Effect of platelet-rich plasma on healing of class III furcation defects treated with autogenous bone grafting and guided tissue regeneration: a histomorphometric study in dogs

• Autor(a) principal: Fernandes, José Marcos Alves [UNESP]
• Data de Publicação: 2011
• Outros Autores: Silva, Emílio Barbosa e [UNESP], Rego, Rodrigo Otávio Citó César [UNESP], Molon, Rafael Scaf de [UNESP], Zandim-Barcelos, Daniela Leal [UNESP], Spolidorio, Luis Carlos [UNESP], Cirelli, Joni Augusto [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://revodontolunesp.com.br/article/51ae4aa81ef1faca3d003848; http://hdl.handle.net/11449/125706
• topic: Furcation defects; Platelets-rich plasma; Guided tissue regeneration; Absorbable membrane; Defeitos de furca; Plasma rico em plaquetas; Regeneração tecidual guiada; Membrana bioabsorvível

The purpose of this study was to evaluate the effects of the platelet-rich plasma (PRP) when used in combination with autogenous bone graft and bioabsorbable membrane (Resolut® ) in the treatment of Class  III furcation defects in dogs. Material and method: Class III furcation defects (5 mm in height and in depth) were surgically created in the mandibular third premolars of five mongrel dogs. After nine weeks, the lesions were treated with scaling and root planning and each defect received one of the following treatments: autogenous bone graft + membrane (group C) or PRP + autogenous bone graft + membrane (group T). After a healing period of 90 days, the animals were sacrificed. Routine histological processing and staining with hematoxilyn and eosin and Masson trichrome were performed and a histomorphometric analysis determined the effect of the treatments on periodontal tissue regereneration. Data were analyzed by Hotelling’s T-squared (p < 0.05). Result: No statistically significant difference between C and T groups was observed by the histomorphometric analysis of the furcation area. Both treatment groups demonstrated similar regenerative results with the furcation defects partially filled and periodontal regeneration limited to the experimental notches of the lesions. (p > 0.05). Conclusion: According to the present results, PRP does not enhance the periodontal regeneration in class III furcation defects treated with autogenous bone graft and bioabsorbable membrane.