In vitro and in vivo safety evaluation of Dipteryx alata Vogel extract
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1472-6882-12-9 http://hdl.handle.net/11449/7504 |
Resumo: | Background: Dipteryx alata Vogel popularly known as baru is an important commercial leguminous tree species from the Brazilian Cerrado, which possess medicinal properties, besides its fruits consumption by animals and humans. The use of the naturally occurring plants as herbal remedies and foods mainly from leaves, seeds, flowers and roots of plants or extracts require precautions before ensuring these are safe and efficacious. The objective of this study was to evaluate the safety of D. alata barks extract.Methods: Vegetal drugs of D. alata barks were submitted to quality control assays and further to the safety assays under 1) in vitro parameter by Salmonella (Ames) mutagenicity, and 2) in vivo parameter on the pregnancy of rats.Results: The extract was non-mutagenic to any of the assessed strains TA97a, TA98, TA100 and TA102 even after metabolic activation (+S9). All in vivo parameters (reproductive ability evaluation, physical development of rat offsprings, and neurobehavioral development assays) showed no changes related to control group.Conclusion: D. alata barks extract is neither mutagenic by the Ames test nor toxic in the pregnancy of rats, with no physical-neurobehavioral consequences on the rat offsprings development. |
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In vitro and in vivo safety evaluation of Dipteryx alata Vogel extractBackground: Dipteryx alata Vogel popularly known as baru is an important commercial leguminous tree species from the Brazilian Cerrado, which possess medicinal properties, besides its fruits consumption by animals and humans. The use of the naturally occurring plants as herbal remedies and foods mainly from leaves, seeds, flowers and roots of plants or extracts require precautions before ensuring these are safe and efficacious. The objective of this study was to evaluate the safety of D. alata barks extract.Methods: Vegetal drugs of D. alata barks were submitted to quality control assays and further to the safety assays under 1) in vitro parameter by Salmonella (Ames) mutagenicity, and 2) in vivo parameter on the pregnancy of rats.Results: The extract was non-mutagenic to any of the assessed strains TA97a, TA98, TA100 and TA102 even after metabolic activation (+S9). All in vivo parameters (reproductive ability evaluation, physical development of rat offsprings, and neurobehavioral development assays) showed no changes related to control group.Conclusion: D. alata barks extract is neither mutagenic by the Ames test nor toxic in the pregnancy of rats, with no physical-neurobehavioral consequences on the rat offsprings development.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)PROBIC/UNISOUNESP São Paulo State Univ, Fac Pharmaceut Sci Araraquara, Dept Biol Sci, BR-14801902 São Paulo, BrazilUniv Sorocaba, Sch Pharm, UNISO, BR-18023000 Sorocaba, SP, BrazilUniv Fed São Paulo, UNIFESP, BR-09972270 Diadema, SP, BrazilFed Univ Tocantins, Postgrad Course Environm Sci, PGCiamb, UFT, BR-77001090 Tocantins, BrazilFed Univ Pampa, UNIPAMPA, BR-97300000 Sao Gabriel, RS, BrazilState Univ Campinas UNICAMP, Piracicaba Dent Sch, BR-13414903 Piracicaba, SP, BrazilUNESP São Paulo State Univ, Fac Pharmaceut Sci Araraquara, Dept Biol Sci, BR-14801902 São Paulo, BrazilFAPESP: 07/53883-6FAPESP: 07/51414-5Biomed Central Ltd.Universidade Estadual Paulista (Unesp)Universidade de Sorocaba (UNISO)Universidade Federal de São Paulo (UNIFESP)Universidade Federal do Tocantins (UFT)Universidade Federal do Pampa (UNIPAMPA)Universidade Estadual de Campinas (UNICAMP)Esteves-Pedro, Natalia MencacciBorim, ThaisaNazato, Virginia SbrugneraSilva, Magali GlauzerLopes, Patricia Santosdos Santos, Marcio GaldinoDal Belo, Chariston AndrePrimila Cardoso, Cassia Regina [UNESP]Varanda, Eliana Aparecida [UNESP]Groppo, Francisco CarlosGerenutti, MarliOshima-Franco, Yoko2014-05-20T13:24:19Z2014-05-20T13:24:19Z2012-02-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://dx.doi.org/10.1186/1472-6882-12-9Bmc Complementary and Alternative Medicine. London: Biomed Central Ltd., v. 12, p. 9, 2012.1472-6882http://hdl.handle.net/11449/750410.1186/1472-6882-12-9WOS:000302312600001WOS000302312600001.pdf7501930236496670Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBMC Complementary and Alternative Medicine2.1090,858info:eu-repo/semantics/openAccess2024-06-24T13:07:38Zoai:repositorio.unesp.br:11449/7504Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:52:20.493863Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
