Quantitation and karyometry of cerebral neuroglia and endothelial cells in liver cirrhosis and in the hepatosplenic schistosomiasis mansoni

Detalhes bibliográficos
Autor(a) principal: Brasileiro-Filho, G.
Data de Publicação: 1989
Outros Autores: Guimaraes, R. C. [UNESP], Pittella, J. E.H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/BF00687885
http://hdl.handle.net/11449/223913
Resumo: A morphological, karyometric, and quantitative study of cerebral neuroglia and endothelial cells of blood capillaries was done in cirrhotic and in hepatosplenic schistosomotic human autopsied cases. Cluster analysis applied to them revealed three subgroups (cirrhosis and schistosomiasis polar groups and one intermediate). The comparison of these three groups with a control revealed increased numbers of astrocytes, oligodendrocytes and endothelial cells, but no nuclear enlargement in the schistosomiasis group; the cirrhosis group exhibited a pronounced nuclear enlargement of both astrocyte and oligodendrocytes but no increase in cell numbers. The intermediate group, which encompasses the majority of pathological cases, is heterogeneous but on average behave as the cirrhosis group in that nuclear enlargement, but no increase in cell numbers, was noted. Such changes could represent a response of the nervous system to the metabolic disturbances present in hepatic and/or portal-systemic encephalopathy. There was a positive correlation between glial and endothelial cell numbers in cerebral cortex, suggesting a functional relationship between the glial cells and the capillary bed. This study points out the importance of clustering the cases, because the physiopathological status of individuals belonging to the same nosological condition can be different. Comparisons considering this aspect should be useful in understanding the progression of the pathological process. © 1989 Springer-Verlag.
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spelling Quantitation and karyometry of cerebral neuroglia and endothelial cells in liver cirrhosis and in the hepatosplenic schistosomiasis mansoniCell numberGlial cellsKariometryLiver cirrhosisSchistosomiasisA morphological, karyometric, and quantitative study of cerebral neuroglia and endothelial cells of blood capillaries was done in cirrhotic and in hepatosplenic schistosomotic human autopsied cases. Cluster analysis applied to them revealed three subgroups (cirrhosis and schistosomiasis polar groups and one intermediate). The comparison of these three groups with a control revealed increased numbers of astrocytes, oligodendrocytes and endothelial cells, but no nuclear enlargement in the schistosomiasis group; the cirrhosis group exhibited a pronounced nuclear enlargement of both astrocyte and oligodendrocytes but no increase in cell numbers. The intermediate group, which encompasses the majority of pathological cases, is heterogeneous but on average behave as the cirrhosis group in that nuclear enlargement, but no increase in cell numbers, was noted. Such changes could represent a response of the nervous system to the metabolic disturbances present in hepatic and/or portal-systemic encephalopathy. There was a positive correlation between glial and endothelial cell numbers in cerebral cortex, suggesting a functional relationship between the glial cells and the capillary bed. This study points out the importance of clustering the cases, because the physiopathological status of individuals belonging to the same nosological condition can be different. Comparisons considering this aspect should be useful in understanding the progression of the pathological process. © 1989 Springer-Verlag.Departamento de Anatomica Patologica Faculdade de Medicina UFMG, Caixa Postal, 340. 30. 130, Belo Horizonte, MGDepartmento de Genetica IBBMA-UNESP, Botucatu, SPDepartmento de Genetica IBBMA-UNESP, Botucatu, SPUniversidade Federal de Minas Gerais (UFMG)Universidade Estadual Paulista (UNESP)Brasileiro-Filho, G.Guimaraes, R. C. [UNESP]Pittella, J. E.H.2022-04-28T19:53:47Z2022-04-28T19:53:47Z1989-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article582-590http://dx.doi.org/10.1007/BF00687885Acta Neuropathologica, v. 77, n. 6, p. 582-590, 1989.0001-63221432-0533http://hdl.handle.net/11449/22391310.1007/BF006878852-s2.0-0024596398Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Neuropathologicainfo:eu-repo/semantics/openAccess2022-04-28T19:53:47Zoai:repositorio.unesp.br:11449/223913Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:41:08.845572Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Quantitation and karyometry of cerebral neuroglia and endothelial cells in liver cirrhosis and in the hepatosplenic schistosomiasis mansoni
title Quantitation and karyometry of cerebral neuroglia and endothelial cells in liver cirrhosis and in the hepatosplenic schistosomiasis mansoni
spellingShingle Quantitation and karyometry of cerebral neuroglia and endothelial cells in liver cirrhosis and in the hepatosplenic schistosomiasis mansoni
Brasileiro-Filho, G.
