Concentração plasmática de diclofenaco sódico em cães, submetidos à fonoforese
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://cpro4576.publiccloud.com.br:8080/editora-consulta/artigo/exibir/exibirArtigo.do?codigo=7186 http://hdl.handle.net/11449/40444 |
Resumo: | The aim of this study was to evaluate the plasma concentration of diclofenac sodium (DS) in dogs submitted to diclofenaco phonophoresis and to evaluate if phonophoresis induces greater absorption of this drug in dogs. Five dogs were used in eight different groups at different times: One group received oral administration of 40mg of DS per dog and seven groups received topical application of emulgel DS. The topical application area was 20cm(2). A continuous ultrasound frequency of 1MHz and intensity of 0.4W cm(-2) was used. Blood collections were performed before the treatment (T0), and 1h (T1) and 4h (T2) after ultrasound application for all groups. DS concentrations in plasma were measured by high performance liquid choramatohraphy (HPLC). There was significant increase of DS plasma concentration only at T1 in the oral administration group. It was not possible to detect any concentration of DS in the plasma of dogs after topical application of DS, even after DS phonophoresis. The facilitation of transdermal penetration by ultrasound has not been verified under the protocol specified in this research. |
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Concentração plasmática de diclofenaco sódico em cães, submetidos à fonoforesePlasma concentration of diclofenac sodium in dogs submitted to diclofenac phonophoresisdogsonophoresisdiclofenac sodiumHPLCThe aim of this study was to evaluate the plasma concentration of diclofenac sodium (DS) in dogs submitted to diclofenaco phonophoresis and to evaluate if phonophoresis induces greater absorption of this drug in dogs. Five dogs were used in eight different groups at different times: One group received oral administration of 40mg of DS per dog and seven groups received topical application of emulgel DS. The topical application area was 20cm(2). A continuous ultrasound frequency of 1MHz and intensity of 0.4W cm(-2) was used. Blood collections were performed before the treatment (T0), and 1h (T1) and 4h (T2) after ultrasound application for all groups. DS concentrations in plasma were measured by high performance liquid choramatohraphy (HPLC). There was significant increase of DS plasma concentration only at T1 in the oral administration group. It was not possible to detect any concentration of DS in the plasma of dogs after topical application of DS, even after DS phonophoresis. The facilitation of transdermal penetration by ultrasound has not been verified under the protocol specified in this research.Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, BrazilUniv Fed Acre, Univ Fed Acre, Rio Branco, AC, BrazilUDESC, Lages, SC, BrazilUNESP, Univ Estadual Julio de Mesquita Filho, Araraquara, SP, BrazilUNESP, Univ Estadual Julio de Mesquita Filho, Araraquara, SP, BrazilArquivo Brasileiro Medicina Veterinaria ZootecniaUniversidade Federal de Santa Maria (UFSM)Universidade Federal do Acre (UFAC)Universidade do Estado de Santa Catarina (UDESC)Universidade Estadual Paulista (Unesp)Pelizzari, C.Raiser, A. G.Mazzanti, A.Souza, S. F.Martins, V. M. V.Peccinini, Rosangela Goncalves [UNESP]Campos, M. L. [UNESP]2014-05-20T15:31:15Z2014-05-20T15:31:15Z2012-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1449-1455application/pdfhttp://cpro4576.publiccloud.com.br:8080/editora-consulta/artigo/exibir/exibirArtigo.do?codigo=7186Arquivo Brasileiro de Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 64, n. 6, p. 1449-1455, 2012.0102-0935http://hdl.handle.net/11449/40444WOS:000313516000007WOS000313516000007.pdf1066743423929093Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporArquivo Brasileiro de Medicina Veterinária e Zootecnia0.2860,248info:eu-repo/semantics/openAccess2023-11-26T06:17:26Zoai:repositorio.unesp.br:11449/40444Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-26T06:17:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Concentração plasmática de diclofenaco sódico em cães, submetidos à fonoforese Plasma concentration of diclofenac sodium in dogs submitted to diclofenac phonophoresis |
