Assembly and antifungal effect of a new fluconazole-carrier nanosystem
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.2217/fmb-2019-0182 http://hdl.handle.net/11449/200287 |
Resumo: | Aim: To assemble, characterize and assess the antifungal effects of a new fluconazole (FLZ)-carrier nanosystem. Materials & methods: The nanosystem was prepared by loading FLZ on chitosan (CS)-coated iron oxide nanoparticles (IONPs). Antifungal effects were evaluated on planktonic cells (by minimum inhibitory concentration determination) and on biofilms (by quantification of cultivable cells, total biomass, metabolism and extracellular matrix) of Candida albicans and Candida glabrata. Results: Characterization results ratified the formation of a nanosystem (<320 nm) with FLZ successfully embedded. IONPs-CS-FLZ nanosystem reduced minimum inhibitory concentration values and, in general, showed similar antibiofilm effects compared with FLZ alone. Conclusion: IONPs-CS-FLZ nanosystem was more effective than FLZ mainly in inhibiting Candida planktonic cells. This nanocarrier has potential to fight fungal infections. |
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Repositório Institucional da UNESP |
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Assembly and antifungal effect of a new fluconazole-carrier nanosystembiofilmsCandidachitosanfluconazoleiron oxide nanoparticlesAim: To assemble, characterize and assess the antifungal effects of a new fluconazole (FLZ)-carrier nanosystem. Materials & methods: The nanosystem was prepared by loading FLZ on chitosan (CS)-coated iron oxide nanoparticles (IONPs). Antifungal effects were evaluated on planktonic cells (by minimum inhibitory concentration determination) and on biofilms (by quantification of cultivable cells, total biomass, metabolism and extracellular matrix) of Candida albicans and Candida glabrata. Results: Characterization results ratified the formation of a nanosystem (<320 nm) with FLZ successfully embedded. IONPs-CS-FLZ nanosystem reduced minimum inhibitory concentration values and, in general, showed similar antibiofilm effects compared with FLZ alone. Conclusion: IONPs-CS-FLZ nanosystem was more effective than FLZ mainly in inhibiting Candida planktonic cells. This nanocarrier has potential to fight fungal infections.Graduate Program in Dentistry (GPD - Master's Degree) University of Western São Paulo (UNOESTE)Department of Preventive and Restorative Dentistry School of Dentistry Araçatuba São Paulo State University (Unesp)School of Dentistry Presidente Prudente University of Western São Paulo (UNOESTE)Chemi Engenharia de MateriaisDepartment of Chemistry Federal University of São Carlos (UFSCar)Department of Preventive and Restorative Dentistry School of Dentistry Araçatuba São Paulo State University (Unesp)University of Western São Paulo (UNOESTE)Universidade Estadual Paulista (Unesp)Chemi Engenharia de MateriaisUniversidade Federal de São Carlos (UFSCar)De Lima, Taynara M.T.Arias, Laís S. [UNESP]Afanaci, Letícia F.Ferraresse, Raphael F.B.De Neto, Francisco N.S. [UNESP]De Lima, Bruno H.R.Straioto, Fabiana G.De Camargo, Emerson R.Pessan, Juliano P. [UNESP]Monteiro, Douglas R.2020-12-12T02:02:37Z2020-12-12T02:02:37Z2020-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article273-285http://dx.doi.org/10.2217/fmb-2019-0182Future Microbiology, v. 15, n. 4, p. 273-285, 2020.1746-09211746-0913http://hdl.handle.net/11449/20028710.2217/fmb-2019-01822-s2.0-85083369822Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFuture Microbiologyinfo:eu-repo/semantics/openAccess2024-09-19T18:32:01Zoai:repositorio.unesp.br:11449/200287Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T18:32:01Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Assembly and antifungal effect of a new fluconazole-carrier nanosystem |
title |
Assembly and antifungal effect of a new fluconazole-carrier nanosystem |
spellingShingle |
Assembly and antifungal effect of a new fluconazole-carrier nanosystem De Lima, Taynara M.T. biofilms Candida chitosan fluconazole iron oxide nanoparticles |
title_short |
Assembly and antifungal effect of a new fluconazole-carrier nanosystem |
title_full |
Assembly and antifungal effect of a new fluconazole-carrier nanosystem |
title_fullStr |
Assembly and antifungal effect of a new fluconazole-carrier nanosystem |
title_full_unstemmed |
Assembly and antifungal effect of a new fluconazole-carrier nanosystem |
title_sort |
Assembly and antifungal effect of a new fluconazole-carrier nanosystem |
author |
De Lima, Taynara M.T. |
author_facet |
De Lima, Taynara M.T. Arias, Laís S. [UNESP] Afanaci, Letícia F. Ferraresse, Raphael F.B. De Neto, Francisco N.S. [UNESP] De Lima, Bruno H.R. Straioto, Fabiana G. De Camargo, Emerson R. Pessan, Juliano P. [UNESP] Monteiro, Douglas R. |
author_role |
author |
author2 |
Arias, Laís S. [UNESP] Afanaci, Letícia F. Ferraresse, Raphael F.B. De Neto, Francisco N.S. [UNESP] De Lima, Bruno H.R. Straioto, Fabiana G. De Camargo, Emerson R. Pessan, Juliano P. [UNESP] Monteiro, Douglas R. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
University of Western São Paulo (UNOESTE) Universidade Estadual Paulista (Unesp) Chemi Engenharia de Materiais Universidade Federal de São Carlos (UFSCar) |
dc.contributor.author.fl_str_mv |
De Lima, Taynara M.T. Arias, Laís S. [UNESP] Afanaci, Letícia F. Ferraresse, Raphael F.B. De Neto, Francisco N.S. [UNESP] De Lima, Bruno H.R. Straioto, Fabiana G. De Camargo, Emerson R. Pessan, Juliano P. [UNESP] Monteiro, Douglas R. |
dc.subject.por.fl_str_mv |
biofilms Candida chitosan fluconazole iron oxide nanoparticles |
topic |
biofilms Candida chitosan fluconazole iron oxide nanoparticles |
description |
Aim: To assemble, characterize and assess the antifungal effects of a new fluconazole (FLZ)-carrier nanosystem. Materials & methods: The nanosystem was prepared by loading FLZ on chitosan (CS)-coated iron oxide nanoparticles (IONPs). Antifungal effects were evaluated on planktonic cells (by minimum inhibitory concentration determination) and on biofilms (by quantification of cultivable cells, total biomass, metabolism and extracellular matrix) of Candida albicans and Candida glabrata. Results: Characterization results ratified the formation of a nanosystem (<320 nm) with FLZ successfully embedded. IONPs-CS-FLZ nanosystem reduced minimum inhibitory concentration values and, in general, showed similar antibiofilm effects compared with FLZ alone. Conclusion: IONPs-CS-FLZ nanosystem was more effective than FLZ mainly in inhibiting Candida planktonic cells. This nanocarrier has potential to fight fungal infections. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:02:37Z 2020-12-12T02:02:37Z 2020-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.2217/fmb-2019-0182 Future Microbiology, v. 15, n. 4, p. 273-285, 2020. 1746-0921 1746-0913 http://hdl.handle.net/11449/200287 10.2217/fmb-2019-0182 2-s2.0-85083369822 |
url |
http://dx.doi.org/10.2217/fmb-2019-0182 http://hdl.handle.net/11449/200287 |
identifier_str_mv |
Future Microbiology, v. 15, n. 4, p. 273-285, 2020. 1746-0921 1746-0913 10.2217/fmb-2019-0182 2-s2.0-85083369822 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Future Microbiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
273-285 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1813546525012262912 |