Assembly and antifungal effect of a new fluconazole-carrier nanosystem

Detalhes bibliográficos
Autor(a) principal: De Lima, Taynara M.T.
Data de Publicação: 2020
Outros Autores: Arias, Laís S. [UNESP], Afanaci, Letícia F., Ferraresse, Raphael F.B., De Neto, Francisco N.S. [UNESP], De Lima, Bruno H.R., Straioto, Fabiana G., De Camargo, Emerson R., Pessan, Juliano P. [UNESP], Monteiro, Douglas R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.2217/fmb-2019-0182
http://hdl.handle.net/11449/200287
Resumo: Aim: To assemble, characterize and assess the antifungal effects of a new fluconazole (FLZ)-carrier nanosystem. Materials & methods: The nanosystem was prepared by loading FLZ on chitosan (CS)-coated iron oxide nanoparticles (IONPs). Antifungal effects were evaluated on planktonic cells (by minimum inhibitory concentration determination) and on biofilms (by quantification of cultivable cells, total biomass, metabolism and extracellular matrix) of Candida albicans and Candida glabrata. Results: Characterization results ratified the formation of a nanosystem (<320 nm) with FLZ successfully embedded. IONPs-CS-FLZ nanosystem reduced minimum inhibitory concentration values and, in general, showed similar antibiofilm effects compared with FLZ alone. Conclusion: IONPs-CS-FLZ nanosystem was more effective than FLZ mainly in inhibiting Candida planktonic cells. This nanocarrier has potential to fight fungal infections.
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spelling Assembly and antifungal effect of a new fluconazole-carrier nanosystembiofilmsCandidachitosanfluconazoleiron oxide nanoparticlesAim: To assemble, characterize and assess the antifungal effects of a new fluconazole (FLZ)-carrier nanosystem. Materials & methods: The nanosystem was prepared by loading FLZ on chitosan (CS)-coated iron oxide nanoparticles (IONPs). Antifungal effects were evaluated on planktonic cells (by minimum inhibitory concentration determination) and on biofilms (by quantification of cultivable cells, total biomass, metabolism and extracellular matrix) of Candida albicans and Candida glabrata. Results: Characterization results ratified the formation of a nanosystem (<320 nm) with FLZ successfully embedded. IONPs-CS-FLZ nanosystem reduced minimum inhibitory concentration values and, in general, showed similar antibiofilm effects compared with FLZ alone. Conclusion: IONPs-CS-FLZ nanosystem was more effective than FLZ mainly in inhibiting Candida planktonic cells. This nanocarrier has potential to fight fungal infections.Graduate Program in Dentistry (GPD - Master's Degree) University of Western São Paulo (UNOESTE)Department of Preventive and Restorative Dentistry School of Dentistry Araçatuba São Paulo State University (Unesp)School of Dentistry Presidente Prudente University of Western São Paulo (UNOESTE)Chemi Engenharia de MateriaisDepartment of Chemistry Federal University of São Carlos (UFSCar)Department of Preventive and Restorative Dentistry School of Dentistry Araçatuba São Paulo State University (Unesp)University of Western São Paulo (UNOESTE)Universidade Estadual Paulista (Unesp)Chemi Engenharia de MateriaisUniversidade Federal de São Carlos (UFSCar)De Lima, Taynara M.T.Arias, Laís S. [UNESP]Afanaci, Letícia F.Ferraresse, Raphael F.B.De Neto, Francisco N.S. [UNESP]De Lima, Bruno H.R.Straioto, Fabiana G.De Camargo, Emerson R.Pessan, Juliano P. [UNESP]Monteiro, Douglas R.2020-12-12T02:02:37Z2020-12-12T02:02:37Z2020-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article273-285http://dx.doi.org/10.2217/fmb-2019-0182Future Microbiology, v. 15, n. 4, p. 273-285, 2020.1746-09211746-0913http://hdl.handle.net/11449/20028710.2217/fmb-2019-01822-s2.0-85083369822Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFuture Microbiologyinfo:eu-repo/semantics/openAccess2024-09-19T18:32:01Zoai:repositorio.unesp.br:11449/200287Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T18:32:01Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Assembly and antifungal effect of a new fluconazole-carrier nanosystem
title Assembly and antifungal effect of a new fluconazole-carrier nanosystem
spellingShingle Assembly and antifungal effect of a new fluconazole-carrier nanosystem
De Lima, Taynara M.T.
