Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.21577/0103-5053.20190189 http://hdl.handle.net/11449/199842 |
Resumo: | The endophytic fungus Microsphaeropsis arundinis was isolated from the capitula of the tropical plant Paepalanthus planifolius (Eriocaulaceae). The fungus was cultivated in seven different media, and the ethyl acetate extracts were tested against tumor cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay. The culture was scaled up using parboiled rice medium, and the crude extract was purified by classical chromatographic analyses, leading to the isolation of seven compounds. The seven compounds isolated from the culture media included a new aromatic polyketide (1) and other known metabolites. The structures of all the compounds were elucidated by 1D and 2D nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HRMS) analyses. An evaluation of the cytotoxicity of all the isolated compounds showed that these compounds exhibit less activity in comparison with the extract cultured in parboiled rice. |
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Repositório Institucional da UNESP |
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Aromatic Polyketides and Macrolides from Microsphaeropsis arundinisAromatic polyketidesMacrolidesMicrosphaeropsis arundinisPaepalanthus planifoliusThe endophytic fungus Microsphaeropsis arundinis was isolated from the capitula of the tropical plant Paepalanthus planifolius (Eriocaulaceae). The fungus was cultivated in seven different media, and the ethyl acetate extracts were tested against tumor cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay. The culture was scaled up using parboiled rice medium, and the crude extract was purified by classical chromatographic analyses, leading to the isolation of seven compounds. The seven compounds isolated from the culture media included a new aromatic polyketide (1) and other known metabolites. The structures of all the compounds were elucidated by 1D and 2D nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HRMS) analyses. An evaluation of the cytotoxicity of all the isolated compounds showed that these compounds exhibit less activity in comparison with the extract cultured in parboiled rice.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Departamento de Química Orgânica Instituto de Química Universidade Estadual Paulista (Unesp)Departamento de Ciências Biológicas Escola de Ciências Farmacêuticas Universidade Estadual Paulista (Unesp)Departamento de Química Orgânica Instituto de Química Universidade Estadual Paulista (Unesp)Departamento de Ciências Biológicas Escola de Ciências Farmacêuticas Universidade Estadual Paulista (Unesp)CNPq: 131233/2016-5FAPESP: 2015/04899-3FAPESP: 2015/11058-5CNPq: 302832/2014-9Universidade Estadual Paulista (Unesp)Botero, Weslei Bruno [UNESP]de Amorim, Marcelo R. [UNESP]Carlos, Iracilda Z. [UNESP]Polesi, Marisa C. [UNESP]dos Santos, Lourdes C. [UNESP]2020-12-12T01:50:46Z2020-12-12T01:50:46Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article364-369application/pdfhttp://dx.doi.org/10.21577/0103-5053.20190189Journal of the Brazilian Chemical Society, v. 31, n. 2, p. 364-369, 2020.1678-47900103-5053http://hdl.handle.net/11449/19984210.21577/0103-5053.20190189S0103-505320200002003642-s2.0-85076837123S0103-50532020000200364.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of the Brazilian Chemical Societyinfo:eu-repo/semantics/openAccess2024-06-24T13:07:37Zoai:repositorio.unesp.br:11449/199842Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:35:19.986974Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis |
title |
Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis |
spellingShingle |
Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis Botero, Weslei Bruno [UNESP] Aromatic polyketides Macrolides Microsphaeropsis arundinis Paepalanthus planifolius |
title_short |
Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis |
title_full |
Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis |
title_fullStr |
Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis |
title_full_unstemmed |
Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis |
title_sort |
Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis |
author |
Botero, Weslei Bruno [UNESP] |
author_facet |
Botero, Weslei Bruno [UNESP] de Amorim, Marcelo R. [UNESP] Carlos, Iracilda Z. [UNESP] Polesi, Marisa C. [UNESP] dos Santos, Lourdes C. [UNESP] |
author_role |
author |
author2 |
de Amorim, Marcelo R. [UNESP] Carlos, Iracilda Z. [UNESP] Polesi, Marisa C. [UNESP] dos Santos, Lourdes C. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Botero, Weslei Bruno [UNESP] de Amorim, Marcelo R. [UNESP] Carlos, Iracilda Z. [UNESP] Polesi, Marisa C. [UNESP] dos Santos, Lourdes C. [UNESP] |
dc.subject.por.fl_str_mv |
Aromatic polyketides Macrolides Microsphaeropsis arundinis Paepalanthus planifolius |
topic |
Aromatic polyketides Macrolides Microsphaeropsis arundinis Paepalanthus planifolius |
description |
The endophytic fungus Microsphaeropsis arundinis was isolated from the capitula of the tropical plant Paepalanthus planifolius (Eriocaulaceae). The fungus was cultivated in seven different media, and the ethyl acetate extracts were tested against tumor cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay. The culture was scaled up using parboiled rice medium, and the crude extract was purified by classical chromatographic analyses, leading to the isolation of seven compounds. The seven compounds isolated from the culture media included a new aromatic polyketide (1) and other known metabolites. The structures of all the compounds were elucidated by 1D and 2D nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HRMS) analyses. An evaluation of the cytotoxicity of all the isolated compounds showed that these compounds exhibit less activity in comparison with the extract cultured in parboiled rice. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:50:46Z 2020-12-12T01:50:46Z 2020-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.21577/0103-5053.20190189 Journal of the Brazilian Chemical Society, v. 31, n. 2, p. 364-369, 2020. 1678-4790 0103-5053 http://hdl.handle.net/11449/199842 10.21577/0103-5053.20190189 S0103-50532020000200364 2-s2.0-85076837123 S0103-50532020000200364.pdf |
url |
http://dx.doi.org/10.21577/0103-5053.20190189 http://hdl.handle.net/11449/199842 |
identifier_str_mv |
Journal of the Brazilian Chemical Society, v. 31, n. 2, p. 364-369, 2020. 1678-4790 0103-5053 10.21577/0103-5053.20190189 S0103-50532020000200364 2-s2.0-85076837123 S0103-50532020000200364.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of the Brazilian Chemical Society |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
364-369 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128831074074624 |