In vitro and in vivo safety evaluation of Dipteryx alata Vogel extract |
title |
In vitro and in vivo safety evaluation of Dipteryx alata Vogel extract |
spellingShingle |
In vitro and in vivo safety evaluation of Dipteryx alata Vogel extract Esteves-Pedro, Natalia Mencacci |
title_short |
In vitro and in vivo safety evaluation of Dipteryx alata Vogel extract |
title_full |
In vitro and in vivo safety evaluation of Dipteryx alata Vogel extract |
title_fullStr |
In vitro and in vivo safety evaluation of Dipteryx alata Vogel extract |
title_full_unstemmed |
In vitro and in vivo safety evaluation of Dipteryx alata Vogel extract |
title_sort |
In vitro and in vivo safety evaluation of Dipteryx alata Vogel extract |
author |
Esteves-Pedro, Natalia Mencacci |
author_facet |
Esteves-Pedro, Natalia Mencacci Borim, Thaisa Nazato, Virginia Sbrugnera Silva, Magali Glauzer Lopes, Patricia Santos dos Santos, Marcio Galdino Dal Belo, Chariston Andre Primila Cardoso, Cassia Regina [UNESP] Varanda, Eliana Aparecida [UNESP] Groppo, Francisco Carlos Gerenutti, Marli Oshima-Franco, Yoko |
author_role |
author |
author2 |
Borim, Thaisa Nazato, Virginia Sbrugnera Silva, Magali Glauzer Lopes, Patricia Santos dos Santos, Marcio Galdino Dal Belo, Chariston Andre Primila Cardoso, Cassia Regina [UNESP] Varanda, Eliana Aparecida [UNESP] Groppo, Francisco Carlos Gerenutti, Marli Oshima-Franco, Yoko |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de Sorocaba (UNISO) Universidade Federal de São Paulo (UNIFESP) Universidade Federal do Tocantins (UFT) Universidade Federal do Pampa (UNIPAMPA) Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Esteves-Pedro, Natalia Mencacci Borim, Thaisa Nazato, Virginia Sbrugnera Silva, Magali Glauzer Lopes, Patricia Santos dos Santos, Marcio Galdino Dal Belo, Chariston Andre Primila Cardoso, Cassia Regina [UNESP] Varanda, Eliana Aparecida [UNESP] Groppo, Francisco Carlos Gerenutti, Marli Oshima-Franco, Yoko |
description |
Background: Dipteryx alata Vogel popularly known as baru is an important commercial leguminous tree species from the Brazilian Cerrado, which possess medicinal properties, besides its fruits consumption by animals and humans. The use of the naturally occurring plants as herbal remedies and foods mainly from leaves, seeds, flowers and roots of plants or extracts require precautions before ensuring these are safe and efficacious. The objective of this study was to evaluate the safety of D. alata barks extract.Methods: Vegetal drugs of D. alata barks were submitted to quality control assays and further to the safety assays under 1) in vitro parameter by Salmonella (Ames) mutagenicity, and 2) in vivo parameter on the pregnancy of rats.Results: The extract was non-mutagenic to any of the assessed strains TA97a, TA98, TA100 and TA102 even after metabolic activation (+S9). All in vivo parameters (reproductive ability evaluation, physical development of rat offsprings, and neurobehavioral development assays) showed no changes related to control group.Conclusion: D. alata barks extract is neither mutagenic by the Ames test nor toxic in the pregnancy of rats, with no physical-neurobehavioral consequences on the rat offsprings development. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-02-03 2014-05-20T13:24:19Z 2014-05-20T13:24:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1472-6882-12-9 Bmc Complementary and Alternative Medicine. London: Biomed Central Ltd., v. 12, p. 9, 2012. 1472-6882 http://hdl.handle.net/11449/7504 10.1186/1472-6882-12-9 WOS:000302312600001 WOS000302312600001.pdf 7501930236496670 |
url |
http://dx.doi.org/10.1186/1472-6882-12-9 http://hdl.handle.net/11449/7504 |
identifier_str_mv |
Bmc Complementary and Alternative Medicine. London: Biomed Central Ltd., v. 12, p. 9, 2012. 1472-6882 10.1186/1472-6882-12-9 WOS:000302312600001 WOS000302312600001.pdf 7501930236496670 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BMC Complementary and Alternative Medicine 2.109 0,858 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
9 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd. |
publisher.none.fl_str_mv |
Biomed Central Ltd. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128869429936128 |