miRTil: An Extensive Repository for Nile Tilapia microRNA Next Generation Sequencing Data

• Autor(a) principal: Bovolenta, Luiz Augusto [UNESP]
• Data de Publicação: 2020
• Outros Autores: Pinhal, Danillo [UNESP], Acencio, Marcio Luis, Oliveira, Arthur Casulli de [UNESP], Moxon, Simon, Martins, Cesar [UNESP], Lemke, Ney [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.3390/cells9081752; http://hdl.handle.net/11449/200824
• topic: database; microRNA; microRNA expression profile; microRNA target prediction; Nile tilapia; post-transcriptional regulation

Nile tilapia is the third most cultivated fish worldwide and a novel model species for evolutionary studies. Aiming to improve productivity and contribute to the selection of traits of economic impact, biotechnological approaches have been intensively applied to species enhancement. In this sense, recent studies have focused on the multiple roles played by microRNAs (miRNAs) in the post-transcriptional regulation of protein-coding genes involved in the emergence of phenotypes with relevance for aquaculture. However, there is still a growing demand for a reference resource dedicated to integrating Nile Tilapia miRNA information, obtained from both experimental and in silico approaches, and facilitating the analysis and interpretation of RNA sequencing data. Here, we present an open repository dedicated to Nile Tilapia miRNAs: the miRTil database. The database stores data on 734 mature miRNAs identified in 11 distinct tissues and five key developmental stages. The database provides detailed information about miRNA structure, genomic context, predicted targets, expression profiles, and relative 5p/3p arm usage. Additionally, miRTil also includes a comprehensive pre-computed miRNA-target interaction network containing 4936 targets and 19,580 interactions.