0 cm H2O was performed. An arterial blood sample was collected at 15 minutes of ventilation at each PEEP level for PaO2 measurement using an automated blood gas machine (PaO2Ref). The agreement between PaO2Sensor and PaO2Ref was assessed by Pearson's correlation, Bland-Altman plot and four-quadrant plot analysis. In the last minute of ventilation at each PEEP level, a slow tidal inflation/deflation manoeuvre was performed. Results: The mean relative bias between PaO2Sensor and PaO2Ref was 4% with limits of agreement between −17% and 29%. The correlation coefficient between PaO2Sensor and PaO2Ref was 0.98 (P <.001). The PaO2Sensor and PaO2Ref concordance rate for changes was 95%. Measurements of PaO2Sensor during the slow inflation/deflation manoeuvre at PEEP 15 and 10 cm H2O were not possible because of significant noise on the PaO2 signal generated by a small blood clot. Main limitations: Small sample size. Conclusion: The tested fibreoptic probe was able to accurately and continuously measure PaO2Sensor in anaesthetised horses undergoing ventilatory manoeuvres. A heparinised system in the catheter used by the fibreoptic sensor should be used to avoid blood clots and artefacts in the PaO2 measurements.William Pritchard Veterinary Medical Teaching Hospital University of California DavisDepartment of Surgical and Radiological Sciences School of Veterinary Medicine University of California DavisNuffield Division of Anaesthetics University of OxfordDepartamento de Cirurgia e Anestesiologia Veterinária Faculdade de Medicina Veterinária e Zootecnia UNESP – Univ. Estadual PaulistaDepartment of Engineering Science University of OxfordCentre for Human and Applied Physiological Sciences King’s College LondonDepartment of Anaesthetics Guy’s and St Thomas’ NHS Foundation TrustAnaesthesiology and Perioperative Intensive Care Vetmeduni ViennaDepartamento de Cirurgia e Anestesiologia Veterinária Faculdade de Medicina Veterinária e Zootecnia UNESP – Univ. Estadual PaulistaUniversity of California DavisUniversity of OxfordUniversidade Estadual Paulista (UNESP)King’s College LondonGuy’s and St Thomas’ NHS Foundation TrustVetmeduni ViennaHummer, Emma V.Soares, Joao H. N.Crockett, Douglas C.Aguiar, Antonio J. A. [UNESP]Tran, Minh C.Cronin, John N.Brosnan, Robert J.Braun, ChristinaFormenti, Federico2022-04-29T08:37:58Z2022-04-29T08:37:58Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1111/evj.13542Equine Veterinary Journal.2042-33060425-1644http://hdl.handle.net/11449/23010310.1111/evj.135422-s2.0-85121609854Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEquine Veterinary Journalinfo:eu-repo/semantics/openAccess2022-04-29T08:37:58Zoai:repositorio.unesp.br:11449/230103Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:37:58Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Continuous measurement of arterial oxygenation in mechanically ventilated horses |
title |
Continuous measurement of arterial oxygenation in mechanically ventilated horses |
spellingShingle |
Continuous measurement of arterial oxygenation in mechanically ventilated horses Hummer, Emma V. anaesthesia arterial oxygenation artificial ventilation horse |
title_short |
Continuous measurement of arterial oxygenation in mechanically ventilated horses |
title_full |
Continuous measurement of arterial oxygenation in mechanically ventilated horses |
title_fullStr |
Continuous measurement of arterial oxygenation in mechanically ventilated horses |
title_full_unstemmed |
Continuous measurement of arterial oxygenation in mechanically ventilated horses |
title_sort |
Continuous measurement of arterial oxygenation in mechanically ventilated horses |
author |
Hummer, Emma V. |
author_facet |
Hummer, Emma V. Soares, Joao H. N. Crockett, Douglas C. Aguiar, Antonio J. A. [UNESP] Tran, Minh C. Cronin, John N. Brosnan, Robert J. Braun, Christina Formenti, Federico |
author_role |
author |
author2 |
Soares, Joao H. N. Crockett, Douglas C. Aguiar, Antonio J. A. [UNESP] Tran, Minh C. Cronin, John N. Brosnan, Robert J. Braun, Christina Formenti, Federico |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
University of California Davis University of Oxford Universidade Estadual Paulista (UNESP) King’s College London Guy’s and St Thomas’ NHS Foundation Trust Vetmeduni Vienna |
dc.contributor.author.fl_str_mv |
Hummer, Emma V. Soares, Joao H. N. Crockett, Douglas C. Aguiar, Antonio J. A. [UNESP] Tran, Minh C. Cronin, John N. Brosnan, Robert J. Braun, Christina Formenti, Federico |
dc.subject.por.fl_str_mv |
anaesthesia arterial oxygenation artificial ventilation horse |
topic |
anaesthesia arterial oxygenation artificial ventilation horse |
description |
Background: The possibility of accurately and continuously measuring arterial oxygen partial pressure (PaO2) in horses may facilitate the management of hypoxaemia during general anaesthesia. Objectives: The aim of this study was to evaluate the ability of a novel fibreoptic sensor to measure PaO2 (PaO2Sensor) continuously and in real time in horses undergoing ventilatory manoeuvres during general anaesthesia. Study design: In vivo experimental study. Methods: Six adult healthy horses were anaesthetised and mechanically ventilated in dorsal recumbency. A fibreoptic sensor was placed in one of the facial arteries through a catheter to continuously measure and record PaO2Sensor. After an alveolar recruitment manoeuvre, a decremental positive end-expiratory pressure (PEEP) titration using 20-minute steps of 5 cm H2O from 20 to 0 cm H2O was performed. An arterial blood sample was collected at 15 minutes of ventilation at each PEEP level for PaO2 measurement using an automated blood gas machine (PaO2Ref). The agreement between PaO2Sensor and PaO2Ref was assessed by Pearson's correlation, Bland-Altman plot and four-quadrant plot analysis. In the last minute of ventilation at each PEEP level, a slow tidal inflation/deflation manoeuvre was performed. Results: The mean relative bias between PaO2Sensor and PaO2Ref was 4% with limits of agreement between −17% and 29%. The correlation coefficient between PaO2Sensor and PaO2Ref was 0.98 (P <.001). The PaO2Sensor and PaO2Ref concordance rate for changes was 95%. Measurements of PaO2Sensor during the slow inflation/deflation manoeuvre at PEEP 15 and 10 cm H2O were not possible because of significant noise on the PaO2 signal generated by a small blood clot. Main limitations: Small sample size. Conclusion: The tested fibreoptic probe was able to accurately and continuously measure PaO2Sensor in anaesthetised horses undergoing ventilatory manoeuvres. A heparinised system in the catheter used by the fibreoptic sensor should be used to avoid blood clots and artefacts in the PaO2 measurements. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-04-29T08:37:58Z 2022-04-29T08:37:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/evj.13542 Equine Veterinary Journal. 2042-3306 0425-1644 http://hdl.handle.net/11449/230103 10.1111/evj.13542 2-s2.0-85121609854 |
url |
http://dx.doi.org/10.1111/evj.13542 http://hdl.handle.net/11449/230103 |
identifier_str_mv |
Equine Veterinary Journal. 2042-3306 0425-1644 10.1111/evj.13542 2-s2.0-85121609854 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Equine Veterinary Journal |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803649832669151232 |