Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/s13293-021-00371-6 http://hdl.handle.net/11449/207924 |
Resumo: | BACKGROUND: Ethanol use is related to a wide variety of negative health outcomes, including cardiovascular diseases. Stress is also involved in numerous pathologies, such as cardiovascular diseases and psychiatric disorders. Sexual dimorphism is an important factor affecting cardiovascular response and has been proposed as a potential risk factor for sex-specific health problems in humans. Here, we evaluated the effect of prolonged ethanol vapor inhalation on arterial pressure, heart rate, and tail skin temperature responses to acute restraint stress, investigating differences between male and female rats. METHODS: We exposed male and female Long-Evans rats to ethanol vapor for 14 h, followed by ethanol withdrawal for 10 h, for 30 consecutive days, or to room air (control groups). The animals underwent surgical implantation of a cannula into the femoral artery for assessment of arterial pressure and heart rate values. The tail skin temperature was measured as an indirect measurement of sympathetic vasomotor response. RESULTS: Chronic ethanol vapor inhalation reduced basal heart rate in both female and male rats. Sex-related difference was observed in the decrease of tail cutaneous temperature evoked by stress, but not in the pressor and tachycardiac responses. Furthermore, prolonged ethanol inhalation enhanced the blood pressure and heart rate increase caused by acute restraint stress in male, but not in female rats. However, no effect of chronic ethanol vapor was observed in the tail cutaneous temperature response to restraint in either sex. CONCLUSION: Chronic ethanol vapor exposure increased the cardiovascular reactivity to stress in male, but not in female rats. |
id |
UNSP_45a8f56481e696ad3f0979386f270ad2 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/207924 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female ratsAlcoholBlood pressureHeart rateRestraint stressSexBACKGROUND: Ethanol use is related to a wide variety of negative health outcomes, including cardiovascular diseases. Stress is also involved in numerous pathologies, such as cardiovascular diseases and psychiatric disorders. Sexual dimorphism is an important factor affecting cardiovascular response and has been proposed as a potential risk factor for sex-specific health problems in humans. Here, we evaluated the effect of prolonged ethanol vapor inhalation on arterial pressure, heart rate, and tail skin temperature responses to acute restraint stress, investigating differences between male and female rats. METHODS: We exposed male and female Long-Evans rats to ethanol vapor for 14 h, followed by ethanol withdrawal for 10 h, for 30 consecutive days, or to room air (control groups). The animals underwent surgical implantation of a cannula into the femoral artery for assessment of arterial pressure and heart rate values. The tail skin temperature was measured as an indirect measurement of sympathetic vasomotor response. RESULTS: Chronic ethanol vapor inhalation reduced basal heart rate in both female and male rats. Sex-related difference was observed in the decrease of tail cutaneous temperature evoked by stress, but not in the pressor and tachycardiac responses. Furthermore, prolonged ethanol inhalation enhanced the blood pressure and heart rate increase caused by acute restraint stress in male, but not in female rats. However, no effect of chronic ethanol vapor was observed in the tail cutaneous temperature response to restraint in either sex. CONCLUSION: Chronic ethanol vapor exposure increased the cardiovascular reactivity to stress in male, but not in female rats.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Laboratory of Neuropsypharmacology School of Pharmaceutical Sciences São Paulo State University (UNESP), Rod. Araraquara-Jaú km 1Joint Graduate Program in Physiological Sciences UFSCar/UNESP, Rod. Washington Luís km 235Laboratory of Pharmacology Paulista Medicine School Universidade Federal de São Paulo - UNIFESP Leal Prado Building, Botucatu 862 StreetVila ClementinoLaboratory of Psychology Psychology Department Universidade Federal de São Carlos - UFSCar, Rod. Washington Luís km 235Joint Graduate Program in Pharmacology Pharmacology and Molecular Biology Institute - INFAR, Três de Maio 100 StreetVila ClementinoBiomedical Sciences Institute Universidade Federal de UberlândiaLaboratory of Neuropsypharmacology School of Pharmaceutical Sciences São Paulo State University (UNESP), Rod. Araraquara-Jaú km 1Joint Graduate Program in Physiological Sciences UFSCar/UNESP, Rod. Washington Luís km 235CNPq: 164060/2014-6FAPESP: 2013/24896-2Universidade Estadual Paulista (Unesp)Universidade Federal de São Paulo (UNIFESP)Universidade Federal de São Carlos (UFSCar)Pharmacology and Molecular Biology Institute - INFARUniversidade Federal de Uberlândia (UFU)Bianchi, Paula C. [UNESP]Gomes-de-Souza, Lucas [UNESP]Costa-Ferreira, Willian [UNESP]Palombo, Paola [UNESP]Carneiro de Oliveira, Paulo E.Engi, Sheila A.Leão, Rodrigo M.Planeta, Cleopatra S. [UNESP]Crestani, Carlos C. [UNESP]Cruz, Fabio C.2021-06-25T11:03:17Z2021-06-25T11:03:17Z2021-03-16info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article27http://dx.doi.org/10.1186/s13293-021-00371-6Biology of sex differences, v. 12, n. 1, p. 27-, 2021.2042-6410http://hdl.handle.net/11449/20792410.1186/s13293-021-00371-62-s2.0-8510314331825147625452809420000-0002-1378-6327Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiology of sex differencesinfo:eu-repo/semantics/openAccess2022-02-09T15:36:37Zoai:repositorio.unesp.br:11449/207924Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:15:21.600607Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats |
