Potenciais interações medicamentosas responsáveis por internações hospitalares
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/227172 |
Resumo: | Drug-drug interactions (DDI) are considered a public health problem, since they may be the cause of negative outcomes for drug users. Research objectives: 1) estimate the prevalence of hospital admissions arising from potential DDI; 2) identify the signs and symptoms of, as well as risk factors for hospitalization related to, potential DDI. A cross-sectional study was performed in the general clinic of a private hospital in upstate São Paulo, in May 2006, focusing on patients over 18 years old, hospitalized for more than 24 hours, who were interviewed about their symptoms, reasons for hospitalization and the drugs taken prior to hospitalization. The odds ratio was calculated in order to identify risk factors. Results: 168 patients had taken more than one drug, of whom 57 showed potential DDI and, in 17 (10.1%), the signs and symptoms of DDI were probably the reason for hospitalization. The most frequent clinical manifestations of potential DDI were disorders in the cardiovascular (44.3%), digestive (17.2%) and musculoskeletal (13.8%) systems and 10% of the DDI identified were considered potentially hazardous. Risk factors for DDI-motivated hospitalization related to gender, age or the use of drugs with a narrow therapeutic range were not detected. Polypharmacy (p<0.0001) was a determining factor for DDI; conversely, old age was a protection factor (p=0.02). Conclusion: pharmacotherapeutic follow-up of patients who use drugs with a narrow therapeutic range is essential, since these drugs are often involved in hazardous DDI. Pharmacotherapeutic follow-up is also recommended for polymedicated patients, to prevent hospitalization arising from avoidable DDI. |
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Potenciais interações medicamentosas responsáveis por internações hospitalaresPotential drug interactions responsible for hospital admissionsDrug-drug interactionDrug-related problemMedication errorsNegative outcome associated with medicinesDrug-drug interactions (DDI) are considered a public health problem, since they may be the cause of negative outcomes for drug users. Research objectives: 1) estimate the prevalence of hospital admissions arising from potential DDI; 2) identify the signs and symptoms of, as well as risk factors for hospitalization related to, potential DDI. A cross-sectional study was performed in the general clinic of a private hospital in upstate São Paulo, in May 2006, focusing on patients over 18 years old, hospitalized for more than 24 hours, who were interviewed about their symptoms, reasons for hospitalization and the drugs taken prior to hospitalization. The odds ratio was calculated in order to identify risk factors. Results: 168 patients had taken more than one drug, of whom 57 showed potential DDI and, in 17 (10.1%), the signs and symptoms of DDI were probably the reason for hospitalization. The most frequent clinical manifestations of potential DDI were disorders in the cardiovascular (44.3%), digestive (17.2%) and musculoskeletal (13.8%) systems and 10% of the DDI identified were considered potentially hazardous. Risk factors for DDI-motivated hospitalization related to gender, age or the use of drugs with a narrow therapeutic range were not detected. Polypharmacy (p<0.0001) was a determining factor for DDI; conversely, old age was a protection factor (p=0.02). Conclusion: pharmacotherapeutic follow-up of patients who use drugs with a narrow therapeutic range is essential, since these drugs are often involved in hazardous DDI. Pharmacotherapeutic follow-up is also recommended for polymedicated patients, to prevent hospitalization arising from avoidable DDI.UNESP Departamento de Fármacos e MedicamentosUNESP Departamento de Fármacos e MedicamentosUniversidade Estadual Paulista (UNESP)Varallo, Fabiana Rossi [UNESP]Costa, Marília Amaral [UNESP]de Carvalho Mastroianni, Patrícia [UNESP]2022-04-29T07:11:50Z2022-04-29T07:11:50Z2013-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article79-85Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 34, n. 1, p. 79-85, 2013.1808-4532http://hdl.handle.net/11449/2271722-s2.0-84877960015Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengporRevista de Ciencias Farmaceuticas Basica e Aplicadainfo:eu-repo/semantics/openAccess2024-06-24T13:46:00Zoai:repositorio.unesp.br:11449/227172Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:11:46.495621Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Potenciais interações medicamentosas responsáveis por internações hospitalares Potential drug interactions responsible for hospital admissions |
