HPV-positive cervical squamous cell carcinoma metastasis to the breast, mimicking primary tumor
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3233/BD-220027 http://hdl.handle.net/11449/246470 |
Resumo: | INTRODUCTION: Metastatic disease to the breast is a rare condition, with contralateral breast metastasis being the most common primary site. CASE PRESENTATION: We present the case of a patient who underwent treatment for an HPV positive squamous cell carcinoma (SCC) of the cervix who, during follow-up, complained of a nodule in her left breast. Anatomopathological results indicating squamous carcinoma, which was not able to be differentiated from breast metaplastic carcinoma. Resection of the lesion was carried out, confirming carcinoma with squamous cell differentiation with negativity for GCDFP-15, mammaglobin, p63 and SOX10, but with positivity for p16 and for high risk HPV, confirming a single metastatic lesion of cervical carcinoma. DISCUSSION/CONCLUSION: In the presence of SCC in the breast, the differential diagnosis may consider the presence of primary lesion, metaplastic carcinoma with squamous cell differentiation or metastatic disease. The use of markers such as p63, SOX10 and p16, may help for a definitive diagnosis. |
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HPV-positive cervical squamous cell carcinoma metastasis to the breast, mimicking primary tumorbreast metastasisCervical cancerHPVmetastasisINTRODUCTION: Metastatic disease to the breast is a rare condition, with contralateral breast metastasis being the most common primary site. CASE PRESENTATION: We present the case of a patient who underwent treatment for an HPV positive squamous cell carcinoma (SCC) of the cervix who, during follow-up, complained of a nodule in her left breast. Anatomopathological results indicating squamous carcinoma, which was not able to be differentiated from breast metaplastic carcinoma. Resection of the lesion was carried out, confirming carcinoma with squamous cell differentiation with negativity for GCDFP-15, mammaglobin, p63 and SOX10, but with positivity for p16 and for high risk HPV, confirming a single metastatic lesion of cervical carcinoma. DISCUSSION/CONCLUSION: In the presence of SCC in the breast, the differential diagnosis may consider the presence of primary lesion, metaplastic carcinoma with squamous cell differentiation or metastatic disease. The use of markers such as p63, SOX10 and p16, may help for a definitive diagnosis.Postgraduate Program in Tocogynecology Medicine School - São Paulo State University (UNESP), SPDepartment of Mastology and Breast Reconstruction Barretos Cancer Hospital, SPPostgraduate Program in Oncology Barretos Cancer Hospital, SPDepartment of Pathology Barretos Cancer Hospital, SPDepartment of Cancer Prevention Barretos Cancer Hospital, SPDepartment of Oncogynecology Barretos Cancer Hospital, SPSurgery Department Division of Mastology Muriaé Cancer Hospital, MGPostgraduate Program in Tocogynecology Medicine School - São Paulo State University (UNESP), SPUniversidade Estadual Paulista (UNESP)Barretos Cancer HospitalMuriaé Cancer HospitalDe Oliveira-Junior, Idam [UNESP]Barbin, Flávia FazzioWatanabe, Anapaula Hidemi UemaDos Reis, RicardoDa Costa Vieira, René Aloisio [UNESP]2023-07-29T12:41:49Z2023-07-29T12:41:49Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article407-411http://dx.doi.org/10.3233/BD-220027Breast Disease, v. 41, n. 1, p. 407-411, 2022.1558-15510888-6008http://hdl.handle.net/11449/24647010.3233/BD-2200272-s2.0-85143917567Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBreast Diseaseinfo:eu-repo/semantics/openAccess2023-07-29T12:41:49Zoai:repositorio.unesp.br:11449/246470Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:09:39.443120Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
HPV-positive cervical squamous cell carcinoma metastasis to the breast, mimicking primary tumor |
title |
HPV-positive cervical squamous cell carcinoma metastasis to the breast, mimicking primary tumor |
spellingShingle |
HPV-positive cervical squamous cell carcinoma metastasis to the breast, mimicking primary tumor De Oliveira-Junior, Idam [UNESP] breast metastasis Cervical cancer HPV metastasis |
title_short |
HPV-positive cervical squamous cell carcinoma metastasis to the breast, mimicking primary tumor |
title_full |
HPV-positive cervical squamous cell carcinoma metastasis to the breast, mimicking primary tumor |
title_fullStr |
HPV-positive cervical squamous cell carcinoma metastasis to the breast, mimicking primary tumor |
title_full_unstemmed |
HPV-positive cervical squamous cell carcinoma metastasis to the breast, mimicking primary tumor |
title_sort |
HPV-positive cervical squamous cell carcinoma metastasis to the breast, mimicking primary tumor |
author |
De Oliveira-Junior, Idam [UNESP] |
author_facet |
De Oliveira-Junior, Idam [UNESP] Barbin, Flávia Fazzio Watanabe, Anapaula Hidemi Uema Dos Reis, Ricardo Da Costa Vieira, René Aloisio [UNESP] |
author_role |
author |
author2 |
Barbin, Flávia Fazzio Watanabe, Anapaula Hidemi Uema Dos Reis, Ricardo Da Costa Vieira, René Aloisio [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Barretos Cancer Hospital Muriaé Cancer Hospital |
dc.contributor.author.fl_str_mv |
De Oliveira-Junior, Idam [UNESP] Barbin, Flávia Fazzio Watanabe, Anapaula Hidemi Uema Dos Reis, Ricardo Da Costa Vieira, René Aloisio [UNESP] |
dc.subject.por.fl_str_mv |
breast metastasis Cervical cancer HPV metastasis |
topic |
breast metastasis Cervical cancer HPV metastasis |
description |
INTRODUCTION: Metastatic disease to the breast is a rare condition, with contralateral breast metastasis being the most common primary site. CASE PRESENTATION: We present the case of a patient who underwent treatment for an HPV positive squamous cell carcinoma (SCC) of the cervix who, during follow-up, complained of a nodule in her left breast. Anatomopathological results indicating squamous carcinoma, which was not able to be differentiated from breast metaplastic carcinoma. Resection of the lesion was carried out, confirming carcinoma with squamous cell differentiation with negativity for GCDFP-15, mammaglobin, p63 and SOX10, but with positivity for p16 and for high risk HPV, confirming a single metastatic lesion of cervical carcinoma. DISCUSSION/CONCLUSION: In the presence of SCC in the breast, the differential diagnosis may consider the presence of primary lesion, metaplastic carcinoma with squamous cell differentiation or metastatic disease. The use of markers such as p63, SOX10 and p16, may help for a definitive diagnosis. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-07-29T12:41:49Z 2023-07-29T12:41:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3233/BD-220027 Breast Disease, v. 41, n. 1, p. 407-411, 2022. 1558-1551 0888-6008 http://hdl.handle.net/11449/246470 10.3233/BD-220027 2-s2.0-85143917567 |
url |
http://dx.doi.org/10.3233/BD-220027 http://hdl.handle.net/11449/246470 |
identifier_str_mv |
Breast Disease, v. 41, n. 1, p. 407-411, 2022. 1558-1551 0888-6008 10.3233/BD-220027 2-s2.0-85143917567 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Breast Disease |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
407-411 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129028015521792 |