Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin children
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.meegid.2021.104828 http://hdl.handle.net/11449/207927 |
Resumo: | Background: Little attention has been devoted to the role of the immunoregulatory HLA-E/-F/−G genes in malaria. We evaluated the entire HLA-E/-F/−G variability in Beninese children highly exposed to Plasmodium falciparum (P.f.) malaria. Methods: 154 unrelated children were followed-up for six months and evaluated for the presence and number of malaria episodes. HLA-E/-F/−G genes were genotyped using massively parallel sequencing. Anti P.f. antibodies were evaluated using ELISA. Results: Children carrying the G allele at HLA-F (−1499,rs183540921) showed increased P.f. asymptomatic/symptomatic ratio, suggesting that these children experienced more asymptomatic P.f. episodes than symptomatic one. Children carrying HLA-G-UTR-03 haplotype exhibited increased risk for symptomatic P.f. episodes and showed lower IgG2 response against P.f. GLURP-R2 when compared to the non-carriers. No associations were observed for the HLA-E gene. Conclusion: HLA-F associations may be related to the differential expression profiles of the encoded immunomodulatory molecules, and the regulatory sites at the HLA-G 3'UTR may be associated to posttranscriptional regulation of HLA-G and to host humoral response against P.f. |
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Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin childrenAntibodyHaplotypeHLA-IbPlasmodium falciparumSNVBackground: Little attention has been devoted to the role of the immunoregulatory HLA-E/-F/−G genes in malaria. We evaluated the entire HLA-E/-F/−G variability in Beninese children highly exposed to Plasmodium falciparum (P.f.) malaria. Methods: 154 unrelated children were followed-up for six months and evaluated for the presence and number of malaria episodes. HLA-E/-F/−G genes were genotyped using massively parallel sequencing. Anti P.f. antibodies were evaluated using ELISA. Results: Children carrying the G allele at HLA-F (−1499,rs183540921) showed increased P.f. asymptomatic/symptomatic ratio, suggesting that these children experienced more asymptomatic P.f. episodes than symptomatic one. Children carrying HLA-G-UTR-03 haplotype exhibited increased risk for symptomatic P.f. episodes and showed lower IgG2 response against P.f. GLURP-R2 when compared to the non-carriers. No associations were observed for the HLA-E gene. Conclusion: HLA-F associations may be related to the differential expression profiles of the encoded immunomodulatory molecules, and the regulatory sites at the HLA-G 3'UTR may be associated to posttranscriptional regulation of HLA-G and to host humoral response against P.f.Institut de Recherche pour le DéveloppementCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Post-graduate Program in Basic and Applied Immunology Ribeirão Preto Medical School University of São Paulo, Avenida Bandeirantes, 3900, Monte AlegreImmunogenetic Laboratory Immunology Department Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Av. Moraes rego, s/n, Campus da UFPE, Cidade UniversitáriaCentre d'Etude et de Recherche sur le Paludisme Associé à la Grossesse et à l'Enfance (CERPAGE) faculté des Sciences de la Santé CotonouUniversité de Paris, UMR 261 MERIT, IRDDépartement de Zoologie faculté des Sciences et Techniques Université d'Abomey-CalaviIntertryp IRD Cirad University of Montpellier, Avenue AgropolisSão Paulo State University (UNESP) School of Medicine Molecular Genetics and Bioinformatics Laboratory, Av. Prof. Dr. Walter Maurício Correa, s/nCentre Médical Saint Joseph Sô AvaCEA DRF-Institut François Jacob Service de Recherches en Hémato-Immunologie, Hopital Saint-LouisUniversité de Paris CEA U976 HIPI Unit (Human Immunology Physiopathology Immunotherapy) Institut de Recherche Saint-LouisDepartamento de Química Faculdade de Filosofia Ciências e Letras de Ribeirão Preto Universidade de São Paulo, AV Bandeirantes, 3900Laboratoire de Biologie et Physiologie Cellulaire Université d'Abomey-CalaviSão Paulo State University (UNESP) Department of Pathology School of MedicineSão Paulo State University (UNESP) School of Medicine Molecular Genetics and Bioinformatics Laboratory, Av. Prof. Dr. Walter Maurício Correa, s/nSão Paulo State University (UNESP) Department of Pathology School of MedicineCAPES: #304931/2014-1CAPES: #466036/2013-5CAPES: 302060/2019-07CAPES: 406594/2013-9CNPq: PROCAD#88881-068436/2014-1Universidade de São Paulo (USP)Universidade Federal de Pernambuco (UFPE)CotonouUniversité de ParisUniversité d'Abomey-CalaviUniversity of MontpellierUniversidade Estadual Paulista (Unesp)Sô AvaService de Recherches en Hémato-ImmunologieInstitut de Recherche Saint-LouisSonon, PaulinTokplonou, LéonidasSadissou, IbrahimM'po, Kuumaaté K.G.Glitho, Sonya S.C.Agniwo, PrivatIbikounlé, MoudachirouSouza, Andréia S. [UNESP]Massaro, Juliana DoblasGonzalez, DanielTchégninougbo, ThéophileAyitchédji, AurèleMassougbodji, AchilleMoreau, PhilippeGarcia, AndréMilet, JacquelineSabbagh, AudreyMendes-Junior, Celso T.Moutairou, Kabirou A.Castelli, Erick C. [UNESP]Courtin, DavidDonadi, Eduardo A.2021-06-25T11:03:24Z2021-06-25T11:03:24Z2021-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.meegid.2021.104828Infection, Genetics and Evolution, v. 92.1567-72571567-1348http://hdl.handle.net/11449/20792710.1016/j.meegid.2021.1048282-s2.0-85103729480Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInfection, Genetics and Evolutioninfo:eu-repo/semantics/openAccess2021-10-23T17:51:55Zoai:repositorio.unesp.br:11449/207927Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:26:43.617980Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin children |
