Exposição de fibroblastos da cápsula de Tenon normal de portadores de pterígio ao 5-fluorouracil e à mitomicina C

Detalhes bibliográficos
Autor(a) principal: Viveiros, Magda Massae Hata [UNESP]
Data de Publicação: 2007
Outros Autores: Schellini, Silvana Artioli [UNESP], Candeias, João [UNESP], Padovani, Carlos Roberto [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/224885
Resumo: Purpose: To evaluate the fibroblast proliferation activity of normal Tenon's capsule from primary and recurrent patients with pterygium. Methods: A randomized prospective study was performed with 41 normal Tenon's capsule fragments from 21 primary and 20 recurrent patients with pterygium. The sample was collected from the inferior cul-de-sac. Proliferation rate from fibroblasts were evaluated after mitomycin C and 5-fluorouracil exposition. Data were submitted to statistical analysis. Results: Of the 41 cultivated normal Tenon's capsules, only 1 from primary and 2 from recurrent pterygium patients proliferated. After antimitotic exposition, the proliferation rate was similar with both drugs. Conclusion: Mitomycin and 5-fluorouracil promote similar inhibition regarding proliferation of normal Tenon's fibroblast cultures.
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spelling Exposição de fibroblastos da cápsula de Tenon normal de portadores de pterígio ao 5-fluorouracil e à mitomicina CExposure of normal Tenon's capsule fibroblasts from pterygium to 5-fluorouracil and mitomycin CAntimitotic agentsConjunctivaFibroblasts/cytologyFluorouracilMitomycinPterygiumRecurrencePurpose: To evaluate the fibroblast proliferation activity of normal Tenon's capsule from primary and recurrent patients with pterygium. Methods: A randomized prospective study was performed with 41 normal Tenon's capsule fragments from 21 primary and 20 recurrent patients with pterygium. The sample was collected from the inferior cul-de-sac. Proliferation rate from fibroblasts were evaluated after mitomycin C and 5-fluorouracil exposition. Data were submitted to statistical analysis. Results: Of the 41 cultivated normal Tenon's capsules, only 1 from primary and 2 from recurrent pterygium patients proliferated. After antimitotic exposition, the proliferation rate was similar with both drugs. Conclusion: Mitomycin and 5-fluorouracil promote similar inhibition regarding proliferation of normal Tenon's fibroblast cultures.Departamento de Oftalmologia Otorrinolaringologia e Cirurgia de Cabeca e Pescoco Faculdade de Medicina Universidade Estadual Pualista Júlio Mesquita Filho - UNESP, Distrito Rubiao Junior, s/n, Botucatu, SP 18610-000Departamento de Oftalmologia Otorrinolaringologia e Cirurgia de Cabeca e Pescoco UNESP, Botucatu, SPDepartamento de Microbiologia Instituto de Biociências UNESP, Botucatu, SPDepartamento de Bioestatística Instituto de Biociências UNESP, Botucatu, SPDepartamento de Oftalmologia Otorrinolaringologia e Cirurgia de Cabeca e Pescoco Faculdade de Medicina Universidade Estadual Pualista Júlio Mesquita Filho - UNESP, Distrito Rubiao Junior, s/n, Botucatu, SP 18610-000Departamento de Oftalmologia Otorrinolaringologia e Cirurgia de Cabeca e Pescoco UNESP, Botucatu, SPDepartamento de Microbiologia Instituto de Biociências UNESP, Botucatu, SPDepartamento de Bioestatística Instituto de Biociências UNESP, Botucatu, SPUniversidade Estadual Paulista (UNESP)Viveiros, Magda Massae Hata [UNESP]Schellini, Silvana Artioli [UNESP]Candeias, João [UNESP]Padovani, Carlos Roberto [UNESP]2022-04-28T20:16:09Z2022-04-28T20:16:09Z2007-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article73-77Arquivos Brasileiros de Oftalmologia, v. 70, n. 1, p. 73-77, 2007.0004-27491678-2925http://hdl.handle.net/11449/2248852-s2.0-34147136704Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporArquivos Brasileiros de Oftalmologiainfo:eu-repo/semantics/openAccess2024-08-16T18:43:52Zoai:repositorio.unesp.br:11449/224885Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T18:43:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Exposição de fibroblastos da cápsula de Tenon normal de portadores de pterígio ao 5-fluorouracil e à mitomicina C