title |
Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats |
spellingShingle |
Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats Bianchi, Paula C. [UNESP] Alcohol Blood pressure Heart rate Restraint stress Sex |
title_short |
Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats |
title_full |
Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats |
title_fullStr |
Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats |
title_full_unstemmed |
Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats |
title_sort |
Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats |
author |
Bianchi, Paula C. [UNESP] |
author_facet |
Bianchi, Paula C. [UNESP] Gomes-de-Souza, Lucas [UNESP] Costa-Ferreira, Willian [UNESP] Palombo, Paola [UNESP] Carneiro de Oliveira, Paulo E. Engi, Sheila A. Leão, Rodrigo M. Planeta, Cleopatra S. [UNESP] Crestani, Carlos C. [UNESP] Cruz, Fabio C. |
author_role |
author |
author2 |
Gomes-de-Souza, Lucas [UNESP] Costa-Ferreira, Willian [UNESP] Palombo, Paola [UNESP] Carneiro de Oliveira, Paulo E. Engi, Sheila A. Leão, Rodrigo M. Planeta, Cleopatra S. [UNESP] Crestani, Carlos C. [UNESP] Cruz, Fabio C. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de São Paulo (UNIFESP) Universidade Federal de São Carlos (UFSCar) Pharmacology and Molecular Biology Institute - INFAR Universidade Federal de Uberlândia (UFU) |
dc.contributor.author.fl_str_mv |
Bianchi, Paula C. [UNESP] Gomes-de-Souza, Lucas [UNESP] Costa-Ferreira, Willian [UNESP] Palombo, Paola [UNESP] Carneiro de Oliveira, Paulo E. Engi, Sheila A. Leão, Rodrigo M. Planeta, Cleopatra S. [UNESP] Crestani, Carlos C. [UNESP] Cruz, Fabio C. |
dc.subject.por.fl_str_mv |
Alcohol Blood pressure Heart rate Restraint stress Sex |
topic |
Alcohol Blood pressure Heart rate Restraint stress Sex |
description |
BACKGROUND: Ethanol use is related to a wide variety of negative health outcomes, including cardiovascular diseases. Stress is also involved in numerous pathologies, such as cardiovascular diseases and psychiatric disorders. Sexual dimorphism is an important factor affecting cardiovascular response and has been proposed as a potential risk factor for sex-specific health problems in humans. Here, we evaluated the effect of prolonged ethanol vapor inhalation on arterial pressure, heart rate, and tail skin temperature responses to acute restraint stress, investigating differences between male and female rats. METHODS: We exposed male and female Long-Evans rats to ethanol vapor for 14 h, followed by ethanol withdrawal for 10 h, for 30 consecutive days, or to room air (control groups). The animals underwent surgical implantation of a cannula into the femoral artery for assessment of arterial pressure and heart rate values. The tail skin temperature was measured as an indirect measurement of sympathetic vasomotor response. RESULTS: Chronic ethanol vapor inhalation reduced basal heart rate in both female and male rats. Sex-related difference was observed in the decrease of tail cutaneous temperature evoked by stress, but not in the pressor and tachycardiac responses. Furthermore, prolonged ethanol inhalation enhanced the blood pressure and heart rate increase caused by acute restraint stress in male, but not in female rats. However, no effect of chronic ethanol vapor was observed in the tail cutaneous temperature response to restraint in either sex. CONCLUSION: Chronic ethanol vapor exposure increased the cardiovascular reactivity to stress in male, but not in female rats. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T11:03:17Z 2021-06-25T11:03:17Z 2021-03-16 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/s13293-021-00371-6 Biology of sex differences, v. 12, n. 1, p. 27-, 2021. 2042-6410 http://hdl.handle.net/11449/207924 10.1186/s13293-021-00371-6 2-s2.0-85103143318 2514762545280942 0000-0002-1378-6327 |
url |
http://dx.doi.org/10.1186/s13293-021-00371-6 http://hdl.handle.net/11449/207924 |
identifier_str_mv |
Biology of sex differences, v. 12, n. 1, p. 27-, 2021. 2042-6410 10.1186/s13293-021-00371-6 2-s2.0-85103143318 2514762545280942 0000-0002-1378-6327 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Biology of sex differences |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
27 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128488631173120 |