Protein-Silica Hybrid Submicron Particles: Preparation and Characterization
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s42250-020-00138-3 http://hdl.handle.net/11449/221595 |
Resumo: | Purpose: Hybrid nanoparticles are an interesting type of particles currently employed in nanomedicine. They can combine the therapeutic and diagnostic functions of their components into one single nanosystem and therefore, can be tweaked according to their applications and desired results. The purpose of this work is to develop an easily tuned nano-system of bovine serum albumin-silica hybrid nanoparticles. Methods: BSA nanoparticles were prepared by nanoprecipitation process using water as the solvent phase and ethanol as the non-solvent. Silica was produced through a sol–gel process and deposited inside the BSA nanoparticles via template deposition. The effect of initial concentrations of raw materials on the structure and colloidal properties of the system was evaluated using FTIR, TGA, TEM, and zeta potential measurements. Results: A hybrid structure of BSA-silica was obtained. The results suggest that the particles size, isoelectric point and silica content of the hybrid nanoparticles can be easily tuned by controlling adequately the concentration of TEOS and ammonia. Conclusion: Our method can be considered as a novel approach for hybrid nanoparticle synthesis. To our knowledge, we report for the first time the synthesis of silica-BSA hybrid particles with a non-core–shell structure. In addition, we proved that that the particles size, isoelectric point and silica content of the hybrid nanoparticles can be easily tuned by controlling adequately the concentration of TEOS and ammonia. |
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Protein-Silica Hybrid Submicron Particles: Preparation and CharacterizationBSACharacterizationHybrid nanoparticlesSilicaPurpose: Hybrid nanoparticles are an interesting type of particles currently employed in nanomedicine. They can combine the therapeutic and diagnostic functions of their components into one single nanosystem and therefore, can be tweaked according to their applications and desired results. The purpose of this work is to develop an easily tuned nano-system of bovine serum albumin-silica hybrid nanoparticles. Methods: BSA nanoparticles were prepared by nanoprecipitation process using water as the solvent phase and ethanol as the non-solvent. Silica was produced through a sol–gel process and deposited inside the BSA nanoparticles via template deposition. The effect of initial concentrations of raw materials on the structure and colloidal properties of the system was evaluated using FTIR, TGA, TEM, and zeta potential measurements. Results: A hybrid structure of BSA-silica was obtained. The results suggest that the particles size, isoelectric point and silica content of the hybrid nanoparticles can be easily tuned by controlling adequately the concentration of TEOS and ammonia. Conclusion: Our method can be considered as a novel approach for hybrid nanoparticle synthesis. To our knowledge, we report for the first time the synthesis of silica-BSA hybrid particles with a non-core–shell structure. In addition, we proved that that the particles size, isoelectric point and silica content of the hybrid nanoparticles can be easily tuned by controlling adequately the concentration of TEOS and ammonia.Campus FranceH2020 European Research CouncilCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)University Lyon University Claude Bernard Lyon-1 CNRS LAGEPP-UMR 5007, 43 Boulevard du 11 Novembre 1918Institute of Chemistry São Paulo State University (UNESP)Institute of Analytical Sciences UMR 5280 Claude Bernard Lyon 1 University University of LyonInstitute of Chemistry São Paulo State University (UNESP)Campus France: 57129895H2020 European Research Council: 643694CAPES: 88881.132878/2016-01LAGEPP-UMR 5007Universidade Estadual Paulista (UNESP)University of LyonVega-Chacón, Jaime [UNESP]Tarhini, MohamadLebaz, NoureddineJafelicci, Miguel [UNESP]Zine, NadiaErrachid, AbdelhamidElaissari, Abdelhamid2022-04-28T19:29:29Z2022-04-28T19:29:29Z2020-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article793-801http://dx.doi.org/10.1007/s42250-020-00138-3Chemistry Africa, v. 3, n. 3, p. 793-801, 2020.2522-57662522-5758http://hdl.handle.net/11449/22159510.1007/s42250-020-00138-32-s2.0-85094155022Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengChemistry Africainfo:eu-repo/semantics/openAccess2022-04-28T19:29:29Zoai:repositorio.unesp.br:11449/221595Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:29:29Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Protein-Silica Hybrid Submicron Particles: Preparation and Characterization |
