Effect of Morus nigra aqueous extract treatment on the maternal-fetal outcome, oxidative stress status and lipid profile of streptozotocin-induced diabetic rats
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jep.2011.09.044 http://hdl.handle.net/11449/12346 |
Resumo: | Ethnopharmacological relevance: Morus nigra, commonly known as black mulberry, is widely used in Brazilian folk medicine for the diabetes treatment.Aim of this study: To evaluate the effect of Morus nigra aqueous extract treatment on maternal lipid and oxidative stress profile, reproductive outcomes, and also fetal anomaly incidence from diabetic and non-diabetic rats.Materials and methods: Diabetes was induced by streptozotocin (40 mg/kg) in virgin female Wistar rats. Morus nigra leaf aqueous extract (400 mg/kg) was administered from day 0 to 20 of pregnancy. At day 21 of pregnancy, all rats were anesthetized and killed to obtain blood samples and maternal-fetal data.Results and conclusion: After treatment with Morus nigra extract, non-diabetic and diabetic rats presented no glycemic changes. Fetuses from diabetic dams, regardless of Morus nigra treatment, were small for pregnancy age. In diabetic dams, plant treatment caused reduced MDA, cholesterol, triglycerides and VLDL levels, and decreased placental index and weight as compared to diabetic group. The fetuses from diabetic rats treated with Morus nigra extract had lower frequency of skeletal and visceral anomalies as compared to diabetic group. Thus, Morus nigra leaf aqueous extract failed to control hyperglycemia in diabetic rats. However, Morus nigra treatment had antioxidant effect, contributing to reduce incidence of internal anomalies in offspring from diabetic dams. (C) 2011 Elsevier B.V. All rights reserved. |
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Effect of Morus nigra aqueous extract treatment on the maternal-fetal outcome, oxidative stress status and lipid profile of streptozotocin-induced diabetic ratsMorus nigraDiabetesPregnancyOxidative stressReproductive outcomeAnomalyEthnopharmacological relevance: Morus nigra, commonly known as black mulberry, is widely used in Brazilian folk medicine for the diabetes treatment.Aim of this study: To evaluate the effect of Morus nigra aqueous extract treatment on maternal lipid and oxidative stress profile, reproductive outcomes, and also fetal anomaly incidence from diabetic and non-diabetic rats.Materials and methods: Diabetes was induced by streptozotocin (40 mg/kg) in virgin female Wistar rats. Morus nigra leaf aqueous extract (400 mg/kg) was administered from day 0 to 20 of pregnancy. At day 21 of pregnancy, all rats were anesthetized and killed to obtain blood samples and maternal-fetal data.Results and conclusion: After treatment with Morus nigra extract, non-diabetic and diabetic rats presented no glycemic changes. Fetuses from diabetic dams, regardless of Morus nigra treatment, were small for pregnancy age. In diabetic dams, plant treatment caused reduced MDA, cholesterol, triglycerides and VLDL levels, and decreased placental index and weight as compared to diabetic group. The fetuses from diabetic rats treated with Morus nigra extract had lower frequency of skeletal and visceral anomalies as compared to diabetic group. Thus, Morus nigra leaf aqueous extract failed to control hyperglycemia in diabetic rats. However, Morus nigra treatment had antioxidant effect, contributing to reduce incidence of internal anomalies in offspring from diabetic dams. (C) 2011 Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Research Support Center (RSC) of the Botucatu Medical School - São Paulo StateUniv Estadual Paulista Unesp, Botucatu Med Sch, Lab Expt Res Gynecol & Obstet, São Paulo, BrazilMato Grosso Fed Univ UFMT, Univ Ctr Araguaia, Inst Biol & Hlth Sci, Barra do Garcas, Mato Grosso, BrazilUniv Estadual Paulista Unesp, Botucatu Med Sch, Lab Expt Res Gynecol & Obstet, São Paulo, BrazilFAPESP: 03/01654-2Elsevier B.V.Universidade Estadual Paulista (Unesp)Universidade Federal de Mato Grosso (UFMT)Volpato, Gustavo Tadeu [UNESP]Calderon, Iracema de Mattos Paranhos [UNESP]Sinzato, S. [UNESP]Campos, Kleber Eduardo de [UNESP]Rudge, Marilza Vieira Cunha [UNESP]Damasceno, Débora Cristina [UNESP]2014-05-20T13:35:53Z2014-05-20T13:35:53Z2011-12-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article691-696application/pdfhttp://dx.doi.org/10.1016/j.jep.2011.09.044Journal of Ethnopharmacology. Clare: Elsevier B.V., v. 138, n. 3, p. 691-696, 2011.0378-8741http://hdl.handle.net/11449/1234610.1016/j.jep.2011.09.044WOS:000298897800007WOS000298897800007.pdf067938762260474367586803888350780000-0002-9227-832XWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Ethnopharmacology3.1151,150info:eu-repo/semantics/openAccess2024-08-16T14:12:51Zoai:repositorio.unesp.br:11449/12346Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:12:51Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effect of Morus nigra aqueous extract treatment on the maternal-fetal outcome, oxidative stress status and lipid profile of streptozotocin-induced diabetic rats |