title |
Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin children |
spellingShingle |
Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin children Sonon, Paulin Antibody Haplotype HLA-Ib Plasmodium falciparum SNV |
title_short |
Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin children |
title_full |
Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin children |
title_fullStr |
Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin children |
title_full_unstemmed |
Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin children |
title_sort |
Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin children |
author |
Sonon, Paulin |
author_facet |
Sonon, Paulin Tokplonou, Léonidas Sadissou, Ibrahim M'po, Kuumaaté K.G. Glitho, Sonya S.C. Agniwo, Privat Ibikounlé, Moudachirou Souza, Andréia S. [UNESP] Massaro, Juliana Doblas Gonzalez, Daniel Tchégninougbo, Théophile Ayitchédji, Aurèle Massougbodji, Achille Moreau, Philippe Garcia, André Milet, Jacqueline Sabbagh, Audrey Mendes-Junior, Celso T. Moutairou, Kabirou A. Castelli, Erick C. [UNESP] Courtin, David Donadi, Eduardo A. |
author_role |
author |
author2 |
Tokplonou, Léonidas Sadissou, Ibrahim M'po, Kuumaaté K.G. Glitho, Sonya S.C. Agniwo, Privat Ibikounlé, Moudachirou Souza, Andréia S. [UNESP] Massaro, Juliana Doblas Gonzalez, Daniel Tchégninougbo, Théophile Ayitchédji, Aurèle Massougbodji, Achille Moreau, Philippe Garcia, André Milet, Jacqueline Sabbagh, Audrey Mendes-Junior, Celso T. Moutairou, Kabirou A. Castelli, Erick C. [UNESP] Courtin, David Donadi, Eduardo A. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de Pernambuco (UFPE) Cotonou Université de Paris Université d'Abomey-Calavi University of Montpellier Universidade Estadual Paulista (Unesp) Sô Ava Service de Recherches en Hémato-Immunologie Institut de Recherche Saint-Louis |
dc.contributor.author.fl_str_mv |
Sonon, Paulin Tokplonou, Léonidas Sadissou, Ibrahim M'po, Kuumaaté K.G. Glitho, Sonya S.C. Agniwo, Privat Ibikounlé, Moudachirou Souza, Andréia S. [UNESP] Massaro, Juliana Doblas Gonzalez, Daniel Tchégninougbo, Théophile Ayitchédji, Aurèle Massougbodji, Achille Moreau, Philippe Garcia, André Milet, Jacqueline Sabbagh, Audrey Mendes-Junior, Celso T. Moutairou, Kabirou A. Castelli, Erick C. [UNESP] Courtin, David Donadi, Eduardo A. |
dc.subject.por.fl_str_mv |
Antibody Haplotype HLA-Ib Plasmodium falciparum SNV |
topic |
Antibody Haplotype HLA-Ib Plasmodium falciparum SNV |
description |
Background: Little attention has been devoted to the role of the immunoregulatory HLA-E/-F/−G genes in malaria. We evaluated the entire HLA-E/-F/−G variability in Beninese children highly exposed to Plasmodium falciparum (P.f.) malaria. Methods: 154 unrelated children were followed-up for six months and evaluated for the presence and number of malaria episodes. HLA-E/-F/−G genes were genotyped using massively parallel sequencing. Anti P.f. antibodies were evaluated using ELISA. Results: Children carrying the G allele at HLA-F (−1499,rs183540921) showed increased P.f. asymptomatic/symptomatic ratio, suggesting that these children experienced more asymptomatic P.f. episodes than symptomatic one. Children carrying HLA-G-UTR-03 haplotype exhibited increased risk for symptomatic P.f. episodes and showed lower IgG2 response against P.f. GLURP-R2 when compared to the non-carriers. No associations were observed for the HLA-E gene. Conclusion: HLA-F associations may be related to the differential expression profiles of the encoded immunomodulatory molecules, and the regulatory sites at the HLA-G 3'UTR may be associated to posttranscriptional regulation of HLA-G and to host humoral response against P.f. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T11:03:24Z 2021-06-25T11:03:24Z 2021-08-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.meegid.2021.104828 Infection, Genetics and Evolution, v. 92. 1567-7257 1567-1348 http://hdl.handle.net/11449/207927 10.1016/j.meegid.2021.104828 2-s2.0-85103729480 |
url |
http://dx.doi.org/10.1016/j.meegid.2021.104828 http://hdl.handle.net/11449/207927 |
identifier_str_mv |
Infection, Genetics and Evolution, v. 92. 1567-7257 1567-1348 10.1016/j.meegid.2021.104828 2-s2.0-85103729480 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Infection, Genetics and Evolution |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129521412472832 |