Biocompatibility, bioactive potential, porosity, and interface analysis calcium silicate repair cements in a dentin tube model

• Autor(a) principal: Inada, Rafaela Nanami Handa [UNESP]
• Data de Publicação: 2023
• Outros Autores: Queiroz, Marcela Borsatto [UNESP], Lopes, Camila Soares [UNESP], Silva, Evelin Carine Alves [UNESP], Torres, Fernanda Ferrari Esteves [UNESP], da Silva, Guilherme Ferreira, Guerreiro-Tanomaru, Juliane Maria [UNESP], Cerri, Paulo Sérgio [UNESP], Tanomaru-Filho, Mário [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1007/s00784-023-05002-5; http://hdl.handle.net/11449/249820
• topic: Biocompatibility; Calcium silicate; Root repair materials; X-ray microtomography

Objectives: This study is to evaluate biocompatibility, bioactive potential, porosity, and dentin/material interface of Bio-C Repair (BIOC-R), MTA Repair HP (MTAHP), and Intermediate Restorative Material (IRM). Materials and methods: Dentin tubes were implanted into subcutaneous of rats for 7, 15, 30, and 60 days. Thickness of capsules, number of inflammatory cells (ICs), interleukin-6 (IL-6), osteocalcin (OCN), and von Kossa were evaluated. Porosity and material/dentin interface voids were also analyzed. Data were submitted to ANOVA and Tukey’s tests (p < 0.05). Results: IRM capsules were thicker and contained greater ICs and IL-6-immunopositive cells at 7 and 15 days. BIOC-R capsules exhibited higher thickness and ICs at 7 days and greater IL-6 at 7 and 15 days than MTAHP (p < 0.05). At 30 and 60 days, no significant difference was observed among the groups. OCN-immunopositive cells, von Kossa-positive, and birefringent structures were observed in BIOC-R and MTAHP. MTAHP exhibited higher porosity and interface voids (p < 0.05). Conclusions: BIOC-R, MTAHP, and IRM are biocompatible. Bioceramics materials demonstrate bioactive potential. MTAHP presented the highest porosity and presence of voids. Clinical relevance: BIOC-R and MTAHP have adequate biological properties. BIOC-R demonstrated lower porosity and presence of voids, which may represent better sealing for its clinical applications.