Oral Lymphoepithelial Cyst: A Collaborative Clinicopathologic Study of 132 Cases from Brazil
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s12105-021-01352-2 http://hdl.handle.net/11449/233211 |
Resumo: | The oral lymphoepithelial cyst (OLC) is an uncommon lesion whose pathogenesis remains poorly understood. The aim of this study was to report the clinicopathologic features of the OLCs and to verify a possible association between OLCs and subgemmal neurogenous plaque (SNP) in the posterior lateral region of the tongue. A retrospective descriptive cross-sectional study was carried out. A total of 106,282 biopsy records of oral and maxillofacial lesions from six oral pathology services in Brazil were analyzed. All cases of OLCs were reviewed, and clinical and histopathological data were collected. Immunohistochemical reactions for S-100 protein were performed to confirm the diagnosis of SNP. Among all lesions, there were 132 (0.11%) cases of OLCs. The series comprised 83 females (62.9%) and 49 males (37.1%), with a 1.7:1 female-to-male ratio and a mean age of 45.8 ± 17.7 years. Most cases involved the tongue (n = 80; 62.0%) and presented clinically as asymptomatic papules or nodules with a yellow or whitish color. Microscopically, most of the cysts were entirely lined by parakeratinized stratified epithelium (n = 89; 67.4%) and filled with desquamated cells, keratin debris, amorphous eosinophilic material, and inflammatory cells in varying amounts. Connection with the epithelium of oral mucosa was observed in 18 cases (13.6%). SNP was found in 9/80 (11.2%) cases involving the tongue. The clinical and demographic features of OLCs were similar to those described in previous studies. Overall, this lesion has a predilection for the posterior region of the tongue of female adults. Clinicians must include the OLC in the differential diagnosis of yellow/white papules and nodules of the oral cavity. |
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Oral Lymphoepithelial Cyst: A Collaborative Clinicopathologic Study of 132 Cases from BrazilDevelopmental cystNon-odontogenic cystOral lymphoepithelial cystOral pathologyThe oral lymphoepithelial cyst (OLC) is an uncommon lesion whose pathogenesis remains poorly understood. The aim of this study was to report the clinicopathologic features of the OLCs and to verify a possible association between OLCs and subgemmal neurogenous plaque (SNP) in the posterior lateral region of the tongue. A retrospective descriptive cross-sectional study was carried out. A total of 106,282 biopsy records of oral and maxillofacial lesions from six oral pathology services in Brazil were analyzed. All cases of OLCs were reviewed, and clinical and histopathological data were collected. Immunohistochemical reactions for S-100 protein were performed to confirm the diagnosis of SNP. Among all lesions, there were 132 (0.11%) cases of OLCs. The series comprised 83 females (62.9%) and 49 males (37.1%), with a 1.7:1 female-to-male ratio and a mean age of 45.8 ± 17.7 years. Most cases involved the tongue (n = 80; 62.0%) and presented clinically as asymptomatic papules or nodules with a yellow or whitish color. Microscopically, most of the cysts were entirely lined by parakeratinized stratified epithelium (n = 89; 67.4%) and filled with desquamated cells, keratin debris, amorphous eosinophilic material, and inflammatory cells in varying amounts. Connection with the epithelium of oral mucosa was observed in 18 cases (13.6%). SNP was found in 9/80 (11.2%) cases involving the tongue. The clinical and demographic features of OLCs were similar to those described in previous studies. Overall, this lesion has a predilection for the posterior region of the tongue of female adults. Clinicians must include the OLC in the differential diagnosis of yellow/white papules and nodules of the oral cavity.Department of Oral Diagnosis Piracicaba Dental School University of Campinas (UNICAMP)Department of Bioscience and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP)School of Dentistry University of Fortaleza (UNIFOR)Department of Oral Diagnosis and Pathology School of Dentistry Federal University of Rio de Janeiro (UFRJ)School of Dentistry State University of Rio de Janeiro (UERJ)Oral Pathology Section Department of Oral Diagnosis Piracicaba Dental School University of Campinas (UNICAMP), Av. Limeira 901, P.O. Box 52Department of Bioscience and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP)Universidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (UNESP)University of Fortaleza (UNIFOR)Universidade Federal do Rio de Janeiro (UFRJ)Universidade do Estado do Rio de Janeiro (UERJ)Cunha, John Lennon SilvaRoza, Ana Luiza Oliveira CorrêaCruz, Vitória Maria SousaRibeiro, Jaqueline Lemes [UNESP]Cavalcante, Israel LealCavalcante, Roberta BarrosoAnbinder, Ana Lia [UNESP]Abrahão, Aline Corrêade Andrade, Bruno Augusto BenevenutoRomañach, Mário JoséPires, Fábio Ramôados Santos-Silva, Alan RogerLopes, Márcio AjudarteVargas, Pablo AgustinSoares, Ciro Dantasde Almeida, Oslei Paes2022-05-01T06:02:06Z2022-05-01T06:02:06Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s12105-021-01352-2Head and Neck Pathology.1936-05681936-055Xhttp://hdl.handle.net/11449/23321110.1007/s12105-021-01352-22-s2.0-85108943319Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengHead and Neck Pathologyinfo:eu-repo/semantics/openAccess2022-05-01T06:02:06Zoai:repositorio.unesp.br:11449/233211Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-05-01T06:02:06Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Oral Lymphoepithelial Cyst: A Collaborative Clinicopathologic Study of 132 Cases from Brazil |