Cell number
Glial cells
Kariometry
Liver cirrhosis
Schistosomiasis
title_short Quantitation and karyometry of cerebral neuroglia and endothelial cells in liver cirrhosis and in the hepatosplenic schistosomiasis mansoni
title_full Quantitation and karyometry of cerebral neuroglia and endothelial cells in liver cirrhosis and in the hepatosplenic schistosomiasis mansoni
title_fullStr Quantitation and karyometry of cerebral neuroglia and endothelial cells in liver cirrhosis and in the hepatosplenic schistosomiasis mansoni
title_full_unstemmed Quantitation and karyometry of cerebral neuroglia and endothelial cells in liver cirrhosis and in the hepatosplenic schistosomiasis mansoni
title_sort Quantitation and karyometry of cerebral neuroglia and endothelial cells in liver cirrhosis and in the hepatosplenic schistosomiasis mansoni
author Brasileiro-Filho, G.
author_facet Brasileiro-Filho, G.
Guimaraes, R. C. [UNESP]
Pittella, J. E.H.
author_role author
author2 Guimaraes, R. C. [UNESP]
Pittella, J. E.H.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Federal de Minas Gerais (UFMG)
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Brasileiro-Filho, G.
Guimaraes, R. C. [UNESP]
Pittella, J. E.H.
dc.subject.por.fl_str_mv Cell number
Glial cells
Kariometry
Liver cirrhosis
Schistosomiasis
topic Cell number
Glial cells
Kariometry
Liver cirrhosis
Schistosomiasis
description A morphological, karyometric, and quantitative study of cerebral neuroglia and endothelial cells of blood capillaries was done in cirrhotic and in hepatosplenic schistosomotic human autopsied cases. Cluster analysis applied to them revealed three subgroups (cirrhosis and schistosomiasis polar groups and one intermediate). The comparison of these three groups with a control revealed increased numbers of astrocytes, oligodendrocytes and endothelial cells, but no nuclear enlargement in the schistosomiasis group; the cirrhosis group exhibited a pronounced nuclear enlargement of both astrocyte and oligodendrocytes but no increase in cell numbers. The intermediate group, which encompasses the majority of pathological cases, is heterogeneous but on average behave as the cirrhosis group in that nuclear enlargement, but no increase in cell numbers, was noted. Such changes could represent a response of the nervous system to the metabolic disturbances present in hepatic and/or portal-systemic encephalopathy. There was a positive correlation between glial and endothelial cell numbers in cerebral cortex, suggesting a functional relationship between the glial cells and the capillary bed. This study points out the importance of clustering the cases, because the physiopathological status of individuals belonging to the same nosological condition can be different. Comparisons considering this aspect should be useful in understanding the progression of the pathological process. © 1989 Springer-Verlag.
publishDate 1989
dc.date.none.fl_str_mv 1989-11-01
2022-04-28T19:53:47Z
2022-04-28T19:53:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/BF00687885
Acta Neuropathologica, v. 77, n. 6, p. 582-590, 1989.
0001-6322
1432-0533
http://hdl.handle.net/11449/223913
10.1007/BF00687885
2-s2.0-0024596398
url http://dx.doi.org/10.1007/BF00687885
http://hdl.handle.net/11449/223913
identifier_str_mv Acta Neuropathologica, v. 77, n. 6, p. 582-590, 1989.
0001-6322
1432-0533
10.1007/BF00687885
2-s2.0-0024596398
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Neuropathologica
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 582-590
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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