Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats

Detalhes bibliográficos
Autor(a) principal: Bianchi, Paula C. [UNESP]
Data de Publicação: 2021
Outros Autores: Gomes-de-Souza, Lucas [UNESP], Costa-Ferreira, Willian [UNESP], Palombo, Paola [UNESP], Carneiro de Oliveira, Paulo E., Engi, Sheila A., Leão, Rodrigo M., Planeta, Cleopatra S. [UNESP], Crestani, Carlos C. [UNESP], Cruz, Fabio C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1186/s13293-021-00371-6
http://hdl.handle.net/11449/207924
Resumo: BACKGROUND: Ethanol use is related to a wide variety of negative health outcomes, including cardiovascular diseases. Stress is also involved in numerous pathologies, such as cardiovascular diseases and psychiatric disorders. Sexual dimorphism is an important factor affecting cardiovascular response and has been proposed as a potential risk factor for sex-specific health problems in humans. Here, we evaluated the effect of prolonged ethanol vapor inhalation on arterial pressure, heart rate, and tail skin temperature responses to acute restraint stress, investigating differences between male and female rats. METHODS: We exposed male and female Long-Evans rats to ethanol vapor for 14 h, followed by ethanol withdrawal for 10 h, for 30 consecutive days, or to room air (control groups). The animals underwent surgical implantation of a cannula into the femoral artery for assessment of arterial pressure and heart rate values. The tail skin temperature was measured as an indirect measurement of sympathetic vasomotor response. RESULTS: Chronic ethanol vapor inhalation reduced basal heart rate in both female and male rats. Sex-related difference was observed in the decrease of tail cutaneous temperature evoked by stress, but not in the pressor and tachycardiac responses. Furthermore, prolonged ethanol inhalation enhanced the blood pressure and heart rate increase caused by acute restraint stress in male, but not in female rats. However, no effect of chronic ethanol vapor was observed in the tail cutaneous temperature response to restraint in either sex. CONCLUSION: Chronic ethanol vapor exposure increased the cardiovascular reactivity to stress in male, but not in female rats.
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spelling Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female ratsAlcoholBlood pressureHeart rateRestraint stressSexBACKGROUND: Ethanol use is related to a wide variety of negative health outcomes, including cardiovascular diseases. Stress is also involved in numerous pathologies, such as cardiovascular diseases and psychiatric disorders. Sexual dimorphism is an important factor affecting cardiovascular response and has been proposed as a potential risk factor for sex-specific health problems in humans. Here, we evaluated the effect of prolonged ethanol vapor inhalation on arterial pressure, heart rate, and tail skin temperature responses to acute restraint stress, investigating differences between male and female rats. METHODS: We exposed male and female Long-Evans rats to ethanol vapor for 14 h, followed by ethanol withdrawal for 10 h, for 30 consecutive days, or to room air (control groups). The animals underwent surgical implantation of a cannula into the femoral artery for assessment of arterial pressure and heart rate values. The tail skin temperature was measured as an indirect measurement of sympathetic vasomotor response. RESULTS: Chronic ethanol vapor inhalation reduced basal heart rate in both female and male rats. Sex-related difference was observed in the decrease of tail cutaneous temperature evoked by stress, but not in the pressor and tachycardiac responses. Furthermore, prolonged ethanol inhalation enhanced the blood pressure and heart rate increase caused by acute restraint stress in male, but not in female rats. However, no effect of chronic ethanol vapor was observed in the tail cutaneous temperature response to restraint in either sex. CONCLUSION: Chronic ethanol vapor exposure increased the cardiovascular reactivity to stress in male, but not in female rats.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Laboratory of Neuropsypharmacology School of Pharmaceutical Sciences São Paulo State University (UNESP), Rod. Araraquara-Jaú km 1Joint Graduate Program in Physiological Sciences UFSCar/UNESP, Rod. Washington Luís km 235Laboratory of Pharmacology Paulista Medicine School Universidade Federal de São Paulo - UNIFESP Leal Prado Building, Botucatu 862 StreetVila ClementinoLaboratory of Psychology Psychology Department Universidade Federal de São Carlos - UFSCar, Rod. Washington Luís km 235Joint Graduate Program in Pharmacology Pharmacology and Molecular Biology Institute - INFAR, Três de Maio 100 StreetVila ClementinoBiomedical Sciences Institute Universidade Federal de UberlândiaLaboratory of Neuropsypharmacology School of Pharmaceutical Sciences São Paulo State University (UNESP), Rod. Araraquara-Jaú km 1Joint Graduate Program in Physiological Sciences UFSCar/UNESP, Rod. Washington Luís km 235CNPq: 164060/2014-6FAPESP: 2013/24896-2Universidade Estadual Paulista (Unesp)Universidade Federal de São Paulo (UNIFESP)Universidade Federal de São Carlos (UFSCar)Pharmacology and Molecular Biology Institute - INFARUniversidade Federal de Uberlândia (UFU)Bianchi, Paula C. [UNESP]Gomes-de-Souza, Lucas [UNESP]Costa-Ferreira, Willian [UNESP]Palombo, Paola [UNESP]Carneiro de Oliveira, Paulo E.Engi, Sheila A.Leão, Rodrigo M.Planeta, Cleopatra S. [UNESP]Crestani, Carlos C. [UNESP]Cruz, Fabio C.2021-06-25T11:03:17Z2021-06-25T11:03:17Z2021-03-16info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article27http://dx.doi.org/10.1186/s13293-021-00371-6Biology of sex differences, v. 12, n. 1, p. 27-, 2021.2042-6410http://hdl.handle.net/11449/20792410.1186/s13293-021-00371-62-s2.0-8510314331825147625452809420000-0002-1378-6327Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiology of sex differencesinfo:eu-repo/semantics/openAccess2022-02-09T15:36:37Zoai:repositorio.unesp.br:11449/207924Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:15:21.600607Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats
title Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats
spellingShingle Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats
Bianchi, Paula C. [UNESP]
Alcohol
Blood pressure
Heart rate
Restraint stress
Sex
title_short Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats
title_full Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats
title_fullStr Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats
title_full_unstemmed Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats
title_sort Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats
author Bianchi, Paula C. [UNESP]
author_facet Bianchi, Paula C. [UNESP]
Gomes-de-Souza, Lucas [UNESP]
Costa-Ferreira, Willian [UNESP]
Palombo, Paola [UNESP]
Carneiro de Oliveira, Paulo E.