title |
Oral Lymphoepithelial Cyst: A Collaborative Clinicopathologic Study of 132 Cases from Brazil |
spellingShingle |
Oral Lymphoepithelial Cyst: A Collaborative Clinicopathologic Study of 132 Cases from Brazil Cunha, John Lennon Silva Developmental cyst Non-odontogenic cyst Oral lymphoepithelial cyst Oral pathology |
title_short |
Oral Lymphoepithelial Cyst: A Collaborative Clinicopathologic Study of 132 Cases from Brazil |
title_full |
Oral Lymphoepithelial Cyst: A Collaborative Clinicopathologic Study of 132 Cases from Brazil |
title_fullStr |
Oral Lymphoepithelial Cyst: A Collaborative Clinicopathologic Study of 132 Cases from Brazil |
title_full_unstemmed |
Oral Lymphoepithelial Cyst: A Collaborative Clinicopathologic Study of 132 Cases from Brazil |
title_sort |
Oral Lymphoepithelial Cyst: A Collaborative Clinicopathologic Study of 132 Cases from Brazil |
author |
Cunha, John Lennon Silva |
author_facet |
Cunha, John Lennon Silva Roza, Ana Luiza Oliveira Corrêa Cruz, Vitória Maria Sousa Ribeiro, Jaqueline Lemes [UNESP] Cavalcante, Israel Leal Cavalcante, Roberta Barroso Anbinder, Ana Lia [UNESP] Abrahão, Aline Corrêa de Andrade, Bruno Augusto Benevenuto Romañach, Mário José Pires, Fábio Ramôa dos Santos-Silva, Alan Roger Lopes, Márcio Ajudarte Vargas, Pablo Agustin Soares, Ciro Dantas de Almeida, Oslei Paes |
author_role |
author |
author2 |
Roza, Ana Luiza Oliveira Corrêa Cruz, Vitória Maria Sousa Ribeiro, Jaqueline Lemes [UNESP] Cavalcante, Israel Leal Cavalcante, Roberta Barroso Anbinder, Ana Lia [UNESP] Abrahão, Aline Corrêa de Andrade, Bruno Augusto Benevenuto Romañach, Mário José Pires, Fábio Ramôa dos Santos-Silva, Alan Roger Lopes, Márcio Ajudarte Vargas, Pablo Agustin Soares, Ciro Dantas de Almeida, Oslei Paes |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (UNESP) University of Fortaleza (UNIFOR) Universidade Federal do Rio de Janeiro (UFRJ) Universidade do Estado do Rio de Janeiro (UERJ) |
dc.contributor.author.fl_str_mv |
Cunha, John Lennon Silva Roza, Ana Luiza Oliveira Corrêa Cruz, Vitória Maria Sousa Ribeiro, Jaqueline Lemes [UNESP] Cavalcante, Israel Leal Cavalcante, Roberta Barroso Anbinder, Ana Lia [UNESP] Abrahão, Aline Corrêa de Andrade, Bruno Augusto Benevenuto Romañach, Mário José Pires, Fábio Ramôa dos Santos-Silva, Alan Roger Lopes, Márcio Ajudarte Vargas, Pablo Agustin Soares, Ciro Dantas de Almeida, Oslei Paes |
dc.subject.por.fl_str_mv |
Developmental cyst Non-odontogenic cyst Oral lymphoepithelial cyst Oral pathology |
topic |
Developmental cyst Non-odontogenic cyst Oral lymphoepithelial cyst Oral pathology |
description |
The oral lymphoepithelial cyst (OLC) is an uncommon lesion whose pathogenesis remains poorly understood. The aim of this study was to report the clinicopathologic features of the OLCs and to verify a possible association between OLCs and subgemmal neurogenous plaque (SNP) in the posterior lateral region of the tongue. A retrospective descriptive cross-sectional study was carried out. A total of 106,282 biopsy records of oral and maxillofacial lesions from six oral pathology services in Brazil were analyzed. All cases of OLCs were reviewed, and clinical and histopathological data were collected. Immunohistochemical reactions for S-100 protein were performed to confirm the diagnosis of SNP. Among all lesions, there were 132 (0.11%) cases of OLCs. The series comprised 83 females (62.9%) and 49 males (37.1%), with a 1.7:1 female-to-male ratio and a mean age of 45.8 ± 17.7 years. Most cases involved the tongue (n = 80; 62.0%) and presented clinically as asymptomatic papules or nodules with a yellow or whitish color. Microscopically, most of the cysts were entirely lined by parakeratinized stratified epithelium (n = 89; 67.4%) and filled with desquamated cells, keratin debris, amorphous eosinophilic material, and inflammatory cells in varying amounts. Connection with the epithelium of oral mucosa was observed in 18 cases (13.6%). SNP was found in 9/80 (11.2%) cases involving the tongue. The clinical and demographic features of OLCs were similar to those described in previous studies. Overall, this lesion has a predilection for the posterior region of the tongue of female adults. Clinicians must include the OLC in the differential diagnosis of yellow/white papules and nodules of the oral cavity. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-05-01T06:02:06Z 2022-05-01T06:02:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s12105-021-01352-2 Head and Neck Pathology. 1936-0568 1936-055X http://hdl.handle.net/11449/233211 10.1007/s12105-021-01352-2 2-s2.0-85108943319 |
url |
http://dx.doi.org/10.1007/s12105-021-01352-2 http://hdl.handle.net/11449/233211 |
identifier_str_mv |
Head and Neck Pathology. 1936-0568 1936-055X 10.1007/s12105-021-01352-2 2-s2.0-85108943319 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Head and Neck Pathology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799965029597970432 |