Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma

Detalhes bibliográficos
Autor(a) principal: Tomo, Saygo [UNESP]
Data de Publicação: 2023
Outros Autores: de Castro, Tamara Fernandes [UNESP], Araújo, Winicius Arildo Ferreira [UNESP], Collado, Francisco Urbano [UNESP], Neto, Sebastião Conrado [UNESP], Biasoli, Éder Ricardo [UNESP], Bernabé, Daniel Galera [UNESP], Miyahara, Glauco Issamu [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.jormas.2022.10.010
http://hdl.handle.net/11449/247753
Resumo: Background: Despite the advances in the classification of oral squamous cell carcinoma (OSCC) based on its extension by the TNM system, there is still a need for methods to better classify the patients to predict prognosis and indicate adjuvant therapy. Objectives: To analyze the influence of the number of positive lymph nodes (PN), lymph node ratio (LNR), and log odds of positive lymph nodes (LODDS) in survival of patients with OSCC. Methods: Clinicopathologic data from patients with OSCC who were treated with curative purposes by surgery and neck dissection (ND) with or without subsequent adjuvant therapies from 1991 to 2015 was retrospectively assessed. The impact of the PN, LNR, LODDS, and other variables on overall survival (OS) and disease-free survival (DFS) was analyzed in univariate and multivariate analyses. Results: One hundred nineteen patients were included in this study. In the univariate analysis the PN had a significant impact on OS (p = 0.001) and DFS (p = 0.020), and the LNR had a significant impact on the OS (p = 0.042). In the multivariate analysis with other relevant clinicopathologic variables, the PN was the only significantly independent factor influencing in the OS (p = 0.017) but not in DFS (p = 0.096). Conclusions: The PN is an independent prognostic indicator for OS and DFS in patients with OSCC and has the potential to aggregate the current AJCC classification. The LNR has potential to be an important prognostic indicator, but the methods for this classification require lapidation. The LODDS did not demonstrate prognostic potential.
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spelling Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinomaLymphatic metastasisOral cancerOral squamous cell carcinomaPrognostic factorsBackground: Despite the advances in the classification of oral squamous cell carcinoma (OSCC) based on its extension by the TNM system, there is still a need for methods to better classify the patients to predict prognosis and indicate adjuvant therapy. Objectives: To analyze the influence of the number of positive lymph nodes (PN), lymph node ratio (LNR), and log odds of positive lymph nodes (LODDS) in survival of patients with OSCC. Methods: Clinicopathologic data from patients with OSCC who were treated with curative purposes by surgery and neck dissection (ND) with or without subsequent adjuvant therapies from 1991 to 2015 was retrospectively assessed. The impact of the PN, LNR, LODDS, and other variables on overall survival (OS) and disease-free survival (DFS) was analyzed in univariate and multivariate analyses. Results: One hundred nineteen patients were included in this study. In the univariate analysis the PN had a significant impact on OS (p = 0.001) and DFS (p = 0.020), and the LNR had a significant impact on the OS (p = 0.042). In the multivariate analysis with other relevant clinicopathologic variables, the PN was the only significantly independent factor influencing in the OS (p = 0.017) but not in DFS (p = 0.096). Conclusions: The PN is an independent prognostic indicator for OS and DFS in patients with OSCC and has the potential to aggregate the current AJCC classification. The LNR has potential to be an important prognostic indicator, but the methods for this classification require lapidation. The LODDS did not demonstrate prognostic potential.Oral Oncology Center São Paulo State University (UNESP) School of DentistryDepartment of Diagnosis and Surgery São Paulo State University (UNESP) School of DentistryOral Oncology Center São Paulo State University (UNESP) School of DentistryDepartment of Diagnosis and Surgery São Paulo State University (UNESP) School of DentistryUniversidade Estadual Paulista (UNESP)Tomo, Saygo [UNESP]de Castro, Tamara Fernandes [UNESP]Araújo, Winicius Arildo Ferreira [UNESP]Collado, Francisco Urbano [UNESP]Neto, Sebastião Conrado [UNESP]Biasoli, Éder Ricardo [UNESP]Bernabé, Daniel Galera [UNESP]Miyahara, Glauco Issamu [UNESP]2023-07-29T13:24:50Z2023-07-29T13:24:50Z2023-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.jormas.2022.10.010Journal of Stomatology, Oral and Maxillofacial Surgery, v. 124, n. 2, 2023.2468-7855http://hdl.handle.net/11449/24775310.1016/j.jormas.2022.10.0102-s2.0-85140072109Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Stomatology, Oral and Maxillofacial Surgeryinfo:eu-repo/semantics/openAccess2024-04-11T20:16:33Zoai:repositorio.unesp.br:11449/247753Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:09:36.272218Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma
title Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma
spellingShingle Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma
Tomo, Saygo [UNESP]
Lymphatic metastasis
Oral cancer
Oral squamous cell carcinoma
Prognostic factors
title_short Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma
title_full Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma
title_fullStr Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma
title_full_unstemmed Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma
title_sort Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma
author Tomo, Saygo [UNESP]
author_facet Tomo, Saygo [UNESP]
de Castro, Tamara Fernandes [UNESP]
Araújo, Winicius Arildo Ferreira [UNESP]
Collado, Francisco Urbano [UNESP]
Neto, Sebastião Conrado [UNESP]
Biasoli, Éder Ricardo [UNESP]
Bernabé, Daniel Galera [UNESP]
Miyahara, Glauco Issamu [UNESP]
author_role author
author2 de Castro, Tamara Fernandes [UNESP]
Araújo, Winicius Arildo Ferreira [UNESP]
Collado, Francisco Urbano [UNESP]
Neto, Sebastião Conrado [UNESP]
Biasoli, Éder Ricardo [UNESP]
Bernabé, Daniel Galera [UNESP]
Miyahara, Glauco Issamu [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Tomo, Saygo [UNESP]
de Castro, Tamara Fernandes [UNESP]
Araújo, Winicius Arildo Ferreira [UNESP]
Collado, Francisco Urbano [UNESP]
Neto, Sebastião Conrado [UNESP]
Biasoli, Éder Ricardo [UNESP]
Bernabé, Daniel Galera [UNESP]
Miyahara, Glauco Issamu [UNESP]
dc.subject.por.fl_str_mv Lymphatic metastasis
Oral cancer
Oral squamous cell carcinoma
Prognostic factors
topic Lymphatic metastasis
Oral cancer
Oral squamous cell carcinoma
Prognostic factors
description Background: Despite the advances in the classification of oral squamous cell carcinoma (OSCC) based on its extension by the TNM system, there is still a need for methods to better classify the patients to predict prognosis and indicate adjuvant therapy. Objectives: To analyze the influence of the number of positive lymph nodes (PN), lymph node ratio (LNR), and log odds of positive lymph nodes (LODDS) in survival of patients with OSCC. Methods: Clinicopathologic data from patients with OSCC who were treated with curative purposes by surgery and neck dissection (ND) with or without subsequent adjuvant therapies from 1991 to 2015 was retrospectively assessed. The impact of the PN, LNR, LODDS, and other variables on overall survival (OS) and disease-free survival (DFS) was analyzed in univariate and multivariate analyses. Results: One hundred nineteen patients were included in this study. In the univariate analysis the PN had a significant impact on OS (p = 0.001) and DFS (p = 0.020), and the LNR had a significant impact on the OS (p = 0.042). In the multivariate analysis with other relevant clinicopathologic variables, the PN was the only significantly independent factor influencing in the OS (p = 0.017) but not in DFS (p = 0.096). Conclusions: The PN is an independent prognostic indicator for OS and DFS in patients with OSCC and has the potential to aggregate the current AJCC classification. The LNR has potential to be an important prognostic indicator, but the methods for this classification require lapidation. The LODDS did not demonstrate prognostic potential.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-29T13:24:50Z
2023-07-29T13:24:50Z
2023-04-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.jormas.2022.10.010
Journal of Stomatology, Oral and Maxillofacial Surgery, v. 124, n. 2, 2023.
2468-7855
http://hdl.handle.net/11449/247753
10.1016/j.jormas.2022.10.010
2-s2.0-85140072109
url http://dx.doi.org/10.1016/j.jormas.2022.10.010
http://hdl.handle.net/11449/247753
identifier_str_mv Journal of Stomatology, Oral and Maxillofacial Surgery, v. 124, n. 2, 2023.
2468-7855
10.1016/j.jormas.2022.10.010
2-s2.0-85140072109
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Stomatology, Oral and Maxillofacial Surgery
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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