Exposure of normal Tenon's capsule fibroblasts from pterygium to 5-fluorouracil and mitomycin C
title Exposição de fibroblastos da cápsula de Tenon normal de portadores de pterígio ao 5-fluorouracil e à mitomicina C
spellingShingle Exposição de fibroblastos da cápsula de Tenon normal de portadores de pterígio ao 5-fluorouracil e à mitomicina C
Viveiros, Magda Massae Hata [UNESP]
Antimitotic agents
Conjunctiva
Fibroblasts/cytology
Fluorouracil
Mitomycin
Pterygium
Recurrence
title_short Exposição de fibroblastos da cápsula de Tenon normal de portadores de pterígio ao 5-fluorouracil e à mitomicina C
title_full Exposição de fibroblastos da cápsula de Tenon normal de portadores de pterígio ao 5-fluorouracil e à mitomicina C
title_fullStr Exposição de fibroblastos da cápsula de Tenon normal de portadores de pterígio ao 5-fluorouracil e à mitomicina C
title_full_unstemmed Exposição de fibroblastos da cápsula de Tenon normal de portadores de pterígio ao 5-fluorouracil e à mitomicina C
title_sort Exposição de fibroblastos da cápsula de Tenon normal de portadores de pterígio ao 5-fluorouracil e à mitomicina C
author Viveiros, Magda Massae Hata [UNESP]
author_facet Viveiros, Magda Massae Hata [UNESP]
Schellini, Silvana Artioli [UNESP]
Candeias, João [UNESP]
Padovani, Carlos Roberto [UNESP]
author_role author
author2 Schellini, Silvana Artioli [UNESP]
Candeias, João [UNESP]
Padovani, Carlos Roberto [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Viveiros, Magda Massae Hata [UNESP]
Schellini, Silvana Artioli [UNESP]
Candeias, João [UNESP]
Padovani, Carlos Roberto [UNESP]
dc.subject.por.fl_str_mv Antimitotic agents
Conjunctiva
Fibroblasts/cytology
Fluorouracil
Mitomycin
Pterygium
Recurrence
topic Antimitotic agents
Conjunctiva
Fibroblasts/cytology
Fluorouracil
Mitomycin
Pterygium
Recurrence
description Purpose: To evaluate the fibroblast proliferation activity of normal Tenon's capsule from primary and recurrent patients with pterygium. Methods: A randomized prospective study was performed with 41 normal Tenon's capsule fragments from 21 primary and 20 recurrent patients with pterygium. The sample was collected from the inferior cul-de-sac. Proliferation rate from fibroblasts were evaluated after mitomycin C and 5-fluorouracil exposition. Data were submitted to statistical analysis. Results: Of the 41 cultivated normal Tenon's capsules, only 1 from primary and 2 from recurrent pterygium patients proliferated. After antimitotic exposition, the proliferation rate was similar with both drugs. Conclusion: Mitomycin and 5-fluorouracil promote similar inhibition regarding proliferation of normal Tenon's fibroblast cultures.
publishDate 2007
dc.date.none.fl_str_mv 2007-01-01
2022-04-28T20:16:09Z
2022-04-28T20:16:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Arquivos Brasileiros de Oftalmologia, v. 70, n. 1, p. 73-77, 2007.
0004-2749
1678-2925
http://hdl.handle.net/11449/224885
2-s2.0-34147136704
identifier_str_mv Arquivos Brasileiros de Oftalmologia, v. 70, n. 1, p. 73-77, 2007.
0004-2749
1678-2925
2-s2.0-34147136704
url http://hdl.handle.net/11449/224885
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Arquivos Brasileiros de Oftalmologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 73-77
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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