Analog Modeling of Human Cognitive Functions with Tripartite Synapses
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/978-3-642-15223-8_35 http://hdl.handle.net/11449/40136 |
Resumo: | Searching for an understanding of how the brain supports conscious processes, cognitive scientists have proposed two main classes of theory: Global Workspace and Information Integration theories. These theories seem to be complementary, but both still lack grounding in terms of brain mechanisms responsible for the production of coherent and unitary conscious states. Here we propose following James Robertson's "Astrocentric Hypothesis" - that conscious processing is based on analog computing in astrocytes. The "hardware" for these computations is calcium waves mediated by adenosine triphosphate signaling. Besides presenting our version of this hypothesis, we also review recent findings on astrocyte morphology that lend support to their functioning as Local Hubs (composed of protoplasmic astrocytes) that integrate synaptic activity, and as a Master Hub (composed, in the human brain, by a combination of interlaminar, fibrous, polarized and varicose projection astrocytes) that integrates whole-brain activity. |
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Repositório Institucional da UNESP |
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Analog Modeling of Human Cognitive Functions with Tripartite SynapsesSearching for an understanding of how the brain supports conscious processes, cognitive scientists have proposed two main classes of theory: Global Workspace and Information Integration theories. These theories seem to be complementary, but both still lack grounding in terms of brain mechanisms responsible for the production of coherent and unitary conscious states. Here we propose following James Robertson's "Astrocentric Hypothesis" - that conscious processing is based on analog computing in astrocytes. The "hardware" for these computations is calcium waves mediated by adenosine triphosphate signaling. Besides presenting our version of this hypothesis, we also review recent findings on astrocyte morphology that lend support to their functioning as Local Hubs (composed of protoplasmic astrocytes) that integrate synaptic activity, and as a Master Hub (composed, in the human brain, by a combination of interlaminar, fibrous, polarized and varicose projection astrocytes) that integrates whole-brain activity.State Univ São Paulo, Inst Biosci, Botucatu, SP, BrazilState Univ São Paulo, Inst Biosci, Botucatu, SP, BrazilSpringer-verlag BerlinUniversidade Estadual Paulista (Unesp)Pereira, Alfredo [UNESP]Furlan, Fabio Augusto2014-05-20T15:30:50Z2014-05-20T15:30:50Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject623-635http://dx.doi.org/10.1007/978-3-642-15223-8_35Model-based Reasoning In Science and Technology: Abduction, Logic and Computational Discovery. Berlin: Springer-verlag Berlin, v. 314, p. 623-635, 2010.1860-949Xhttp://hdl.handle.net/11449/40136WOS:0002889349000350000-0002-5960-041XWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengModel-based Reasoning In Science and Technology: Abduction, Logic and Computational Discoveryinfo:eu-repo/semantics/openAccess2021-10-23T21:41:34Zoai:repositorio.unesp.br:11449/40136Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:32:44.437516Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Analog Modeling of Human Cognitive Functions with Tripartite Synapses |
title |
Analog Modeling of Human Cognitive Functions with Tripartite Synapses |
spellingShingle |
Analog Modeling of Human Cognitive Functions with Tripartite Synapses Pereira, Alfredo [UNESP] |
title_short |
Analog Modeling of Human Cognitive Functions with Tripartite Synapses |
title_full |
Analog Modeling of Human Cognitive Functions with Tripartite Synapses |
title_fullStr |
Analog Modeling of Human Cognitive Functions with Tripartite Synapses |
title_full_unstemmed |
Analog Modeling of Human Cognitive Functions with Tripartite Synapses |
title_sort |
Analog Modeling of Human Cognitive Functions with Tripartite Synapses |
author |
Pereira, Alfredo [UNESP] |
author_facet |
Pereira, Alfredo [UNESP] Furlan, Fabio Augusto |
author_role |
author |
author2 |
Furlan, Fabio Augusto |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Pereira, Alfredo [UNESP] Furlan, Fabio Augusto |
description |
Searching for an understanding of how the brain supports conscious processes, cognitive scientists have proposed two main classes of theory: Global Workspace and Information Integration theories. These theories seem to be complementary, but both still lack grounding in terms of brain mechanisms responsible for the production of coherent and unitary conscious states. Here we propose following James Robertson's "Astrocentric Hypothesis" - that conscious processing is based on analog computing in astrocytes. The "hardware" for these computations is calcium waves mediated by adenosine triphosphate signaling. Besides presenting our version of this hypothesis, we also review recent findings on astrocyte morphology that lend support to their functioning as Local Hubs (composed of protoplasmic astrocytes) that integrate synaptic activity, and as a Master Hub (composed, in the human brain, by a combination of interlaminar, fibrous, polarized and varicose projection astrocytes) that integrates whole-brain activity. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 2014-05-20T15:30:50Z 2014-05-20T15:30:50Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/978-3-642-15223-8_35 Model-based Reasoning In Science and Technology: Abduction, Logic and Computational Discovery. Berlin: Springer-verlag Berlin, v. 314, p. 623-635, 2010. 1860-949X http://hdl.handle.net/11449/40136 WOS:000288934900035 0000-0002-5960-041X |
url |
http://dx.doi.org/10.1007/978-3-642-15223-8_35 http://hdl.handle.net/11449/40136 |
identifier_str_mv |
Model-based Reasoning In Science and Technology: Abduction, Logic and Computational Discovery. Berlin: Springer-verlag Berlin, v. 314, p. 623-635, 2010. 1860-949X WOS:000288934900035 0000-0002-5960-041X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Model-based Reasoning In Science and Technology: Abduction, Logic and Computational Discovery |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
623-635 |
dc.publisher.none.fl_str_mv |
Springer-verlag Berlin |
publisher.none.fl_str_mv |
Springer-verlag Berlin |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129217560313856 |