Engi, Sheila A.
Leão, Rodrigo M.
Planeta, Cleopatra S. [UNESP]
Crestani, Carlos C. [UNESP]
Cruz, Fabio C.
author_role author
author2 Gomes-de-Souza, Lucas [UNESP]
Costa-Ferreira, Willian [UNESP]
Palombo, Paola [UNESP]
Carneiro de Oliveira, Paulo E.
Engi, Sheila A.
Leão, Rodrigo M.
Planeta, Cleopatra S. [UNESP]
Crestani, Carlos C. [UNESP]
Cruz, Fabio C.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de São Carlos (UFSCar)
Pharmacology and Molecular Biology Institute - INFAR
Universidade Federal de Uberlândia (UFU)
dc.contributor.author.fl_str_mv Bianchi, Paula C. [UNESP]
Gomes-de-Souza, Lucas [UNESP]
Costa-Ferreira, Willian [UNESP]
Palombo, Paola [UNESP]
Carneiro de Oliveira, Paulo E.
Engi, Sheila A.
Leão, Rodrigo M.
Planeta, Cleopatra S. [UNESP]
Crestani, Carlos C. [UNESP]
Cruz, Fabio C.
dc.subject.por.fl_str_mv Alcohol
Blood pressure
Heart rate
Restraint stress
Sex
topic Alcohol
Blood pressure
Heart rate
Restraint stress
Sex
description BACKGROUND: Ethanol use is related to a wide variety of negative health outcomes, including cardiovascular diseases. Stress is also involved in numerous pathologies, such as cardiovascular diseases and psychiatric disorders. Sexual dimorphism is an important factor affecting cardiovascular response and has been proposed as a potential risk factor for sex-specific health problems in humans. Here, we evaluated the effect of prolonged ethanol vapor inhalation on arterial pressure, heart rate, and tail skin temperature responses to acute restraint stress, investigating differences between male and female rats. METHODS: We exposed male and female Long-Evans rats to ethanol vapor for 14 h, followed by ethanol withdrawal for 10 h, for 30 consecutive days, or to room air (control groups). The animals underwent surgical implantation of a cannula into the femoral artery for assessment of arterial pressure and heart rate values. The tail skin temperature was measured as an indirect measurement of sympathetic vasomotor response. RESULTS: Chronic ethanol vapor inhalation reduced basal heart rate in both female and male rats. Sex-related difference was observed in the decrease of tail cutaneous temperature evoked by stress, but not in the pressor and tachycardiac responses. Furthermore, prolonged ethanol inhalation enhanced the blood pressure and heart rate increase caused by acute restraint stress in male, but not in female rats. However, no effect of chronic ethanol vapor was observed in the tail cutaneous temperature response to restraint in either sex. CONCLUSION: Chronic ethanol vapor exposure increased the cardiovascular reactivity to stress in male, but not in female rats.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T11:03:17Z
2021-06-25T11:03:17Z
2021-03-16
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1186/s13293-021-00371-6
Biology of sex differences, v. 12, n. 1, p. 27-, 2021.
2042-6410
http://hdl.handle.net/11449/207924
10.1186/s13293-021-00371-6
2-s2.0-85103143318
2514762545280942
0000-0002-1378-6327
url http://dx.doi.org/10.1186/s13293-021-00371-6
http://hdl.handle.net/11449/207924
identifier_str_mv Biology of sex differences, v. 12, n. 1, p. 27-, 2021.
2042-6410
10.1186/s13293-021-00371-6
2-s2.0-85103143318
2514762545280942
0000-0002-1378-6327
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biology of sex differences
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 27
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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