Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jormas.2022.10.010 http://hdl.handle.net/11449/247753 |
Resumo: | Background: Despite the advances in the classification of oral squamous cell carcinoma (OSCC) based on its extension by the TNM system, there is still a need for methods to better classify the patients to predict prognosis and indicate adjuvant therapy. Objectives: To analyze the influence of the number of positive lymph nodes (PN), lymph node ratio (LNR), and log odds of positive lymph nodes (LODDS) in survival of patients with OSCC. Methods: Clinicopathologic data from patients with OSCC who were treated with curative purposes by surgery and neck dissection (ND) with or without subsequent adjuvant therapies from 1991 to 2015 was retrospectively assessed. The impact of the PN, LNR, LODDS, and other variables on overall survival (OS) and disease-free survival (DFS) was analyzed in univariate and multivariate analyses. Results: One hundred nineteen patients were included in this study. In the univariate analysis the PN had a significant impact on OS (p = 0.001) and DFS (p = 0.020), and the LNR had a significant impact on the OS (p = 0.042). In the multivariate analysis with other relevant clinicopathologic variables, the PN was the only significantly independent factor influencing in the OS (p = 0.017) but not in DFS (p = 0.096). Conclusions: The PN is an independent prognostic indicator for OS and DFS in patients with OSCC and has the potential to aggregate the current AJCC classification. The LNR has potential to be an important prognostic indicator, but the methods for this classification require lapidation. The LODDS did not demonstrate prognostic potential. |
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Repositório Institucional da UNESP |
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Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinomaLymphatic metastasisOral cancerOral squamous cell carcinomaPrognostic factorsBackground: Despite the advances in the classification of oral squamous cell carcinoma (OSCC) based on its extension by the TNM system, there is still a need for methods to better classify the patients to predict prognosis and indicate adjuvant therapy. Objectives: To analyze the influence of the number of positive lymph nodes (PN), lymph node ratio (LNR), and log odds of positive lymph nodes (LODDS) in survival of patients with OSCC. Methods: Clinicopathologic data from patients with OSCC who were treated with curative purposes by surgery and neck dissection (ND) with or without subsequent adjuvant therapies from 1991 to 2015 was retrospectively assessed. The impact of the PN, LNR, LODDS, and other variables on overall survival (OS) and disease-free survival (DFS) was analyzed in univariate and multivariate analyses. Results: One hundred nineteen patients were included in this study. In the univariate analysis the PN had a significant impact on OS (p = 0.001) and DFS (p = 0.020), and the LNR had a significant impact on the OS (p = 0.042). In the multivariate analysis with other relevant clinicopathologic variables, the PN was the only significantly independent factor influencing in the OS (p = 0.017) but not in DFS (p = 0.096). Conclusions: The PN is an independent prognostic indicator for OS and DFS in patients with OSCC and has the potential to aggregate the current AJCC classification. The LNR has potential to be an important prognostic indicator, but the methods for this classification require lapidation. The LODDS did not demonstrate prognostic potential.Oral Oncology Center São Paulo State University (UNESP) School of DentistryDepartment of Diagnosis and Surgery São Paulo State University (UNESP) School of DentistryOral Oncology Center São Paulo State University (UNESP) School of DentistryDepartment of Diagnosis and Surgery São Paulo State University (UNESP) School of DentistryUniversidade Estadual Paulista (UNESP)Tomo, Saygo [UNESP]de Castro, Tamara Fernandes [UNESP]Araújo, Winicius Arildo Ferreira [UNESP]Collado, Francisco Urbano [UNESP]Neto, Sebastião Conrado [UNESP]Biasoli, Éder Ricardo [UNESP]Bernabé, Daniel Galera [UNESP]Miyahara, Glauco Issamu [UNESP]2023-07-29T13:24:50Z2023-07-29T13:24:50Z2023-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.jormas.2022.10.010Journal of Stomatology, Oral and Maxillofacial Surgery, v. 124, n. 2, 2023.2468-7855http://hdl.handle.net/11449/24775310.1016/j.jormas.2022.10.0102-s2.0-85140072109Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Stomatology, Oral and Maxillofacial Surgeryinfo:eu-repo/semantics/openAccess2024-04-11T20:16:33Zoai:repositorio.unesp.br:11449/247753Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:09:36.272218Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma |
