A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin

Detalhes bibliográficos
Autor(a) principal: Rocha, Mackson Martins
Data de Publicação: 2022
Outros Autores: Dariva, Isabela, Zornoff, Gabriela Comelli, De Laurentis, Giovanna Sanches, Mendes, Giulia Carli, Santana, Maycon Giovani, Miguel, Guilherme Chohfi de, Ferreira, Rui Seabra [UNESP], Sciani, Juliana Mozer, Priolli, Denise Goncalves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/1678-9199-JVATITD-2021-0067
http://hdl.handle.net/11449/218845
Resumo: Background: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis. Herein, we propose an approach based on intrametastatic melittin injection to treat bone metastases in colorectal cancer. Methods: Following the characterization of melittin and antiproliferative tests in vitro, a single dose was injected through intrametastatic route into the mouse bone metastasis model. Following treatment, metastasis growth was evaluated. Results: A single dose of melittin was able to inhibit metastasis growth. Histological analysis showed necrosis and inflammatory processes in melittin-treated metastasis. Except by mild weight loss, no other systemic effects were observed. Conclusion: Our data suggest that melittin might be a promising agent for the future development of treatment strategies aiming to reduce the metastasis skeletal-related impact in colorectal cancer patients with bone metastasis.
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spelling A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittinBone metastasisMelittinIntratumoral injectionColorectal neoplasmsBee venomBackground: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis. Herein, we propose an approach based on intrametastatic melittin injection to treat bone metastases in colorectal cancer. Methods: Following the characterization of melittin and antiproliferative tests in vitro, a single dose was injected through intrametastatic route into the mouse bone metastasis model. Following treatment, metastasis growth was evaluated. Results: A single dose of melittin was able to inhibit metastasis growth. Histological analysis showed necrosis and inflammatory processes in melittin-treated metastasis. Except by mild weight loss, no other systemic effects were observed. Conclusion: Our data suggest that melittin might be a promising agent for the future development of treatment strategies aiming to reduce the metastasis skeletal-related impact in colorectal cancer patients with bone metastasis.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Sao Francisco Univ, Multidisciplinary Lab, Postgrad Program Hlth Sci, Braganca Paulista, SP, BrazilSao Francisco Univ, Med Sch, Braganca Paulista, SP, BrazilSao Francisco Univ, Nursing Sch, Braganca Paulista, SP, BrazilSao Paulo State Univ UNESP, Ctr Studies Venoms & Venomous Anim CEVAP, Botucatu, SP, BrazilSao Paulo State Univ UNESP, Ctr Studies Venoms & Venomous Anim CEVAP, Botucatu, SP, BrazilFAPESP: 2018/21471-5Cevap-sao Paulo State Univ-unespSao Francisco UnivUniversidade Estadual Paulista (UNESP)Rocha, Mackson MartinsDariva, IsabelaZornoff, Gabriela ComelliDe Laurentis, Giovanna SanchesMendes, Giulia CarliSantana, Maycon GiovaniMiguel, Guilherme Chohfi deFerreira, Rui Seabra [UNESP]Sciani, Juliana MozerPriolli, Denise Goncalves2022-04-28T17:23:20Z2022-04-28T17:23:20Z2022-03-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10http://dx.doi.org/10.1590/1678-9199-JVATITD-2021-0067Journal Of Venomous Animals And Toxins Including Tropical Diseases. Botucatu: Cevap-sao Paulo State Univ-unesp, v. 28, 10 p., 2022.http://hdl.handle.net/11449/21884510.1590/1678-9199-JVATITD-2021-0067WOS:000771735900001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Venomous Animals And Toxins Including Tropical Diseasesinfo:eu-repo/semantics/openAccess2024-04-11T15:28:17Zoai:repositorio.unesp.br:11449/218845Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:35:23.095835Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin
title A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin
spellingShingle A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin
Rocha, Mackson Martins
Bone metastasis
Melittin
Intratumoral injection
Colorectal neoplasms
Bee venom
title_short A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin
title_full A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin
title_fullStr A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin
title_full_unstemmed A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin
title_sort A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin
author Rocha, Mackson Martins
author_facet Rocha, Mackson Martins
Dariva, Isabela
Zornoff, Gabriela Comelli
De Laurentis, Giovanna Sanches
Mendes, Giulia Carli
Santana, Maycon Giovani
Miguel, Guilherme Chohfi de
Ferreira, Rui Seabra [UNESP]
Sciani, Juliana Mozer
Priolli, Denise Goncalves
author_role author
author2 Dariva, Isabela
Zornoff, Gabriela Comelli
De Laurentis, Giovanna Sanches
Mendes, Giulia Carli
Santana, Maycon Giovani
Miguel, Guilherme Chohfi de
Ferreira, Rui Seabra [UNESP]
Sciani, Juliana Mozer
Priolli, Denise Goncalves
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Sao Francisco Univ
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Rocha, Mackson Martins
Dariva, Isabela
Zornoff, Gabriela Comelli
De Laurentis, Giovanna Sanches
Mendes, Giulia Carli
Santana, Maycon Giovani
Miguel, Guilherme Chohfi de
Ferreira, Rui Seabra [UNESP]
Sciani, Juliana Mozer
Priolli, Denise Goncalves
dc.subject.por.fl_str_mv Bone metastasis
Melittin
Intratumoral injection
Colorectal neoplasms
Bee venom
topic Bone metastasis
Melittin
Intratumoral injection
Colorectal neoplasms
Bee venom
description Background: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis. Herein, we propose an approach based on intrametastatic melittin injection to treat bone metastases in colorectal cancer. Methods: Following the characterization of melittin and antiproliferative tests in vitro, a single dose was injected through intrametastatic route into the mouse bone metastasis model. Following treatment, metastasis growth was evaluated. Results: A single dose of melittin was able to inhibit metastasis growth. Histological analysis showed necrosis and inflammatory processes in melittin-treated metastasis. Except by mild weight loss, no other systemic effects were observed. Conclusion: Our data suggest that melittin might be a promising agent for the future development of treatment strategies aiming to reduce the metastasis skeletal-related impact in colorectal cancer patients with bone metastasis.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-28T17:23:20Z
2022-04-28T17:23:20Z
2022-03-14
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1678-9199-JVATITD-2021-0067
Journal Of Venomous Animals And Toxins Including Tropical Diseases. Botucatu: Cevap-sao Paulo State Univ-unesp, v. 28, 10 p., 2022.
http://hdl.handle.net/11449/218845
10.1590/1678-9199-JVATITD-2021-0067
WOS:000771735900001
url http://dx.doi.org/10.1590/1678-9199-JVATITD-2021-0067
http://hdl.handle.net/11449/218845
identifier_str_mv Journal Of Venomous Animals And Toxins Including Tropical Diseases. Botucatu: Cevap-sao Paulo State Univ-unesp, v. 28, 10 p., 2022.
10.1590/1678-9199-JVATITD-2021-0067
WOS:000771735900001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal Of Venomous Animals And Toxins Including Tropical Diseases
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10
dc.publisher.none.fl_str_mv Cevap-sao Paulo State Univ-unesp
publisher.none.fl_str_mv Cevap-sao Paulo State Univ-unesp
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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