Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts

Detalhes bibliográficos
Autor(a) principal: Calvo, Tamara Regina [UNESP]
Data de Publicação: 2011
Outros Autores: Primila Cardoso, Cassia Regina [UNESP], da Silva Moura, Adriana Candido [UNESP], Santos, Lourdes Campaner dos [UNESP], Syllos Colus, Ilce Mara, Vilegas, Wagner [UNESP], Varanda, Eliana Aparecida [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1093/ecam/nep123
http://hdl.handle.net/11449/7500
Resumo: Indigofera truxillensis and I. suffruticosa, are used as a source of indigo dye and to treat several diseases. The mutagenic activity of the methanolic extracts from aerial parts, glycerolipid, flavonoid and alkaloid fractions of the extract were evaluated by means of Salmonella/microsome assays using TA100, TA98, TA102 and TA97a strains. The methanolic extract of I. truxillensis showed mutagenic activity in the TA98 strain without S9 while glycerolipid fraction was devoid of activity. The flavonoid and alkaloid fractions of both plants showed mutagenicity. Chemical analysis of flavonoid fractions of I. truxillensis and I. suffruticosa resulted in the identification of kaempferol, quercetin and their derivatives. The alkaloid fraction of both the species contained indigo and indirubin and indigo was found mainly responsible for the mutagenic activity.
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spelling Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial PartsIndigofera truxillensis and I. suffruticosa, are used as a source of indigo dye and to treat several diseases. The mutagenic activity of the methanolic extracts from aerial parts, glycerolipid, flavonoid and alkaloid fractions of the extract were evaluated by means of Salmonella/microsome assays using TA100, TA98, TA102 and TA97a strains. The methanolic extract of I. truxillensis showed mutagenic activity in the TA98 strain without S9 while glycerolipid fraction was devoid of activity. The flavonoid and alkaloid fractions of both plants showed mutagenicity. Chemical analysis of flavonoid fractions of I. truxillensis and I. suffruticosa resulted in the identification of kaempferol, quercetin and their derivatives. The alkaloid fraction of both the species contained indigo and indirubin and indigo was found mainly responsible for the mutagenic activity.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)UNESP São Paulo State Univ, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Araraquara, SP, BrazilUNESP São Paulo State Univ, Inst Quim Araraquara, Dept Quim Organ, BR-14800900 São Paulo, BrazilUEL Londrina State Univ, Ctr Biol Sci, Dept Gen Biol, BR-86051990 Londrina, PR, BrazilUNESP São Paulo State Univ, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Araraquara, SP, BrazilUNESP São Paulo State Univ, Inst Quim Araraquara, Dept Quim Organ, BR-14800900 São Paulo, BrazilHindawi Publishing CorporationUniversidade Estadual Paulista (Unesp)Universidade Estadual de Londrina (UEL)Calvo, Tamara Regina [UNESP]Primila Cardoso, Cassia Regina [UNESP]da Silva Moura, Adriana Candido [UNESP]Santos, Lourdes Campaner dos [UNESP]Syllos Colus, Ilce MaraVilegas, Wagner [UNESP]Varanda, Eliana Aparecida [UNESP]2014-05-20T13:24:18Z2014-05-20T13:24:18Z2011-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://dx.doi.org/10.1093/ecam/nep123Evidence-based Complementary and Alternative Medicine. New York: Hindawi Publishing Corporation, p. 9, 2011.1741-427Xhttp://hdl.handle.net/11449/750010.1093/ecam/nep123WOS:000293413300001WOS000293413300001.pdf35382536406029770000-0003-3032-2556Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEvidence-based Complementary and Alternative Medicine2.064info:eu-repo/semantics/openAccess2024-06-24T13:08:25Zoai:repositorio.unesp.br:11449/7500Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:39:12.633960Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts
title Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts
spellingShingle Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts
Calvo, Tamara Regina [UNESP]
title_short Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts
title_full Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts
title_fullStr Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts
title_full_unstemmed Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts
title_sort Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts
author Calvo, Tamara Regina [UNESP]
author_facet Calvo, Tamara Regina [UNESP]
Primila Cardoso, Cassia Regina [UNESP]
da Silva Moura, Adriana Candido [UNESP]
Santos, Lourdes Campaner dos [UNESP]
Syllos Colus, Ilce Mara
Vilegas, Wagner [UNESP]
Varanda, Eliana Aparecida [UNESP]
author_role author
author2 Primila Cardoso, Cassia Regina [UNESP]
da Silva Moura, Adriana Candido [UNESP]
Santos, Lourdes Campaner dos [UNESP]
Syllos Colus, Ilce Mara
Vilegas, Wagner [UNESP]
Varanda, Eliana Aparecida [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Estadual de Londrina (UEL)
dc.contributor.author.fl_str_mv Calvo, Tamara Regina [UNESP]
Primila Cardoso, Cassia Regina [UNESP]
da Silva Moura, Adriana Candido [UNESP]
Santos, Lourdes Campaner dos [UNESP]
Syllos Colus, Ilce Mara
Vilegas, Wagner [UNESP]
Varanda, Eliana Aparecida [UNESP]
description Indigofera truxillensis and I. suffruticosa, are used as a source of indigo dye and to treat several diseases. The mutagenic activity of the methanolic extracts from aerial parts, glycerolipid, flavonoid and alkaloid fractions of the extract were evaluated by means of Salmonella/microsome assays using TA100, TA98, TA102 and TA97a strains. The methanolic extract of I. truxillensis showed mutagenic activity in the TA98 strain without S9 while glycerolipid fraction was devoid of activity. The flavonoid and alkaloid fractions of both plants showed mutagenicity. Chemical analysis of flavonoid fractions of I. truxillensis and I. suffruticosa resulted in the identification of kaempferol, quercetin and their derivatives. The alkaloid fraction of both the species contained indigo and indirubin and indigo was found mainly responsible for the mutagenic activity.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
2014-05-20T13:24:18Z
2014-05-20T13:24:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1093/ecam/nep123
Evidence-based Complementary and Alternative Medicine. New York: Hindawi Publishing Corporation, p. 9, 2011.
1741-427X
http://hdl.handle.net/11449/7500
10.1093/ecam/nep123
WOS:000293413300001
WOS000293413300001.pdf
3538253640602977
0000-0003-3032-2556
url http://dx.doi.org/10.1093/ecam/nep123
http://hdl.handle.net/11449/7500
identifier_str_mv Evidence-based Complementary and Alternative Medicine. New York: Hindawi Publishing Corporation, p. 9, 2011.
1741-427X
10.1093/ecam/nep123
WOS:000293413300001
WOS000293413300001.pdf
3538253640602977
0000-0003-3032-2556
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Evidence-based Complementary and Alternative Medicine
2.064
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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