title |
Protein-Silica Hybrid Submicron Particles: Preparation and Characterization |
spellingShingle |
Protein-Silica Hybrid Submicron Particles: Preparation and Characterization Vega-Chacón, Jaime [UNESP] BSA Characterization Hybrid nanoparticles Silica |
title_short |
Protein-Silica Hybrid Submicron Particles: Preparation and Characterization |
title_full |
Protein-Silica Hybrid Submicron Particles: Preparation and Characterization |
title_fullStr |
Protein-Silica Hybrid Submicron Particles: Preparation and Characterization |
title_full_unstemmed |
Protein-Silica Hybrid Submicron Particles: Preparation and Characterization |
title_sort |
Protein-Silica Hybrid Submicron Particles: Preparation and Characterization |
author |
Vega-Chacón, Jaime [UNESP] |
author_facet |
Vega-Chacón, Jaime [UNESP] Tarhini, Mohamad Lebaz, Noureddine Jafelicci, Miguel [UNESP] Zine, Nadia Errachid, Abdelhamid Elaissari, Abdelhamid |
author_role |
author |
author2 |
Tarhini, Mohamad Lebaz, Noureddine Jafelicci, Miguel [UNESP] Zine, Nadia Errachid, Abdelhamid Elaissari, Abdelhamid |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
LAGEPP-UMR 5007 Universidade Estadual Paulista (UNESP) University of Lyon |
dc.contributor.author.fl_str_mv |
Vega-Chacón, Jaime [UNESP] Tarhini, Mohamad Lebaz, Noureddine Jafelicci, Miguel [UNESP] Zine, Nadia Errachid, Abdelhamid Elaissari, Abdelhamid |
dc.subject.por.fl_str_mv |
BSA Characterization Hybrid nanoparticles Silica |
topic |
BSA Characterization Hybrid nanoparticles Silica |
description |
Purpose: Hybrid nanoparticles are an interesting type of particles currently employed in nanomedicine. They can combine the therapeutic and diagnostic functions of their components into one single nanosystem and therefore, can be tweaked according to their applications and desired results. The purpose of this work is to develop an easily tuned nano-system of bovine serum albumin-silica hybrid nanoparticles. Methods: BSA nanoparticles were prepared by nanoprecipitation process using water as the solvent phase and ethanol as the non-solvent. Silica was produced through a sol–gel process and deposited inside the BSA nanoparticles via template deposition. The effect of initial concentrations of raw materials on the structure and colloidal properties of the system was evaluated using FTIR, TGA, TEM, and zeta potential measurements. Results: A hybrid structure of BSA-silica was obtained. The results suggest that the particles size, isoelectric point and silica content of the hybrid nanoparticles can be easily tuned by controlling adequately the concentration of TEOS and ammonia. Conclusion: Our method can be considered as a novel approach for hybrid nanoparticle synthesis. To our knowledge, we report for the first time the synthesis of silica-BSA hybrid particles with a non-core–shell structure. In addition, we proved that that the particles size, isoelectric point and silica content of the hybrid nanoparticles can be easily tuned by controlling adequately the concentration of TEOS and ammonia. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-09-01 2022-04-28T19:29:29Z 2022-04-28T19:29:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s42250-020-00138-3 Chemistry Africa, v. 3, n. 3, p. 793-801, 2020. 2522-5766 2522-5758 http://hdl.handle.net/11449/221595 10.1007/s42250-020-00138-3 2-s2.0-85094155022 |
url |
http://dx.doi.org/10.1007/s42250-020-00138-3 http://hdl.handle.net/11449/221595 |
identifier_str_mv |
Chemistry Africa, v. 3, n. 3, p. 793-801, 2020. 2522-5766 2522-5758 10.1007/s42250-020-00138-3 2-s2.0-85094155022 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Chemistry Africa |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
793-801 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803649299645464576 |