Aderências peritoneais em eqüinos: tratamento profilático com carboximetilcelulose

Detalhes bibliográficos
Autor(a) principal: Lopes, Marco Aurélio Ferreira
Data de Publicação: 1998
Outros Autores: Dearo, Antônio Cézar De Oliveira, Iamaguti, Paulo [UNESP], Thomassian, Armen [UNESP], Figueiredo, Laura Maria Alvares De [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0103-84781998000300012
http://hdl.handle.net/11449/212774
Resumo: Peritoneal adhesions form very often in horses submitted to laparotomy. Adhesions may be assymptomatic or they could cause complications such as colic and intestinal obstruction, sometimes with vascular strangulation. To evaluate intra-peritoneal use of carboxymethylcellulose (CMC) in prevention of peritoneal adhesions in horses, the following experiment was conducted: eighteen clinically normal mixed breed horses were anesthetized and submitted to ventral midline laparotomy. Lesions in the distal jejunum were produced to induce peritoneal adhesion formation. In four horses (block I) six lesions were created: one segment 45cm in length was submitted to ischemia by ocluding mural circulation and mesenteric vessels for two hours; in five small areas with approximately three x five centimeters serosal abrasion was produced by rubbing a dry gauze sponge 100 times with a single chromic catgut suture placed in the center through the seromuscular layer. For the other fourteen animals (block II) the model adopted was similar with small chances: instead of one ischemic segment, four segments 25cm in length were created: abrasïon of the five areas was produced with the jaw of an open Rochester forceps; the suture made in the center of the abrasion areas was a line of a simple continuous pattern with 2.5cm in length approximately. Horses were randomly placed into two groups. In nine animals (treatment group), a volume of 7 ml/kg of 1%cmC was instilled in the peritoneal cavity before abdominal wall synthesis. In the other nine animals (control group) the wall was sutured in the same way, but no drug was instilled in the peritoneal cavity. Horses were monitored daily. All animals were submitted to euthanasiu and necropsy fourteen days after surgery. Six of the nine animals in the control group and four of nine animals of treatment group developed peritaneal adhesions. There were no significant differences between the numher of animals with adhesians in the two groups nor between the number and the grade of adhesions developed in the groups. Animals in the treatment group did not show any sign of toxicity or hypersensivity forcmC. Based on these results it may be concluded that carboxymethylcellulose was not efficient in preventing peritoneal adhesions in equine small intestine induced by serosal abrasion and ischemia. Also it may be concluded that this drug did not cause any collateral effects neither impaired peritoneal healing.
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spelling Aderências peritoneais em eqüinos: tratamento profilático com carboximetilcelulosePeritoneal adhesions in horses: prophylactic treatment with carboxymethylcelulloseadhesionsperitoneumabdominal surgeryintestino, equineaderênciasperitôniocirurgia abdominalintestinoeqüinoPeritoneal adhesions form very often in horses submitted to laparotomy. Adhesions may be assymptomatic or they could cause complications such as colic and intestinal obstruction, sometimes with vascular strangulation. To evaluate intra-peritoneal use of carboxymethylcellulose (CMC) in prevention of peritoneal adhesions in horses, the following experiment was conducted: eighteen clinically normal mixed breed horses were anesthetized and submitted to ventral midline laparotomy. Lesions in the distal jejunum were produced to induce peritoneal adhesion formation. In four horses (block I) six lesions were created: one segment 45cm in length was submitted to ischemia by ocluding mural circulation and mesenteric vessels for two hours; in five small areas with approximately three x five centimeters serosal abrasion was produced by rubbing a dry gauze sponge 100 times with a single chromic catgut suture placed in the center through the seromuscular layer. For the other fourteen animals (block II) the model adopted was similar with small chances: instead of one ischemic segment, four segments 25cm in length were created: abrasïon of the five areas was produced with the jaw of an open Rochester forceps; the suture made in the center of the abrasion areas was a line of a simple continuous pattern with 2.5cm in length approximately. Horses were randomly placed into two groups. In nine animals (treatment group), a volume of 7 ml/kg of 1%cmC was instilled in the peritoneal cavity before abdominal wall synthesis. In the other nine animals (control group) the wall was sutured in the same way, but no drug was instilled in the peritoneal cavity. Horses were monitored daily. All animals were submitted to euthanasiu and necropsy fourteen days after