title |
Concentração plasmática de diclofenaco sódico em cães, submetidos à fonoforese |
spellingShingle |
Concentração plasmática de diclofenaco sódico em cães, submetidos à fonoforese Pelizzari, C. dog sonophoresis diclofenac sodium HPLC |
title_short |
Concentração plasmática de diclofenaco sódico em cães, submetidos à fonoforese |
title_full |
Concentração plasmática de diclofenaco sódico em cães, submetidos à fonoforese |
title_fullStr |
Concentração plasmática de diclofenaco sódico em cães, submetidos à fonoforese |
title_full_unstemmed |
Concentração plasmática de diclofenaco sódico em cães, submetidos à fonoforese |
title_sort |
Concentração plasmática de diclofenaco sódico em cães, submetidos à fonoforese |
author |
Pelizzari, C. |
author_facet |
Pelizzari, C. Raiser, A. G. Mazzanti, A. Souza, S. F. Martins, V. M. V. Peccinini, Rosangela Goncalves [UNESP] Campos, M. L. [UNESP] |
author_role |
author |
author2 |
Raiser, A. G. Mazzanti, A. Souza, S. F. Martins, V. M. V. Peccinini, Rosangela Goncalves [UNESP] Campos, M. L. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Santa Maria (UFSM) Universidade Federal do Acre (UFAC) Universidade do Estado de Santa Catarina (UDESC) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Pelizzari, C. Raiser, A. G. Mazzanti, A. Souza, S. F. Martins, V. M. V. Peccinini, Rosangela Goncalves [UNESP] Campos, M. L. [UNESP] |
dc.subject.por.fl_str_mv |
dog sonophoresis diclofenac sodium HPLC |
topic |
dog sonophoresis diclofenac sodium HPLC |
description |
The aim of this study was to evaluate the plasma concentration of diclofenac sodium (DS) in dogs submitted to diclofenaco phonophoresis and to evaluate if phonophoresis induces greater absorption of this drug in dogs. Five dogs were used in eight different groups at different times: One group received oral administration of 40mg of DS per dog and seven groups received topical application of emulgel DS. The topical application area was 20cm(2). A continuous ultrasound frequency of 1MHz and intensity of 0.4W cm(-2) was used. Blood collections were performed before the treatment (T0), and 1h (T1) and 4h (T2) after ultrasound application for all groups. DS concentrations in plasma were measured by high performance liquid choramatohraphy (HPLC). There was significant increase of DS plasma concentration only at T1 in the oral administration group. It was not possible to detect any concentration of DS in the plasma of dogs after topical application of DS, even after DS phonophoresis. The facilitation of transdermal penetration by ultrasound has not been verified under the protocol specified in this research. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-12-01 2014-05-20T15:31:15Z 2014-05-20T15:31:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://cpro4576.publiccloud.com.br:8080/editora-consulta/artigo/exibir/exibirArtigo.do?codigo=7186 Arquivo Brasileiro de Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 64, n. 6, p. 1449-1455, 2012. 0102-0935 http://hdl.handle.net/11449/40444 WOS:000313516000007 WOS000313516000007.pdf 1066743423929093 |
url |
http://cpro4576.publiccloud.com.br:8080/editora-consulta/artigo/exibir/exibirArtigo.do?codigo=7186 http://hdl.handle.net/11449/40444 |
identifier_str_mv |
Arquivo Brasileiro de Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 64, n. 6, p. 1449-1455, 2012. 0102-0935 WOS:000313516000007 WOS000313516000007.pdf 1066743423929093 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Arquivo Brasileiro de Medicina Veterinária e Zootecnia 0.286 0,248 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1449-1455 application/pdf |
dc.publisher.none.fl_str_mv |
Arquivo Brasileiro Medicina Veterinaria Zootecnia |
publisher.none.fl_str_mv |
Arquivo Brasileiro Medicina Veterinaria Zootecnia |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965081495142400 |