title |
Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma |
spellingShingle |
Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma Tomo, Saygo [UNESP] Lymphatic metastasis Oral cancer Oral squamous cell carcinoma Prognostic factors |
title_short |
Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma |
title_full |
Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma |
title_fullStr |
Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma |
title_full_unstemmed |
Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma |
title_sort |
Influence of different methods for classification of lymph node metastases on the survival of patients with oral squamous cell carcinoma |
author |
Tomo, Saygo [UNESP] |
author_facet |
Tomo, Saygo [UNESP] de Castro, Tamara Fernandes [UNESP] Araújo, Winicius Arildo Ferreira [UNESP] Collado, Francisco Urbano [UNESP] Neto, Sebastião Conrado [UNESP] Biasoli, Éder Ricardo [UNESP] Bernabé, Daniel Galera [UNESP] Miyahara, Glauco Issamu [UNESP] |
author_role |
author |
author2 |
de Castro, Tamara Fernandes [UNESP] Araújo, Winicius Arildo Ferreira [UNESP] Collado, Francisco Urbano [UNESP] Neto, Sebastião Conrado [UNESP] Biasoli, Éder Ricardo [UNESP] Bernabé, Daniel Galera [UNESP] Miyahara, Glauco Issamu [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Tomo, Saygo [UNESP] de Castro, Tamara Fernandes [UNESP] Araújo, Winicius Arildo Ferreira [UNESP] Collado, Francisco Urbano [UNESP] Neto, Sebastião Conrado [UNESP] Biasoli, Éder Ricardo [UNESP] Bernabé, Daniel Galera [UNESP] Miyahara, Glauco Issamu [UNESP] |
dc.subject.por.fl_str_mv |
Lymphatic metastasis Oral cancer Oral squamous cell carcinoma Prognostic factors |
topic |
Lymphatic metastasis Oral cancer Oral squamous cell carcinoma Prognostic factors |
description |
Background: Despite the advances in the classification of oral squamous cell carcinoma (OSCC) based on its extension by the TNM system, there is still a need for methods to better classify the patients to predict prognosis and indicate adjuvant therapy. Objectives: To analyze the influence of the number of positive lymph nodes (PN), lymph node ratio (LNR), and log odds of positive lymph nodes (LODDS) in survival of patients with OSCC. Methods: Clinicopathologic data from patients with OSCC who were treated with curative purposes by surgery and neck dissection (ND) with or without subsequent adjuvant therapies from 1991 to 2015 was retrospectively assessed. The impact of the PN, LNR, LODDS, and other variables on overall survival (OS) and disease-free survival (DFS) was analyzed in univariate and multivariate analyses. Results: One hundred nineteen patients were included in this study. In the univariate analysis the PN had a significant impact on OS (p = 0.001) and DFS (p = 0.020), and the LNR had a significant impact on the OS (p = 0.042). In the multivariate analysis with other relevant clinicopathologic variables, the PN was the only significantly independent factor influencing in the OS (p = 0.017) but not in DFS (p = 0.096). Conclusions: The PN is an independent prognostic indicator for OS and DFS in patients with OSCC and has the potential to aggregate the current AJCC classification. The LNR has potential to be an important prognostic indicator, but the methods for this classification require lapidation. The LODDS did not demonstrate prognostic potential. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:24:50Z 2023-07-29T13:24:50Z 2023-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jormas.2022.10.010 Journal of Stomatology, Oral and Maxillofacial Surgery, v. 124, n. 2, 2023. 2468-7855 http://hdl.handle.net/11449/247753 10.1016/j.jormas.2022.10.010 2-s2.0-85140072109 |
url |
http://dx.doi.org/10.1016/j.jormas.2022.10.010 http://hdl.handle.net/11449/247753 |
identifier_str_mv |
Journal of Stomatology, Oral and Maxillofacial Surgery, v. 124, n. 2, 2023. 2468-7855 10.1016/j.jormas.2022.10.010 2-s2.0-85140072109 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Stomatology, Oral and Maxillofacial Surgery |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129398913630208 |