surgery. Six of the nine animals in the control group and four of nine animals of treatment group developed peritaneal adhesions. There were no significant differences between the numher of animals with adhesians in the two groups nor between the number and the grade of adhesions developed in the groups. Animals in the treatment group did not show any sign of toxicity or hypersensivity forcmC. Based on these results it may be concluded that carboxymethylcellulose was not efficient in preventing peritoneal adhesions in equine small intestine induced by serosal abrasion and ischemia. Also it may be concluded that this drug did not cause any collateral effects neither impaired peritoneal healing.As aderências peritoneais formam-se freqüentemente nos eqüinos submetidos a laparotomia. As aderências podem ser assintomáticas ou podem causar complicações como cólica e osbstrução intestinal, às vezes com estrangulamento vascular. Com o objetivo de avaliar a eficiência do uso intraperitoneal de carboximetilcelulose (CMC) na prevenção de aderências peritoneais em eqüinos, fez-se o seguinte experimento: dezoito eqüinos clinicamente normais, sem raça definida (SRD), foram anestesiados e submetidos a laparotomia na linha mediana ventral, quando se produziu lesões no jejuno distal para induzir a formação de aderências peritoneais. Em quatro animais (bloco I) foram criadas seis lesões: um segmento com aproximadamente 45cm de comprimento foi submetido à isquemia, através da ligadura da circulação mural e dos vasos mesentéricos por duas horas; em cinco pequenas áreas, com cerca de três por cinco centímetros, foi feita abrasão da serosa pela fricção 100 vezes de uma gaze seca e um ponto simples seromuscular de categute cromado foi aplicado no seu centro. Nos outros 14 animais (bloco II). o modelo adotado foi semelhante com pequenas modificações: ao invés de um segmento de isquemia foram criados quatro segmentos com 25cm de comprimento; a abrasão das cinco pequenas áreas foi feita com uma pinça Rochester aberta e não com uma gaze seca; a sutura seromuscular com categute aplicada no centro das áreas de abrasão foi uma linha contínua simples, com aproximadamente 2,5cm de comprimento e não um ponto simples. Os animais foram aleatoriamente divididos em dois grupos. Em dois animais do bloco I e sete animais do bloco II (grupo tratamento), antes da síntese da parede abdominal, foi instilada, na cavidade peritoneal, uma solução decmC a 7% na dose de 7 ml/kg. Nos outros nove animais (grupo controle) a parede foi suturada da mesma forma, mas nenhum medicamento foi aplicado na cavidade peritoneal. Os eqüinos foram examinados diariamente. Quatorze dias após a cirurgia, todos os animais sofreram eutanásia e foram submetidos à necropsia. Seis, dentre os nove animais do grupo controle e quatro, dentre os nove animais do grupo tratamento, desenvolveram aderências perítoneais. Não houve diferença significativa entre o número de animais com aderências nem entre o número ou o grau das aderências formadas nos dois grupos. Os animais do grupo tratamento não apresentaram qualquer sinal de toxicidade ou hipersensibilidade àcmC. Concluiu-se que a carboximetilcelulose não foi eficiente na prevenção de aderências peritoneais no intestino delgado de eqüinos induzidas por abrasão da serosa e isquemia. Concluiu-se também que esta droga não causou efeitos colaterais e não prejudicou a cicatrização do peritônio.Universidade Federal de Viçosa, Departamento de VeterináriaUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária e ZootecniaUniversidade Estadual de LondrinaUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária e ZootecniaUniversidade Federal de Santa MariaUniversidade Federal de ViçosaUniversidade Estadual Paulista (Unesp)Universidade Estadual de LondrinaLopes, Marco Aurélio FerreiraDearo, Antônio Cézar De OliveiraIamaguti, Paulo [UNESP]Thomassian, Armen [UNESP]Figueiredo, Laura Maria Alvares De [UNESP]2021-07-14T10:45:01Z2021-07-14T10:45:01Z1998-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article423-430application/pdfhttp://dx.doi.org/10.1590/S0103-84781998000300012Ciência Rural. Santa Maria, RS, Brazil: Universidade Federal de Santa Maria, v. 28, n. 3, p. 423-430, 1998.0103-84781678-4596http://hdl.handle.net/11449/21277410.1590/S0103-84781998000300012S0103-84781998000300012S0103-84781998000300012.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporCiência Ruralinfo:eu-repo/semantics/openAccess2024-01-16T06:31:53Zoai:repositorio.unesp.br:11449/212774Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:10:20.160531Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Aderências peritoneais em eqüinos: tratamento profilático com carboximetilcelulose
Peritoneal adhesions in horses: prophylactic treatment with carboxymethylcelullose
title Aderências peritoneais em eqüinos: tratamento profilático com carboximetilcelulose
spellingShingle Aderências peritoneais em eqüinos: tratamento profilático com carboximetilcelulose