biofilms
Candida
chitosan
fluconazole
iron oxide nanoparticles
title_short Assembly and antifungal effect of a new fluconazole-carrier nanosystem
title_full Assembly and antifungal effect of a new fluconazole-carrier nanosystem
title_fullStr Assembly and antifungal effect of a new fluconazole-carrier nanosystem
title_full_unstemmed Assembly and antifungal effect of a new fluconazole-carrier nanosystem
title_sort Assembly and antifungal effect of a new fluconazole-carrier nanosystem
author De Lima, Taynara M.T.
author_facet De Lima, Taynara M.T.
Arias, Laís S. [UNESP]
Afanaci, Letícia F.
Ferraresse, Raphael F.B.
De Neto, Francisco N.S. [UNESP]
De Lima, Bruno H.R.
Straioto, Fabiana G.
De Camargo, Emerson R.
Pessan, Juliano P. [UNESP]
Monteiro, Douglas R.
author_role author
author2 Arias, Laís S. [UNESP]
Afanaci, Letícia F.
Ferraresse, Raphael F.B.
De Neto, Francisco N.S. [UNESP]
De Lima, Bruno H.R.
Straioto, Fabiana G.
De Camargo, Emerson R.
Pessan, Juliano P. [UNESP]
Monteiro, Douglas R.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv University of Western São Paulo (UNOESTE)
Universidade Estadual Paulista (Unesp)
Chemi Engenharia de Materiais
Universidade Federal de São Carlos (UFSCar)
dc.contributor.author.fl_str_mv De Lima, Taynara M.T.
Arias, Laís S. [UNESP]
Afanaci, Letícia F.
Ferraresse, Raphael F.B.
De Neto, Francisco N.S. [UNESP]
De Lima, Bruno H.R.
Straioto, Fabiana G.
De Camargo, Emerson R.
Pessan, Juliano P. [UNESP]
Monteiro, Douglas R.
dc.subject.por.fl_str_mv biofilms
Candida
chitosan
fluconazole
iron oxide nanoparticles
topic biofilms
Candida
chitosan
fluconazole
iron oxide nanoparticles
description Aim: To assemble, characterize and assess the antifungal effects of a new fluconazole (FLZ)-carrier nanosystem. Materials & methods: The nanosystem was prepared by loading FLZ on chitosan (CS)-coated iron oxide nanoparticles (IONPs). Antifungal effects were evaluated on planktonic cells (by minimum inhibitory concentration determination) and on biofilms (by quantification of cultivable cells, total biomass, metabolism and extracellular matrix) of Candida albicans and Candida glabrata. Results: Characterization results ratified the formation of a nanosystem (<320 nm) with FLZ successfully embedded. IONPs-CS-FLZ nanosystem reduced minimum inhibitory concentration values and, in general, showed similar antibiofilm effects compared with FLZ alone. Conclusion: IONPs-CS-FLZ nanosystem was more effective than FLZ mainly in inhibiting Candida planktonic cells. This nanocarrier has potential to fight fungal infections.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T02:02:37Z
2020-12-12T02:02:37Z
2020-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.2217/fmb-2019-0182
Future Microbiology, v. 15, n. 4, p. 273-285, 2020.
1746-0921
1746-0913
http://hdl.handle.net/11449/200287
10.2217/fmb-2019-0182
2-s2.0-85083369822
url http://dx.doi.org/10.2217/fmb-2019-0182
http://hdl.handle.net/11449/200287
identifier_str_mv Future Microbiology, v. 15, n. 4, p. 273-285, 2020.
1746-0921
1746-0913
10.2217/fmb-2019-0182
2-s2.0-85083369822
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Future Microbiology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 273-285
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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