title |
Potenciais interações medicamentosas responsáveis por internações hospitalares |
spellingShingle |
Potenciais interações medicamentosas responsáveis por internações hospitalares Varallo, Fabiana Rossi [UNESP] Drug-drug interaction Drug-related problem Medication errors Negative outcome associated with medicines |
title_short |
Potenciais interações medicamentosas responsáveis por internações hospitalares |
title_full |
Potenciais interações medicamentosas responsáveis por internações hospitalares |
title_fullStr |
Potenciais interações medicamentosas responsáveis por internações hospitalares |
title_full_unstemmed |
Potenciais interações medicamentosas responsáveis por internações hospitalares |
title_sort |
Potenciais interações medicamentosas responsáveis por internações hospitalares |
author |
Varallo, Fabiana Rossi [UNESP] |
author_facet |
Varallo, Fabiana Rossi [UNESP] Costa, Marília Amaral [UNESP] de Carvalho Mastroianni, Patrícia [UNESP] |
author_role |
author |
author2 |
Costa, Marília Amaral [UNESP] de Carvalho Mastroianni, Patrícia [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Varallo, Fabiana Rossi [UNESP] Costa, Marília Amaral [UNESP] de Carvalho Mastroianni, Patrícia [UNESP] |
dc.subject.por.fl_str_mv |
Drug-drug interaction Drug-related problem Medication errors Negative outcome associated with medicines |
topic |
Drug-drug interaction Drug-related problem Medication errors Negative outcome associated with medicines |
description |
Drug-drug interactions (DDI) are considered a public health problem, since they may be the cause of negative outcomes for drug users. Research objectives: 1) estimate the prevalence of hospital admissions arising from potential DDI; 2) identify the signs and symptoms of, as well as risk factors for hospitalization related to, potential DDI. A cross-sectional study was performed in the general clinic of a private hospital in upstate São Paulo, in May 2006, focusing on patients over 18 years old, hospitalized for more than 24 hours, who were interviewed about their symptoms, reasons for hospitalization and the drugs taken prior to hospitalization. The odds ratio was calculated in order to identify risk factors. Results: 168 patients had taken more than one drug, of whom 57 showed potential DDI and, in 17 (10.1%), the signs and symptoms of DDI were probably the reason for hospitalization. The most frequent clinical manifestations of potential DDI were disorders in the cardiovascular (44.3%), digestive (17.2%) and musculoskeletal (13.8%) systems and 10% of the DDI identified were considered potentially hazardous. Risk factors for DDI-motivated hospitalization related to gender, age or the use of drugs with a narrow therapeutic range were not detected. Polypharmacy (p<0.0001) was a determining factor for DDI; conversely, old age was a protection factor (p=0.02). Conclusion: pharmacotherapeutic follow-up of patients who use drugs with a narrow therapeutic range is essential, since these drugs are often involved in hazardous DDI. Pharmacotherapeutic follow-up is also recommended for polymedicated patients, to prevent hospitalization arising from avoidable DDI. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-04-01 2022-04-29T07:11:50Z 2022-04-29T07:11:50Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 34, n. 1, p. 79-85, 2013. 1808-4532 http://hdl.handle.net/11449/227172 2-s2.0-84877960015 |
identifier_str_mv |
Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 34, n. 1, p. 79-85, 2013. 1808-4532 2-s2.0-84877960015 |
url |
http://hdl.handle.net/11449/227172 |
dc.language.iso.fl_str_mv |
eng por |
language |
eng por |
dc.relation.none.fl_str_mv |
Revista de Ciencias Farmaceuticas Basica e Aplicada |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
79-85 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129170436259840 |