Lopes, Marco Aurélio Ferreira
adhesions
peritoneum
abdominal surgery
intestino, equine
aderências
peritônio
cirurgia abdominal
intestino
eqüino
title_short Aderências peritoneais em eqüinos: tratamento profilático com carboximetilcelulose
title_full Aderências peritoneais em eqüinos: tratamento profilático com carboximetilcelulose
title_fullStr Aderências peritoneais em eqüinos: tratamento profilático com carboximetilcelulose
title_full_unstemmed Aderências peritoneais em eqüinos: tratamento profilático com carboximetilcelulose
title_sort Aderências peritoneais em eqüinos: tratamento profilático com carboximetilcelulose
author Lopes, Marco Aurélio Ferreira
author_facet Lopes, Marco Aurélio Ferreira
Dearo, Antônio Cézar De Oliveira
Iamaguti, Paulo [UNESP]
Thomassian, Armen [UNESP]
Figueiredo, Laura Maria Alvares De [UNESP]
author_role author
author2 Dearo, Antônio Cézar De Oliveira
Iamaguti, Paulo [UNESP]
Thomassian, Armen [UNESP]
Figueiredo, Laura Maria Alvares De [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de Viçosa
Universidade Estadual Paulista (Unesp)
Universidade Estadual de Londrina
dc.contributor.author.fl_str_mv Lopes, Marco Aurélio Ferreira
Dearo, Antônio Cézar De Oliveira
Iamaguti, Paulo [UNESP]
Thomassian, Armen [UNESP]
Figueiredo, Laura Maria Alvares De [UNESP]
dc.subject.por.fl_str_mv adhesions
peritoneum
abdominal surgery
intestino, equine
aderências
peritônio
cirurgia abdominal
intestino
eqüino
topic adhesions
peritoneum
abdominal surgery
intestino, equine
aderências
peritônio
cirurgia abdominal
intestino
eqüino
description Peritoneal adhesions form very often in horses submitted to laparotomy. Adhesions may be assymptomatic or they could cause complications such as colic and intestinal obstruction, sometimes with vascular strangulation. To evaluate intra-peritoneal use of carboxymethylcellulose (CMC) in prevention of peritoneal adhesions in horses, the following experiment was conducted: eighteen clinically normal mixed breed horses were anesthetized and submitted to ventral midline laparotomy. Lesions in the distal jejunum were produced to induce peritoneal adhesion formation. In four horses (block I) six lesions were created: one segment 45cm in length was submitted to ischemia by ocluding mural circulation and mesenteric vessels for two hours; in five small areas with approximately three x five centimeters serosal abrasion was produced by rubbing a dry gauze sponge 100 times with a single chromic catgut suture placed in the center through the seromuscular layer. For the other fourteen animals (block II) the model adopted was similar with small chances: instead of one ischemic segment, four segments 25cm in length were created: abrasïon of the five areas was produced with the jaw of an open Rochester forceps; the suture made in the center of the abrasion areas was a line of a simple continuous pattern with 2.5cm in length approximately. Horses were randomly placed into two groups. In nine animals (treatment group), a volume of 7 ml/kg of 1%cmC was instilled in the peritoneal cavity before abdominal wall synthesis. In the other nine animals (control group) the wall was sutured in the same way, but no drug was instilled in the peritoneal cavity. Horses were monitored daily. All animals were submitted to euthanasiu and necropsy fourteen days after surgery. Six of the nine animals in the control group and four of nine animals of treatment group developed peritaneal adhesions. There were no significant differences between the numher of animals with adhesians in the two groups nor between the number and the grade of adhesions developed in the groups. Animals in the treatment group did not show any sign of toxicity or hypersensivity forcmC. Based on these results it may be concluded that carboxymethylcellulose was not efficient in preventing peritoneal adhesions in equine small intestine induced by serosal abrasion and ischemia. Also it may be concluded that this drug did not cause any collateral effects neither impaired peritoneal healing.
publishDate 1998
dc.date.none.fl_str_mv 1998-09
2021-07-14T10:45:01Z
2021-07-14T10:45:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0103-84781998000300012
Ciência Rural. Santa Maria, RS, Brazil: Universidade Federal de Santa Maria, v. 28, n. 3, p. 423-430, 1998.
0103-8478
1678-4596
http://hdl.handle.net/11449/212774
10.1590/S0103-84781998000300012
S0103-84781998000300012
S0103-84781998000300012.pdf
url http://dx.doi.org/10.1590/S0103-84781998000300012
http://hdl.handle.net/11449/212774
identifier_str_mv Ciência Rural. Santa Maria, RS, Brazil: Universidade Federal de Santa Maria, v. 28, n. 3, p. 423-430, 1998.
0103-8478
1678-4596
10.1590/S0103-84781998000300012
S0103-84781998000300012
S0103-84781998000300012.pdf
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Ciência Rural
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 423-430
application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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