Effects of methoxyflurane on intraocular and cerebrospinal fluid pressure in dogs with spontaneous or artificial respiration
Autor(a) principal: | |
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Data de Publicação: | 1979 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/230792 |
Resumo: | Methoxyflurane (0.2 ml/kg over 5 min), administered by inhalation to dogs with spontaneous respiration, resulted approximately 10 minutes later in a significant increase of intraocular pressure (IOP) (13.3 mm Hg), cerebrospinal fluid pressure (CSFP) (9.4 mm Hg), and venous pressure (VP) (6 mm Hg), as well as a significant decrease in arterial pressure (AP) (23.3 mm Hg), respiratory frequency (3.2 mov/min) and respiratory amplitude (7.1 mm). These alterations occurred concomitantly with respiratory acidosis, an increase in serum K+ and Cl-, increased osmolarity of the aqueous humor, and an elevation of K+ and Cl- in cerebrospinal fluid (CSF). However, if CSF was allowed to drain freely so that no increase of CSFP occurred, there was only a small increase of IOP (3.7 mm Hg). Under these latter conditions, there also was a decrease of arterial pressure (20.7 mm Hg), respiratory frequency (9.5 mov/min) and respiratory amplitude (2.1 mm). When dogs were ventilated artificially the above changes were greatly attenuated. They were limited to a small but significant rise of CSFP (4.7 mm Hg), a decrease in AP (20.7 mm Hg) and a decrease of HCO3- (7.6 mEq/) of arterial blood. The possible mechanisms involved in the action of methoxyflurane on IOP were discussed and it was pointed out that this anesthetic agent might be used for inducing anesthesia; however, it would be necessary to avoid respiratory depression, in order to prevent intracranial and ocular hypertension. |
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Effects of methoxyflurane on intraocular and cerebrospinal fluid pressure in dogs with spontaneous or artificial respirationMethoxyflurane (0.2 ml/kg over 5 min), administered by inhalation to dogs with spontaneous respiration, resulted approximately 10 minutes later in a significant increase of intraocular pressure (IOP) (13.3 mm Hg), cerebrospinal fluid pressure (CSFP) (9.4 mm Hg), and venous pressure (VP) (6 mm Hg), as well as a significant decrease in arterial pressure (AP) (23.3 mm Hg), respiratory frequency (3.2 mov/min) and respiratory amplitude (7.1 mm). These alterations occurred concomitantly with respiratory acidosis, an increase in serum K+ and Cl-, increased osmolarity of the aqueous humor, and an elevation of K+ and Cl- in cerebrospinal fluid (CSF). However, if CSF was allowed to drain freely so that no increase of CSFP occurred, there was only a small increase of IOP (3.7 mm Hg). Under these latter conditions, there also was a decrease of arterial pressure (20.7 mm Hg), respiratory frequency (9.5 mov/min) and respiratory amplitude (2.1 mm). When dogs were ventilated artificially the above changes were greatly attenuated. They were limited to a small but significant rise of CSFP (4.7 mm Hg), a decrease in AP (20.7 mm Hg) and a decrease of HCO3- (7.6 mEq/) of arterial blood. The possible mechanisms involved in the action of methoxyflurane on IOP were discussed and it was pointed out that this anesthetic agent might be used for inducing anesthesia; however, it would be necessary to avoid respiratory depression, in order to prevent intracranial and ocular hypertension.Dept. Farmacol., Inst. Bas. Biol., Med. Agric. Campus Botucatu, Univ. Estad. Paulista Julio de Mesquita Filho, BotucatuUniversidade Estadual Paulista (UNESP)Vassilieff, I.De Oliveira Vassilieff, V. S.Chagas, A. M.2022-04-29T08:42:01Z2022-04-29T08:42:01Z1979-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article33-39Brazilian Journal of Medical and Biological Research, v. 12, n. 1, p. 33-39, 1979.0100-879Xhttp://hdl.handle.net/11449/2307922-s2.0-0018778575Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccess2022-04-29T08:42:01Zoai:repositorio.unesp.br:11449/230792Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:42:01Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of methoxyflurane on intraocular and cerebrospinal fluid pressure in dogs with spontaneous or artificial respiration |
title |
Effects of methoxyflurane on intraocular and cerebrospinal fluid pressure in dogs with spontaneous or artificial respiration |
spellingShingle |
Effects of methoxyflurane on intraocular and cerebrospinal fluid pressure in dogs with spontaneous or artificial respiration Vassilieff, I. |
title_short |
Effects of methoxyflurane on intraocular and cerebrospinal fluid pressure in dogs with spontaneous or artificial respiration |
title_full |
Effects of methoxyflurane on intraocular and cerebrospinal fluid pressure in dogs with spontaneous or artificial respiration |
title_fullStr |
Effects of methoxyflurane on intraocular and cerebrospinal fluid pressure in dogs with spontaneous or artificial respiration |
title_full_unstemmed |
Effects of methoxyflurane on intraocular and cerebrospinal fluid pressure in dogs with spontaneous or artificial respiration |
title_sort |
Effects of methoxyflurane on intraocular and cerebrospinal fluid pressure in dogs with spontaneous or artificial respiration |
author |
Vassilieff, I. |
author_facet |
Vassilieff, I. De Oliveira Vassilieff, V. S. Chagas, A. M. |
author_role |
author |
author2 |
De Oliveira Vassilieff, V. S. Chagas, A. M. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Vassilieff, I. De Oliveira Vassilieff, V. S. Chagas, A. M. |
description |
Methoxyflurane (0.2 ml/kg over 5 min), administered by inhalation to dogs with spontaneous respiration, resulted approximately 10 minutes later in a significant increase of intraocular pressure (IOP) (13.3 mm Hg), cerebrospinal fluid pressure (CSFP) (9.4 mm Hg), and venous pressure (VP) (6 mm Hg), as well as a significant decrease in arterial pressure (AP) (23.3 mm Hg), respiratory frequency (3.2 mov/min) and respiratory amplitude (7.1 mm). These alterations occurred concomitantly with respiratory acidosis, an increase in serum K+ and Cl-, increased osmolarity of the aqueous humor, and an elevation of K+ and Cl- in cerebrospinal fluid (CSF). However, if CSF was allowed to drain freely so that no increase of CSFP occurred, there was only a small increase of IOP (3.7 mm Hg). Under these latter conditions, there also was a decrease of arterial pressure (20.7 mm Hg), respiratory frequency (9.5 mov/min) and respiratory amplitude (2.1 mm). When dogs were ventilated artificially the above changes were greatly attenuated. They were limited to a small but significant rise of CSFP (4.7 mm Hg), a decrease in AP (20.7 mm Hg) and a decrease of HCO3- (7.6 mEq/) of arterial blood. The possible mechanisms involved in the action of methoxyflurane on IOP were discussed and it was pointed out that this anesthetic agent might be used for inducing anesthesia; however, it would be necessary to avoid respiratory depression, in order to prevent intracranial and ocular hypertension. |
publishDate |
1979 |
dc.date.none.fl_str_mv |
1979-12-01 2022-04-29T08:42:01Z 2022-04-29T08:42:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Brazilian Journal of Medical and Biological Research, v. 12, n. 1, p. 33-39, 1979. 0100-879X http://hdl.handle.net/11449/230792 2-s2.0-0018778575 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research, v. 12, n. 1, p. 33-39, 1979. 0100-879X 2-s2.0-0018778575 |
url |
http://hdl.handle.net/11449/230792 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
33-39 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803046111751962624 |