title |
Effect of Morus nigra aqueous extract treatment on the maternal-fetal outcome, oxidative stress status and lipid profile of streptozotocin-induced diabetic rats |
spellingShingle |
Effect of Morus nigra aqueous extract treatment on the maternal-fetal outcome, oxidative stress status and lipid profile of streptozotocin-induced diabetic rats Volpato, Gustavo Tadeu [UNESP] Morus nigra Diabetes Pregnancy Oxidative stress Reproductive outcome Anomaly |
title_short |
Effect of Morus nigra aqueous extract treatment on the maternal-fetal outcome, oxidative stress status and lipid profile of streptozotocin-induced diabetic rats |
title_full |
Effect of Morus nigra aqueous extract treatment on the maternal-fetal outcome, oxidative stress status and lipid profile of streptozotocin-induced diabetic rats |
title_fullStr |
Effect of Morus nigra aqueous extract treatment on the maternal-fetal outcome, oxidative stress status and lipid profile of streptozotocin-induced diabetic rats |
title_full_unstemmed |
Effect of Morus nigra aqueous extract treatment on the maternal-fetal outcome, oxidative stress status and lipid profile of streptozotocin-induced diabetic rats |
title_sort |
Effect of Morus nigra aqueous extract treatment on the maternal-fetal outcome, oxidative stress status and lipid profile of streptozotocin-induced diabetic rats |
author |
Volpato, Gustavo Tadeu [UNESP] |
author_facet |
Volpato, Gustavo Tadeu [UNESP] Calderon, Iracema de Mattos Paranhos [UNESP] Sinzato, S. [UNESP] Campos, Kleber Eduardo de [UNESP] Rudge, Marilza Vieira Cunha [UNESP] Damasceno, Débora Cristina [UNESP] |
author_role |
author |
author2 |
Calderon, Iracema de Mattos Paranhos [UNESP] Sinzato, S. [UNESP] Campos, Kleber Eduardo de [UNESP] Rudge, Marilza Vieira Cunha [UNESP] Damasceno, Débora Cristina [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de Mato Grosso (UFMT) |
dc.contributor.author.fl_str_mv |
Volpato, Gustavo Tadeu [UNESP] Calderon, Iracema de Mattos Paranhos [UNESP] Sinzato, S. [UNESP] Campos, Kleber Eduardo de [UNESP] Rudge, Marilza Vieira Cunha [UNESP] Damasceno, Débora Cristina [UNESP] |
dc.subject.por.fl_str_mv |
Morus nigra Diabetes Pregnancy Oxidative stress Reproductive outcome Anomaly |
topic |
Morus nigra Diabetes Pregnancy Oxidative stress Reproductive outcome Anomaly |
description |
Ethnopharmacological relevance: Morus nigra, commonly known as black mulberry, is widely used in Brazilian folk medicine for the diabetes treatment.Aim of this study: To evaluate the effect of Morus nigra aqueous extract treatment on maternal lipid and oxidative stress profile, reproductive outcomes, and also fetal anomaly incidence from diabetic and non-diabetic rats.Materials and methods: Diabetes was induced by streptozotocin (40 mg/kg) in virgin female Wistar rats. Morus nigra leaf aqueous extract (400 mg/kg) was administered from day 0 to 20 of pregnancy. At day 21 of pregnancy, all rats were anesthetized and killed to obtain blood samples and maternal-fetal data.Results and conclusion: After treatment with Morus nigra extract, non-diabetic and diabetic rats presented no glycemic changes. Fetuses from diabetic dams, regardless of Morus nigra treatment, were small for pregnancy age. In diabetic dams, plant treatment caused reduced MDA, cholesterol, triglycerides and VLDL levels, and decreased placental index and weight as compared to diabetic group. The fetuses from diabetic rats treated with Morus nigra extract had lower frequency of skeletal and visceral anomalies as compared to diabetic group. Thus, Morus nigra leaf aqueous extract failed to control hyperglycemia in diabetic rats. However, Morus nigra treatment had antioxidant effect, contributing to reduce incidence of internal anomalies in offspring from diabetic dams. (C) 2011 Elsevier B.V. All rights reserved. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-08 2014-05-20T13:35:53Z 2014-05-20T13:35:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jep.2011.09.044 Journal of Ethnopharmacology. Clare: Elsevier B.V., v. 138, n. 3, p. 691-696, 2011. 0378-8741 http://hdl.handle.net/11449/12346 10.1016/j.jep.2011.09.044 WOS:000298897800007 WOS000298897800007.pdf 0679387622604743 6758680388835078 0000-0002-9227-832X |
url |
http://dx.doi.org/10.1016/j.jep.2011.09.044 http://hdl.handle.net/11449/12346 |
identifier_str_mv |
Journal of Ethnopharmacology. Clare: Elsevier B.V., v. 138, n. 3, p. 691-696, 2011. 0378-8741 10.1016/j.jep.2011.09.044 WOS:000298897800007 WOS000298897800007.pdf 0679387622604743 6758680388835078 0000-0002-9227-832X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Ethnopharmacology 3.115 1,150 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
691-696 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128199066910720 |